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1. 发明申请

WO2018080653A1 AUTOTITRATION OF THERAPY USING DETECTED ELECTRICAL ACTIVITY 审中-公开
标题翻译：使用检测的电活性进行治疗的自动化
公开(公告)号：WO2018080653A1
公开(公告)日：2018-05-03
申请号：PCT/US2017/051441
申请日：2017-09-14
申请人： MEDTRONIC, INC.
发明人： SU, Xin , BRINK, Thaddeus S. , NELSON, Dwight E.
IPC分类号： A61N1/36 , A61N1/372
摘要： This disclosure relates to devices, systems, and methods for autotitrating stimulation parameters. In one example, a method includes controlling an implantable medical device to deliver electrical stimulation to a patient according to a plurality of electrical stimulation parameter sets, each electrical stimulation parameter set of the plurality of electrical stimulation parameter sets defining a respective electrical stimulation signal deliverable to the patient, obtaining, by one or more processors and for each electrical stimulation parameter set of the plurality of electrical stimulation parameter sets, a respective signal representative of an electrical response sensed from the patient in response to the electrical stimulation delivered to the patient according to the respective electrical stimulation parameter set, and determining, by the one or more processors and based on the obtained respective signals, a primary electrical stimulation parameter set that defines electrical stimulation therapy deliverable to the patient by the implantable medical device.
摘要翻译：本公开涉及用于自动刺激刺激参数的装置，系统和方法。在一个示例中，一种方法包括：控制可植入医疗设备以根据多个电刺激参数集向患者传递电刺激，所述多个电刺激参数集中的每个电刺激参数集定义可递送至患者通过一个或多个处理器并且对于多个电刺激参数组中的每个电刺激参数组获得表示响应于根据以下方式递送给患者的电刺激从患者感测的电响应的相应信号相应的电刺激参数组，并且由一个或多个处理器并且基于获得的各个信号来确定限定可由植入式医疗设备递送给患者的电刺激治疗的主电刺激参数集。

2. 发明申请

WO2011156288A3 ADAPTIVE STIMULATION FOR TREATING URGENCY OR INCONTINENCE 审中-公开
公开(公告)号：WO2011156288A3
公开(公告)日：2011-12-15
申请号：PCT/US2011/039322
申请日：2011-06-06
申请人： MEDTRONIC, INC. , SU, Xin , NELSON, Dwight, E.
发明人： SU, Xin , NELSON, Dwight, E.
IPC分类号： A61N1/36 , A61N1/05 , A61B5/03
摘要： In one example, a system includes a therapy module and a processor. The processor detects a voiding event of a patient and controls the therapy module to deliver electrical stimulation to the patient at a first intensity level for a period of time in response to the detection of the voiding event. Immediately following the period of time, the processor controls the therapy module to increase intensity of the electrical stimulation from the first intensity level to a second intensity level before a subsequent voiding event of the patient by at least controlling the therapy module to deliver stimulation to the patient at a plurality of intermediate intensity levels between the first and second intensity levels prior to delivering stimulation to the patient at the second intensity level following the detection of the voiding event.

3. 发明申请

WO2011156287A2 SELECTIVE TERMINATION OF STIMULATION TO DELIVER POST-STIMULATION THERAPEUTIC EFFECT 审中-公开
标题翻译：选择性终止刺激以提供刺激后治疗效果
公开(公告)号：WO2011156287A2
公开(公告)日：2011-12-15
申请号：PCT/US2011/039315
申请日：2011-06-06
申请人： MEDTRONIC, INC. , SU, Xin , NELSON, Dwight, E.
发明人： SU, Xin , NELSON, Dwight, E.
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61B5/0031 , A61B5/04001 , A61B5/04882 , A61B5/1116 , A61B5/205 , A61B5/4047 , A61B5/4836 , A61N1/0514
摘要： In some examples, electrical stimulation is delivered to a patient such that selective termination of the stimulation causes a therapeutic effect in the patient after termination of the electrical stimulation to the patient. The electrical stimulation may be insufficient to produce a desired therapeutic effect in the patient during stimulation, but sufficient to induce a post-stimulation desired therapeutic effect following termination of the stimulation. In some examples, the electrical stimulation may be sub-threshold electrical stimulation. In some examples, the desired therapeutic effect may alleviate bladder dysfunction, bowel dysfunction, or other disorders. The stimulation may be selectively terminated in response to one or more therapy trigger events to induce the post-stimulation therapeutic effect.
摘要翻译：在一些示例中，将电刺激递送给患者，使得刺激的选择性终止在终止对患者的电刺激之后在患者中引起治疗效果。电刺激可能不足以在刺激期间在患者中产生期望的治疗效果，但足以在终止刺激后诱导刺激后期望的治疗效果。在一些示例中，电刺激可以是亚阈值电刺激。在一些实例中，期望的治疗效果可以缓解膀胱功能障碍，肠功能障碍或其它障碍。可以响应于一个或多个治疗触发事件来选择性地终止刺激以诱导刺激后治疗效果。

