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1. 发明申请

US20120289544A1 COMBINATIONS OF SOLIFENACIN AND SALIVARY STIMULANTS FOR THE TREATMENT OF OVERACTIVE BLADDER 有权
标题翻译：用于治疗过敏性叶片的溶胶素和唾液酸凝胶的组合
公开(公告)号：US20120289544A1
公开(公告)日：2012-11-15
申请号：US13476883
申请日：2012-05-21
申请人： Mehdi PABORJI , Wendy Jade Limayo HERNANDEZ , Kenneth L. DUCHIN , Roger S. FLUGEL
发明人： Mehdi PABORJI , Wendy Jade Limayo HERNANDEZ , Kenneth L. DUCHIN , Roger S. FLUGEL
IPC分类号： A61K31/439 , A61P13/00
CPC分类号： A61K31/4178 , A61K31/4725 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release solifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release solifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release solifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.
摘要翻译：本文公开了包含治疗有效量的延长释放索非那新或其药学上可接受的盐和治疗有效量的毛果芸香碱或其药学上可接受的盐的药物组合物。本文还公开了治疗患有膀胱过度活动症的患者的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放索非那新或其药学上可接受的盐和治疗有效量毛果芸香碱或其药学上可接受的盐。本文还公开了减轻患有其中的患者的膀胱过度活动症的副作用的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放索非那新或其药学上可接受的盐以及治疗有效量的毛果芸香碱或其药学上可接受的盐。

2. 发明申请

US20120289567A1 COMBINATIONS OF DARIFENACIN AND SALIVARY STIMULANTS FOR THE TREATMENT OF OVERACTIVE BLADDER 审中-公开
公开(公告)号：US20120289567A1
公开(公告)日：2012-11-15
申请号：US13476901
申请日：2012-05-21
申请人： Mehdi PABORJI , Kenneth L. DUCHIN , Wendy Jade Limayo HERNANDEZ , Roger S. FLUGEL
发明人： Mehdi PABORJI , Kenneth L. DUCHIN , Wendy Jade Limayo HERNANDEZ , Roger S. FLUGEL
IPC分类号： A61K31/4178 , A61P13/10
CPC分类号： A61K31/4025 , A61K31/4178 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release darifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release darifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release darifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.

3. 发明申请

US20120289560A1 COMBINATIONS OF TOLTERODINE AND SALIVARY STIMULANTS FOR THE TREATMENT OF OVERACTIVE BLADDER 审中-公开
标题翻译：用于治疗过敏性叶片的铁妥黄素和唾液酸凝胶的组合
公开(公告)号：US20120289560A1
公开(公告)日：2012-11-15
申请号：US13467177
申请日：2012-05-09
申请人： Mehdi PABORJI , Kenneth L. DUCHIN , Wendy Jade Limayo HERNANDEZ , Roger S. FLUGEL
发明人： Mehdi PABORJI , Kenneth L. DUCHIN , Wendy Jade Limayo HERNANDEZ , Roger S. FLUGEL
IPC分类号： A61K31/4178 , A61P13/10
CPC分类号： A61K31/137 , A61K31/4178 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release tolterodine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release tolterodine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release tolterodine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.
摘要翻译：本文公开了包含治疗有效量的延长释放托特罗定或其药学上可接受的盐和治疗有效量的毛果芸香碱或其药学上可接受的盐的药物组合物。本文还公开了治疗患有膀胱过度活动症的患者的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放托非罗定或其药学上可接受的盐和治疗有效量毛果芸香碱或其药学上可接受的盐。本文还公开了减轻患有其中的患者的膀胱过度活动症的副作用的方法，该方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放托特罗定或其药学上可接受的盐以及治疗有效量的毛果芸香碱或其药学上可接受的盐。

