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1. 发明专利

JP2010235520A Agent for preventing blood vessel from aging 有权
标题翻译：用于防止老年人流血的药剂
公开(公告)号：JP2010235520A
公开(公告)日：2010-10-21
申请号：JP2009085718
申请日：2009-03-31
申请人： Meiji Pharmaceutical Univ , Nof Corp , 学校法人明治薬科大学 , 日油株式会社
发明人： MOTOJIMA KIYOTO , MITA MITSUO , OKUBO TAKESHI
IPC分类号： A61K31/685 , A61P9/00
摘要： PROBLEM TO BE SOLVED: To provide an agent for preventing blood vessels from aging.
SOLUTION: The agent for preventing blood vessels from aging includes phosphatidylserine or a salt thereof as an active constituent. The content of phosphatidylserine is preferably ≥50 mass%. The phosphatidylserine can be obtained by a method of such as enzymatically converting soy bean lecithin in the presence of serine. The energy supply amount by the phosphatidylserine is preferably 0.5-35% of a total energy supply amount by lipid. Particularly, it is preferable to ingest approximately 0.5-3 g of the phosphatidylserine a day.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供防止血管老化的药剂。解决方案：用于防止血管衰老的药剂包括磷脂酰丝氨酸或其盐作为活性成分。磷脂酰丝氨酸的含量优选为≥50质量％。磷脂酰丝氨酸可以通过在丝氨酸存在下酶促转化大豆卵磷脂的方法获得。磷脂酰丝氨酸的能量供给量优选为脂质的总能量供给量的0.5〜35％。特别优选每天摄取约0.5-3g磷脂酰丝氨酸。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2010105946A Muscle protein enhancer and drug or food containing the same 审中-公开
标题翻译：肌肉蛋白增强剂和含有其的药物或食物
公开(公告)号：JP2010105946A
公开(公告)日：2010-05-13
申请号：JP2008278649
申请日：2008-10-29
申请人： Nof Corp , 日油株式会社
发明人： ISAJI TOMOYA , OKUBO TAKESHI , ASADA MASAKI , KIDO YASUHIRO , KUWAHADA MASASHI , KOBAYASHI YUKIKO , TADA ERIKO
IPC分类号： A61K31/685 , A23L1/30 , A61P3/02 , A61P21/00
摘要： PROBLEM TO BE SOLVED: To provide a muscle protein enhancer which enhances the muscle protein to maintain or recover good muscle by taking notice of the muscle tissue in preventing decubitus and improving its condition since bedridden patients are increasing with an increase of the elderly in recent years and, in conjunction therewith, the decubitus becomes an issue of public concern.
SOLUTION: The muscle protein enhancer has a phospholipid containing not less than 15 mass% docosahexaenoic acid in the constituting fatty acids as an active ingredient. The muscle protein enhancer has a phospholipid derived from fish eggs as the phospholipid.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种肌肉蛋白质增强剂，其通过注意肌肉组织以预防褥疮和改善其状况来增强肌肉蛋白质以维持或恢复良好的肌肉，因为卧床患者随着老年人的增加而增加近年来，与此同时，褥疮成为公众关注的问题。解决方案：肌肉蛋白增强剂在构成的脂肪酸中作为活性成分具有含有不少于15质量％的二十二碳六烯酸的磷脂。肌肉蛋白增强剂具有来源于鱼卵作为磷脂的磷脂。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2015007001A ワーキングメモリー改善剤审中-公开
标题翻译：工作记忆改善
公开(公告)号：JP2015007001A
公开(公告)日：2015-01-15
申请号：JP2013132027
申请日：2013-06-24
申请人：日油株式会社 , Nof Corp
发明人： YUHAKU ATSUSHI , IEMITSU MOTOYUKI , OKUBO TAKESHI
IPC分类号： A61K31/685 , A23L1/30 , A61P25/28
摘要：【課題】ワーキングメモリー改善効果を示す組成物として有効な食品や医薬品を提供すること。【解決手段】sn−グリセロ(3)ホスホコリンを有効成分として含有するワーキングメモリー改善剤。当該ワーキングメモリー改善剤は、好適には、身体活動強度で3〜6METs(メッツ)、且つ身体活動量で1EX(エクササイズ)以上の身体活動と併用される。【選択図】なし
摘要翻译：要解决的问题：提供作为显示工作记忆改善效果的组合物的食品和药物有效。解决方案：工作记忆改进剂包含sn-甘油（3）磷酸胆碱作为活性成分。工作记忆改进剂优选地以身体活动强度为3-6个MET的身体活动和身体活动量为1EX以上的身体活动使用。

