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1. 发明申请

WO2014151751A9 MEDICAL LEADS AND TECHNIQUES FOR MANUFACTURING THE SAME 审中-公开
标题翻译：医疗领导者和制造同样的技术
公开(公告)号：WO2014151751A9
公开(公告)日：2014-09-25
申请号：PCT/US2014/026386
申请日：2014-03-13
申请人： MEDTRONIC, INC.
发明人： SHI, Alan , JANZIG, Darren A. , LI, Bernard Q. , STONE, Richard T. , SEELEY, Dale F. , CONG, Peng
IPC分类号： A61N1/375 , A61N1/05
摘要： In some examples, the disclosure relates to a medical device comprising a lead including an electrically conductive lead wire; and an electrode electrically coupled to the lead wire, the electrode including a substrate and a coating on an outer surface of the substrate, wherein the lead wire is formed of a composition comprising titanium or titanium alloys, wherein the substrate is formed of a composition comprising one or more of titanium, tantalum, niobium, and alloys thereof, wherein the coating comprises at least one of Pt, TiN, IrOx, and poly(dioctyl-bithiophene) (PDOT). In some examples, the lead wire may be coupled to the lead wire via a weld, such as, e.g., a laser weld.
摘要翻译：在一些示例中，本公开涉及一种医疗装置，该医疗装置包括：包括导电引线的引线; 以及电耦合到所述引线的电极，所述电极包括衬底和在所述衬底的外表面上的涂层，其中所述引线由包含钛或钛合金的组合物形成，其中所述衬底由包含钛，钽，铌及其合金中的一种或多种，其中所述涂层包含Pt，TiN，IrOx和聚（二辛基 - 联噻吩）（PDOT）中的至少一种。在一些示例中，引线可以经由焊接（例如激光焊接）耦合到引线。

2. 发明申请

WO2010104622A1 OPTICAL FEEDTHROUGH FOR JOINING MODULAR MEDICAL DEVICES THROUGH THE USE OF A RADIANT ENERGY SOURCE 审中-公开
标题翻译：通过使用辐射能源来接合模块化医疗设备的光学
公开(公告)号：WO2010104622A1
公开(公告)日：2010-09-16
申请号：PCT/US2010/022685
申请日：2010-02-01
申请人： MEDTRONIC, INC. , ROBINSON, Reginald D. , DIFFERDING, David D. , JOHNSON, James A. , LI, Bernard Q. , LINDNER, Gerald G. , TISCHENDORF, Brad C. , THOM, Andrew J.
发明人： ROBINSON, Reginald D. , DIFFERDING, David D. , JOHNSON, James A. , LI, Bernard Q. , LINDNER, Gerald G. , TISCHENDORF, Brad C. , THOM, Andrew J.
IPC分类号： A61N1/375 , B29C65/00
CPC分类号： B23K26/206 , A61N1/375 , B23K26/21 , B29C65/14 , B29C65/1406 , B29C65/16 , B29C65/4845 , B29C66/54 , B29C2035/0827 , G02B6/3897 , G02B6/4248
摘要： In general, the disclosure is directed toward transmitting radiant energy across a boundary of a medical device via an optical feedthrough. A system for transmitting radiant energy across a boundary of a medical device includes a first functional module (30) of a medical device, a second functional module (32) of the medical device, an optical feedthrough assembly (40) coupled to the first functional module, and a radiant energy source (60) that emits a beam (62) through the optical feedthrough assembly to perform a manufacturing process on the first functional module and the second functional module.
摘要翻译：通常，本公开涉及经由光学馈通穿过医疗装置的边界发射辐射能。用于在医疗装置的边界上传送辐射能的系统包括医疗装置的第一功能模块（30），医疗装置的第二功能模块（32），耦合到第一功能模块模块和辐射能源（60），其通过光学馈通组件发射光束（62），以在第一功能模块和第二功能模块上执行制造过程。

