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1. 发明公开

EP1981534A2 INDOLEAMINE 2,3-DIOXYGENASE PATHWAYS IN THE GENERATION OF REGULATORY T CELLS 审中-公开
标题翻译：吲哚胺2,3-双加氧酶-WAY在生产调节性T细胞
公开(公告)号：EP1981534A2
公开(公告)日：2008-10-22
申请号：EP07717763.2
申请日：2007-01-05
申请人： Medical College of Georgia Research Institute, Inc , Chen, Wei , Blazar, Bruce R. , Munn, David , Mellor, Andrew , Regents of the University of Minnesota
发明人： CHEN, Wei , BLAZAR, Bruce, R. , MUNN, David , MELLOR, Andrew
IPC分类号： A61K39/00 , A61K31/405
CPC分类号： C07D471/04 , A61K31/405 , C07D209/12 , C07D209/14 , C07D209/20 , C07D209/36 , C07D209/40 , C07D209/94 , C07D213/74 , C07D215/26 , C07D233/56 , C07D307/77 , C07D307/92 , C07D311/92 , C07D333/58 , C07D403/06 , C07D417/04 , C07D491/04 , C07D513/04
摘要： The present invention provides methods for the control of the generation of regulatory T cells (Tregs) and uses thereof.

2. 发明申请

WO2007081878A2 INDOLEAMINE 2,3-DIOXYGENASE PATHWAYS IN THE GENERATION OF REGULATORY T CELLS 审中-公开
公开(公告)号：WO2007081878A2
公开(公告)日：2007-07-19
申请号：PCT/US2007/000404
申请日：2007-01-05
申请人： MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC. , CHEN, Wei , BLAZAR, Bruce, R. , MUNN, David , MELLOR, Andrew
发明人： CHEN, Wei , BLAZAR, Bruce, R. , MUNN, David , MELLOR, Andrew
IPC分类号： A61K39/00 , A61K31/405
CPC分类号： C07D471/04 , A61K31/405 , C07D209/12 , C07D209/14 , C07D209/20 , C07D209/36 , C07D209/40 , C07D209/94 , C07D213/74 , C07D215/26 , C07D233/56 , C07D307/77 , C07D307/92 , C07D311/92 , C07D333/58 , C07D403/06 , C07D417/04 , C07D491/04 , C07D513/04
摘要： The present invention provides methods for the control of the generation of regulatory T cells (Tregs) and uses thereof.
摘要翻译：本发明提供了用于控制调节性T细胞（Treg）的产生及其用途的方法。

3. 发明申请

WO2007050405A2 THE INDUCTION OF INDOLEAMINE 2,3-DIOXYGENASE IN DENDRITIC CELLS BY TLR LIGANDS AND USES THEREOF 审中-公开
标题翻译：通过TLR配体诱导印度细胞中吲哚啉2,3-二氧化物的研究及其用途
公开(公告)号：WO2007050405A2
公开(公告)日：2007-05-03
申请号：PCT/US2006/040796
申请日：2006-10-20
申请人： MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC. , MELLOR, Andrew , MUNN, David
发明人： MELLOR, Andrew , MUNN, David
IPC分类号： A61K39/00 , A61K31/404
CPC分类号： A61K39/001 , A61K31/404 , A61K2039/55516 , A61K2039/55561
摘要： The induction of indoleamine 2,3-dioxygenase (IDO) in an IDO-competent subset of dendritic cells by TLR ligands, including TLR9 ligands, and various uses thereof are presented.
摘要翻译：介绍了通过TLR配体（包括TLR9配体）在树突状细胞的IDO能力子集中诱导吲哚胺2,3-双加氧酶（IDO）及其各种用途。

