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1. 发明授权

US07910551B2 Gene differentially expressed in breast and bladder cancer and encoded polypeptides 失效
标题翻译：在乳腺癌和膀胱癌和编码多肽中差异表达的基因
公开(公告)号：US07910551B2
公开(公告)日：2011-03-22
申请号：US12393860
申请日：2009-02-26
申请人： Maurice Zauderer , Elizabeth E. Evans , Melinda A. Borrello
发明人： Maurice Zauderer , Elizabeth E. Evans , Melinda A. Borrello
IPC分类号： A61K38/00 , A61K31/00 , A61K38/28 , A01N61/00 , A01N37/18 , G01N33/24 , G01N33/00
CPC分类号： C07K14/47
摘要： The present invention relates to a novel human gene that is differentially expressed in human carcinoma. More specifically, the present invention relates to methods of treating or preventing a disorder in a subject. The invention further relates to uses of C35 polypeptides in immunogenic compositions or vaccines, to induce antibody or T cell-mediated immunity against target cells, such as tumor cells, that express the C35 gene. The present invention further relates to use of C35 polypeptides in diagnosing a pathological condition or susceptibility to a pathological condition in a subject.
摘要翻译：本发明涉及在人癌中差异表达的新型人基因。更具体地，本发明涉及治疗或预防受试者中的病症的方法。本发明还涉及C35多肽在免疫原性组合物或疫苗中的用途，以诱导针对表达C35基因的靶细胞例如肿瘤细胞的抗体或T细胞介导的免疫。本发明还涉及C35多肽在诊断受试者病理状况或病理状况易感性方面的应用。

2. 发明授权

US07563882B2 Polynucleotides encoding antibodies that bind to the C35 polypeptide 失效
标题翻译：编码结合C35多肽的抗体的多核苷酸
公开(公告)号：US07563882B2
公开(公告)日：2009-07-21
申请号：US10457829
申请日：2003-06-10
申请人： Maurice Zauderer , Elizabeth E. Evans
发明人： Maurice Zauderer , Elizabeth E. Evans
IPC分类号： C07H21/04 , C12P21/04 , C12N15/00 , A61K39/395 , C12P21/08 , C07K16/00
CPC分类号： C07K16/32 , A61K38/00 , C07K14/4748 , C07K2317/56 , C07K2319/00
摘要： The present invention relates to a novel human gene that is differentially expressed in human carcinoma. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named C35 that is overexpressed in human breast and bladder carcinoma. This invention also relates to C35 polypeptide, in particular C35 peptide epitopes and C35 peptide epitope analogs, as well as vectors, host cells, antibodies directed to C35 polypeptides, and the recombinant methods for producing the same. The present invention further relates to diagnostic methods for detecting carcinomas, including human breast carcinomas. The present invention further relates to the formulation and use of the C35 gene and polypeptides, in particular C35 peptide epitopes and C35 peptide epitope analogs, in immunogenic compositions or vaccines, to induce antibody or cell-mediated immunity against target cells, such as tumor cells, that express the C35 gene. The invention further relates to screening methods for identifying agonists and antagonists of C35 activity.
摘要翻译：本发明涉及在人癌中差异表达的新型人基因。更具体地，本发明涉及编码在人乳腺癌和膀胱癌中过表达的名为C35的新型人多肽的多核苷酸。本发明还涉及C35多肽，特别是C35肽表位和C35肽表位类似物，以及载体，宿主细胞，针对C35多肽的抗体及其制备方法。本发明还涉及用于检测癌症的诊断方法，包括人乳腺癌。本发明还涉及在免疫原性组合物或疫苗中C35基因和多肽，特别是C35肽表位和C35肽表位类似物的配制和用途，以诱导针对靶细胞例如肿瘤细胞的抗体或细胞介导的免疫，表达C35基因。本发明还涉及鉴定C35活性的激动剂和拮抗剂的筛选方法。

