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1. 发明申请

WO2019051018A1 MARKER MONITORING VIA A MEDICAL DEVICE 审中-公开
公开(公告)号：WO2019051018A1
公开(公告)日：2019-03-14
申请号：PCT/US2018/049652
申请日：2018-09-06
申请人： MEDTRONIC, INC.
发明人： BURNES, John E. , CARNEY, James K. , KUHN, Jonathan L. , PHELPS, Mark J. , SVENNING KRISTENSEN, Jesper , KATRA, Rodolphe
IPC分类号： A61B5/00 , A61N1/375 , A61M5/172 , G01N21/64 , A61B5/145
摘要： In some examples, a medical system includes a medical device. The medical device may include a housing configured to be implanted in a target site of a patient, a light emitter configured to emit a signal configured to cause a fluorescent marker to emit a fluoresced signal into the target site, and a light detector that may be configured to detect the fluoresced signal. The medical system may include processing circuitry configured to determine a characteristic of the fluorescent marker based on the emitted signal and the fluoresced signal. The characteristic of the fluorescent marker may be indicative of a presence of a compound in the patient, and the processing circuitry may be configured to track the presence of the compound of the patient based on the characteristic of the fluorescent marker.

2. 发明申请

WO2010144668A1 TISSUE OXYGENATION MONITORING IN HEART FAILURE 审中-公开
标题翻译：心脏失效组织氧化监测
公开(公告)号：WO2010144668A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/038117
申请日：2010-06-10
申请人： MEDTRONIC, INC. , CINBIS, Can , CARNEY, James K. , KUHN, Jonathan L. , ANDERSON, David A.
发明人： CINBIS, Can , CARNEY, James K. , KUHN, Jonathan L. , ANDERSON, David A.
IPC分类号： A61N1/365
CPC分类号： A61N1/36557
摘要： A medical device for monitoring delivery of a therapy that includes a therapy delivery module to deliver a therapy, a controller to set a therapy delivery control parameter, an optical sensor to produce a signal corresponding to tissue light attenuation, and a processor configured to compute a tissue oxygenation measurement from the optical sensor signal, wherein the controller, the optical sensor, and the processor operate cooperatively to determine a setting of the therapy delivery control parameter corresponding to a maximum tissue oxygenation.
摘要翻译：一种用于监测治疗递送的医疗装置，其包括用于递送疗法的治疗递送模块，用于设置治疗递送控制参数的控制器，用于产生对应于组织光衰减的信号的光学传感器，以及被配置为计算来自光学传感器信号的组织氧合测量，其中所述控制器，所述光学传感器和所述处理器协同工作以确定对应于最大组织氧合的所述治疗传递控制参数的设置。

3. 发明申请

WO2010144649A1 SHOCK REDUCTION USING ABSOLUTE CALIBRATED TISSUE OXYGEN SATURATION AND TOTAL HEMOGLOBIN VOLUME FRACTION 审中-公开
标题翻译：使用绝对标准组织氧气饱和和总HEMOGLOBIN体积分数减少减少
公开(公告)号：WO2010144649A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/038084
申请日：2010-06-10
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , CARNEY, James K.
发明人： KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , CARNEY, James K.
IPC分类号： A61B5/1455 , A61B5/00 , A61N1/362 , A61N1/365 , A61N1/39
CPC分类号： A61N1/3622 , A61B5/02028 , A61B5/0215 , A61B5/042 , A61B5/1116 , A61B5/14542 , A61B5/1459 , A61N1/36557 , A61N1/3956
摘要： An implantable medical device that includes an optical sensor for providing a signal corresponding to light attenuation by a volume of blood perfused tissue, a control module coupled to the optical sensor controlling the light emitted by the optical sensor, a monitoring module receiving an optical sensor output signal and measuring light attenuation, a tissue electrode for stimulating the volume of blood perfused tissue, a pulse generator coupled to the tissue electrode for delivering electrical stimulation to the volume of blood-perfused tissue, and a processor coupled to the cardiac electrode and the monitoring module and configured to detect an arrhythmia in response to the depolarization signals, compute a tissue oxygenation measurement and control the pulse generator to deliver electrical stimulation to the volume of blood-perfused tissue in response to detecting the arrhythmia, and detect a hemodynamic status of the arrhythmia in response to at least one of a detected rate of tissue oxygenation decline and a detected rate of tissue oxygenation recovery.
摘要翻译：一种可植入医疗装置，其包括：光学传感器，用于通过一定量的血液灌注组织提供对应于光衰减的信号;耦合到所述光学传感器的控制模块，所述控制模块控制由所述光学传感器发射的光;监测模块，其接收光学传感器输出信号和测量光衰减的组织电极，用于刺激血液灌注组织的体积的组织电极，耦合到组织电极的脉冲发生器，用于向血液灌注组织的体积输送电刺激，以及耦合到心脏电极和监测器模块并且被配置为响应于去极化信号检测心律失常，计算组织氧合测量并控制脉冲发生器以响应于检测到心律失常而向血液灌注组织的体积递送电刺激，并且检测血液动力学状态响应于检测到的tis的速率中的至少一种的心律失常检测氧合反应的下降和组织氧合恢复率。

