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1. 发明授权

US5216011A Stable solutions of mitomycin C 失效
标题翻译： MITOMYCIN C的稳定解决方案
公开(公告)号：US5216011A
公开(公告)日：1993-06-01
申请号：US401713
申请日：1989-09-01
申请人： Mehdi Paborji , Joseph B. Bogardus , Shreeram N. Agharkar , William P. Coppola
发明人： Mehdi Paborji , Joseph B. Bogardus , Shreeram N. Agharkar , William P. Coppola
IPC分类号： A61K9/08 , A61K9/00 , A61K31/40 , A61K47/10 , A61P35/00
CPC分类号： A61K31/40 , A61K47/10 , A61K9/0019
摘要： A stable solution of mitomycin C in propylene glycol or propylene glycol/water is disclosed. The solutions have an acceptable shelf-life of greater than 24 months at 4.degree. C. and can be injected directly or diluted with water or other aqueous parenteral vehicle for parenteral administration.

2. 发明申请

US20090275629A1 THERAPY FOR THE TREATMENT OF DISEASE 审中-公开
标题翻译：治疗疾病的治疗方法
公开(公告)号：US20090275629A1
公开(公告)日：2009-11-05
申请号：US12503432
申请日：2009-07-15
申请人： Mehdi Paborji
发明人： Mehdi Paborji
IPC分类号： A61K31/4178 , A61P25/00
CPC分类号： A61K31/4178 , A61K31/00 , A61K31/137 , A61K31/216 , A61K31/4025 , A61K31/4172 , A61K31/439 , A61K31/46 , A61K31/717 , A61K33/06 , A61K36/482 , A61K36/68 , A61K36/72 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising various combinations of an antimuscarinic or an anticholinergic agent, a compound that causes stimulation of salivary glands, and a compound that relieves constipation. Also disclosed are methods of treating a patient suffering from overactive bladder comprising administering to the patient the above pharmaceutical composition.
摘要翻译：本文公开了包含抗毒蕈碱或抗胆碱能药物的各种组合，引起唾液腺刺激的化合物和缓解便秘的化合物的药物组合物。还公开了治疗患有膀胱过度活动症的患者的方法，包括向患者施用上述药物组合物。

3. 发明授权

US07781472B2 Therapy for the treatment of disease 有权
公开(公告)号：US07781472B2
公开(公告)日：2010-08-24
申请号：US12710310
申请日：2010-02-22
申请人： Mehdi Paborji
发明人： Mehdi Paborji
IPC分类号： A61K31/4178 , A61K31/216
CPC分类号： A61K31/4178 , A61K31/00 , A61K31/137 , A61K31/216 , A61K31/4025 , A61K31/4172 , A61K31/439 , A61K31/46 , A61K31/717 , A61K33/06 , A61K36/482 , A61K36/68 , A61K36/72 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising oxybutynin, or a free base thereof or a pharmaceutically acceptable salt thereof, and pilocarpine, or a free base thereof or a pharmaceutically acceptable salt thereof. Also disclosed are methods of treating a patient suffering from overactive bladder comprising administering to the patient the above pharmaceutical composition.

4. 发明授权

US09415013B2 Pharmaceutical formulations 有权
标题翻译：药物制剂
公开(公告)号：US09415013B2
公开(公告)日：2016-08-16
申请号：US13078881
申请日：2011-04-01
申请人： Mehdi Paborji , Robert V. Tuohy, III , Peter R. P. Freed , Roger S. Flugel
发明人： Mehdi Paborji , Robert V. Tuohy, III , Peter R. P. Freed , Roger S. Flugel
IPC分类号： A61P13/10 , A61K31/445 , A61K31/4178 , A61K31/4174 , A61K9/16 , A61K9/50
CPC分类号： A61K9/1652 , A61K9/1617 , A61K9/1676 , A61K9/5047 , A61K9/5078 , A61K9/5084 , A61K31/222 , A61K31/4178
摘要： Disclosed herein are pharmaceutical compositions comprising a plurality of first beads each comprising: a core; a first layer comprising pilocarpine or a pharmaceutically acceptable salt thereof; and a second layer comprising a first polymer. Also disclosed are pharmaceutical compositions comprising a plurality of second beads each comprising: a core; and a first layer comprising tolterodine or a pharmaceutically acceptable salt thereof. Further disclosed are pharmaceutical formulations comprising: a) a plurality of the first beads; b) a plurality of the second beads; or c) a plurality of the first beads and a plurality of the second beads.
摘要翻译：本文公开了包含多个第一珠粒的药物组合物，每个第一珠粒各自包含：核心; 包含毛果芸香碱或其药学上可接受的盐的第一层; 和包含第一聚合物的第二层。还公开了包含多个第二珠粒的药物组合物，每个第二珠粒各自包含：核心; 以及包含托特罗定或其药学上可接受的盐的第一层。进一步公开的是药物制剂，其包含：a）多个第一珠粒; b）多个第二珠粒; 或c）多个第一珠和多个第二珠。

