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1. 发明授权

US09404914B2 Microfluidic system for controlling a concentration profile of molecules capable of stimulating a target 有权
标题翻译：用于控制能够刺激靶标的分子的浓度分布的微流体系统
公开(公告)号：US09404914B2
公开(公告)日：2016-08-02
申请号：US14003206
申请日：2012-03-02
申请人： Maxime Dahan , Mathieu Morel , Jean-Christophe Galas , Vincent Studer , Denis Bartolo
发明人： Maxime Dahan , Mathieu Morel , Jean-Christophe Galas , Vincent Studer , Denis Bartolo
IPC分类号： G01N33/50 , G01N21/63 , B81B1/00 , B01L3/00 , C12M3/06
CPC分类号： G01N33/5008 , B01J2219/00639 , B01L3/5027 , B01L3/502715 , B01L3/502753 , B01L3/502761 , B01L2200/027 , B01L2200/0647 , B01L2200/0652 , B01L2300/0627 , B01L2300/0681 , B01L2300/0816 , B01L2300/0848 , B01L2300/0851 , B01L2300/087 , B01L2300/163 , C12M23/16
摘要： The invention relates to a microfluidic system for controlling a concentration profile of molecules capable of stimulating a target, for example formed by an assembly of living cells, this system comprising: —a microfluidic device (1) comprising at least one microfluidic channel (4) equipped with at least one inlet orifice (21) and with at least one outlet orifice (22) for at least one fluid; —at least one means for supplying the microfluidic channel (4) with at least one fluid comprising molecules capable of stimulating the target; —at least one chamber (8) or another microfluidic channel comprising a base (6) intended to receive the target; and —at least one microporous membrane (5) separating the chamber (8) or the other microfluidic channel from the microfluidic channel (4), said microporous membrane (5) being positioned away from the base (6) so that when the supply means provides the microfludic channel (4) with said at least one fluid flowing in laminar flow in contact with the microporous membrane (5), the molecules capable of stimulating the target then diffuse, after having passed through the microporous membrane (5) through the chamber (8) or said other microfluidic channel in order to finally form a stable concentration profile in this chamber (8) or this other microfluidic channel.
摘要翻译：本发明涉及用于控制能够刺激靶的分子的浓度分布的微流体系统，例如通过活细胞的组装形成，该系统包括： - 微流体装置（1），其包含至少一个微流体通道（4）装备有至少一个入口孔口（21）和至少一个用于至少一种流体的出口孔口（22）; - 至少一种用于向所述微流体通道（4）供应至少一种包含能够刺激所述靶的分子的流体的装置; - 至少一个腔室（8）或另一个微流体通道，其包括用于接收靶的基部（6）以及 - 将所述腔室（8）或所述另一个微流体通道与所述微流体通道（4）分开的至少一个微孔膜（5），所述微多孔膜（5）远离所述基座（6）定位，使得当所述供给装置提供微流体通道（4）与所述至少一种流体在微流体中与微多孔膜（5）接触流动的流体，然后在穿过微孔膜（5）通过腔室之后，能够刺激靶的分子扩散（8）或所述其它微流体通道，以便最终在该腔室（8）或该另一微流体通道中形成稳定的浓度分布。

2. 发明授权

US09164083B2 Microfluidic system for controlling the concentration of molecules for stimulating a target 有权
标题翻译：用于控制分子浓度用于刺激靶的微流体系统
公开(公告)号：US09164083B2
公开(公告)日：2015-10-20
申请号：US14113136
申请日：2012-04-20
申请人： Maxime Dahan , Mathieu Morel , Jean-Christophe Galas , Vincent Studer , Denis Bartolo
发明人： Maxime Dahan , Mathieu Morel , Jean-Christophe Galas , Vincent Studer , Denis Bartolo
IPC分类号： G01N33/50 , G01N21/63 , B81B1/00 , B01L3/00 , C12M3/06
CPC分类号： G01N33/5008 , B01J2219/00639 , B01L3/5027 , B01L3/502715 , B01L3/502753 , B01L3/502761 , B01L2200/027 , B01L2200/0647 , B01L2200/0652 , B01L2300/0627 , B01L2300/0681 , B01L2300/0816 , B01L2300/0848 , B01L2300/0851 , B01L2300/087 , B01L2300/163 , C12M23/16
摘要： The invention relates to a microfluidic system for controlling a card for the concentration of molecules capable of stimulating a target, for example formed by an assembly of living cells, characterized in that the system comprises a microfluidic device (1) comprising: n≧1 microfluidic channel(s) (4, 40), the or each channel being provided with at least one inlet orifice for at least one fluid and with at least one outlet orifice for this fluid; n≧2 openings (47, 470) formed in the microfluidic channel or distributed in the various microfluidic channels, said openings being arranged in one and the same plane so that they form a network having at least one dimension in this plane, the numbers n of microfluidic channel(s) and n of openings being linked by the relationship (I) with 1≦i≦n and n the number of openings for the channel c; at least one microporous membrane (5) covering the network of openings, the target being intended to be positioned on the side of the membrane which is opposite the microfluidic channel(s); one or more fluid feed means for feeding the or each microfluidic channel with fluid, at least one of these fluids comprising molecules for stimulating the target.
摘要翻译：本发明涉及一种用于控制卡的浓度的微流体系统，该分子能够刺激靶，例如通过活细胞组装形成，其特征在于该系统包括微流体装置（1），其包括：n≥1微流体通道（4,40），该通道或每个通道设置有用于至少一种流体的至少一个入口孔口和用于该流体的至少一个出口孔口; n≥2个开口（47,470），其形成在微流体通道中或分布在各种微流体通道中，所述开口布置在同一平面中，使得它们形成在该平面中具有至少一个维度的网络，数字n 的微流体通道和n个开口通过关系式（I）与1＆nlE; i＆nlE; n和n相关联，n是通道c的开口数; 覆盖开口网络的至少一个微孔膜（5），所述靶旨在位于所述膜的与所述微流体通道相对的一侧上; 一个或多个流体供给装置，用于将流体或每个微流体通道供给流体，这些流体中的至少一个包含用于刺激靶的分子。