3. 发明申请

WO2012145127A1 LARGE-PITCH COIL CONFIGURATIONS FOR A MEDICAL DEVICE 审中-公开
标题翻译：医疗设备的大型线圈配置
公开(公告)号：WO2012145127A1
公开(公告)日：2012-10-26
申请号：PCT/US2012/030671
申请日：2012-03-27
申请人： MEDTRONIC, INC. , MCINTYRE, Peter B. , LI, Bernard Q. , WANG, Ling , ZHANG, Shangqian P.
发明人： MCINTYRE, Peter B. , LI, Bernard Q. , WANG, Ling , ZHANG, Shangqian P.
IPC分类号： A61N1/05 , A61L31/02 , B21C37/04 , C22F1/18 , B21F45/00 , H01B7/04
CPC分类号： A61N1/05 , C22C14/00 , C22F1/183 , Y10T29/49071
摘要： Techniques related to coils for medical device are disclosed. One example coil may comprise multiple filars, each being formed of a biocompatible beta titanium alloy having an elastic modulus ranging from 30 GigaPascals (GPa) to 90GPa and comprising at least two elements from a group consisting of titanium, molybdenum, niobium, tantalum, zirconium, chromium, iron and tin. At least one of the multiple filars may be electrically insulated one from another. A structural body, such as a lead body, may carry the coil. One or more filars may carry a low- resistance core. A method for forming the coils is also disclosed. Further, a medical electrical lead comprising such a coil is also disclosed.
摘要翻译：公开了与医疗装置的线圈有关的技术。一个示例性线圈可以包括多个丝状体，每个丝线由具有30千兆帕（GPa）至90GPa的弹性模量的生物相容性β钛合金形成，并且包含由钛，钼，铌，钽，锆组成的组中的至少两种元素，铬，铁和锡。多个丝线中的至少一个可以彼此电绝缘。诸如引线体的结构体可以承载线圈。一个或多个丝带可以携带低电阻芯。还公开了一种用于形成线圈的方法。此外，还公开了包括这种线圈的医用电线。

4. 发明申请

WO2010117560A1 WIRE CONFIGURATION AND METHOD OF MAKING FOR AN IMPLANTABLE MEDICAL APPARATUS 审中-公开
标题翻译：可植入医疗器械的线路配置和制作方法
公开(公告)号：WO2010117560A1
公开(公告)日：2010-10-14
申请号：PCT/US2010/027329
申请日：2010-03-15
申请人： MEDTRONIC, INC. , WANG, Ling , LI, Bernard Q.
发明人： WANG, Ling , LI, Bernard Q.
IPC分类号： A61N1/05 , H01B7/04 , B21C37/04 , A61N1/02
CPC分类号： A61N1/05 , A61N1/0472 , A61N1/0488 , A61N1/0551 , Y10T29/49002
摘要： A filar includes an inner conductive core that is formed of a low-resistivity material such as silver having a resistivity of less than 20μΩ per centimeter. A conductive coil is provided around the core to form a filar. This coil is formed of a biocompatible alloy or super alloy having an ultimate tensile strength (UTS) of between 150 kilo pounds per square inch (ksi) and 280 ksi at room temperature. Examples of such alloys include CoCrMo, CoFeCrMo, and CoFeNiCrMo. In one specific embodiment, the alloy is MP35N (CoNiCrMo), which may be low-titanium ("low-ti") MP35N. One or more such filars may be included within a wire. This wire may be carried by an implantable medical apparatus such as a lead, lead extension, or catheter. The wire may electrically couple elements such as connector electrodes to conducting electrodes or sensors.
摘要翻译：丝状物包括由诸如银的低电阻率材料形成的内导电芯，其电阻率小于每厘米20μO。在芯周围设置导电线圈以形成丝状体。该线圈由在室温下具有150千磅/平方英寸（ksi）和280ksi之间的极限拉伸强度（UTS）的生物相容性合金或超级合金形成。这种合金的实例包括CoCrMo，CoFeCrMo和CoFeNiCrMo。在一个具体实施方案中，合金是MP35N（CoNiCrMo），其可以是低钛（“低钛”）MP35N。一根或多根这样的丝状物可以包括在线内。该线可以由诸如铅，引线延伸或导管的可植入医疗设备携带。导线可以将诸如连接器电极的元件电耦合到导电电极或传感器。

5. 发明申请

WO2010104623A1 SYSTEM AND METHOD FOR RELEASING A MATERIAL WITHIN A MEDICAL DEVICE BY IRRADIATING A SEAL THROUGH AN OPTICAL FEEDTHROUGH 审中-公开
标题翻译：通过照射光学辐射密封而在医疗装置中释放材料的系统和方法
公开(公告)号：WO2010104623A1
公开(公告)日：2010-09-16
申请号：PCT/US2010/022686
申请日：2010-02-01
申请人： MEDTRONIC, INC. , ROBINSON, Reginald D. , DIFFERDING, David D. , JOHNSON, James A. , LI, Bernard Q. , LINDNER, Gerald G. , TISCHENDORF, Brad C. , THOM, Andrew J.
发明人： ROBINSON, Reginald D. , DIFFERDING, David D. , JOHNSON, James A. , LI, Bernard Q. , LINDNER, Gerald G. , TISCHENDORF, Brad C. , THOM, Andrew J.
IPC分类号： A61J1/20 , A61M39/14
CPC分类号： A61M5/14276 , A61M5/1407 , A61M39/04 , A61M2205/368
摘要： In general, the disclosure is directed toward releasing material (61) within a medical device via an optical feedthrough (44). A system (30) for releasing material with a medical device comprises a cup (40) that holds a material, wherein the cup includes a discharge port (46), a seal disc (42) that seals the material within the cup, an optical feedthrough assembly coupled to the cup, a shell (38) that defines a chamber within a medical device, wherein the optical feedthrough assembly is coupled to the shell, and a radiant energy source (50) that shines a beam (52) through the optical feedthrough assembly to puncture the seal disc to allow the material to enter the chamber via the discharge port.
摘要翻译：通常，本公开涉及经由光学馈通（44）在医疗装置内释放材料（61）。用于用医疗装置释放材料的系统（30）包括保持材料的杯（40），其中所述杯包括排出口（46），密封所述杯内的材料的密封盘（42），光学耦合到所述杯的馈通组件，限定医疗装置内的腔室的壳体（38），其中所述光学馈通组件耦合到所述壳体，以及辐射能量源（50），其将光束（52）照射通过所述光学器件馈通组件以刺穿密封盘以允许材料经由排出口进入腔室。

