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1. 发明专利

JP2010252657A Keto reductase mutant 有权
标题翻译： KETO减少突变体
公开(公告)号：JP2010252657A
公开(公告)日：2010-11-11
申请号：JP2009104555
申请日：2009-04-22
申请人： Meiji Seika Kaisha Ltd , 明治製菓株式会社
发明人： MAZUKA FUSUKE , FUKUSHIMA TAKAE , SUMIDA NAOMI , YANAI KOJI
IPC分类号： C12N15/09 , C07H15/252 , C12N1/21 , C12N9/02 , C12P19/56
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a keto reductase mutant which can be used for efficient production of a daunorubicin derivative, to provide a DNA encoding the mutant, to provide a transformant to which the DNA is transferred and which produces the daunorubicin derivative, and to provide a method for producing the daunorubicin derivative with the transformant.
SOLUTION: This keto reductase mutant is obtained by replacing one or more amino acid residues selected from the group consisting of amino acids at places corresponding to the 42, 149, 153, 270 and 306-amino acids in the amino acid sequence of the keto reductase (EvaE) of a chloroeremomycin-producing microorganism (Amycolatopsis orientalis) by other amino acid residues.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供可用于有效生产柔红霉素衍生物的酮还原酶突变体，以提供编码突变体的DNA，以提供DNA转移的转化体，并产生柔红霉素衍生物并提供用转化体生产柔红霉素衍生物的方法。解决方案：该酮还原酶突变体是通过在氨基酸序列的氨基酸序列中替换选自与对应于第42,149,153,270和306个氨基酸的位置处的氨基酸所选择的一个或多个氨基酸残基获得的由其它氨基酸残基产生的产生叶绿体霉素的微生物（Amycolatopsis orientalis）的酮还原酶（EvaE）。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2004173537A Biosynthesis gene for kanamycin 审中-公开
标题翻译： KANAMYCIN的生物基因组
公开(公告)号：JP2004173537A
公开(公告)日：2004-06-24
申请号：JP2002341504
申请日：2002-11-25
申请人： Meiji Seika Kaisha Ltd , 明治製菓株式会社
发明人： YANAI KOJI , SUMIDA NAOMI , OKAKURA KAORU , HOSHIKO SHIGERU , MURAKAMI TAKESHI
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10
摘要： PROBLEM TO BE SOLVED: To isolate a DNA fragment containing biosynthesis genes for kanamycin, analyze its base sequence and specify each biosynthesis gene. SOLUTION: A genome DNA library is prepared from a genome DNA of Streptomyces kanamyceticus and the DNA fragment containing genes involving biosynthesis of the kanamycin is found from the genome DNA library. Analysis of functions concerning biosynthesis pathway of the kanamycin is carried out by decoding these genes. COPYRIGHT: (C)2004,JPO
摘要翻译：待解决的问题：为了分离含有卡那霉素生物合成基因的DNA片段，分析其碱基序列并指定每个生物合成基因。解决方案：从链霉菌（Streptomyces kanamyceticus）的基因组DNA制备基因组DNA文库，从基因组DNA文库发现含有涉及卡那霉素生物合成的基因的DNA片段。通过对这些基因进行解码来进行卡那霉素生物合成途径的功能分析。版权所有（C）2004，JPO