4. 发明申请

US20120289547A1 COMBINATIONS OF PROPIVERINE AND SALIVARY STIMULANTS FOR THE TREATMENT OF OVERACTIVE BLADDER 审中-公开
标题翻译：丙肝和唾液乳液联合用于治疗过敏性叶片
公开(公告)号：US20120289547A1
公开(公告)日：2012-11-15
申请号：US13468002
申请日：2012-05-09
申请人： Mehdi PABORJI , Wendy Jade Limayo HERNANDEZ , Kenneth L. DUCHIN , Roger S. FLUGEL
发明人： Mehdi PABORJI , Wendy Jade Limayo HERNANDEZ , Kenneth L. DUCHIN , Roger S. FLUGEL
IPC分类号： A61K31/445 , A61P13/10
CPC分类号： A61K31/445 , A61K31/4178 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release propiverine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release propiverine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release propiverine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.
摘要翻译：本文公开了包含治疗有效量的延长释放丙哌嗪或其药学上可接受的盐和治疗有效量的毛果芸香碱或其药学上可接受的盐的药物组合物。本文还公开了治疗患有膀胱过度活动症的患者的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放促丙素或其药学上可接受的盐和治疗有效量毛果芸香碱或其药学上可接受的盐。本文还公开了减轻患有其中的患者的膀胱过度活动症的副作用的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放素或药学上可接受的盐以及治疗有效量的毛果芸香碱或其药学上可接受的盐。

5. 发明申请

US20120289539A1 COMBINATIONS OF TROSPIUM AND SALIVARY STIMULANTS FOR THE TREATMENT OF OVERACTIVE BLADDER 审中-公开
公开(公告)号：US20120289539A1
公开(公告)日：2012-11-15
申请号：US13476912
申请日：2012-05-21
申请人： Mehdi PABORJI , Kenneth L. DUCHIN , Wendy Jade Limayo HERNANDEZ , Roger S. FLUGEL
发明人： Mehdi PABORJI , Kenneth L. DUCHIN , Wendy Jade Limayo HERNANDEZ , Roger S. FLUGEL
IPC分类号： A61K31/439 , A61P13/10
CPC分类号： A61K31/46 , A61K31/4178 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.

6. 发明申请

US20120289529A1 COMBINATIONS OF TROSPIUM AND SALIVARY STIMULANTS FOR THE TREATMENT OF OVERACTIVE BLADDER 审中-公开
标题翻译：用于治疗过敏性叶片的铁和唾液的组合
公开(公告)号：US20120289529A1
公开(公告)日：2012-11-15
申请号：US13467244
申请日：2012-05-09
申请人： Mehdi PABORJI , Kenneth L. DUCHIN , Wendy Jade Limayo HERNANDEZ , Roger S. FLUGEL
发明人： Mehdi PABORJI , Kenneth L. DUCHIN , Wendy Jade Limayo HERNANDEZ , Roger S. FLUGEL
IPC分类号： A61K31/46 , A61P13/10
CPC分类号： A61K31/46 , A61K31/4178 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.
摘要翻译：本文公开了包含治疗有效量的延长释放蚤或其药学上可接受的盐和治疗有效量的毛果芸香碱或其药学上可接受的盐的药物组合物。本文还公开了治疗患有膀胱过度活动症的患者的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放蚤或其药学上可接受的盐和治疗有效量毛果芸香碱或其药学上可接受的盐。本文还公开了减轻患有其中的患者的膀胱过度活动症的副作用的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放蚤或其药学上可接受的盐以及治疗有效量的毛果芸香碱或其药学上可接受的盐。

7. 发明申请

US20140194454A1 COMBINATIONS OF TROSPIUM AND SALIVARY STIMULANTS FOR THE TREATMENT OF OVERACTIVE BLADDER 审中-公开
标题翻译：用于治疗过敏性叶片的铁和唾液的组合
公开(公告)号：US20140194454A1
公开(公告)日：2014-07-10
申请号：US14205168
申请日：2014-03-11
申请人： Mehdi PABORJI , Kenneth L. DUCHIN , Wendy Jade Limayo HERNANDEZ , Roger S. FLUGEL
发明人： Mehdi PABORJI , Kenneth L. DUCHIN , Wendy Jade Limayo HERNANDEZ , Roger S. FLUGEL
IPC分类号： A61K31/46 , A61K31/4178
CPC分类号： A61K31/46 , A61K31/4178 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of immediate release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of immediate release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of immediate release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.
摘要翻译：本文公开了包含治疗有效量的立即释放蚤或其药学上可接受的盐和治疗有效量的毛果芸香碱或其药学上可接受的盐的药物组合物。本文还公开了治疗患有膀胱过度活动症的患者的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的立即释放蚤或其药学上可接受的盐和治疗有效量毛果芸香碱或其药学上可接受的盐。本文还公开了减轻患有其中的患者的膀胱过度活动症的副作用的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的立即释放蚤或其药学上可接受的盐以及治疗有效量的毛果芸香碱或其药学上可接受的盐。