3. 发明申请

US20140080206A1 MICROFLUIDIC SYSTEM FOR CONTROLLING A CONCENTRATION PROFILE OF MOLECULES CAPABLE OF STIMULATING A TARGET 有权
标题翻译：用于控制能够刺激目标的分子浓度分布的微流控系统
公开(公告)号：US20140080206A1
公开(公告)日：2014-03-20
申请号：US14003206
申请日：2012-03-02
申请人： Maxime Dahan , Mathieu Morel , Jean-Christophe Galas , Vincent Studer , Denis Bartolo
发明人： Maxime Dahan , Mathieu Morel , Jean-Christophe Galas , Vincent Studer , Denis Bartolo
IPC分类号： G01N33/50
CPC分类号： G01N33/5008 , B01J2219/00639 , B01L3/5027 , B01L3/502715 , B01L3/502753 , B01L3/502761 , B01L2200/027 , B01L2200/0647 , B01L2200/0652 , B01L2300/0627 , B01L2300/0681 , B01L2300/0816 , B01L2300/0848 , B01L2300/0851 , B01L2300/087 , B01L2300/163 , C12M23/16
摘要： The invention relates to a microfluidic system for controlling a concentration profile of molecules capable of stimulating a target, for example formed by an assembly of living cells, this system comprising: -a microfluidic device (1) comprising at least one microfluidic channel (4) equipped with at least one inlet orifice (21) and with at least one outlet orifice (22) for at least one fluid; -at least one means for supplying the microfluidic channel (4) with at least one fluid comprising molecules capable of stimulating the target; -at least one chamber (8) or another microfluidic channel comprising a base (6) intended to receive the target; and -at least one microporous membrane (5) separating the chamber (8) or the other microfluidic channel from the microfluidic channel (4), said microporous membrane (5) being positioned away from the base (6) so that when the supply means provides the microfludic channel (4) with said at least one fluid flowing in laminar flow in contact with the microporous membrane (5), the molecules capable of stimulating the target then diffuse, after having passed through the microporous membrane (5) through the chamber (8) or said other microfluidic channel in order to finally form a stable concentration profile in this chamber (8) or this other microfluidic channel.
摘要翻译：本发明涉及用于控制能够刺激靶的分子的浓度分布的微流体系统，例如通过活细胞的组装形成，该系统包括： - 微流体装置（1），其包含至少一个微流体通道（4）装备有至少一个入口孔口（21）和至少一个用于至少一种流体的出口孔口（22）; - 至少一种用于向所述微流体通道（4）供应至少一种包含能够刺激所述靶的分子的流体的装置; - 至少一个腔室（8）或另一个微流体通道，其包括用于接收靶的基部（6）以及 - 将所述腔室（8）或所述另一个微流体通道与所述微流体通道（4）分开的至少一个微孔膜（5），所述微多孔膜（5）远离所述基座（6）定位，使得当所述供给装置提供微流体通道（4）与所述至少一种流体在微流体中与微多孔膜（5）接触流动的流体，然后在经过微孔膜（5）通过腔室之后，能够刺激靶的分子扩散（8）或所述其它微流体通道，以便最终在该腔室（8）或该另一微流体通道中形成稳定的浓度分布。