3. 发明专利

JP2010273580A Method for preparing crystallized mother liquor of 1-kestose 审中-公开
标题翻译：用于制备1-KESTOSE的结晶母液的方法
公开(公告)号：JP2010273580A
公开(公告)日：2010-12-09
申请号：JP2009127780
申请日：2009-05-27
申请人： Meiji Seika Kaisha Ltd , 明治製菓株式会社
发明人： MURASHIMA KOICHIRO , TANI MASATO , NAKANE KIMITAKA , YANAI KOJI , SAKAMOTO KAZUYUKI , TAMURA TAKAYOSHI , HASEGAWA TOSHIBUMI , TAKAHASHI HIROMASA , MURAKAMI TAKESHI
IPC分类号： C12P19/00 , C12N9/24 , C12N15/09
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a new method for easily and inexpensively preparing the crystallized mother liquid of 1-kestose without performing pseudo-moving bed type chromatographic separation on which manufacturing costs are spent. SOLUTION: A method for preparing the crystallized mother liquid of 1-kestose includes: (1) bringing β-fructofuranosidase into contact with sucrose in enzyme solution containing β-fructofuranosidase and glucose oxidase to generate 1-kestose; (2) converting glucose by-produced by the reaction of the process (1) into gluconic acid by glucose oxidase in the solution; and (3) removing the generated gluconic acid from the solution to increase 1-kestose purity in neutral sugar in the solution to 70% or above. As the β-fructofuranosidase, a specific β-fructofuranosidase mutant is used. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种容易且廉价地制备1-kesto的结晶母液的新方法，而不进行花费制造成本的假移动床型色谱分离。解决方案：1-kestose结晶母液的制备方法包括：（1）使β-呋喃果糖苷酶与含有β-呋喃果糖苷酶和葡萄糖氧化酶的酶溶液中的蔗糖接触，产生1-kestose; （2）通过溶液中葡萄糖氧化酶将由方法（1）反应产生的葡萄糖转化成葡萄糖酸; 和（3）从溶液中除去产生的葡萄糖酸，使溶液中的中性糖的1-kestose纯度提高到70％以上。作为β-呋喃果糖苷酶，使用特异的β-呋喃果糖苷酶突变体。版权所有（C）2011，JPO＆INPIT

4. 发明专利

JP2004313022A Endoglucanase mte1 and cellulase preparation containing the same 审中-公开
公开(公告)号：JP2004313022A
公开(公告)日：2004-11-11
申请号：JP2003107958
申请日：2003-04-11
申请人： Meiji Seika Kaisha Ltd , 明治製菓株式会社
发明人： HAMAYA TORU , BABA HIROKO , YANAI KOJI
IPC分类号： A23K1/00 , A23K1/165 , C11D3/386 , C12N1/15 , C12N1/19 , C12N9/42 , C12N15/09 , C12R1/865 , C12S3/08 , C12S11/00
摘要： PROBLEM TO BE SOLVED: To provide an endoglucanase which is useful for the napping reduction, touch improvement, appearance improvement, color clarification and color local change of cellulose-containing yarns, employment in detergent compositions, the deinking of waste paper, the freeness improvement of paper pulp, and the like. SOLUTION: The new endoglucanase MTE1 is isolated and purified from Myriococcum thermophilum. In addition, a gene encoding the endoglucanase MTE1 is isolated and then expressed in a host such as Humicola insolens or Trichoderma viride. COPYRIGHT: (C)2005,JPO&NCIPI

5. 发明专利

JP2004180638A Gentamicin biosynthesis gene 审中-公开
标题翻译： GENTAMICIN BIOSYNTHESIS GENE
公开(公告)号：JP2004180638A
公开(公告)日：2004-07-02
申请号：JP2002354537
申请日：2002-12-06
申请人： Meiji Seika Kaisha Ltd , 明治製菓株式会社
发明人： YANAI KOJI , HOSHIKO SHIGERU , MURAKAMI TAKESHI
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10
摘要： PROBLEM TO BE SOLVED: To isolate DNA fragments containing a gentamicin biosynthesis gene, and to analyze its base sequence thereby specifying individual biosynthesis genes. SOLUTION: A genome DNA library is constructed from the genome DNA of Micromonospora echinospora or Micromonospora purpurea and the DNA fragments containing the gene participating in the gentamicin biosynthesis are picked out from the library. Then, these genes are decoded to analyze the genetic functions relating to the synthetic pathway of gentamicin. COPYRIGHT: (C)2004,JPO&NCIPI

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