6. 发明申请

WO2015134859A1 TITANIUM ALLOY CONTACT RING ELEMENT HAVING LOW MODULUS AND LARGE ELASTIC ELONGATION 审中-公开
标题翻译：具有低模量和大弹性拉伸的钛合金接头环元件
公开(公告)号：WO2015134859A1
公开(公告)日：2015-09-11
申请号：PCT/US2015/019154
申请日：2015-03-06
申请人： MEDTRONIC, INC.
发明人： LI, Bernard Q. , SHI, Alan , SORENSEN, Daniel D. , JANZIG, Darren C. , BUSH, Margaret
IPC分类号： A61N1/00 , C22C14/00 , C22F1/18
CPC分类号： A61N1/05 , A61N1/00 , A61N1/3752 , B23H9/00 , C22C14/00 , C22F1/183 , Y10T29/49826 , Y10T29/49872
摘要： A method of forming a medical device contact element includes annealing an elongated rod of Ti-15Mo alloy material to form an annealed rod having a Young's Modulus of less than 13.5 Mpsi and an elastic range or strain of at least 0.7%. Then forming a contact ring element from the annealed rod and assembling the contact ring element into a medical device. Contact rings and lead receptacles including the same are also described.
摘要翻译：形成医疗器械接触元件的方法包括退火细长的Ti-15Mo合金材料棒以形成具有小于13.5Mpsi的杨氏模量和至少0.7％的弹性范围或应变的退火棒。然后从退火的杆形成接触环元件并将接触环元件组装到医疗装置中。还描述了包括其的接触环和引线插座。

7. 发明申请

WO2014144213A1 MEDICAL LEADS AND TECHNIQUES FOR MANUFACTURING THE SAME 审中-公开
标题翻译：医疗领域及其制造技术
公开(公告)号：WO2014144213A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/028523
申请日：2014-03-14
申请人： MEDTRONIC, INC.
发明人： CHEN, Xingfu , LI, Bernard Q. , STONE, Richard T. , SEELEY, Dale F. , SHI, Alan
IPC分类号： A61N1/375 , A61N1/05
CPC分类号： A61N1/05 , A61N1/375 , H05K13/00 , Y10T29/49117
摘要： In some examples, the disclosure relates to a medical device comprising a lead including an electrically conductive lead wire; and an electrode electrically coupled to the lead wire, the electrode including a first portion and a second portion, wherein the first portion defines an exposed outer surface of the electrode and is electrically coupled to the second portion along a first interface, wherein the second portion is electrically coupled to the lead wire along a second interface different from the first interface via welding to couple the lead wire to the electrode, wherein an electrical signal may be transferred between the lead wire and exposed outer surface of the first portion via the second portion, and wherein the first portion is formed from a first material having a first composition, and the second portion is formed from a second material having a second composition different from the first composition.
摘要翻译：在一些实例中，本发明涉及一种包括导线的医疗装置，该引线包括导电引线; 以及电连接到所述引线的电极，所述电极包括第一部分和第二部分，其中所述第一部分限定所述电极的暴露的外表面，并且沿着第一界面电连接到所述第二部分，其中所述第二部分通过焊接，沿着与第一接口不同的第二接口电耦合到引线，以将引线耦合到电极，其中电信号可以经由第二部分在引线和第一部分的暴露的外表面之间传递，并且其中所述第一部分由具有第一组合物的第一材料形成，并且所述第二部分由具有不同于所述第一组合物的第二组成的第二材料形成。