4. 发明申请

WO2011031739A1 METHOD AND APPARATUS FOR POST-SHOCK EVALUATION USING TISSUE OXYGENATION MEASUREMENTS 审中-公开
标题翻译：使用组织氧化测量法进行后期评估的方法和装置
公开(公告)号：WO2011031739A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/048103
申请日：2010-09-08
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , HAVEL, William J.
发明人： KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , HAVEL, William J.
IPC分类号： A61N1/39 , A61B5/00
CPC分类号： A61B5/14551 , A61B5/1459 , A61B5/6846 , A61B5/7285 , A61N1/36557 , A61N1/3925 , A61N1/3956
摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a therapy delivery module coupled to the electrode to deliver a therapy via the electrode in response to the sensed cardiac signals, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the optical sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy, and a controller coupled to the therapy delivery module and the sensor, the controller configured to determine tissue oxygenation measurements in response to the output signal, determine a tissue oxygenation trend in response to the tissue oxygenation measurements, and determine whether the delivered therapy restored cardiac hemodynamic function in response to the determined tissue oxygenation trend.
摘要翻译：一种用于递送疗法的方法和装置，其包括用于感测心脏信号并递送治疗的电极;治疗递送模块，其耦合到所述电极，以响应于所感测的心脏信号经由所述电极递送治疗;发射光和检测的传感器发射由邻近光学传感器的组织体积散射的光以产生相应的检测到的光强度输出信号;耦合到传感器的控制模块，用于响应于递送治疗来控制传感器的光发射;以及控制器，耦合到治疗递送模块和传感器，所述控制器被配置为响应于输出信号确定组织氧合测量，响应于组织氧合测量确定组织氧合趋势，并且确定所递送的治疗是否响应于所确定的组织氧合来恢复心脏血液动力学功能趋势。

5. 发明申请

WO2010144665A1 DEVICE AND METHOD FOR MONITORING OF ABSOLUTE OXYGEN SATURATION AND TOTAL HEMOGLOBIN CONCENTRATION 审中-公开
标题翻译：用于监测绝对氧化饱和度和总HEMOGLOBIN浓度的装置和方法
公开(公告)号：WO2010144665A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/038114
申请日：2010-06-10
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , CINBIS, Can , CARNEY, James K. , ANDERSON, David A.
发明人： KUHN, Jonathan L. , CINBIS, Can , CARNEY, James K. , ANDERSON, David A.
IPC分类号： A61B5/00
CPC分类号： A61B5/14552 , A61B5/0084 , A61B5/14546 , A61B5/1459 , A61B5/7239 , A61N1/36557
摘要： A medical device for monitoring of oxygen saturation includes an optical sensor adapted for positioning adjacent to a tissue volume. The optical sensor has a light emitting portion capable of emitting light at a plurality of wavelengths and a light detecting portion capable of generating an electrical output signal corresponding to light incident on the detecting portion. A control module coupled to the optical sensor controls the light emitted by the light emitting portion. A monitoring module receives the output signal from the light detecting portion and computes a volume-independent measure of oxygen saturation in the volume of tissue using the output signal.
摘要翻译：用于监测氧饱和度的医疗装置包括适于邻近组织体积定位的光学传感器。光学传感器具有能够发射多个波长的光的发光部和能够产生与入射到检测部上的光对应的电输出信号的光检测部。耦合到光学传感器的控制模块控制由发光部分发射的光。监测模块接收来自光检测部分的输出信号，并使用输出信号计算组织体积中的氧饱和度的体积无关测量。

