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1. 发明申请

WO2016086074A1 SUBCORTICAL (THALAMIC) AUTOMATED SEIZURE DETECTION FOR CONTINGENT THERAPY DELIVERY SYSTEMS AND METHODS 审中-公开
标题翻译：自动检测系统（THALAMIC）自动检测系统和方法
公开(公告)号：WO2016086074A1
公开(公告)日：2016-06-02
申请号：PCT/US2015/062550
申请日：2015-11-24
申请人： OSORIO, Ivan
发明人： OSORIO, Ivan , WENNBERG, Richard
IPC分类号： A61B5/04
CPC分类号： A61B5/04001 , A61B5/4094 , A61B5/6868 , A61N1/05 , A61N1/0534 , A61N1/36139
摘要： A thalamic medical device system enables automated detection of epileptic seizures and optionally providing contingent thalamic stimulation triggered by automated seizure detection. The thalamic medical device system includes an implantable medical device connected to an electrode assembly and a lead. The electrode assembly has at least one electrode surgically implanted into an anterior thalamic nuclei or a centro-median thalamic nuclei of a brain. The implanted medical device is configured to detect electrical signals and analyze detected electrical signals using a seizure detection algorithm, and further configured to deliver electrical stimulation to the anterior thalamic nuclei or centro-median thalamic nuclei via the electrode assembly when a seizure is detected.
摘要翻译：丘脑医疗设备系统能够自动检测癫痫发作，并可选择性地提供由自动发作检测触发的偶然丘脑刺激。丘脑医疗装置系统包括连接到电极组件和引线的可植入医疗装置。电极组件具有通过手术植入脑丘的前丘脑核或中心丘脑核中的至少一个电极。植入的医疗装置被配置为检测电信号并且使用缉获检测算法分析检测到的电信号，并且还被配置为当检测到发作时经由电极组件将电刺激递送到前丘脑核或中心中间丘脑核。

2. 发明申请

WO2011159592A1 A SYSTEMS APPROACH TO DISEASE STATE, HEALTH, AND COMORBIDITY 审中-公开
标题翻译：疾病状况，健康和共同体系的系统方法
公开(公告)号：WO2011159592A1
公开(公告)日：2011-12-22
申请号：PCT/US2011/040130
申请日：2011-06-13
申请人： FLINTS HILLS SCIENTIFIC, LLC , OSORIO, Ivan
发明人： OSORIO, Ivan
IPC分类号： G06F19/00
CPC分类号： G16H50/20 , G06F19/00 , G16H50/30
摘要： Methods, systems, and apparatus for assessing a state of a primary disease or a comorbidity associated with a primary disease are provided. The methods comprise receiving at least one autonomic index, neurologic index, stress marker index, psychiatric index, endocrine index, adverse effect of therapy index, physical fitness index, or quality of life index of a patient; comparing the at least one index to at least one reference value; and assessing a state of a primary disease or a body system of the patient that is a site of the comorbidity, based on the comparison. A computer readable program storage device encoded with instructions that, when executed by a computer, perform a method described above is also provided. A medical device system capable of implementing a method described above is also provided.
摘要翻译：提供了用于评估原发性疾病状态或与原发性疾病相关的并发症的方法，系统和装置。所述方法包括接受患者的至少一个自主指数，神经学指标，应激标志物指数，精神指数，内分泌指数，治疗指数的不良影响，身体健康指数或生活质量指数。将所述至少一个索引与至少一个参考值进行比较; 并且基于比较来评估作为合并症的部位的患者的原发性疾病或身体系统的状态。一种计算机可读程序存储装置，其编码有指令，当由计算机执行时执行上述方法。还提供了能够实现上述方法的医疗装置系统。

