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1. 发明申请

WO2004036370A2 CHANNEL-SELECTIVE BLANKING FOR A MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：用于医疗设备系统的通道选择性保护
公开(公告)号：WO2004036370A2
公开(公告)日：2004-04-29
申请号：PCT/US2003/032908
申请日：2003-10-15
申请人： MEDTRONIC INC. , FREI, Mark, G. , OSORIO, Ivan , RISE, Mark, T. , GIFTAKIS, Jonathon, E. , GRAVES, Nina, M.
发明人： FREI, Mark, G. , OSORIO, Ivan , RISE, Mark, T. , GIFTAKIS, Jonathon, E. , GRAVES, Nina, M.
IPC分类号： G06F
CPC分类号： A61N1/37264 , A61N1/36146 , A61N2/00
摘要： Apparatuses and methods selectively blank a neurological channel of a medical device system in the treatment of a nervous system disorder. A selected signal of a selected channel may be blanked if it is determined that the selected signal may be affected by an artifact when the medical device system delivers a treatment therapy. The selected signal may be blanked by hardware, in which the selected electrode is disconnected from the selected channel (which may include an selected amplifier) and is connected to a fixed voltage in order to avoid saturation of the selected amplifier. The selected channel may be blanked by software, in which a signal processor is instructed not to process neurological data on the selected channel for a determined time duration. Embodiments may combine hardware and software blanking for the selected signal.
摘要翻译：装置和方法选择性地将医疗装置系统的神经通道置于神经系统疾病的治疗中。如果在医疗设备系统递送治疗疗法时确定所选择的信号可能受到伪像的影响，则选定信道的所选信号可能被消隐。所选择的信号可能被硬件消隐，其中所选择的电极与所选择的通道（其可以包括所选择的放大器）断开连接，并且连接到固定电压，以避免所选放大器的饱和。所选择的通道可以被软件置空，其中指示信号处理器不在所选择的通道上处理确定的持续时间的神经学数据。实施例可以组合所选信号的硬件和软件消隐。

2. 发明申请

WO1997039795A1 APPARATUS FOR TREATING NEURODEGENERATIVE DISORDERS 审中-公开
标题翻译：用于治疗神经损伤性疾病的装置
公开(公告)号：WO1997039795A1
公开(公告)日：1997-10-30
申请号：PCT/US1997005118
申请日：1997-03-28
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , RISE, Mark, T.
IPC分类号： A61N01/36
CPC分类号： A61N1/36171 , A61N1/36067 , A61N1/36082
摘要： Techniques for stimulating the brain (B) to reduce the effects of neurodegenerative disorders by means of an implantable signal generator (10) and electrode (115). A sensor (28, 30) is used to detect the symptons resulting from the disorder. A microprocessor algorithm analyzes the output from the sensor in order to regulate the stimulation delivered to the brain.
摘要翻译：用于刺激脑（B）的技术通过可植入信号发生器（10）和电极（115）来减少神经变性疾病的影响。传感器（28,30）用于检测由紊乱引起的症状。微处理器算法分析传感器的输出，以调节传递到大脑的刺激。

3. 发明申请

WO2004036376A3 MULTI-MODAL OPERATION OF A MEDICAL DEVICE SYSTEM 审中-公开
公开(公告)号：WO2004036376A3
公开(公告)日：2004-04-29
申请号：PCT/US2003/032997
申请日：2003-10-15
申请人： MEDTRONIC INC. , OSORIO, Ivan , FREI, Mark, G. , RISE, Mark, T. , SCHAFFNER, Scott, F. , GRAVES, Nina, M.
发明人： OSORIO, Ivan , FREI, Mark, G. , RISE, Mark, T. , SCHAFFNER, Scott, F. , GRAVES, Nina, M.
IPC分类号： A61B17/52
摘要： Apparatuses and methods support multi-modal operation of a medical device system for a nervous system disorder. The medical device system comprises an implanted component (953) and an external component (950) and supports a first feature and a second feature that are associated with the treatment therapy. The medical device system supports both features when the implanted component (953) and the external component (950) are coupled. If the external component (950) is decoupled, the implanted component (953) continues to support the first feature. Moreover, the embodiment may support a plurality of features during a treatment interval. Another aspect of the invention allows for modularly expanding a medical device system in order to add a feature that enhances existing functionality or that provides additional functionality. In an embodiment, a module that is associated with an external component (950) of the medical device system supports the added feature.