6. 发明申请

WO2009076063A1 IMPLANTABLE OPTICAL SENSOR AND METHOD FOR MANUFACTURE 审中-公开
标题翻译：可植入的光学传感器及其制造方法
公开(公告)号：WO2009076063A1
公开(公告)日：2009-06-18
申请号：PCT/US2008/084675
申请日：2008-11-25
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , CINBIS, Can , ECKER, Robert M. , DAVIS, Timothy J. , KNOWLES, Shawn D.
发明人： KUHN, Jonathan L. , CINBIS, Can , ECKER, Robert M. , DAVIS, Timothy J. , KNOWLES, Shawn D.
IPC分类号： A61B5/00
CPC分类号： A61B5/14542 , A61B5/0084 , A61B5/0086 , A61B5/14532 , A61B5/14552 , A61B5/1459 , A61B5/6846 , A61B2562/02 , A61B2562/043 , A61B2562/146
摘要： An implantable optical sensor and associated manufacturing method include a sensor housing having an inner surface and an outer surface and a window formed in the housing extending between the housing inner surface and the housing outer surface. An opto-electronic device enclosed within the housing and having a photonic surface is operatively positioned proximate the window for emitting light through the window or detecting light through the window. An optical coupling member is positioned between the opto-electronic device and the window for reducing light reflection at a surface within the implantable optical sensor.
摘要翻译：可植入光学传感器和相关联的制造方法包括具有内表面和外表面的传感器外壳和形成在壳体中的窗口，该壳体在壳体内表面和壳体外表面之间延伸。封闭在壳体内并具有光子表面的光电器件可操作地定位在窗口附近，用于通过窗口发射光或通过窗口检测光。光耦合构件位于光电器件和窗口之间，用于减少可植入光学传感器内的表面处的光反射。

7. 发明申请

WO2018187264A3 IMPLANTABLE LEAD 审中-公开
公开(公告)号：WO2018187264A3
公开(公告)日：2018-10-11
申请号：PCT/US2018/025795
申请日：2018-04-03
申请人： MEDTRONIC, INC.
发明人： BOONE, Mark R. , KUHN, Jonathan L.
IPC分类号： A61N1/39 , A61N1/05 , A61N1/375
摘要： Various embodiments of a sealed package and a method of forming such package are disclosed. The package includes a housing, a substrate hermetically sealed to the housing, and a light source disposed on a first major surface of the substrate. The package further includes a detector disposed on the first major surface of the substrate and having a detecting surface. The package also includes a masking layer disposed on at least one of the first major surface and a second major surface of the substrate, where the masking layer includes a first aperture aligned with an emission axis of the light source in a direction orthogonal to the first major surface of the substrate. The masking layer further includes a second aperture aligned with a detection axis of the detector in a direction orthogonal to the first major surface of the substrate.

