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1. 发明专利

JPS5753494A Antibiotic substance sf-2080d and its preparation 失效
标题翻译：抗生素SF-2080D及其制备方法
公开(公告)号：JPS5753494A
公开(公告)日：1982-03-30
申请号：JP12842480
申请日：1980-09-16
申请人： Meiji Seika Kaisha Ltd
发明人： KOYAMA MASAO , INOUE SHIGEHARU , EZAKI NORIO , KOJIMA MICHIO , SHIYOUMURA TAKASHI , ITOU TATSUO
IPC分类号： C07G11/00 , A61K35/74 , A61P31/04 , C12P1/06 , C12R1/465
摘要： NEW MATERIAL:SF-2080D substance having the following characteristics: elemental analysis (%), C36.41, H 1.10, N 3.78, Cl 49.58; molecular weight, 357 (mass spectrum, Cl=35); molecular formula, C
11 H
4 Cl
5 NO
2 ; melting point, 195W198°C; [α]D
25 =0°(C=1.0, methanol); color reactions, positive to Lemieux, FeCl
3 , and Beilstein reactions, negative to ninhydrin reaction; yellow acicular crystal; solubility, easily soluble in acetone and ethyl acetate, soluble in methanol and chloroform, hardly soluble in water n-hexane; etc.
USE: Antimicrobial agent. Remarkably effective fo Gram-positive bacteria, and effective to Gram-negative bacteria and fungi. Useful as drug, animal drug, pesticide, and disinfectant.
PROCESS: The compound can be prepared by culturing a bacterial strain belonging to Streptomyces genus, e.g. Streptomyces sp. SF-2080 (FERM-P No.5072) in a medium, e.g. by aerobic deep-tank cultivation, at 28W32°C.
COPYRIGHT: (C)1982,JPO&Japio
摘要翻译：新材料：具有以下特征的SF-2080D物质：元素分析（％），C36.41，H 1.10，N 3.78，Cl 49.58; 分子量357（质谱，Cl = 35）; 分子式C11H4Cl5NO2; 熔点195-198℃; αD 25 = 0°（C = 1.0，甲醇）; 颜色反应，对Lemieux，FeCl3和Beilstein反应呈正相反应，与茚三酮反应; 黄色针状结晶; 溶解性好，易溶于丙酮和乙酸乙酯，易溶于甲醇和氯仿，难溶于水正己烷; 用途：抗菌剂。对革兰氏阳性菌有显着效果，对革兰氏阴性细菌和真菌有效。用作药物，动物药物，农药和消毒剂。方法：该化合物可以通过培养属于链霉菌属（Streptomyces）属的细菌菌株，例如，链霉菌属 SF-2080（FERM-P No.5072）。通过有氧深层培养，28-32℃。

2. 发明专利

JPS61132192A Novel antibiotic: sf-2330, its preparation and carcinostatic agent containing same as active ingredient 失效
标题翻译：新型抗生素：SF-2330，其制剂和含有相同活性成分的致癌剂
公开(公告)号：JPS61132192A
公开(公告)日：1986-06-19
申请号：JP25405684
申请日：1984-12-03
申请人： Meiji Seika Kaisha Ltd
发明人： ITO JIRO , TSUYUKI TADASHI , SHOMURA TAKASHI , HISAMATSU MITSURU , KOJIMA MICHIO , INOUE SHIGEHARU
IPC分类号： C07G11/00 , A61K31/35 , A61K35/74 , A61P35/00 , C07D407/14 , C12P1/06 , C12P17/16 , C12R1/465
摘要： PURPOSE: A microorganism in Streptomyces, capable of producing the title substance is cultured and the title substance is collected from the culture mixture whereby the title antibiotic which is used as a carcinostatic agent is produced.
CONSTITUTION: A microorganism in Streptomyces, capable of producing SF-2330, such as Streptomyces sp. SF2330 (FERM 7919) is cultured under aerobic conditions and SF-2330 is collected according in a usual manner. The substance inhibits the proliferation of the cells of mouse leukemia P-388, thus being a novel antibiotic used as a carcinostatic agent. The substance has following physical and chemical properties: elementary analyses; C67.35%, H3.65%; molucular formula;C
22 H
14 O
7 : molecular weight, 390; ultraviolet absorption spectra in methanol given in the chart.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：目的：培养能够产生标题物质的链霉菌中的微生物，从培养混合物中收集标题物质，由此生产用作制癌剂的标题抗生素。构成：能够产生SF-2330的链霉菌中的微生物，例如链霉菌属（Streptomyces sp。）。在有氧条件下培养SF2330（FERM7919），按常规方式收集SF-2330。该物质抑制小鼠白血病P-388细胞的增殖，因此是用作制癌剂的新型抗生素。该物质具有以下物理和化学性质：基本分析; C67.35％，H3.65％; 醇溶配方; C22H14O7：分子量390; 甲醇中的紫外吸收光谱见图。