4. 发明申请

WO2011156286A2 STIMULATION THERAPY FOR BLADDER DYSFUNCTION 审中-公开
标题翻译：用于刀片功能的刺激治疗
公开(公告)号：WO2011156286A2
公开(公告)日：2011-12-15
申请号：PCT/US2011/039311
申请日：2011-06-06
申请人： MEDTRONIC, INC. , SU, Xin , NELSON, Dwight, E.
发明人： SU, Xin , NELSON, Dwight, E.
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61B5/0031 , A61B5/04001 , A61B5/04882 , A61B5/1116 , A61B5/205 , A61B5/4047 , A61B5/4836 , A61N1/0514
摘要： A medical system may include a control module and a therapy delivery module configured to generate and deliver electrical stimulation therapy to a patient. The control module may be configured to control the therapy delivery module to deliver electrical stimulation at a first stimulation intensity for a first time period, to deliver electrical stimulation at a second stimulation intensity for a second time period immediately following the first time period, and to deliver electrical stimulation at the first stimulation intensity for a third time period immediately following the second time period. The second stimulation intensity may be less than the first stimulation intensity. The electrical stimulation may elicit a first inhibitory physiological response during the first time period and a second inhibitory physiological response during the second time period. The second inhibitory physiological response may be greater than the first inhibitory physiological response.
摘要翻译：医疗系统可以包括控制模块和治疗递送模块，其被配置为产生并向患者递送电刺激治疗。控制模块可以被配置为控制治疗递送模块以第一时间段的第一刺激强度递送电刺激，以在第一时间段之后的第二时间段中以第二刺激强度递送电刺激，以及在第二时间段之后的第三时间段内以第一刺激强度递送电刺激。第二刺激强度可能小于第一刺激强度。电刺激可以在第一时间段期间引起第一抑制性生理反应，并在第二时间段期间引起第二抑制性生理反应。第二抑制生理反应可能大于第一抑制生理反应。

5. 发明申请

WO2018195465A1 LEAD PLACEMENT FOR NERVE STIMULATION 审中-公开
公开(公告)号：WO2018195465A1
公开(公告)日：2018-10-25
申请号：PCT/US2018/028626
申请日：2018-04-20
申请人： MEDTRONIC, INC.
发明人： SU, Xin , DINSMOOR, David A. , AGRAN, Jason E.
IPC分类号： A61N1/05 , A61N1/36 , A61B5/0488 , A61N1/372
摘要： Example systems for positioning an implantable electrode may include a stimulation circuitry, a sensing circuitry, and processing circuitry. The stimulation circuitry may generate electrical stimulation deliverable to a patient. The sensing circuitry may sense electromyographic (EMG) responses. The processing circuitry may control the stimulation circuitry to deliver the electrical stimulation at a plurality of different stimulation metric levels at each of a plurality of different positions. The processing circuitry may sense, via the sensing circuitry, electromyographic (EMG) responses to the electrical stimulation. The processing circuitry may score one or more of the different positions for chronic implantation of at least one implantable electrode. The scoring may be based on a stimulation metric level greater than a predetermined metric threshold sufficient to evoke at least some of the sensed EMG responses, and a level of the at least some of the sensed EMG responses.