8. 发明申请

WO2016032637A1 INTERVENTIONAL MEDICAL SYSTEMS, DEVICES, AND COMPONENTS THEREOF 审中-公开
标题翻译：传统医疗系统，设备和组件
公开(公告)号：WO2016032637A1
公开(公告)日：2016-03-03
申请号：PCT/US2015/040870
申请日：2015-07-17
申请人： MEDTRONIC, INC.
发明人： GRUBAC, Vladimir , ANDERSON, Thomas A. , KUHN, Jonathan L. , SWENSON, Richard W. , CAMPBELL, Michael P.
IPC分类号： A61N1/375
CPC分类号： A61N1/057 , A61N1/362 , A61N1/3756
摘要： A fixation member component, for example, employed by a relatively compact implantable medical device, includes a plurality of fingers; each finger includes a first segment extending from a fixed end of the corresponding finger, and a second segment extending from the corresponding first segment to a free end of the corresponding finger. Each first segment is elastically deformable from a relaxed to an extended condition, and from the relaxed to a compressed condition, and includes a peripheral portion and a central cut-out portion, framed by the peripheral portion. In the compressed condition, a free tip of the cut-out portion of some or all of the fingers may lodge against opposing tissue surfaces, via a spring force of the compressed fingers. Each second segment and cut-out portion is preferably configured to prevent penetration thereof within tissue at the implant site.
摘要翻译：例如由相对紧凑的可植入医疗装置使用的固定构件部件包括多个手指; 每个手指包括从相应手指的固定端延伸的第一段和从对应的第一段延伸到相应手指的自由端的第二段。每个第一段可从松弛到伸长状态弹性变形，并且从松弛到可压缩状态，并且包括由周边部分构成的周边部分和中央切口部分。在压缩状态下，部分或全部手指的切口部分的自由尖端经由压缩手指的弹簧力抵靠在相对的组织表面上。每个第二段和切口部分优选地构造成防止在植入部位的组织内的穿透。

9. 发明申请

WO2011031597A1 METHOD AND APPARATUS FOR POST-SHOCK EVALUATION USING TISSUE OXYGENATION MEASUREMENTS 审中-公开
标题翻译：使用组织氧化测量法进行后期评估的方法和装置
公开(公告)号：WO2011031597A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/047450
申请日：2010-09-01
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , HAVEL, William J.
发明人： KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , HAVEL, William J.
IPC分类号： A61N1/39 , A61B5/00
CPC分类号： A61B5/14551 , A61B5/1459 , A61B5/6846 , A61B5/7285 , A61N1/36557 , A61N1/3925 , A61N1/3956
摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a therapy delivery module coupled to the electrode to deliver a therapy via the electrode in response to the sensed cardiac signals, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy; and a controller coupled to the therapy delivery module and the sensor, the controller configured to determine a tissue oxygenation measurement in response to the output signal, and determine whether the delivered therapy was successful in restoring cardiac hemodynamic function in response to the tissue oxygenation measurement.
摘要翻译：一种用于递送治疗的方法和装置，其包括用于感测心脏信号并递送治疗的电极，治疗递送模块，其耦合到所述电极，以响应于感测到的心脏信号经由所述电极递送治疗;发射光和检测的传感器发射由邻近传感器的组织体积散射的光，以产生相应的检测到的光强度输出信号;控制模块，其耦合到所述传感器以响应于递送所述治疗来控制所述传感器的光发射; 以及耦合到所述治疗递送模块和所述传感器的控制器，所述控制器被配置为响应于所述输出信号确定组织氧合测量，并且确定所递送的治疗是否成功响应于所述组织氧合测量来恢复心脏血液动力学功能。

10. 发明申请

WO2010144667A1 TISSUE OXYGENATION MONITORING IN HEART FAILURE 审中-公开
标题翻译：心脏失效组织氧化监测
公开(公告)号：WO2010144667A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/038116
申请日：2010-06-10
申请人： MEDTRONIC, INC. , CINBIS, Can , CARNEY, James K. , KUHN, Jonathan L. , ANDERSON, David A.
发明人： CINBIS, Can , CARNEY, James K. , KUHN, Jonathan L. , ANDERSON, David A.
IPC分类号： A61N1/365
CPC分类号： A61N1/36557
摘要： A medical device system and associated method control the delivery of a heart failure therapy to a patient. The system includes an activity sensor and detects a change in activity level of the patient. The system further include an optical sensor to sense signal corresponding to tissue light attenuation. The system computes a tissue oxygenation measurement in response to detecting a change in activity level. A parameter controlling delivery of the heart failure therapy is adjusted in response to detecting the decreased tissue oxygenation.
摘要翻译：医疗装置系统和相关联的方法控制对患者的心力衰竭治疗的递送。该系统包括活动传感器并检测患者的活动水平的变化。该系统还包括用于感测对应于组织光衰减的信号的光学传感器。响应于检测到活动水平的变化，系统计算组织氧合测量。响应于检测到减少的组织氧合而调整控制心力衰竭治疗递送的参数。

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