3. 发明专利

JPS6188885A Novel antibiotic substance sf-2370 and its preparation 失效
标题翻译：新型抗生素SF-2370及其制备方法
公开(公告)号：JPS6188885A
公开(公告)日：1986-05-07
申请号：JP21052484
申请日：1984-10-09
申请人： Meiji Seika Kaisha Ltd
发明人： NAKAZAWA TADASHI , KAWASHIMA YUKO , TAKASE YUKIO , ISHIHARA MAMORU , TAKEDA TANETO , SHOMURA TAKASHI , SEZAKI MASAJI , KOJIMA MICHIO
IPC分类号： C07G11/00 , A61K31/475 , A61K35/74 , A61P31/04 , C07D498/18 , C12P1/06 , C12P17/18 , C12R1/03
摘要： NEW MATERIAL:The novel antibiotic substance SF-2370 having the following properties. Appearance, neutral crystalline substance having pale yellow color; elemental analysis, C 69.50%, H 4.74%, N 8.88%; molecular formula, C
27 H
21 N
3 O
5 [molecular weight is 467 (mass analysis, FD-MS)]; melting point, 256°C; specific rotation, [α]D
25 =+57° (C 0.1, methanol); color reactions, positive to Greig- Leaback reagent, and negative to ninhydrin and ferric chloride reagents; solubility, soluble in pyridine, dimethyl-formamide, dimethyl sulfoxide, methyl cellosolve and chloroform, hardly soluble in methanol and ethyl acetate, and insoluble in water and n-hexane.
USE: Antibacterial and antifungal agent.
PREPARATION: A microbial strain belonging to Actinomadura genus and capable of producing SF-2370 substance is cultured, and the objective antibiotic substance SF-2370 is separated from the culture product.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：新材料：具有以下特性的新型抗生素SF-2370。外观，中性结晶物质，淡黄色; 元素分析，C 69.50％，H 4.74％，N 8.88％; 分子式C27H21N3O5 [分子量为467（质谱分析，FD-MS）]; 熔点256℃; 比旋转，αD 25 = + 57度。（C 0.1，甲醇）; 彩色反应，对Greig-Leaback试剂呈阳性，对于茚三酮和氯化铁试剂为阴性; 溶解性，溶于吡啶，二甲基甲酰胺，二甲基亚砜，甲基溶纤剂和氯仿，几乎不溶于甲醇和乙酸乙酯，不溶于水和正己烷。用途：抗菌和抗真菌剂。制备：培养属于放线菌属的能够产生SF-2370物质的微生物菌株，将目的抗生素物质SF-2370与培养物分离。