6. 发明申请

WO2011059948A1 DEEP BRAIN STIMULATION FOR SLEEP AND MOVEMENT DISORDERS 审中-公开
标题翻译：睡眠和运动障碍的深层脑刺激
公开(公告)号：WO2011059948A1
公开(公告)日：2011-05-19
申请号：PCT/US2010/055943
申请日：2010-11-09
申请人： MEDTRONIC, INC. , WU, Jianping , NELSON, Dwight E. , SU, Xin , MOLNAR, Gregory F.
发明人： WU, Jianping , NELSON, Dwight E. , SU, Xin , MOLNAR, Gregory F.
IPC分类号： A61N1/36
CPC分类号： A61B5/4812 , A61B5/4082 , A61N1/0534 , A61N1/36078 , A61N1/36082
摘要： Delivery of electrical stimulation to the substantia nigra and the subthalamic nucleus of a brain of a patient are independently controlled in order to treat sleep and movement disorders. Electrical stimulation of the subthalamic nucleus may be effective in treating symptoms associated with a movement disorder, and electrical stimulation of the substantia nigra may be effective in treating symptoms associated with a sleep disorder. During a sleep state of the patient, a sleep stage of the patient may be determined, and an electrical stimulation device may be controlled based on the determined sleep stage. Electrical stimulation of the substantia nigra and subthalamic nucleus may be delivered at substantially the same time or at different times.
摘要翻译：为了治疗睡眠和运动障碍，独立地控制向患者的脑黑质和下丘脑核的电刺激递送。下丘脑核的电刺激可能有效地治疗与运动障碍相关的症状，并且黑质的电刺激可能有效治疗与睡眠障碍相关的症状。在患者的睡眠状态期间，可以确定患者的睡眠阶段，并且可以基于所确定的睡眠阶段来控制电刺激装置。黑质和丘脑底核的电刺激可以在相同的时间或在不同的时间被递送。

7. 发明申请

WO2018053336A1 DORSAL SPINAL COLUMN CHARACTERIZATION SYSTEM USING EVOKED POTENTIALS 审中-公开
标题翻译：用诱发电位Dorsal脊柱表征系统
公开(公告)号：WO2018053336A1
公开(公告)日：2018-03-22
申请号：PCT/US2017/051885
申请日：2017-09-15
申请人： MEDTRONIC, INC.
发明人： DINSMOOR, David A. , DENISON, Timothy J. , SU, Xin
IPC分类号： A61N1/36
摘要： This disclosure relates to methods, devices, and systems for delivering and adjusting stimulation therapy. In one example, a method comprising delivering, by a stimulation electrode, electrical stimulation as a candidate therapy to a patient according to a set of candidate therapy parameters, the stimulation electrode located in proximity to the dorsal column of a patient; sensing, by a sensing electrode, an electrically evoked compound action potential (eECAP) signal in response to the delivery of the electrical stimulation; and classifying, by a processor, the sensed eECAP signal generated in response to the application of the candidate therapy relative to an eECAP baseline is disclosed.
摘要翻译：本公开涉及用于递送和调节刺激治疗的方法，设备和系统。在一个示例中，一种方法，包括：由刺激电极根据一组候选治疗参数将电刺激作为候选治疗传递给患者，所述刺激电极位于患者的背部柱附近; 通过感测电极感测响应于所述电刺激的递送的电诱发复合动作电位（eECAP）信号; 以及由处理器分类响应于候选疗法相对于eECAP基线的应用而生成的感测到的eECAP信号。

8. 发明申请

WO2018089418A1 STIMULATION VECTOR SELECTION USING PULSE WIDTH DATA 审中-公开
标题翻译：使用脉冲宽度数据的刺激向量选择
公开(公告)号：WO2018089418A1
公开(公告)日：2018-05-17
申请号：PCT/US2017/060529
申请日：2017-11-08
申请人： MEDTRONIC, INC.
发明人： DINSMOOR, David A. , SU, Xin
IPC分类号： A61N1/36 , A61N1/37
摘要： A method of programming an implantable medical device (IMD) configured to provide electrical stimulation via a plurality of stimulation vectors during delivery of the electrical stimulation of a plurality of pulse widths to a neural target. The method may comprise comparing strength-duration curve data for the plurality of stimulation vectors to one another, the strength-duration curve data representing, for respective pulse widths and stimulation vectors, a corresponding stimulation strength that evokes a physiological response associated with the neural target. The method may comprise selecting at least one stimulation vector of the plurality of stimulation vectors based on the comparison of the strength-duration curve data for the plurality of stimulation vectors. The method may comprise programming, in response to the selection, the IMD to deliver the electrical stimulation to the neural target via the selected at least one stimulation vector.
摘要翻译：一种对可植入医疗装置（IMD）进行编程的方法，所述可植入医疗装置被配置为在将多个脉冲宽度的电刺激递送至神经靶标期间经由多个刺激向量提供电刺激。该方法可以包括将多个刺激矢量的强度 - 持续时间曲线数据相互比较，强度 - 持续时间曲线数据针对各个脉冲宽度和刺激矢量表示唤起与神经靶标相关联的生理反应的对应刺激强度。该方法可以包括基于多个刺激向量的强度 - 持续时间曲线数据的比较来选择多个刺激向量中的至少一个刺激向量。该方法可以包括响应于该选择而编程IMD以经由所选择的至少一个刺激向量将电刺激递送至神经靶标。