4. 发明申请

WO2003087347A1 ANTIGEN-PRESENTING CELL POPULATIONS AND THEIR USE AS REAGENTS FOR ENHANCING OR REDUCING IMMUNE TOLERANCE 审中-公开
标题翻译：抗原细胞群体及其用作增强或减少免疫耐受性的试剂
公开(公告)号：WO2003087347A1
公开(公告)日：2003-10-23
申请号：PCT/US2002/011319
申请日：2002-04-12
申请人： MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC. , MELLOR, Andrew , MUNN, David
发明人： MELLOR, Andrew , MUNN, David
IPC分类号： C12N5/00
CPC分类号： C12N5/064 , A61K2035/122 , C12N2501/22 , C12N2501/23 , C12N2501/70
摘要： The present invention is based on the discovery antigen-presenting cells (APCs) may be generated to have predetermined levels of expression of the intracellular enzyme, indoleamine 2,3-dioxygenase (IDO). Because expression of high levels of IDO is correlated with a reduced ability to stimulate T cell responses and an enhanced ability to induce immunologic tolerance, APCs having high levels of IDO may be used to increase tolerance in the immune system, as for example in transplant therapy or treatment of autoimmune disorders. For example, APCs having high levels of IDO, and expressing or loaded with at least one antigen from a donor tissue may be used to increase tolerance of the recipient to the donor's tissue. Alternatively, APCs having reduced levels of IDO expression and expressing or loaded with at least one antigen from a cancer or infectious pathogen may be used as vaccines to promote T cell responses and increase immunity.
摘要翻译：本发明基于发现抗原呈递细胞（APC）可以被产生以具有细胞内酶，吲哚胺2,3-双加氧酶（IDO）的预定水平的表达。因为高水平的IDO的表达与刺激T细胞应答的能力降低以及增强的诱导免疫耐受能力相关联，所以具有高水平IDO的APC可用于增加免疫系统的耐受性，例如在移植治疗或治疗自身免疫性疾病。例如，可以使用具有高水平的IDO并且表达或加载来自供体组织的至少一种抗原的APC来增加受体与供体组织的耐受性。或者，具有降低的IDO表达水平并且表达或加载至少一种来自癌症或感染性病原体的抗原的APC可以用作促进T细胞应答并增加免疫力的疫苗。

5. 发明公开

EP1937303A2 THE INDUCTION OF INDOLEAMINE 2,3-DIOXYGENASE IN DENDRITIC CELLS BY TLR LIGANDS AND USES THEREOF 审中-公开
标题翻译：确保-吲哚胺2,3-加氧酶树突状细胞TLR配体及其用途
公开(公告)号：EP1937303A2
公开(公告)日：2008-07-02
申请号：EP06836384.5
申请日：2006-10-20
申请人： Medical College Of Georgia Research Institute, Inc.
发明人： MELLOR, Andrew , MUNN, David
IPC分类号： A61K39/00 , A61K31/404
CPC分类号： A61K39/001 , A61K31/404 , A61K2039/55516 , A61K2039/55561
摘要： The induction of indoleamine 2,3-dioxygenase (IDO) in an IDO-competent subset of dendritic cells by TLR ligands, including TLR9 ligands, and various uses thereof are presented.

6. 发明公开

EP1501918A1 ANTIGEN-PRESENTING CELL POPULATIONS AND THEIR USE AS REAGENTS FOR ENHANCING OR REDUCING IMMUNE TOLERANCE 审中-公开
标题翻译：抗原细胞群及其作为试剂增益或减少免疫耐受
公开(公告)号：EP1501918A1
公开(公告)日：2005-02-02
申请号：EP02807233.8
申请日：2002-04-12
申请人： Medical College Of Georgia Research Institute, Inc.
发明人： MELLOR, Andrew , MUNN, David
IPC分类号： C12N5/00 , C12N5/02 , G01N33/53 , A61K45/00 , A61K47/00 , A01N63/00 , A01N65/00
CPC分类号： C12N5/064 , A61K2035/122 , C12N2501/22 , C12N2501/23 , C12N2501/70
摘要： The present invention is based on the discovery antigen-presenting cells (APCs) may be generated to have predetermined levels of expression of the intracellular enzyme, indoleamine 2,3-dioxygenase (IDO). Because expression of high levels of IDO is correlated with a reduced ability to stimulate T cell responses and an enhanced ability to induce immunologic tolerance, APCs having high levels of IDO may be used to increase tolerance in the immune system, as for example in transplant therapy or treatment of autoimmune disorders. For example, APCs having high levels of IDO, and expressing or loaded with at least one antigen from a donor tissue may be used to increase tolerance of the recipient to the donor's tissue. Alternatively, APCs having reduced levels of IDO expression and expressing or loaded with at least one antigen from a cancer or infectious pathogen may be used as vaccines to promote T cell responses and increase immunity.