4. 发明专利

JPS6121090A Novel phosphorus-containing compound and preparation thereof 失效
标题翻译：新颖的含磷化合物及其制备方法
公开(公告)号：JPS6121090A
公开(公告)日：1986-01-29
申请号：JP14242084
申请日：1984-07-11
申请人： Meiji Seika Kaisha Ltd
发明人： IMAI SATOSHI , SATOU ATSUYUKI , MIYAMOTO MASASHI , KAWAMURA KENJI , TSURUOKA TAKASHI , KOJIMA MICHIO
IPC分类号： C07F9/48 , C07F9/30 , C12P9/00 , C12R1/465 , C12R1/55
摘要： NEW MATERIAL:2-Phosphinomethylamlic acid expressed by the formula or a salt thereof.
USE: Capable of improving the production of a substance SF-1293 by adding the above-mentioned novel substance to a process for production and cultivation of the substance SF-1293 useful as a herbicide.
PREPARATION: A microorganism, belonging to the genus Streptomyces, and producing the 2-phosphinometrylmalic acid is cultivated to give a culture, and the aimed 2-phosphominomethylamid acid is collected from the resultant culture. Preferably, fluoroacetic acid or a salt thereof is added to the culture medium for the microorganism producing the 2-phosphominomethylamlic acid.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：新材料：由下式表示的2-膦酰基甲基氨基酸或其盐。用途：通过将上述新物质加入可用作除草剂的物质SF-1293的生产和培养方法中，能够改善物质SF-1293的生产。制备：培养属于链霉菌属的微生物，并生产2-膦酸异丙醇酸，得到培养物，从所得培养物中收集目标的2-磷酸二甲基氨基甲酸。优选将氟乙酸或其盐加入产生2-磷酸二甲基甲基氨基酸的微生物的培养基中。

5. 发明专利

JPS5781498A New antibiotic sf-2103a substance and its preparation 失效
标题翻译：新型抗生素SF-2103A物质及其制备
公开(公告)号：JPS5781498A
公开(公告)日：1982-05-21
申请号：JP15763180
申请日：1980-11-11
申请人： Meiji Seika Kaisha Ltd
发明人： ITOU TATSUO , SHIYOUMURA TAKASHI , KOJIMA MICHIO , EZAKI NORIO , SEZAKI MASAJI , NIWA TOMIZOU
IPC分类号： C07G11/00 , A61K31/397 , A61K31/40 , A61K35/74 , A61P31/04 , C07D477/00 , C12P1/06 , C12P17/18 , C12R1/465
摘要： NEW MATERIAL:An antibiotic substance SF-2103A or its salt. Its trisodium salt shows following properties: white powder by freeze-drying; it shows unclear melting point, browing at 168 °C and decomposing with evolving gas; [α]D
20 = -16.3° (c=1, water); elementary analyses (%): as C
9 H
8 NO
10 S
2 Na
3 .2H
2 O, N 3,00, O 23.62, H 2.44, N 3.00, O 42.16 (remaining after subtraction of other elements), S 13.81, Na 14.97 (by atomic absorption spectroscopy); esily soluble in water, soluble in methanol, insoluble in ethyl acetate, chloroform; positive to Lemieux and Ehrlich reagents and negative to ninhydrin reagent.
USE: Antibiotic against gram-positive and -negative bacteria including resistant bacteria.
PREPARATION: For example, a strain of Streptomyces sp SF-2103, which has been separated from the soil in Katsuura of KII peninsula, (FERM 5636) is cultured by the submerged fermentation method at 23W30°C.
COPYRIGHT: (C)1982,JPO&Japio
摘要翻译：新材料：抗生素SF-2103A或其盐。其三钠盐具有以下性质：通过冷冻干燥的白色粉末; 它显示不清楚的熔点，浏览168度，并与演化气体分解; αD 20 = -16.3度（c = 1，水）; 元素分析（％）：作为C 9 H 8 NO 10 S 2 Na 3·2H 2 O，N 3,00，O 23.62，H 2.44，N 3.00，O 42.16（减去其他元素后剩余），S 13.81，Na 14.97（通过原子吸收光谱）; 易溶于水，溶于甲醇，不溶于乙酸乙酯，氯仿; 对Lemieux和Ehrlich试剂呈阳性，对茚三酮试剂阴性。用途：抗革兰氏阳性和阴性细菌（包括抗性细菌）的抗生素。制备：例如，通过浸没发酵法在23-30℃培养已经从KII半岛Katsuura的土壤中分离出的Streptomyces sp SF-2103菌株（FERM 5636）。

