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1. 发明申请

WO2003106040A3 CENTRIFUGE SYSTEM AND AUTOMATED PROCESSING OF BLOOD 审中-公开
公开(公告)号：WO2003106040A3
公开(公告)日：2003-12-24
申请号：PCT/US2003/018527
申请日：2003-06-12
申请人： MEDTRONIC, INC.
发明人： DOLECK, Victor, D. , MERTE, Kenneth, E. , MCINTOSH, Kevin, D. , BERG, Gary , MALCOLM, David , SITKO, Vitally, G.
IPC分类号： B04B5/04
摘要： A centrifugal method, and corresponding system, for processing blood to collect platelet rich plasma. A separation chamber is filled with blood from a fill syringe by rotating the separation chamber at fill rotation rate and pumping the blood from the fill syringe. A soft spin is used to initially separate red blood cells from platelets by spinning the separation chamber at a soft spin rate. A percentage of the blood is drawn from the separation chamber back into the fill syringe to remove separated red blood cells. A second portion of the separated blood is drawn from the separation chamber until a red blood cell/platelet interface is detected. A hard spin is performed by spinning the separation chamber at a higher rate and connecting tubing is cleared of red blood cells by drawing a predetermined clearing volume. The platelet rich plasma is then collected in the collection syringe.

2. 发明公开

EP1414581A1 FLEXIBLE CENTRIFUGE BAG AND METHODS OF USE 审中-公开
标题翻译：灵活的离心机袋及使用方法
公开(公告)号：EP1414581A1
公开(公告)日：2004-05-06
申请号：EP02733961.3
申请日：2002-04-05
申请人： Medtronic, Inc.
发明人： DOLECEK, Victor, D. , MALCOLM, David
IPC分类号： B04B5/04 , A61M1/36
CPC分类号： A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2202/0423 , B01D17/0217 , B01D21/262 , B01D21/302 , B01D2221/10 , B01J13/0069 , B04B5/0428 , B04B5/0442 , B04B2005/045
摘要： A flexible, disposable centrifuge bag (226) for receiving and holding a fluid sample, comprising one or more tubes (248, 250) and upper and lower flexible sheets (234, 236) having doughnut shaped configurations. The upper and lower sheets are superimposed and completely sealed together at their outer perimeters (238) to define an outer perimeter (240) of the centrifuge bag. The inner perimeter of the bag defines a central core (242). The tubes are sandwiched between the upper and lower sheets and extend from the central core of the centrifuge bag. The upper and lower sheets are sealed together at their inner perimeters such that the tubes are sealed between said upper and lower sheets at the inner perimeter. The bag may be used to harvest platelet rich plasma from whole blood in either a batch method or while simultaneously infusing additional aliquots of whole blood into the bag during centrifugation.

3. 发明申请

WO2002081096A1 FLEXIBLE CENTRIFUGE BAG AND METHODS OF USE 审中-公开
标题翻译：柔性中心袋和使用方法
公开(公告)号：WO2002081096A1
公开(公告)日：2002-10-17
申请号：PCT/US2002/010991
申请日：2002-04-05
申请人： MEDTRONIC, INC.
发明人： DOLECEK, Victor, D. , MALCOLM, David
IPC分类号： B04B5/04
CPC分类号： A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2202/0423 , B01D17/0217 , B01D21/262 , B01D21/302 , B01D2221/10 , B01J13/0069 , B04B5/0428 , B04B5/0442 , B04B2005/045
摘要： A flexible, disposable centrifuge bag (226) for receiving and holding a fluid sample, comprising one or more tubes (248, 250) and upper and lower flexible sheets (234, 236) having doughnut shaped configurations. The upper and lower sheets are superimposed and completely sealed together at their outer perimeters (238) to define an outer perimeter (240) of the centrifuge bag. The inner perimeter of the bag defines a central core (242). The tubes are sandwiched between the upper and lower sheets and extend from the central core of the centrifuge bag. The upper and lower sheets are sealed together at their inner perimeters such that the tubes are sealed between said upper and lower sheets at the inner perimeter. The bag may be used to harvest platelet rich plasma from whole blood in either a batch method or while simultaneously infusing additional aliquots of whole blood into the bag during centrifugation.
摘要翻译：一种用于接收和保持流体样品的柔性一次性离心机袋（226），包括一个或多个管（248,250）以及具有环形构型的上下柔性片（234,236）。上板和下板在其外周（238）处重叠并完全密封在一起以限定离心机袋的外周（240）。袋的内周限定了中心芯（242）。管夹在上下片之间并从离心机袋的中心芯延伸。上下板在其内周边密封在一起，使得管在内周边处密封在所述上板和下板之间。该袋可以用于以批量方法从全血中收集富含血小板的血浆，或者在离心过程中同时将额外的全血量等分进入袋中。