9. 发明申请

WO2012024286A2 URGENCY THERAPY WITH NEUROMODULATION AND C-AFFERENT NERVE DESENSITIZATION 审中-公开
标题翻译：紧急神经修复和神经系统神经衰弱的紧急治疗
公开(公告)号：WO2012024286A2
公开(公告)日：2012-02-23
申请号：PCT/US2011/047903
申请日：2011-08-16
申请人： MEDTRONIC, INC. , SU, Xin , MOLNAR, Gregory F. , NELSON, Dwight E.
发明人： SU, Xin , NELSON, Dwight E.
IPC分类号： A61N1/36 , A61M5/172
CPC分类号： A61N1/36007 , A61K31/165 , A61M5/14276 , A61M5/1723 , A61M2205/054 , A61M2210/1085 , A61N1/36057 , A61N1/3606 , A61N1/36071 , A61N1/36171 , G06F19/00 , G06F19/3468 , G06F19/3481
摘要： Systems, devices, and methods may be used for treating bladder dysfunction, such as urgency and pelvic pain. In one example, a method includes administering a pharmacological agent to a patient in a dosage sufficient to desensitize a C-afferent nerve fiber of the patient. Additionally, the method includes delivering stimulation to activate a nerve fiber proximate to the C-afferent nerve fiber via an electrode electrically coupled to an implantable medical device. In some examples, the nerve fiber may be different than the C-afferent nerve fiber, the stimulation of the nerve fiber may elicit an inhibitory physiological related to voiding in the patient, and/or the stimulation substantially may not activate the C-afferent nerve fiber after desensitization of the nerve fiber via the administration of the pharmacological agent.
摘要翻译：系统，装置和方法可用于治疗膀胱功能障碍，例如紧急和盆腔疼痛。在一个实例中，一种方法包括以足以使患者的C型传入神经纤维脱敏的剂量向患者施用药理学试剂。另外，该方法包括传递刺激以通过电耦合到可植入医疗装置的电极来激活靠近C型传入神经纤维的神经纤维。在一些实例中，神经纤维可能不同于C型传入神经纤维，神经纤维的刺激可引起与患者排尿有关的抑制性生理学和/或刺激基本上不能激活C型传入神经通过施用药理学试剂使神经纤维脱敏后的纤维。

10. 发明申请

WO2012024269A2 URGENCY THERAPY WITH NEUROMODULATION AND C-AFFERENT NERVE DESENSITIZATION 审中-公开
标题翻译：神经调节和C反应神经脱敏紧急治疗
公开(公告)号：WO2012024269A2
公开(公告)日：2012-02-23
申请号：PCT/US2011/047874
申请日：2011-08-16
申请人： MEDTRONIC, INC. , SU, Xin , MOLNAR, Gregory F. , NELSON, Dwight E.
发明人： SU, Xin , NELSON, Dwight E.
IPC分类号： A61N1/36 , A61M5/172
CPC分类号： A61N1/36007 , A61K31/165 , A61M5/14276 , A61M5/1723 , A61M2205/054 , A61M2210/1085 , A61N1/36057 , A61N1/3606 , A61N1/36071 , A61N1/36171 , G06F19/00 , G06F19/3468 , G06F19/3481
摘要： Systems, devices, and methods may be used for treating bladder dysfunction, such as urgency and pelvic pain. In one example, a method includes administering a pharmacological agent to a patient in a dosage sufficient to desensitize a C-afferent nerve fiber of the patient. Additionally, the method includes delivering stimulation to activate a nerve fiber proximate to the C-afferent nerve fiber via an electrode electrically coupled to an implantable medical device. In some examples, the nerve fiber may be different than the C-afferent nerve fiber, the stimulation of the nerve fiber may elicit an inhibitory physiological related to voiding in the patient, and/or the stimulation substantially may not activate the C-afferent nerve fiber after desensitization of the nerve fiber via the administration of the pharmacological agent.
摘要翻译：系统，装置和方法可以用于治疗膀胱功能障碍，例如尿急和骨盆疼痛。在一个实例中，方法包括以足以使患者的C-传入神经纤维脱敏的剂量向患者施用药理学试剂。此外，该方法包括递送刺激以经由电耦合到可植入医疗装置的电极激活接近C传入神经纤维的神经纤维。在一些示例中，神经纤维可以不同于C-传入神经纤维，神经纤维的刺激可以引起与患者中的排泄有关的抑制性生理学，和/或刺激基本上可以不激活C-传入神经通过施用药理学试剂对神经纤维脱敏后的纤维。

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