4. 发明专利

JP2013203729A Collagen production promoter 审中-公开
标题翻译：胶原生产促销
公开(公告)号：JP2013203729A
公开(公告)日：2013-10-07
申请号：JP2012077771
申请日：2012-03-29
申请人： Nof Corp , 日油株式会社 , Osaka City Univ , 公立大学法人大阪市立大学
发明人： OKUBO TAKESHI , YUASA AKIKO , YUASA ISAO
IPC分类号： A61K8/55 , A23L1/30 , A61K8/19 , A61K8/44 , A61K8/60 , A61Q19/00 , A61Q19/08
摘要： PROBLEM TO BE SOLVED: To provide a collagen production promoter ameliorating the turnover of the skin by directly promoting the collagen production in the fibroblasts in the cutis layer, and capable of maintaining the dermal function thereby.SOLUTION: There is provided a collagen production promoter containing sn-glycero(3)phosphocholine as an active ingredient.
摘要翻译：要解决的问题：提供通过直接促进切片层中的成纤维细胞中的胶原蛋白生成并且能够维持皮肤功能的胶原产生促进剂来改善皮肤的周转。解决方案：提供含有（3）磷酸胆碱作为活性成分。

5. 发明专利

JP2013202005A Curcumin-containing oil and fat, and method for producing the same 审中-公开
标题翻译：含有含油腻油和脂肪的方法及其生产方法
公开(公告)号：JP2013202005A
公开(公告)日：2013-10-07
申请号：JP2012076144
申请日：2012-03-29
申请人： National Agriculture & Food Research Organization , 独立行政法人農業・食品産業技術総合研究機構 , Nof Corp , 日油株式会社
发明人： ISOBE SEIICHIRO , TAKENAKA MAKIKO , OKUBO TAKESHI
IPC分类号： A23L1/30 , A23D9/02
摘要： PROBLEM TO BE SOLVED: To provide a method for industrially efficiently producing a curcumin-containing oil and fat with high safety, and to provide the curcumin-containing oil and fat having excellent safety.SOLUTION: This curcumin-containing oil and fat is formed by dissolving curcumins in a medium-chain fatty acid triglyceride. In a method for producing the curcumin-containing oil and fat, a mixture of Curcuma and the medium-chain fatty acid triglyceride is ground by use of a wet type grinding mill, and next, oil is squeezed.
摘要翻译：要解决的问题：提供一种工业上高效率地制造含有姜黄素的油脂的方法，并且提供具有优异安全性的含有姜黄素的油脂。解决方案：该含姜黄素的油脂由将姜黄素溶解在中链脂肪酸甘油三酯中。在含有姜黄素的油脂的制造方法中，使用湿式研磨机研磨姜黄和中链脂肪酸甘油三酯的混合物，然后挤压油。