4. 发明申请

WO2004034882A2 CLUSTERING OF RECORDED PATIENT NEUROLOGICAL ACTIVITY TO DETERMINE LENGTH OF A NEUROLOGICAL EVENT 审中-公开
标题翻译：记录患者神经活动的聚集，以确定神经病学活动的长度
公开(公告)号：WO2004034882A2
公开(公告)日：2004-04-29
申请号：PCT/US2003/032940
申请日：2003-10-15
申请人： MEDTRONIC INC. , FREI, Mark, G. , OSORIO, Ivan , GRAVES, Nina, M. , SCHAFFNER, Scott, F. , RISE, Mark, T. , GIFTAKIS, Jonathon, E. , CARLSON, David, L.
发明人： FREI, Mark, G. , OSORIO, Ivan , GRAVES, Nina, M. , SCHAFFNER, Scott, F. , RISE, Mark, T. , GIFTAKIS, Jonathon, E. , CARLSON, David, L.
IPC分类号： A61B
CPC分类号： A61B5/04012 , A61B5/0476 , A61B5/4094 , A61B5/7217 , A61N1/36025 , A61N1/36082 , A61N1/361 , Y10S128/92
摘要： Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each n th detection cluster.
摘要翻译：装置和方法检测与神经系统疾病的神经系统事件（例如癫痫发作），与治疗疗法相关联的更新治疗参数相关联的检测簇。当最大比例超过强度阈值时，检测到簇的出现。如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联。因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。可以通过提供电刺激，药物输注或组合来提供治疗治疗。治疗参数可以针对治疗疗法的每个第m个连续的组应用或针对每个第n个检测簇进行更新。

5. 发明申请

WO1997042990A1 TECHNIQUES FOR TREATING EPILEPSY BY BRAIN STIMULATION AND DRUG INFUSION 审中-公开
标题翻译：通过脑刺激和药物输注治疗癫痫的技术
公开(公告)号：WO1997042990A1
公开(公告)日：1997-11-20
申请号：PCT/US1997007115
申请日：1997-04-28
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , WARD, Scott , RISE, Mark, T.
IPC分类号： A61M05/142
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2210/0693 , G06F19/00
摘要： Techniques using one or more drugs and electrical stimulation for treating a neurological disorder, including epilepsy, by means of an implantable signal generator and electrode and an implantable pump and catheter. A sensor is used to detect a seizure or symptoms resulting from the onset of a seizure. A microprocessor algorithm analyzes the output from the sensor in order to regulate the stimulation and drug dosage delivered to the neural tissue.
摘要翻译：使用一种或多种药物和电刺激来通过可植入信号发生器和电极以及可植入泵和导管治疗神经障碍（包括癫痫）的技术。传感器用于检测由癫痫发作引起的癫痫发作或症状。微处理器算法分析传感器的输出，以调节传递到神经组织的刺激和药物剂量。

6. 发明申请

WO2010051382A1 MOOD CIRCUIT MONITORING TO CONTROL THERAPY DELIVERY 审中-公开
标题翻译： MOOD电路监控以控制治疗
公开(公告)号：WO2010051382A1
公开(公告)日：2010-05-06
申请号：PCT/US2009/062609
申请日：2009-10-29
申请人： MEDTRONIC, INC. , GIFTAKIS, Jonathon, E. , RISE, Mark, T. , CARLSON, David , STYPULKOWSKI, Paul, H. , STANSLASKI, Scott, R. , JENSEN, Randy, M. , DENISON, Timothy, J.
发明人： GIFTAKIS, Jonathon, E. , RISE, Mark, T. , CARLSON, David , STYPULKOWSKI, Paul, H. , STANSLASKI, Scott, R. , JENSEN, Randy, M. , DENISON, Timothy, J.
IPC分类号： A61B5/0476 , A61N1/36 , A61B5/16
CPC分类号： A61B5/0476 , A61B5/0205 , A61B5/024 , A61B5/0488 , A61B5/16 , A61B5/4076 , A61B5/4839 , A61B5/486 , A61M21/00 , A61M2021/0072 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/36082
摘要： Brain signals may be monitored at different locations of a mood circuit in order to determine a mood state of the patient. A relationship (e.g., a ratio) between frequency band characteristics of the monitored brain signals may be indicative of a particular mood state. In some examples, therapy parameter values that define the therapy delivered to the patient may be selected to maintain a target relationship (e.g., a target ratio) between the frequency band characteristics of the brain signals monitored within the mood circuit. In addition, in some examples, therapy delivery to the patient may be controlled based on the frequency band characteristics of brain signals sensed at different portions of the mood circuit.
摘要翻译：可以在心情电路的不同位置监测脑信号，以便确定患者的情绪状态。所监视的脑信号的频带特性之间的关系（例如，比率）可以指示特定的情绪状态。在一些示例中，可以选择限定递送给患者的治疗的治疗参数值，以在心情电路内监测的脑信号的频带特性之间维持目标关系（例如，目标比率）。此外，在一些示例中，可以基于在心情电路的不同部分感测到的脑信号的频带特性来控制对患者的治疗递送。