4. 发明申请

US20140113366A1 MICROFLUIDIC SYSTEM FOR CONTROLLING THE CONCENTRATION OF MOLECULES FOR STIMULATING A TARGET 有权
标题翻译：用于控制用于刺激目标的分子浓度的微流控系统
公开(公告)号：US20140113366A1
公开(公告)日：2014-04-24
申请号：US14113136
申请日：2012-04-20
申请人： Maxime Dahan , Mathieu Morel , Jean-Christophe Galas , Vincent Studer , Denis Bartolo
发明人： Maxime Dahan , Mathieu Morel , Jean-Christophe Galas , Vincent Studer , Denis Bartolo
IPC分类号： G01N33/50
CPC分类号： G01N33/5008 , B01J2219/00639 , B01L3/5027 , B01L3/502715 , B01L3/502753 , B01L3/502761 , B01L2200/027 , B01L2200/0647 , B01L2200/0652 , B01L2300/0627 , B01L2300/0681 , B01L2300/0816 , B01L2300/0848 , B01L2300/0851 , B01L2300/087 , B01L2300/163 , C12M23/16
摘要： The invention relates to a microfluidic system for controlling a card for the concentration of molecules capable of stimulating a target, for example formed by an assembly of living cells, characterized in that the system comprises a microfluidic device (1) comprising: n≧1 microfluidic channel(s) (4, 40), the or each channel being provided with at least one inlet orifice for at least one fluid and with at least one outlet orifice for this fluid; n≧2 openings (47, 470) formed in the microfluidic channel or distributed in the various microfluidic channels, said openings being arranged in one and the same plane so that they form a network having at least one dimension in this plane, the numbers n of microfluidic channel(s) and n of openings being linked by the relationship (I) with 1≦i≦n and n the number of openings for the channel c; at least one microporous membrane (5) covering the network of openings, the target being intended to be positioned on the side of the membrane which is opposite the microfluidic channel(s); one or more fluid feed means for feeding the or each microfluidic channel with fluid, at least one of these fluids comprising molecules for stimulating the target.
摘要翻译：本发明涉及一种用于控制卡的浓度的微流体系统，该分子能够刺激靶，例如通过活细胞组装形成，其特征在于该系统包括微流体装置（1），其包括：n≥1微流体通道（4,40），该通道或每个通道设置有用于至少一种流体的至少一个入口孔口和用于该流体的至少一个出口孔口; n≥2个开口（47,470），其形成在微流体通道中或分布在各种微流体通道中，所述开口布置在同一平面中，使得它们形成在该平面中具有至少一个维度的网络，数字n 的微流体通道和n个开口通过关系式（I）与1＆nlE; i＆nlE; n和n相关联，n是通道c的开口数; 覆盖开口网络的至少一个微孔膜（5），所述靶旨在位于所述膜的与所述微流体通道相对的一侧上; 一个或多个流体供给装置，用于将流体或每个微流体通道供给流体，这些流体中的至少一个包含用于刺激靶的分子。

5. 发明申请

US20130117205A1 METHOD OF IDENTIFYING A PROTOCOL GIVING RISE TO A DATA FLOW 有权
标题翻译：识别提交数据流的协议的方法
公开(公告)号：US20130117205A1
公开(公告)日：2013-05-09
申请号：US13635650
申请日：2011-03-17
申请人： Renaud Dubois , Mathieu Morel , Paul Gompel
发明人： Renaud Dubois , Mathieu Morel , Paul Gompel
IPC分类号： G06N99/00
CPC分类号： G06N99/005 , H04L41/142 , H04L43/026 , H04L43/18 , H04L63/0236 , H04L67/02
摘要： Method of identifying a protocol at the origin of a data flow. The method of identifying a protocol giving rise to a packet flow comprises the following steps: a capture of the flow of the protocol to be identified, statistical classification of the flow, comprising an extraction of the classification parameters and a comparison of the classification parameters with statistical models constructed during a learning phase. The statistical classification comprises: a first phase of global statistical classification; and a step of synthesis of the results of the first and second classification phases so as to identify the protocol giving rise to the flow.
摘要翻译：在数据流的起源处识别协议的方法。识别引起分组流的协议的方法包括以下步骤：捕获要识别的协议的流程，流的统计分类，包括提取分类参数以及分类参数与在学习阶段构建的统计模型。统计分类包括：全球统计分类的第一阶段; 以及合成第一和第二分类阶段的结果以识别产生流程的协议的步骤。

6. 发明授权

US08903749B2 Method of identifying a protocol giving rise to a data flow 有权
标题翻译：识别引起数据流的协议的方法
公开(公告)号：US08903749B2
公开(公告)日：2014-12-02
申请号：US13635650
申请日：2011-03-17
申请人： Renaud Dubois , Mathieu Morel , Paul Gompel
发明人： Renaud Dubois , Mathieu Morel , Paul Gompel
IPC分类号： G06N5/02 , G06N99/00 , H04L12/26 , H04L12/24 , H04L29/06 , H04L29/08
CPC分类号： G06N99/005 , H04L41/142 , H04L43/026 , H04L43/18 , H04L63/0236 , H04L67/02
摘要： Method of identifying a protocol at the origin of a data flow. The method of identifying a protocol giving rise to a packet flow comprises the following steps: —a capture of the flow of the protocol to be identified, —statistical classification of the flow, comprising an extraction of the classification parameters and a comparison of the classification parameters with statistical models constructed during a learning phase. The statistical classification comprises: —a first phase of global statistical classification; and —a step of synthesis of the results of the first and second classification phases so as to identify the protocol giving rise to the flow.
摘要翻译：在数据流的起源处识别协议的方法。识别引起分组流的协议的方法包括以下步骤： - 捕获要识别的协议的流程， - 流的统计分类，包括提取分类参数和分类的比较在学习阶段建立统计模型的参数。统计分类包括： - 全球统计分类的第一阶段; 以及 - 合成第一和第二分类阶段的结果的步骤，以便识别导致流程的协议。

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