6. 发明专利

JPS59216592A Production of phosphonoformic acid 失效
标题翻译：生产磷酸
公开(公告)号：JPS59216592A
公开(公告)日：1984-12-06
申请号：JP9159083
申请日：1983-05-26
申请人： Meiji Seika Kaisha Ltd
发明人： IMAI SATOSHI , TSURUOKA TAKASHI , MIYAMOTO MASASHI , TAKEBE HIDEAKI , SATOU ATSUYUKI , KOJIMA MICHIO
IPC分类号： C12P7/40
摘要： PURPOSE: To obtain phosphonoformic acid with a high productivity by breeding species to be used and changed in cultivation conditions, by cultivating a strain of the genus Streptomyces under aerobic conditions, and collecting the phosphonoformic acid from the resultant culture fluid.
CONSTITUTION: A strain belonging to the genus Streptomyces, e.g. Streptomyces hygroscopicus SF-1293 strain (FERM-P No. 996), is cultivated in a culture medium used usually for cultivating a microorganism of the genus Streptomyces under aerobic conditions preferably at about 28°C for 4W6 days. The resultant culture fluid is then usually subjected to chromatography, etc. to give the aimed phosphonoformic acid.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过在需氧条件下培养链霉菌属菌株，并从所得培养液中收集膦酰甲酸，以培养物种并通过培育条件种植而获得具有高生产率的膦酰基酸。构成：属于链霉菌属的菌株，例如吸水链霉菌SF-1293菌株（FERM-P No.996）培养在通常用于在需氧条件下培养链霉菌属微生物的培养基中，优选在约28℃下培养4-6天。然后将得到的培养液通常进行色谱等，得到目标膦酰甲酸。

7. 发明专利

JPS5743694A Preparation of antibiotic dactimicin 失效
标题翻译：抗生素的制备
公开(公告)号：JPS5743694A
公开(公告)日：1982-03-11
申请号：JP11647980
申请日：1980-08-26
申请人： Meiji Seika Kaisha Ltd
发明人： MIYAJI SHINJI , OOBA KAZUNORI , AMANO SHIYOUICHI , SHIYOUMURA TAKASHI , KOJIMA MICHIO , ITOU TATSUO
IPC分类号： C12P19/48 , C12R1/01
摘要： PURPOSE: To collect the titled antibiotic from a culture, by cultivating a microorganism, belonging to the genus Dactylosporangium, and capable of producing the titled antibiotic.
CONSTITUTION: A species of the genus Dactylosporangium, e.g. Dactylosporangium vinaceum SF-2127 (FERM-P No. 5610) or Dactylosporangium matsuzakiense, is cultivated in an ordinary culture medium containing a carbon source, e.g. glucose, starch syrup or starch, a nitrogen source, e.g. soybean flour, peptone or meat extract, and an inorganic salt, under aerobic conditions, and the resultant dactimicin produced and accumulated in the culture fluid is then isolated. After the removal of the microbial cells, the isolation and purification steps are carried out by the chromatography with a cation exchange resin, desalination etc. to give the aimed dactimicin of high purity.
COPYRIGHT: (C)1982,JPO&Japio
摘要翻译：目的：从培养物中收集属于Dactylosporangium属的微生物，并能够生产标题抗生素从文化中收集标题抗生素。构成：Dactylosporangium属的种类，例如将Dactylosporangium vinaceum SF-2127（FERM-P No.5610）或Dactylosporangium matsuzakiense在含有碳源的普通培养基中培养。葡萄糖，淀粉糖浆或淀粉，氮源，例如。大豆粉，蛋白胨或肉提取物和无机盐，然后分离产生并积累在培养液中的所得到的活性二聚糖。除去微生物细胞后，通过用阳离子交换树脂，脱盐等进行色谱分离和纯化步骤，得到高纯度的目标番茄红素。