3. 发明授权

US06800442B2 Methods of selecting polynucleotides encoding antigens 有权
标题翻译：选择编码抗原的多核苷酸的方法
公开(公告)号：US06800442B2
公开(公告)日：2004-10-05
申请号：US10034350
申请日：2002-01-03
申请人： Maurice Zauderer
发明人： Maurice Zauderer
IPC分类号： C12Q168
CPC分类号： C12N15/1086 , C12N15/1034
摘要： The present invention relates to novel methods for the identification of antigens recognized by cytotoxic T cells (CTLs) and specific for human tumors, cancers, and infected cells, and the use of such antigens in immunogenic compositions or vaccines to induce regression of tumors, cancers, or infections in mammals, including humans. The invention encompasses methods for induction and isolation of cytotoxic T cells specific for human tumors, cancers and infected cells, and for improved selection of genes that encode the target antigens recognized by these specific T cells. The invention also relates to differential display methods that improve resolution of, and that reduce the frequency of false positives of DNA fragments that are differentially expressed in tumorous, cancerous, or infected tissues versus normal tissues. The invention further relates to the engineering of recombinant viruses as expression vectors for tumor, cancer, or infected cell-specific antigens.
摘要翻译：本发明涉及用于鉴定由细胞毒性T细胞（CTL）识别并且对人肿瘤，癌症和感染细胞特异性的抗原的新方法，以及在免疫原性组合物或疫苗中使用这些抗原诱导肿瘤，癌症消退，或哺乳动物，包括人类的感染。本发明包括用于诱导和分离对人肿瘤，癌症和感染细胞特异性的细胞毒性T细胞的方法，以及改进编码由这些特异性T细胞识别的靶抗原的基因的选择。本发明还涉及差异显示方法，其提高在肿瘤，癌性或感染组织中与正常组织差异表达的DNA片段的分离度并降低其误差的频率。本发明还涉及重组病毒作为肿瘤，癌症或感染的细胞特异性抗原的表达载体的工程。

4. 发明授权

US07968688B2 Antibodies that bind to the C35 polypeptide 有权
标题翻译：结合C35多肽的抗体
公开(公告)号：US07968688B2
公开(公告)日：2011-06-28
申请号：US12350937
申请日：2009-01-08
申请人： Maurice Zauderer , Elizabeth E. Evans
发明人： Maurice Zauderer , Elizabeth E. Evans
IPC分类号： C12P21/08 , C07K16/00 , A61K39/395 , C12P21/04
CPC分类号： C07K16/32 , A61K38/00 , C07K14/4748 , C07K2317/56 , C07K2319/00
摘要： The present invention relates to a novel human gene that is differentially expressed in human carcinoma. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named C35 that is overexpressed in human breast and bladder carcinoma. This invention also relates to C35 polypeptide, in particular C35 peptide epitopes and C35 peptide epitope analogs, as well as vectors, host cells, antibodies directed to C35 polypeptides, and the recombinant methods for producing the same. The present invention further relates to diagnostic methods for detecting carcinomas, including human breast carcinomas. The present invention further relates to the formulation and use of the C35 gene and polypeptides, in particular C35 peptide epitopes and C35 peptide epitope analogs, in immunogenic compositions or vaccines, to induce antibody or cell-mediated immunity against target cells, such as tumor cells, that express the C35 gene. The invention further relates to screening methods for identifying agonists and antagonists of C35 activity.
摘要翻译：本发明涉及在人癌中差异表达的新型人基因。更具体地，本发明涉及编码在人乳腺癌和膀胱癌中过表达的名为C35的新型人多肽的多核苷酸。本发明还涉及C35多肽，特别是C35肽表位和C35肽表位类似物，以及载体，宿主细胞，针对C35多肽的抗体及其制备方法。本发明还涉及用于检测癌症的诊断方法，包括人乳腺癌。本发明还涉及在免疫原性组合物或疫苗中C35基因和多肽，特别是C35肽表位和C35肽表位类似物的配制和用途，以诱导针对靶细胞例如肿瘤细胞的抗体或细胞介导的免疫，表达C35基因。本发明还涉及鉴定C35活性的激动剂和拮抗剂的筛选方法。

5. 发明申请

US20090312263A1 Gene Differentially Expressed in Breast and Bladder Cancer and Encoded Polypeptides 失效
标题翻译：基因差异表达在乳腺癌和膀胱癌和编码多肽
公开(公告)号：US20090312263A1
公开(公告)日：2009-12-17
申请号：US12393860
申请日：2009-02-26
申请人： Maurice Zauderer , Elizabeth E. Evans , Melinda A. Borrello
发明人： Maurice Zauderer , Elizabeth E. Evans , Melinda A. Borrello
IPC分类号： A61K38/08 , A61K38/10 , A61P35/00
CPC分类号： C07K14/47
摘要： The present invention relates to a novel human gene that is differentially expressed in human carcinoma. More specifically, the present invention relates to methods of treating or preventing a disorder in a subject. The invention further relates to uses of C35 polypeptides in immunogenic compositions or vaccines, to induce antibody or T cell-mediated immunity against target cells, such as tumor cells, that express the C35 gene. The present invention further relates to use of C35 polypeptides in diagnosing a pathological condition or susceptibility to a pathological condition in a subject.
摘要翻译：本发明涉及在人癌中差异表达的新型人基因。更具体地，本发明涉及治疗或预防受试者中的病症的方法。本发明还涉及C35多肽在免疫原性组合物或疫苗中的用途，以诱导针对表达C35基因的靶细胞例如肿瘤细胞的抗体或T细胞介导的免疫。本发明还涉及C35多肽在诊断受试者病理状况或病理状况易感性方面的应用。