7. 发明申请

WO2009129493A1 ANALYZING A WASHOUT PERIOD CHARACTERISTIC FOR PSYCHIATRIC DISORDER THERAPY DELIVERY 审中-公开
标题翻译：分析精神疾病治疗方法的出院期特征
公开(公告)号：WO2009129493A1
公开(公告)日：2009-10-22
申请号：PCT/US2009/041015
申请日：2009-04-17
申请人： MEDTRONIC, INC. , GIFTAKIS, Jonathon, E. , RISE, Mark, T. , STYPULKOWSKI, Paul, H. , DENISON, Timothy, J.
发明人： GIFTAKIS, Jonathon, E. , RISE, Mark, T. , STYPULKOWSKI, Paul, H. , DENISON, Timothy, J.
IPC分类号： G06F19/00
CPC分类号： G16H40/63 , A61M5/14276 , A61M5/1723 , A61M2005/14208 , A61M2205/3561 , A61M2205/3592 , A61M2210/0693 , A61N1/08 , A61N1/36025 , A61N1/36082 , A61N1/37211 , G06F19/00 , G16H40/40
摘要： A characteristic of a washout period following the delivery of therapy to a patient according to a therapy program may be determined based on a physiological parameter of the patient. A washout period includes the period of time during which a carryover effect from the therapy dissipates. The washout period characteristic may include, for example, a duration of the washout period, an amplitude or a trend in a physiological signal during the washout period or a power level or a ratio of power levels in frequency bands of the physiological signal. In some embodiments, washout period characteristics associated with a plurality of therapy programs may be used to compare the programs. In other embodiments, a washout period characteristic may be used to determine a mood state of the patient and, in some cases, modify a therapy program. Monitoring a washout period may also be useful for timing therapy program trials.
摘要翻译：根据治疗程序向患者输送治疗后的清洗期间的特征可以基于患者的生理参数来确定。清洗期包括治疗所产生的结转效应消散的时间。清洗期间特征可以包括例如清洗期间的持续时间，清洗期间的生理信号的幅度或趋势，或生理信号的频带的功率水平或功率水平的比率。在一些实施例中，可以使用与多个治疗程序相关联的清除期特征来比较程序。在其他实施例中，清洗周期特征可以用于确定患者的情绪状态，并且在一些情况下可以修改治疗程序。监测清洗期也可能对时间治疗方案试验有用。

8. 发明申请

WO1997039796A1 APPARATUS FOR TREATING MOVEMENT DISORDERS BY CLOSED LOOP BRAIN STIMULATION 审中-公开
标题翻译：用于通过闭合环路刺激来治疗运动障碍的装置
公开(公告)号：WO1997039796A1
公开(公告)日：1997-10-30
申请号：PCT/US1997005519
申请日：1997-04-02
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , RISE, Mark, T. , KING, Gary, W.
IPC分类号： A61N01/36
CPC分类号： A61N1/36067 , A61N1/0534
摘要： Techniques for stimulating the brain (B) to treat movement disorders resulting in abnormal motor behavior by means of an implantable signal generator (10) and electrode (115). A sensor (130) is used to detect the symptoms resulting from the motion disorders. A microprocessor algorithm anaylzes the output from the sensor in order to regulate the stimulation delivered to the brain.
摘要翻译：用于刺激大脑的技术（B）通过可植入信号发生器（10）和电极（115）来治疗导致异常运动行为的运动障碍。传感器（130）用于检测由运动障碍引起的症状。微处理器算法对传感器的输出进行分析，以调节传递到大脑的刺激。