4. 发明申请

WO2002081095A1 MICRONCENTRIFUGE AND DRIVE THEREFOR 审中-公开
标题翻译： MICRONCENTRIFGGE和驱动器
公开(公告)号：WO2002081095A1
公开(公告)日：2002-10-17
申请号：PCT/US2002/010721
申请日：2002-04-05
申请人： MEDTRONIC, INC.
发明人： DOLECEK, Victor, D. , MALCOLM, David
IPC分类号： B04B5/04
CPC分类号： B04B15/02 , A61M1/3693 , A61M1/3696 , A61M2202/0427 , A61M2205/331 , A61M2205/3368 , B04B5/0428 , B04B5/0442 , B04B9/08 , B04B9/10 , B04B11/04 , B04B13/00 , B04B2005/045 , B04B2013/006
摘要： A belt-driven blood centrifuge (20) with side-mounted drive motor (24) for rotating the centrifuge at a rotation speed selected to separate blood components. The centrifuge includes a drive shaft assembly (28) rotated at an input rotation speed and a rotor assembly (200) rotatably linked to the drive shaft assembly rotated at an output rotation speed twice the input rotational speed. A drive motor is provided with a drive pulley to drive a belt (26), a chain, and the like to provide the motive force to rotate the drive shaft at the input rotation speed. In one embodiment, a belt is provided to contact both the pulley of the drive motor and an outer surface of a rotatable shell (32) of the drive shaft assembly. A base (12) is included in the centrifuge upon which the drive shaft assembly is mounted. The drive motor is positioned adjacent the drive shaft assembly and mounted on the base.
摘要翻译：一种带式驱动的血液离心机（20），其具有用于以选择用于分离血液成分的旋转速度旋转离心机的侧面安装的驱动马达（24）。离心机包括以输入转速旋转的驱动轴组件（28）和转子组件（200），转子组件（200）可旋转地连接到以输入转速两倍的输出转速旋转的驱动轴组件。驱动马达设置有用于驱动皮带（26），链条等的驱动皮带轮，以提供以输入旋转速度旋转驱动轴的动力。在一个实施例中，提供带以接触驱动马达的滑轮和驱动轴组件的可旋转外壳（32）的外表面。基座（12）包括在安装有驱动轴组件的离心机中。驱动马达定位在驱动轴组件附近并安装在基座上。

5. 发明申请

WO2003026802A2 BLOOD CENTRIFUGE WITH EXTERIOR MOUNTED, SELF-BALANCING COLLECTION CHAMBERS 审中-公开
标题翻译：自主安装的血液分离器，自平衡收集器
公开(公告)号：WO2003026802A2
公开(公告)日：2003-04-03
申请号：PCT/US2002/028158
申请日：2002-09-04
申请人： MEDTRONIC,INC.
发明人： DOLECEK, Victor, D. , MALCOLM, David , MCINTOSH, Kevin, D.
IPC分类号： B04B5/04
CPC分类号： B04B5/0428 , B04B5/0442 , B04B2005/045
摘要： A centrifuge disposable or separation assembly having a collection chamber for receiving and holding a fluid to be centrifuged, the chamber having an outer perimeter, an inner perimeter, a generally circular cross-sectional area, and a conical outboard collecting portion. The collection chamber is typically formed from relatively rigid, molded plastic or other materials. A mounting assembly is included as part of the invention to mount of the centrifuge disposable relative to the centrifuge rotor to facilitate balancing for smooth centrifuge rotation. The chamber further ports in communication near the outboard portions of the chamber to provide fluid communication to a tubing, which may be single lumen for discontinuous embodiments in which a single tube is used for fill and extraction and multi-lumen for continuous fill and extraction embodiments in which an inlet lumen is used for fill and one or more outlet lumens are used for extraction of separated components.
摘要翻译：离心机一次性或分离组件，其具有用于接收和保持要离心的流体的收集室226，该腔室具有外周边，内周边，大体圆形横截面积和锥形外侧收集部分216。腔室通常由相对刚性的模制塑料或其它材料形成。作为本发明的一部分，包括安装组件202以将离心机相对于离心机转子安装成一次性，以便平衡离心机的旋转。腔室还具有在腔室的外侧附近连通的端口210，以提供与管道208的流体连通，管道208可以是用于不连续实施例的单腔，其中单个管用于填充和抽出，并且多腔用于连续填充以及其中使用入口腔用于填充的提取实施例，并且使用一个或多个出口腔来提取分离的组件。

