专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

2. 发明授权

US5837265A Chemically-modified clostridiatoxin with improved properties 失效
标题翻译：化学修饰的梭菌毒素具有改善的性质
公开(公告)号：US5837265A
公开(公告)日：1998-11-17
申请号：US612571
申请日：1996-03-08
申请人： Mauricio Montal , Antonio Ferrer-Montiel
发明人： Mauricio Montal , Antonio Ferrer-Montiel
IPC分类号： A61K38/00 , A61K39/08 , C07K14/33 , A61K39/00 , A61K39/02 , A61K39/06
CPC分类号： C07K14/33 , A61K39/08 , A61K38/00 , Y10S424/832
摘要： The invention consists of modified Clostridium neurotoxin compounds, pharmaceutical compositions containing such compounds and methods for preparing such compounds. In particular, the compounds of the invention are purified Clostridium botulinum and Clostridium tetani neurotoxins in which the tyrosine residues have been modified to have a negative charge (e.g., by covalent attachment of a phosphate or sulphate thereto) or in which the tyrosine residues have been substituted with amino acids having a negative charge (e.g., glutamate, aspartate, or negatively charged, non-natural amino acids). Toxins having phosphorylated tyrosine residues in both the light and heavy chains of the toxins are preferred. Methods for enzymatic and chemical modification of tyrosine residues in purified Clostridium neurotoxins are provided.
摘要翻译：本发明由改良的梭状芽胞杆菌神经毒素化合物，含有这些化合物的药物组合物和制备这些化合物的方法组成。特别地，本发明的化合物是精制的肉毒梭菌和破伤风梭菌神经毒素，其中酪氨酸残基被修饰为具有负电荷（例如，通过共价连接磷酸盐或硫酸盐）或其中酪氨酸残基已被由具有负电荷的氨基酸（例如谷氨酸，天冬氨酸或带负电荷的非天然氨基酸）取代。在毒素的轻链和重链都具有磷酸化酪氨酸残基的毒素是优选的。提供了纯化的梭菌属神经毒素中酪氨酸残基酶促和化学修饰的方法。

IPRDB

热门服务

关于我们

友情链接

联系方式