9. 发明申请

WO2009129478A2 TIMING THERAPY EVALUATION TRIALS 审中-公开
标题翻译：时间治疗评估试验
公开(公告)号：WO2009129478A2
公开(公告)日：2009-10-22
申请号：PCT/US2009/040988
申请日：2009-04-17
申请人： MEDTRONIC, INC. , GIFTAKIS, Jonathon, E. , RISE, Mark, T. , STYPULKOWSKI, Paul, H. , DENISON, Timothy, J.
发明人： GIFTAKIS, Jonathon, E. , RISE, Mark, T. , STYPULKOWSKI, Paul, H. , DENISON, Timothy, J.
IPC分类号： A61N1/36
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2005/14208 , A61M2205/3561 , A61M2205/3592 , A61M2210/0693 , A61N1/08 , A61N1/36025 , A61N1/36082 , A61N1/37211 , G06F19/00 , G06F19/3481 , G16H40/40 , G16H40/63
摘要： A characteristic of a washout period following the delivery of therapy to a patient according to a therapy program may be determined based on a physiological parameter of the patient. A washout period includes the period of time during which a carryover effect from the therapy delivery dissipates. Monitoring a washout period may be useful for timing the delivery of therapy according to different therapy programs during a therapy evaluation period. For example, at least one physiological signal of the patient may be monitored to automatically determine when a washout period has ended, e.g., when stimulation and carryover effects of therapy delivery according to a first therapy program have substantially dissipated, in order to determine when therapy delivery according to a second therapy program can be initiated.
摘要翻译：根据治疗程序向患者输送治疗后的清洗期间的特征可以基于患者的生理参数来确定。清洗期包括治疗期间遗留结果消失的时间。在治疗评估期间，根据不同的治疗方案，监测清除期可能有助于按时交付治疗。例如，可以监测患者的至少一个生理信号，以便自动确定何时清除期已经结束，例如，当根据第一治疗程序的治疗递送的刺激和携带效应已经基本消散时，为了确定何时治疗可以启动根据第二疗法程序的递送。

10. 发明申请

WO2009129462A2 THERAPY TARGET SELECTION FOR PSYCHIATRIC DISORDER THERAPY 审中-公开
标题翻译：治疗精神疾病治疗方案的治疗目标选择
公开(公告)号：WO2009129462A2
公开(公告)日：2009-10-22
申请号：PCT/US2009/040957
申请日：2009-04-17
申请人： MEDTRONIC, INC. , RISE, Mark, T. , GIFTAKIS, Jonathon, E.
发明人： RISE, Mark, T. , GIFTAKIS, Jonathon, E.
IPC分类号： A61N1/36
CPC分类号： A61N1/36082
摘要： Target tissue sites for therapy delivery to a patient may be selected based on the patient symptoms or a patient mood state. The therapy delivery may be used to manage a psychiatric disorder of the patient. Selected therapy sites may be weighted based on factors, such as the severity of the patient symptom or mood state or the type of patient symptom or mood state. In some cases, therapy delivery to the patient may be controlled based on the weighting factors. For example, the weighting factors may control the intensity of the therapy delivery or the frequency of the therapy delivery. In some examples, the weighting factors may dynamically change based on the patient's changing symptoms or mood disorders.
摘要翻译：可以基于患者症状或患者情绪状态来选择用于治疗递送给患者的靶组织位点。治疗递送可用于治疗患者的精神疾病。可以基于诸如患者症状或情绪状态的严重性或患者症状或情绪状态的类型的因素来加权所选择的治疗部位。在一些情况下，可以基于加权因子来控制对患者的治疗递送。例如，加权因子可以控制治疗递送的强度或治疗递送的频率。在一些示例中，加权因子可以基于患者的改变的症状或情绪障碍而动态地改变。

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