5. 发明授权

US09132124B2 Combinations of solifenacin and salivary stimulants for the treatment of overactive bladder 有权
标题翻译：用于治疗膀胱过度活动的索非那新和唾液兴奋剂的组合
公开(公告)号：US09132124B2
公开(公告)日：2015-09-15
申请号：US13476883
申请日：2012-05-21
申请人： Mehdi Paborji , Wendy Jade Limayo Hernandez , Kenneth L. Duchin , Roger S. Flugel
发明人： Mehdi Paborji , Wendy Jade Limayo Hernandez , Kenneth L. Duchin , Roger S. Flugel
IPC分类号： A61K31/4178 , A61K31/4725
CPC分类号： A61K31/4178 , A61K31/4725 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release solifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release solifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release solifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.
摘要翻译：本文公开了包含治疗有效量的延长释放索非那新或其药学上可接受的盐和治疗有效量的毛果芸香碱或其药学上可接受的盐的药物组合物。本文还公开了治疗患有膀胱过度活动症的患者的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放索非那新或其药学上可接受的盐和治疗有效量毛果芸香碱或其药学上可接受的盐。本文还公开了减轻患有其中的患者的膀胱过度活动症的副作用的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放索非那新或其药学上可接受的盐以及治疗有效量的毛果芸香碱或其药学上可接受的盐。

6. 发明授权

US08470864B2 Compositions and methods for the treatment of overactive bladder 有权
标题翻译：用于治疗膀胱过动症的组合物和方法
公开(公告)号：US08470864B2
公开(公告)日：2013-06-25
申请号：US12710301
申请日：2010-02-22
申请人： Mehdi Paborji
发明人： Mehdi Paborji
IPC分类号： A61K31/00 , A61K31/137 , A61K31/216 , A61K31/46
CPC分类号： A61K31/4178 , A61K31/00 , A61K31/137 , A61K31/216 , A61K31/4025 , A61K31/4172 , A61K31/439 , A61K31/46 , A61K31/717 , A61K33/06 , A61K36/482 , A61K36/68 , A61K36/72 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising oxybutynin or tolterodine, or a free base thereof or a pharmaceutically acceptable salt thereof, and pilocarpine, or a free base thereof or a pharmaceutically acceptable salt thereof. Also disclosed are methods of treating a patient suffering from overactive bladder comprising administering to the patient the above pharmaceutical composition.
摘要翻译：本文公开了包含奥昔布宁或托特罗定或其游离碱或其药学上可接受的盐，毛果芸香碱或其游离碱或其药学上可接受的盐的药物组合物。还公开了治疗患有膀胱过度活动症的患者的方法，包括向患者施用上述药物组合物。