8. 发明专利

JPS5756492A Antibiotic sf-2080c and its preparation 失效
标题翻译：抗生素SF-2080C及其制备
公开(公告)号：JPS5756492A
公开(公告)日：1982-04-05
申请号：JP12842380
申请日：1980-09-16
申请人： Meiji Seika Kaisha Ltd
发明人： EZAKI NORIO , SHIYOUMURA TAKASHI , KOJIMA MICHIO , KOYAMA MASAO , INOUE SHIGEHARU , ITOU TATSUO
IPC分类号： C07G11/00 , A61K35/74 , A61P31/04 , C12P1/06 , C12R1/465
摘要： NEW MATERIAL:Substance SF-2080 having following properties: elementary analysis, C 40.92%, H 1.53%, N 4.24% and chlorine 43.63; molecular weight, 323 (measured by means of mass spectrum, Cl=35); molecular formula, C
11 H
5 Cl
4 NO
2 ; melting point, 220W221°C, specific rotatory power,[α]D
25 =0 (c=1.0 in methanol); positive to Lemieux, ferric chloride and Beilstein reactions, negative to ninhydrin reaction; yellow needle crystal; weakly acidic; easily soluble in acetone and ethyl acetate, soluble in methanol and chloroform, hard soluble in water and n-hexane.
USE: Antibiotic against gram-positive bacteria: it is used as a medicine, drug for verterinary, antispetic agent or intermediate thereof.
PREPARATION: A strain in Streptomyces such as Streptomyces sp SF-2080 (FERM- 5072) is aerobically cultured by the submerged fermentation at 28W32°C.
COPYRIGHT: (C)1982,JPO&Japio
摘要翻译：新材料：具有以下特性的物质SF-2080：元素分析，C 40.92％，H 1.53％，N 4.24％和氯43.63; 分子量323（通过质谱测定，Cl = 35）; 分子式C11H5Cl4NO2; 熔点220-221℃，比旋光度，αD 25 = 0（甲醇中c = 1.0）; 阳性对Lemieux，氯化铁和Beilstein反应，负向茚三酮反应; 黄针晶; 弱酸性易溶于丙酮和乙酸乙酯，溶于甲醇和氯仿，难溶于水和正己烷。用途：针对革兰氏阳性菌的抗生素：用作药物，药物用于复方，抗反应剂或其中间体。制备：在28-32摄氏度的浸没发酵中，将链霉菌如Streptomyces sp SF-2080（FERM-5072）中的菌株进行有氧培养。

9. 发明专利

JPS5736989A Preparation of novel antibiotic substance sf-2103a 失效
标题翻译：空值
公开(公告)号：JPS5736989A
公开(公告)日：1982-02-27
申请号：JP11299680
申请日：1980-08-19
申请人： Meiji Seika Kaisha Ltd
发明人： ITO TATSUO , SHOMURA TAKASHI , KOJIMA MICHIO , EZAKI NORIO , SEZAKI MASAJI , NIWA TOMIZO
IPC分类号： C07G11/00 , A61K35/74 , A61P31/04 , C12P1/06 , C12R1/465
摘要： PURPOSE: To prepare a novel antibiotic substance SF-2103A substance, having β- lactamase inhibiting activity and exhibiting synergistic antibacterial activity by the combined use with a β-lactam antibiotic substance, by culturing actinomyces belonging to Streptomyces genus.
CONSTITUTION: A novel microbial species belonging to Streptomyces genus, Streptomyces sulfonofaciens SF-2103 (FERM-P No.5636), is inoculated in a nutrient medium. and cultured under aerobic conditions. The objective novel antibiotic substance, SF-2103A substance, or its salt, can be separated from the cultured product.
COPYRIGHT: (C)1982,JPO&Japio
摘要翻译：目的：通过培养属于链霉菌属的放线菌，制备具有β-内酰胺酶抑制活性并通过与β-内酰胺抗生素物质联合使用具有协同抗菌活性的新型抗生素物质SF-2103A物质。构成：将一种属于链霉菌属（Streptomyces genus），链霉菌属（Streptomyces sulphofaciens）SF-2103（FERM-P No.5636）的新型微生物菌种接种在营养培养基中。并在有氧条件下培养。可将目的新型抗生素物质SF-2103A物质或其盐与培养产物分离。

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