6. 发明公开

EP1531941A2 CENTRIFUGE SYSTEM AND AUTOMATED PROCESSING OF BLOOD 有权转让
标题翻译：血液的自动处理
公开(公告)号：EP1531941A2
公开(公告)日：2005-05-25
申请号：EP03760288.5
申请日：2003-06-12
申请人： Medtronic Inc.
发明人： DOLECK, Victor, D. , MERTE, Kenneth, E. , MCINTOSH, Kevin, D. , BERG, Gary , MALCOLM, David , SITKO, Vitally, G.
IPC分类号： B04B5/04 , A61M1/36 , B04B13/00 , B04B7/02
CPC分类号： A61M1/3693 , A61M1/1081 , A61M1/3696 , A61M2202/0415 , A61M2202/0427 , A61M2202/0429 , A61M2205/331 , B04B5/0442 , B04B7/02 , B04B13/00 , A61M2202/0092
摘要： A centrifugal method, and corresponding system, for processing blood to collect platelet rich plasma. A separation chamber is filled with blood from a fill syringe by rotating the separation chamber at fill rotation rate and pumping the blood from the fill syringe. A soft spin is used to initially separate red blood cells from platelets by spinning the separation chamber at a soft spin rate. A percentage of the blood is drawn from the separation chamber back into the fill syringe to remove separated red blood cells. A second portion of the separated blood is drawn from the separation chamber until a red blood cell/platelet interface is detected. A hard spin is performed by spinning the separation chamber at a higher rate and connecting tubing is cleared of red blood cells by drawing a predetermined clearing volume. The platelet rich plasma is then collected in the collection syringe.

7. 发明公开

EP1436089A2 BLOOD CENTRIFUGE WITH EXTERIOR MOUNTED, SELF-BALANCING COLLECTION CHAMBERS 有权
标题翻译：与OUTSIDE血液离心机安装自动平衡收集室
公开(公告)号：EP1436089A2
公开(公告)日：2004-07-14
申请号：EP02766230.3
申请日：2002-09-04
申请人： Medtronic, Inc.
发明人： DOLECEK, Victor, D. , MALCOLM, David , MCINTOSH, Kevin, D.
IPC分类号： B04B5/04
CPC分类号： B04B5/0428 , B04B5/0442 , B04B2005/045
摘要： A centrifuge disposable or separation assembly having a collection chamber (226) for receiving and holding a fluid to be centrifuged, the chamber having an outer perimeter, an inner perimeter, a generally circular cross-sectional area, and a conical outboard collecting portion (216). The collection chamber is typically formed from relatively rigid, molded plastic or other materials. A mounting assembly (202) is included as part of the invention to mount of the centrifuge disposable relative to the centrifuge rotor to facilitate balancing for smooth centrifuge rotation. The chamber further has ports (210) in communication near the outboard portions of the chamber to provide fluid communication to a tubing (208), which may be single lumen for discontinuous embodiments in which a single tube is used for fill and extraction and multi-lumen for continuous fill and extraction embodiments in which an inlet lumen is used for fill and one or more outlet lumens are used for extraction of separated components.

8. 发明公开

EP1423204A1 MICRONCENTRIFUGE AND DRIVE THEREFOR 有权
标题翻译：微量离心机及其驱动
公开(公告)号：EP1423204A1
公开(公告)日：2004-06-02
申请号：EP02763954.1
申请日：2002-04-05
申请人： Medtronic, INC.
发明人： DOLECEK, Victor, D. , MALCOLM, David
IPC分类号： B04B5/04 , B04B9/08
CPC分类号： B04B15/02 , A61M1/3693 , A61M1/3696 , A61M2202/0427 , A61M2205/331 , A61M2205/3368 , B04B5/0428 , B04B5/0442 , B04B9/08 , B04B9/10 , B04B11/04 , B04B13/00 , B04B2005/045 , B04B2013/006
摘要： A belt-driven blood centrifuge (20) with side-mounted drive motor (24) for rotating the centrifuge at a rotation speed selected to separate blood components. The centrifuge includes a drive shaft assembly (28) rotated at an input rotation speed and a rotor assembly (200) rotatably linked to the drive shaft assembly rotated at an output rotation speed twice the input rotational speed. A drive motor is provided with a drive pulley to drive a belt (26), a chain, and the like to provide the motive force to rotate the drive shaft at the input rotation speed. In one embodiment, a belt is provided to contact both the pulley of the drive motor and an outer surface of a rotatable shell (32) of the drive shaft assembly. A base (12) is included in the centrifuge upon which the drive shaft assembly is mounted. The drive motor is positioned adjacent the drive shaft assembly and mounted on the base.

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