8. 发明申请

WO2014089485A1 MINIMALLY INVASIVE IMPLANTABLE NEUROSTIMULATION SYSTEM 审中-公开
标题翻译：微型可入侵神经系统
公开(公告)号：WO2014089485A1
公开(公告)日：2014-06-12
申请号：PCT/US2013/073669
申请日：2013-12-06
申请人： MEDTRONIC, INC.
发明人： TISCHENDORF, Brad C. , KAST, John E. , MILTICH, Thomas P. , MUNNS, Gordon O. , ROLES, Randy S. , SCHMIDT, Craig L. , VIAVATTINE, Joseph J. , NIELSEN, Christian S. , TAMIRISA, Prabhakar A. , CHASENSKY, Anthony M. , REITERER, Markus W. , PAIDOSH, Chris J. , ROBINSON, Reginald D. , LI, Bernard Q. , SCOTT, Erik R. , FALKNER, Phillip C. , WEI, Xuan K. , BONDE, Eric H.
IPC分类号： A61N1/378 , A61N1/372 , A61N1/02 , A61N1/36
CPC分类号： A61B17/00234 , A61N1/02 , A61N1/05 , A61N1/0551 , A61N1/36 , A61N1/36007 , A61N1/36021 , A61N1/3605 , A61N1/36053 , A61N1/36057 , A61N1/36067 , A61N1/36071 , A61N1/36139 , A61N1/37205 , A61N1/37211 , A61N1/37223 , A61N1/37235 , A61N1/37247 , A61N1/37252 , A61N1/3727 , A61N1/375 , A61N1/3754 , A61N1/3756 , A61N1/3787 , F04C2270/0421
摘要： An implantable medical device (IMD) has a housing enclosing an electronic circuit. The housing includes a first housing portion, a second housing portion and a joint coupling the first housing portion to the second housing portion. A polymer enclosure member surrounds the joint and circumscribes the housing in various embodiments. Other embodiments of an IMD housing are disclosed.
摘要翻译：可植入医疗装置（IMD）具有包围电子电路的外壳。壳体包括第一壳体部分，第二壳体部分和将第一壳体部分联接到第二壳体部分的接合部。在各种实施例中，聚合物外壳构件围绕接头并围绕外壳。公开了IMD外壳的其它实施例。

9. 发明申请

WO2012145120A1 CABLE WITH WIRES FORMED OF A BETA TITANIUM ALLOY FOR A MEDICAL DEVICE 审中-公开
标题翻译：具有形成用于医疗装置的钛合金的线的电缆
公开(公告)号：WO2012145120A1
公开(公告)日：2012-10-26
申请号：PCT/US2012/030270
申请日：2012-03-23
申请人： MEDTRONIC, INC. , LI, Bernard Q. , WANG, Ling
发明人： LI, Bernard Q. , WANG, Ling
IPC分类号： C22C14/00 , C22F1/18 , A61N1/05
CPC分类号： A61N1/05 , A61B17/1215 , A61B17/1219 , A61N1/0529 , A61N1/0551 , C22C14/00 , C22F1/183 , H01B7/048
摘要： Techniques are disclosed related to cables that may be used within a medical device. According to one example, a cable may comprise multiple wires (200). Each wire may be formed of a biocompatible beta titanium alloy having an elastic modulus ranging from 30 GigaPascals (GPa) to 90 GPa and comprising at least two elements selected from a group of titanium, molybdenum, niobium, tantalum, zirconium, chromium, iron and tin. The cable may be heated (206) to a stress - relieve temperature of the beta titanium alloy to allow the cable to retain a desired configuration while remaining ductile. The cable may be included within a medical device, such as a medical electrical lead.
摘要翻译：公开了可以在医疗装置内使用的电缆的技术。根据一个示例，电缆可以包括多根电线（200）。每个线可以由具有30千兆帕（GPa）至90GPa的弹性模量的生物相容性β钛合金形成，并且包括选自钛，钼，铌，钽，锆，铬，铁中的至少两种元素，以及锡。电缆可以被加热（206）到β钛合金的应力释放温度，以允许电缆保持所需的构造，同时保持延性。电缆可以包括在医疗设备中，例如医疗电线。

10. 发明授权

EP2117618B1 IMPLANTABLE MEDICAL DEVICE WITH TITANIUM ALLOY HOUSING 有权
标题翻译：住房泰坦合金的植入式医疗
公开(公告)号：EP2117618B1
公开(公告)日：2010-11-03
申请号：EP07717009.0
申请日：2007-01-23
申请人： Medtronic, Inc.
发明人： LI, Bernard Q. , GREVIOUS, John J. , DAVIS, Timothy J. , PERZ, Leroy , PAIDOSH, Chris J. , KAST, John E. , MIESEL, Keith A. , JANZIG, Darren A. , LINDNER, Gerald G.
IPC分类号： A61L31/02 , C22C14/00
CPC分类号： C22C14/00 , A61L31/022 , A61N1/375
摘要： An implantable medical device (10) includes a housing (20) comprising a titanium alloy selected from the group consisting of Ti-4.5Al-3V-2Fe-2Mo-0.15O, Ti-4Al-2.5V-1.5Fe-0.25O, Ti-6Al-2Sn-4Zr-2Mo, Ti-3Al-2.5V, and combinations thereof.

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