7. 发明申请

WO2009095643A2 METHOD AND APPARATUS FOR MEASURING THE TEMPERATURE OF A SHEET MATERIAL 审中-公开
标题翻译：测量材料温度的方法和装置
公开(公告)号：WO2009095643A2
公开(公告)日：2009-08-06
申请号：PCT/GB2009/000173
申请日：2009-01-22
申请人： LAND INSTRUMENTS INTERNATIONAL LIMITED , BEYNON, Thomas, Geoffrey, Ronald , RIDLEY, Ian, Hamilton , METCALFE, Stuart, Francis , MELLOR, Andrew , WILEMAN, Ben
发明人： BEYNON, Thomas, Geoffrey, Ronald , RIDLEY, Ian, Hamilton , METCALFE, Stuart, Francis , MELLOR, Andrew , WILEMAN, Ben
IPC分类号： G01J5/00 , G01J5/52
CPC分类号： G01J5/0022 , B21B38/006 , G01J5/505 , G01J5/522 , G01J2005/0029 , G01J2005/0077 , G01J2005/0085
摘要： A method of measuring the temperature of a sheet material is provided. The sheet material is arranged such that it forms at least one side of a cavity so as to enhance the effective emissivity of the sheet material in the vicinity of the cavity. The method comprises: a) generating a thermal image of at least part of the inside of the cavity using a thermal imaging device to detect radiation emitted by the cavity, the thermal image comprising a plurality of pixels each having a pixel value representative of radiation emitted by a respective region of the cavity; b) identifying a first subset of the plurality of pixels whose pixel values meet predetermined criteria; c) using the identified first subset of pixels to determine a line on the thermal image representative of optimal emissivity enhancement in the cavity; and d) selecting a second subset of the plurality of pixels based on the determined line and generating a temperature profile along the determined line derived from the pixel values associated with each of the second subset of pixels.
摘要翻译：提供了测量片材温度的方法。片材被布置成使得其形成空腔的至少一个侧面，以便增强片材在空腔附近的有效辐射率。该方法包括：a）使用热成像装置产生至少部分腔体的热图像，以检测由腔体发射的辐射，热图像包括多个像素，每个像素具有表示辐射的辐射的像素值通过腔的相应区域; b）识别其像素值满足预定标准的多个像素的第一子集; c）使用所识别的第一子像素来确定表示所述空腔中的最佳发射率增强的热图像上的线; 以及d）基于所确定的线选择所述多个像素的第二子集，并且沿着与所述第二子像素中的每一个相关联的像素值导出的所确定的线产生温度曲线。

8. 发明申请

WO2004097389A2 THERMAL IMAGING SYSTEM AND METHOD 审中-公开
标题翻译：热成像系统和方法
公开(公告)号：WO2004097389A2
公开(公告)日：2004-11-11
申请号：PCT/GB2004/001778
申请日：2004-04-23
申请人： LAND INSTRUMENTS INTERNATIONAL LIMITED , RIDLEY, Ian, Hamilton , MELLOR, Andrew , CHAMBERLAIN, Gary, Roy
发明人： RIDLEY, Ian, Hamilton , MELLOR, Andrew , CHAMBERLAIN, Gary, Roy
IPC分类号： G01N25/72
CPC分类号： G01J5/10 , G01J2005/0051 , G01J2005/0081 , G01N25/72 , H04N5/33
摘要： A thermal imaging system and method for quantitative thermal mapping of a scene. The system comprises a thermal imaging device, a heat source of known temperature and emissivity located within the scene viewed by the thermal imaging device and a processor adapted to generate a calibrated temperature map of the scene from the data supplied by the thermal imaging device, based on the known temperature of the heat source. This enables accurate temperature measurements to be made using inexpensive uncooled Focal Plane Array detectors.
摘要翻译：一种用于场景的定量热映射的热成像系统和方法。该系统包括热成像装置，已知温度的热源和位于由热成像装置观看的场景内的发射率，以及处理器，其适于根据由热成像装置提供的数据生成校准的温度图，在已知的热源温度下。这使得可以使用廉价的未冷却的焦平面阵列检测器进行精确的温度测量。

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