7. 发明申请

US20050075271A1 Crystalline beta2 adrenergic receptor agonist 审中-公开
标题翻译：结晶β2肾上腺素能受体激动剂
公开(公告)号：US20050075271A1
公开(公告)日：2005-04-07
申请号：US10627555
申请日：2003-07-25
申请人： Martin Linsell , John Jacobsen , Davar Khossravi , Mehdi Paborji , Weijiang Zhang
发明人： Martin Linsell , John Jacobsen , Davar Khossravi , Mehdi Paborji , Weijiang Zhang
IPC分类号： A61K9/12 , A61K9/72 , A61K31/167 , A61K31/56 , A61K31/573 , A61P9/00 , A61P11/00 , A61P11/04 , A61P15/06 , A61P25/00 , A61P29/00 , C07C213/04 , C07C213/10 , C07C215/30 , C07C233/43 , A61K31/00
CPC分类号： C07C213/04 , C07C215/30 , C07C233/43
摘要： The invention provides a crystalline salt form of a novel β2 adrenergic receptor agonist. The invention also provides pharmaceutical compositions comprising the crystalline form, formulations containing the pharmaceutical compositions, methods of using the crystalline salt form to treat diseases associated with β2 adrenergic receptor activity, and processes useful for preparing such a crystalline compound.
摘要翻译：本发明提供新型β2肾上腺素能受体激动剂的结晶盐形式。本发明还提供包含结晶形式的药物组合物，含有药物组合物的制剂，使用结晶盐形式治疗与β2肾上腺素能受体活性相关的疾病的方法，以及可用于制备这种结晶化合物的方法。

8. 发明授权

US08940763B2 Combinations of solifenacin and salivary stimulants for the treatment of overactive bladder 有权
公开(公告)号：US08940763B2
公开(公告)日：2015-01-27
申请号：US13467195
申请日：2012-05-09
申请人： Mehdi Paborji , Wendy Jade Limayo Hernandez , Kenneth L. Duchin , Roger S. Flugel
发明人： Mehdi Paborji , Wendy Jade Limayo Hernandez , Kenneth L. Duchin , Roger S. Flugel
IPC分类号： A01N43/90 , A61K31/44 , A01N43/50 , A61K31/415 , C07D453/02 , C07D233/00 , A61K31/4725 , A61K31/4178
CPC分类号： A61K31/4178 , A61K31/4725 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release solifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release solifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release solifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.

9. 发明授权

US07678821B2 Compositions for the treatment of overactive bladder 有权
标题翻译：用于治疗膀胱过动症的组合物
公开(公告)号：US07678821B2
公开(公告)日：2010-03-16
申请号：US11467760
申请日：2006-08-28
申请人： Mehdi Paborji
发明人： Mehdi Paborji
IPC分类号： A61K31/4178 , A61K31/137
CPC分类号： A61K31/4178 , A61K31/00 , A61K31/137 , A61K31/216 , A61K31/4025 , A61K31/4172 , A61K31/439 , A61K31/46 , A61K31/717 , A61K33/06 , A61K36/482 , A61K36/68 , A61K36/72 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising combinations of tolterodine, an antimuscarinic agent, and pilocarpine, a compound that causes stimulation of salivary glands. Also disclosed are methods of treating a patient suffering from overactive bladder comprising administering to the patient said pharmaceutical composition.
摘要翻译：本文公开了包含托特罗定，抗毒蕈碱剂和毛果芸香碱的组合的药物组合物，其是引起刺激唾液腺的化合物。还公开了治疗患有膀胱过度活动症的患者的方法，包括向患者施用所述药物组合物。

10. 发明授权

US07666894B2 Therapy for the treatment of disease 有权
标题翻译：治疗疾病治疗
公开(公告)号：US07666894B2
公开(公告)日：2010-02-23
申请号：US12555806
申请日：2009-09-08
申请人： Mehdi Paborji
发明人： Mehdi Paborji
IPC分类号： A61K31/4178 , A61K31/216
CPC分类号： A61K31/4178 , A61K31/00 , A61K31/137 , A61K31/216 , A61K31/4025 , A61K31/4172 , A61K31/439 , A61K31/46 , A61K31/717 , A61K33/06 , A61K36/482 , A61K36/68 , A61K36/72 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising oxybutynin, or a free base thereof or a pharmaceutically acceptable salt thereof, and pilocarpine, or a free base thereof or a pharmaceutically acceptable salt thereof. Also disclosed are methods of treating a patient suffering from overactive bladder comprising administering to the patient the above pharmaceutical composition.
摘要翻译：本文公开了包含奥昔布宁或其游离碱或其药学上可接受的盐，毛果芸香碱或其游离碱或其药学上可接受的盐的药物组合物。还公开了治疗患有膀胱过度活动症的患者的方法，包括向患者施用上述药物组合物。

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