3. 发明申请

WO2011137235A1 METHODS FOR DETECTING A SEIZURE FROM CARDIAC DATA 审中-公开
标题翻译：检测心脏病数据的方法
公开(公告)号：WO2011137235A1
公开(公告)日：2011-11-03
申请号：PCT/US2011/034308
申请日：2011-04-28
申请人： CYBERONICS, INC. , OSORIO, Ivan , FREI, Mark
发明人： OSORIO, Ivan , FREI, Mark
IPC分类号： A61B5/0245
CPC分类号： A61B5/0245 , A61B5/02405 , A61B5/0456 , A61B5/4094 , G06F19/00
摘要： Methods, systems, and apparatus for detecting a seizure in a patient. The determination is performed by collecting cardiac data; determining valid heart beats suitable for seizure detection from the cardiac data; calculating heart rate data of interest from the valid heart beats; and identifying a seizure event from the heart rate data. The medical device may then take a responsive action, such as warning, logging the time of the seizure, computing and storing one or more seizure severity indices, and/or treating the seizure. Also, methods for quantifying the quality of a fiducial time marker for a candidate heart beat, quantifying the quality of a candidate heart beat, or determining a time of beat sequence of the patient's heart. Also, methods of modifying constraints use in one or more beat validity tests.
摘要翻译：用于检测患者癫痫发作的方法，系统和装置。该确定是通过收集心脏数据进行的; 从心脏数据确定适合于发作检测的有效心跳; 从有效的心跳中计算感兴趣的心率数据; 并从心率数据识别癫痫事件。然后，医疗装置可以采取响应动作，例如警告，记录癫痫发作的时间，计算和存储一个或多个癫痫发作严重程度指数，和/或治疗癫痫发作。此外，用于量化候选心跳的基准时间标记的质量的方法，量化候选心跳的质量或确定患者心脏的搏动序列的时间。此外，修改约束的方法在一个或多个节拍有效性测试中使用。

4. 发明申请

WO2006083744A1 ANCHORING OF A MEDICAL DEVICE COMPONENT ADJACENT A DURA OF THE BRAIN OR SPINAL CORD 审中-公开
标题翻译：医疗器械组件的附着物邻近脑或脊髓的DURA
公开(公告)号：WO2006083744A1
公开(公告)日：2006-08-10
申请号：PCT/US2006/003096
申请日：2006-01-25
申请人： MEDTRONIC, INC. , OSORIO, Ivan
发明人： OSORIO, Ivan
IPC分类号： A61N1/05 , A61N1/372
CPC分类号： A61N1/0531 , A61B5/4094 , A61B5/6864 , A61N1/0539 , A61N1/0553
摘要： A method and implantable medical device system capable of being anchored in a head or spinal cord of a patient. During implant, the dura of the patient is partially removed and the medical device component 202 is placed on one side of the dura. The medical device component 202 contains one or more anchors that mate with one or more nuts placed on the other side of the dura. The medical device component 202 is thereby attached to the dura in a substantially fixed position relative to the head or spinal cord.
摘要翻译：一种能够锚定在患者的头部或脊髓中的方法和可植入的医疗装置系统。在植入期间，患者的硬膜被部分地去除，并且医疗装置部件202被放置在硬脑膜的一侧。医疗器械部件202包含一个或多个锚定件，其与置于硬脑膜另一侧的一个或多个螺母配合。因此，医疗装置部件202相对于头部或脊髓以基本上固定的位置附接到硬脑膜。

5. 发明申请

WO2004034982A2 CYCLE MODE PROVIDING REDUNDANT BACK-UP TO ENSURE TERMINATION OF TREATMENT THERAPY IN A MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：提供冗余备份的循环模式，以确保医疗设备系统中的治疗终止治疗
公开(公告)号：WO2004034982A2
公开(公告)日：2004-04-29
申请号：PCT/US2003/032572
申请日：2003-10-15
申请人： MEDTRONIC INC. , OSORIO, Ivan , BHAVARAJU, Naresh, C. , CARLSON, David, L. , JENSEN, Randy, M.
发明人： OSORIO, Ivan , BHAVARAJU, Naresh, C. , CARLSON, David, L. , JENSEN, Randy, M.
IPC分类号： A61K
CPC分类号： A61N1/37252 , A61N1/36064 , A61N1/36135 , A61N1/37235
摘要： A medical device system having a redundant back-up mechanism to ensure that treatment therapy is turned off after a given time duration. Once the treatment therapy is initiated, a cycle ON timer is set. If the ON timer expires prior to receiving any instruction to turn off the treatment therapy, the device responsively turns off the treatment therapy, thereby ensuring that the treatment therapy is not delivered beyond that which is desired.
摘要翻译：一种具有冗余备用机制的医疗装置系统，以确保治疗疗法在给定的持续时间之后被关闭。一旦开始治疗，就设置一个循环ON定时器。如果接通定时器在接收任何关闭治疗疗法的指令之前过期，则该设备响应地关闭治疗疗法，从而确保治疗疗法不会超出期望的范围。