8. 发明申请

US20120289563A1 COMBINATIONS OF IMIDAFENACIN AND SALIVARY STIMULANTS FOR THE TREATMENT OF OVERACTIVE BLADDER 审中-公开
标题翻译： IMIDAFENACIN和SALIVARY STIMULANTS用于治疗过敏性叶片的组合
公开(公告)号：US20120289563A1
公开(公告)日：2012-11-15
申请号：US13467248
申请日：2012-05-09
申请人： Mehdi PABORJI , Wendy Jade Limayo HERNANDEZ , Kenneth L. DUCHIN , Roger S. FLUGEL
发明人： Mehdi PABORJI , Wendy Jade Limayo HERNANDEZ , Kenneth L. DUCHIN , Roger S. FLUGEL
IPC分类号： A61K31/4178 , A61P13/10
CPC分类号： A61K31/4174 , A61K31/4178 , A61K2300/00
摘要： Disclosed are pharmaceutical compositions comprising a therapeutically effective amount of immediate release or orally disintegrating imidafenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of immediate release or orally disintegrating imidafenacin, or pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or pharmaceutically acceptable salt thereof. Also disclosed are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of immediate release or orally disintegrating imidafenacin, or pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or pharmaceutically acceptable salt thereof.
摘要翻译：公开了药物组合物，其包含治疗有效量的立即释放或口服崩解的咪达方案，或其药学上可接受的盐和治疗有效量的毛果芸香碱或其药学上可接受的盐。还公开了治疗患有膀胱过度活动症的患者的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的即时释放或口服崩解的咪达那新或其药学上可接受的盐，以及治疗有效的毛果芸香碱或其药学上可接受的盐的量。还公开了减轻患有其中的患者的膀胱过度活动症的副作用的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的即时释放或口服分解的阿米达海星或药学上可接受的其盐和治疗有效量的毛果芸香碱或其药学上可接受的盐。

9. 发明申请

US20120289543A1 COMBINATIONS OF SOLIFENACIN AND SALIVARY STIMULANTS FOR THE TREATMENT OF OVERACTIVE BLADDER 有权
公开(公告)号：US20120289543A1
公开(公告)日：2012-11-15
申请号：US13467195
申请日：2012-05-09
申请人： Mehdi PABORJI , Wendy Jade Limayo HERNANDEZ , Kenneth L. DUCHIN , Roger S. FLUGEL
发明人： Mehdi PABORJI , Wendy Jade Limayo HERNANDEZ , Kenneth L. DUCHIN , Roger S. FLUGEL
IPC分类号： A61K31/4725 , A61P13/10
CPC分类号： A61K31/4178 , A61K31/4725 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release solifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release solifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release solifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.

10. 发明申请

US20120289530A1 COMBINATIONS OF TROSPIUM AND SALIVARY STIMULANTS FOR THE TREATMENT OF OVERACTIVE BLADDER 审中-公开
公开(公告)号：US20120289530A1
公开(公告)日：2012-11-15
申请号：US13468012
申请日：2012-05-09
申请人： Mehdi PABORJI , Kenneth L. DUCHIN , Wendy Jade Limayo HERNANDEZ , Roger S. FLUGEL
发明人： Mehdi PABORJI , Kenneth L. DUCHIN , Wendy Jade Limayo HERNANDEZ , Roger S. FLUGEL
IPC分类号： A61K31/46 , A61P13/10
CPC分类号： A61K31/46 , A61K31/4178 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of immediate release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of immediate release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of immediate release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.

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