6. 发明专利

JP2011046668A Regulator for sustained secretion of glp-1 and insulin 审中-公开
标题翻译：用于GLP-1和胰岛素的持续分泌的调节剂
公开(公告)号：JP2011046668A
公开(公告)日：2011-03-10
申请号：JP2009198183
申请日：2009-08-28
申请人： Nof Corp , Pharma Frontier Kk , ファルマフロンティア株式会社 , 日油株式会社
发明人： OKUBO TAKESHI , TSUSHIMA SAWAE , TAKAHARA YOSHIYUKI
IPC分类号： A61K31/20 , A61K9/10 , A61K31/19 , A61K31/202 , A61K36/53 , A61P1/04 , A61P3/10 , A61P5/48 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a regulator for sustained secretion of not only GLP-1 (glucagon-like peptide-1) but also insulin, which can promote secretion of GLP-1 and secretion of insulin and further can sustain blood concentration of these at high level, and in addition, to provide a food composition including the regulator for sustained secretion.
SOLUTION: The regulator can promote secretion of GLP-1 and insulin in blood, and further can sustain the GLP-1 and insulin in blood at high level for a long time, by utilizing a free fatty acid acting as a ligand to GT01 protein, further emulsifying the free fatty acid, namely involving the free fatty acid in an emulsion, and administering the resultant.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供不仅可以分泌GLP-1（胰高血糖素样肽-1）而且可以促进GLP-1的分泌和胰岛素分泌并进一步维持血液的胰岛素的调节剂这些浓度在高水平，此外，提供包括用于持续分泌的调节剂的食物组合物。调节剂可以促进血液中GLP-1和胰岛素的分泌，并且可以通过利用作为配体的游离脂肪酸进一步维持长时间高水平的血液中的GLP-1和胰岛素 GT01蛋白质，进一步乳化游离脂肪酸，即在乳剂中包含游离脂肪酸，并施用所得物。版权所有（C）2011，JPO＆INPIT

7. 发明专利

JP2010189344A Agent for lowering blood acetaldehyde level 有权
标题翻译：降低血液乙酰胆碱水平的药剂
公开(公告)号：JP2010189344A
公开(公告)日：2010-09-02
申请号：JP2009036936
申请日：2009-02-19
申请人： Nof Corp , 日油株式会社
发明人： OKUBO TAKESHI , ITO TOSHIHIRO
IPC分类号： A61K31/045 , A23L1/30 , A23L2/52 , A61P3/00
摘要： PROBLEM TO BE SOLVED: To provide an agent for lowering a blood acetaldehyde level, exhibiting excellent effects for lowering the blood acetaldehyde level, safely usable, preventing or reducing the occurrence of symptom of hangover such as retching, nausea and dizziness, caused by drinking, and useful for preventing or reducing liver function failure caused by an alcohol, and to provide a food and drink for lowering the blood acetaldehyde level. SOLUTION: The agent for lowering the blood acetaldehyde level, and the food and drink for lowering the blood acetaldehyde level contain one or more kinds selected from the group consisting of 22-36C higher aliphatic alcohols as active ingredients. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：为了提供降低血液乙醛水平的药剂，显示出优异的降低血液乙醛水平的效果，可安全使用，预防或减少诸如呕吐，恶心和眩晕的宿醉症状的发生，引起通过饮用，可用于预防或减少由酒精引起的肝功能衰竭，并提供用于降低血液乙醛水平的食物和饮料。解决方案：用于降低血液乙醛水平的药剂和用于降低血液乙醛水平的食品和饮料含有选自22-36℃高级脂族醇作为活性成分的一种或多种。版权所有（C）2010，JPO＆INPIT

8. 发明专利

JP2010053054A Method of ameliorating sleep 审中-公开
标题翻译：睡眠障碍的方法
公开(公告)号：JP2010053054A
公开(公告)日：2010-03-11
申请号：JP2008217607
申请日：2008-08-27
申请人： Nof Corp , 日油株式会社
发明人： KOBAYASHI TOSHITAKA , ISHIKAWA TORU , OKUBO TAKESHI , TSUSHIMA SAWAE
IPC分类号： A61K35/60 , A61P25/20
摘要： PROBLEM TO BE SOLVED: To provide a method of ameliorating the quality of sleep by improving physical constitution with the use of a safe material derived from a natural substance since the method of ameliorating sleep which can obtain an effect by taking for a long period while improving the physical constitution as with a herbal medicine, separately from a quick acting drug such as a hypnotic and a sleep inducer is demanded for a person having sleep disorders. SOLUTION: The method of ameliorating sleep comprises orally taking 0.1-10 g fish egg oil extracted from fish eggs per day for two months or more. A capsule filled with 0.03-0.5 mg fish egg oil is used in the method of ameliorating sleep. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供一种通过使用来自天然物质的安全材料改善身体构成来改善睡眠质量的方法，因为改善睡眠的方法可以通过长时间获得效果而对于具有睡眠障碍的人，要求与诸如催眠和睡眠诱导剂的快速作用药物分开地改善身体素质的时期。解决方案：改善睡眠的方法包括每天从鱼卵中提取0.1-10克鱼卵油两个月以上。在改善睡眠的方法中使用装有0.03-0.5毫克鱼卵油的胶囊。版权所有（C）2010，JPO＆INPIT