6. 发明申请

WO2012122066A9 DETECTING, ASSESSING AND MANAGING EXTREME EPILEPTIC EVENTS 审中-公开
标题翻译：检测，评估和管理极端有趣的事件
公开(公告)号：WO2012122066A9
公开(公告)日：2012-11-29
申请号：PCT/US2012027639
申请日：2012-03-03
申请人： FLINT HILLS SCIENT LLC , OSORIO IVAN
发明人： OSORIO IVAN
IPC分类号： A61B5/0476
CPC分类号： A61B5/4094 , A61B5/0205 , A61B5/02405 , A61B5/0476 , A61B5/08 , A61B5/11 , A61B5/165 , A61B5/4035 , A61B5/4842 , A61N1/36064
摘要： Methods, system and apparatus for identifying extreme epileptic events are provided. In one aspect, an inter-seizure interval (ISI) value related to at least two seizure events is determined, compared to a reference value, and an extreme seizure event is determined from the comparison. In another aspect, a first seizure event is detected, and a body index affected by the seizure is determined. An extreme seizure event is determined when a second seizure event occurs prior to the body index value returning to a reference value. Another method includes determining an one index from body data, identifying a seizure event based upon the index, determining at least one seizure severity index (SSI) value for the seizure, comparing the SSI value to a reference value, and determining an extreme seizure event from the comparison. A further method includes determining an increased risk of death and responding to the increased risk.
摘要翻译：提供了确定极端癫痫事件的方法，系统和装置。在一个方面，与参考值相比，确定与至少两个发作事件相关的癫痫发作时间间隔（ISI）值，并从比较确定极端发作事件。在另一方面，检测到第一发作事件，并确定受癫痫发作影响的身体指数。在身体指标值返回到参考值之前发生第二次发作事件时，确定极度发作事件。另一种方法包括根据身体数据确定一个索引，基于该索引识别癫痫事件，确定癫痫发作的至少一个癫痫发作严重程度指数（SSI）值，将SSI值与参考值进行比较，以及确定极度癫痫发作事件从比较。另一种方法包括确定增加的死亡风险和对风险增加的应对。

7. 发明申请

WO2012037359A1 DETECTING OR VALIDATING A DETECTION OF A STATE CHANGE FROM A TEMPLATE OF HEART RATE DERIVATIVE SHAPE OR HEART BEAT WAVE COMPLEX 审中-公开
标题翻译：检测或验证从心率衍生形状或心脏波形波形复合体的状态变化的检测
公开(公告)号：WO2012037359A1
公开(公告)日：2012-03-22
申请号：PCT/US2011/051776
申请日：2011-09-15
申请人： FLINT HILLS SCIENTIFIC, LLC , OSORIO, Ivan , FREI, Mark, G.
发明人： OSORIO, Ivan , FREI, Mark, G.
IPC分类号： A61B5/0452 , A61N1/36
CPC分类号： A61B5/4094 , A61B5/02405 , A61B5/0245 , A61B5/04012 , A61B5/04014 , A61B5/0452 , A61B5/04525 , A61B5/0456 , A61B5/0468 , A61B5/7246 , A61B5/7275 , A61N1/36053 , A61N1/36064
摘要： Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.
摘要翻译：用于通过匹配心脏数据序列，心率变异数据序列或心跳复合体的至少一部分中的一个或多个的形状来检测和/或验证状态变化的检测的方法，系统和装置，衍生自心脏数据，到适当的模板。

8. 发明申请

WO2007106343A3 PROBABILISTIC NEUROLOGICAL DISORDER TREATMENT 审中-公开
标题翻译：概率神经疾病的治疗
公开(公告)号：WO2007106343A3
公开(公告)日：2007-11-01
申请号：PCT/US2007005674
申请日：2007-03-06
申请人： MEDTRONIC INC , OSORIO IVAN , FREI MARK G
发明人： OSORIO IVAN , FREI MARK G
IPC分类号： A61N1/36 , A61B5/0476 , G06F19/00
CPC分类号： G06F19/3481 , A61B5/0006 , A61B5/0476 , A61B5/4094 , A61N1/36082 , A61N1/361 , G16H50/20
摘要： Disclosed are probabilistic approaches to patient evaluation, warning and treatment of a neurological disorder. Disclosed techniques estimate probability distribution functions or cumulative distribution functions, determined by relying on representative historical profiles, comprising information in short and/or long timescales obtained at times that may be intermittent or temporally discontinuous from each other or from other events of interest. The patient may thereby be treated based on the determined probability information.
摘要翻译：公开了患者评估，预警和治疗神经疾病的概率方法。所公开的技术估计概率分布函数或累积分布函数，该概率分布函数或累积分布函数通过依赖于代表性历史概况来确定，该概率分布函数或累积分布函数包括在彼此间或者从其他感兴趣事件可能间歇或暂时不连续的时间获得的短和/ 由此可以基于所确定的概率信息来治疗患者。

9. 发明申请

WO2004034880A3 TIMED DELAY FOR REDELIVERY OF TREATMENT THERAPY FOR A MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：定时延迟用于医疗设备系统的治疗治疗
公开(公告)号：WO2004034880A3
公开(公告)日：2004-07-22
申请号：PCT/US0332909
申请日：2003-10-15
申请人： MEDTRONIC INC , FREI MARK G , OSORIO IVAN , BHAVARAJU NARESH C , CARLSON DAVID L , GIFTAKIS JONATHON E , GRAVES NINA M
发明人： FREI MARK G , OSORIO IVAN , BHAVARAJU NARESH C , CARLSON DAVID L , GIFTAKIS JONATHON E , GRAVES NINA M
IPC分类号： A61B20060101 , A61B5/00 , A61B5/04 , A61B5/0476
CPC分类号： A61B5/04012 , A61B5/0476 , A61B5/4094 , A61B5/7217 , A61N1/36025 , A61N1/36082 , A61N1/361 , Y10S128/92
摘要： Apparatus (100) and method support a repetitive administration of a therapeutic treatment through a delivery unit (953) during a neurological event, such as a seizure, of a nervous system disorder. The medical device system monitors signal data from a sensor and through an amplifier. A neurological event is detected by a medical device system using a detection algorithm. Consequently, a electrical stimulation pulse is applied to an electrode. During the delivery of the electrical stimulation pulse, the medical device system blanks signal data that is associated with the electrode. Subsequently, additional blanking is providing during a time interval in which signal artifacts may occur and the amplifier is stabilizing. The medical device system then collects signal data for the detection algorithm to stabilize. Subsequently, the medical device system collects additional signal data in order to obtain statistically meaningful data. If the medical device system detects a continuation of the seizure, therapeutic treatment continues.
摘要翻译：装置（100）和方法支持在神经系统疾病的神经事件（例如癫痫发作）期间通过递送单元（953）重复施用治疗性治疗。医疗设备系统监控来自传感器和放大器的信号数据。通过使用检测算法的医疗装置系统检测到神经系统事件。因此，电刺激脉冲被施加到电极。在递送电刺激脉冲期间，医疗装置系统消除与电极相关联的信号数据。随后，在可能发生信号伪影的时间间隔内提供额外的消隐，并且放大器正在稳定。然后，医疗装置系统收集用于检测算法的信号数据以稳定。随后，医疗设备系统收集附加信号数据，以获得统计上有意义的数据。如果医疗器械系统检测到持续的癫痫发作，则继续治疗。

10. 发明申请

WO2004034881A3 SIGNAL QUALITY MONITORING AND CONTROL FOR A MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：医疗设备系统的信号质量监测与控制
公开(公告)号：WO2004034881A3
公开(公告)日：2004-07-01
申请号：PCT/US0332938
申请日：2003-10-15
申请人： MEDTRONIC INC , FREI MARK G , OSORIO IVAN , WERDER JONATHAN C , CARLSON DAVID L
发明人： FREI MARK G , OSORIO IVAN , WERDER JONATHAN C , CARLSON DAVID L
IPC分类号： A61B20060101 , A61B1/00 , A61B5/00 , A61B5/04 , A61B5/05 , A61N1/36 , A61N1/37 , A61N1/372
CPC分类号： A61N1/37252 , A61B5/04012 , A61B5/048 , A61B5/4094 , A61N1/36014 , A61N1/36064 , A61N1/36082 , A61N1/3702 , A61N1/37229
摘要： Method and apparatus for detecting possible interference in a neurological signal received from a monitoring element of a medical device system. The monitoring element monitors a condition or a symptom of a nervous system disorder being treated and provides a neurological signal to the medical device system for purposes of providing closed-loop feedback control. The system analyzes various parameters of the received signal by taking instantaneous measurements of data points in moving window and thereby determining whether the signal is of poor quality. If the signal is of determined poor quality, it is removed from consideration in the closed-loop feedback control system until it is determined that the signal quality has sufficiently been restored.
摘要翻译：用于检测从医疗设备系统的监视元件接收的神经信号中可能的干扰的方法和装置。监测元件监测正在治疗的神经系统疾病的状况或症状，并为了提供闭环反馈控制的目的而向医疗设备系统提供神经信号。系统通过对移动窗口中的数据点进行瞬时测量来分析接收信号的各种参数，从而确定信号质量是否差。如果信号质量差，则在闭环反馈控制系统中将其从考虑中移除，直到确定信号质量已被充分恢复。

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