9. 发明专利

JP2014129254A Anti-aging composition for skin 审中-公开
标题翻译：皮肤抗老化组合物
公开(公告)号：JP2014129254A
公开(公告)日：2014-07-10
申请号：JP2012286538
申请日：2012-12-28
申请人： Nof Corp , 日油株式会社
发明人： OKUBO TAKESHI
IPC分类号： A61K36/28 , A23L1/30 , A61K8/55 , A61K8/97 , A61K31/685 , A61P9/00 , A61P17/00 , A61P43/00 , A61Q19/08
摘要： PROBLEM TO BE SOLVED: To provide an anti-aging composition for the skin useful as an MMP-13 production inhibitor, neovascularization inhibitor, and anti-wrinkle agent, containing an extract of the Asteraceae Tagetes species plant combined with a sn-Glycero-3-phosphocholine.SOLUTION: The anti-aging composition contains the extract of the Asteraceae Tagetes species plant (marigold) combined with sn-Glycero-3-phosphocholine, and has an MMP-13 production inhibiting action, angiogenesis inhibiting action, and anti-wrinkle action.
摘要翻译：要解决的问题：提供一种用作可用作MMP-13产生抑制剂，新生血管抑制剂和抗皱剂的皮肤的抗衰老组合物，其含有菊酯类植物提取物与sn-甘油-3 - 磷酸胆碱。解决方案：抗衰老组合物含有菊酯科植物（万寿菊）与sn-甘油-3-磷酸胆碱结合的提取物，具有MMP-13产生抑制作用，血管生成抑制作用和抗皱纹行动。

10. 发明专利

JP2014129253A Skin function improving agent 审中-公开
标题翻译：皮肤功能改善剂
公开(公告)号：JP2014129253A
公开(公告)日：2014-07-10
申请号：JP2012286530
申请日：2012-12-28
申请人： Nof Corp , 日油株式会社
发明人： OKUBO TAKESHI
IPC分类号： A61K36/28 , A23L1/30 , A61K8/97 , A61P17/00 , A61P29/00 , A61P43/00 , A61Q17/00 , A61Q19/08
摘要： PROBLEM TO BE SOLVED: To provide food products and pharmaceuticals which include extracts of plants of the genus Matricaria in the family Asteraceae as active ingredients, wherein the food products and pharmaceuticals are MMP-1 production inhibitors, and antiinflammatory agents, and have the action to keep skin firmness and the action to prevent wrinkles, and further are effective in improvement of scleroderma.SOLUTION: This invention provides skin function improving agents, antiinflammatory agents, anti-wrinkle agents, and anti-scleroderma agents which include extracts of plants of the genus Matricaria in the family Asteraceae as active ingredients.
摘要翻译：要解决的问题：提供包括菊科植物提取物在菊科中作为活性成分的食品和药物，其中食品和药物是MMP-1生产抑制剂和抗炎剂，并且具有作用保持皮肤紧实度和防止皱纹的作用，进一步有效改善硬皮病。解决方案：本发明提供皮肤功能改善剂，抗炎剂，抗皱剂和抗硬皮病药，其包括属植物的提取物菊科作为菊科作为活性成分。

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