6. 发明申请

US20090081210A1 Methods of Killing Tumor Cells by Targeting Internal Antigens Exposed on Apoptotic Tumor Cells 审中-公开
标题翻译：通过靶向暴露于凋亡性肿瘤细胞的内部抗原杀死肿瘤细胞的方法
公开(公告)号：US20090081210A1
公开(公告)日：2009-03-26
申请号：US12125849
申请日：2008-05-22
申请人： Elizabeth E. Evans , Mark J. Paris , Deepak M. Sahasrabudhe , Maurice Zauderer , Ernest S. Smith
发明人： Elizabeth E. Evans , Mark J. Paris , Deepak M. Sahasrabudhe , Maurice Zauderer , Ernest S. Smith
IPC分类号： A61K39/395 , C07K16/18 , C12N15/11 , C12N15/00 , C12N5/06
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/73
摘要： The invention provides in vitro and in vivo methods of killing cancer cells, including therapeutic methods in humans, and also provides antibodies specific for the cancer specific antigen C35, and polynucleotides encoding such antibodies, as well as therapeutic and diagnostic methods of using such antibodies.
摘要翻译：本发明提供了杀死癌细胞的体外和体内方法，包括在人体中的治疗方法，并且还提供对癌症特异性抗原C35特异性的抗体，以及编码这种抗体的多核苷酸以及使用这种抗体的治疗和诊断方法。

7. 发明申请

US20080305111A1 Anti-C35 antibodies for treating cancer 审中-公开
标题翻译：抗C35抗体治疗癌症
公开(公告)号：US20080305111A1
公开(公告)日：2008-12-11
申请号：US11812996
申请日：2007-06-22
申请人： Elizabeth E. Evans , Mark J. Paris , Deepak M. Sahasrabudhe , Maurice Zauderer , Ernest S. Smith
发明人： Elizabeth E. Evans , Mark J. Paris , Deepak M. Sahasrabudhe , Maurice Zauderer , Ernest S. Smith
IPC分类号： A61K39/395 , C12N5/00 , C07K16/00 , C07H21/00 , C12N15/63 , C12P21/00 , G01N33/53 , A61P35/00
CPC分类号： C07K16/30 , A61K39/39558 , A61K45/06 , A61K2039/507 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/92 , A61K2300/00
摘要： The present invention is directed to methods of killing cancer cells, the methods comprising administering at least one C35 antibody and a chemotherapeutic agent. In some preferred embodiments, two C35 antibodies are administered with a chemotherapeutic agent. The present invention is further directed to C35 antibodies useful in these methods.
摘要翻译：本发明涉及杀死癌细胞的方法，所述方法包括施用至少一种C35抗体和化学治疗剂。在一些优选的实施方案中，两种C35抗体与化学治疗剂一起施用。本发明还涉及可用于这些方法的C35抗体。

8. 发明申请

US20050266425A1 Methods for producing and identifying multispecific antibodies 审中-公开
标题翻译：用于产生和鉴定多特异性抗体的方法
公开(公告)号：US20050266425A1
公开(公告)日：2005-12-01
申请号：US11024251
申请日：2004-12-29
申请人： Maurice Zauderer , Mark Paris
发明人： Maurice Zauderer , Mark Paris
IPC分类号： C07K16/28 , C07K16/46 , C12N5/06 , C12N15/10 , C12P21/06 , C12Q1/68 , G01N33/53 , G01N33/68
CPC分类号： G01N33/6854 , C07K16/283 , C07K16/2866 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/622 , C12N15/1086 , C12N15/1093
摘要： The present invention relates to a high efficiency method of expressing multispecific antibodies in eukaryotic cells. The invention is further drawn to a method of producing immunoglobulin heavy and light chain libraries, particularly using the trimolecular recombination method, for expression in eukaryotic cells. The invention further provides methods of selecting and screening for multispecific antibodies, and antigen-binding fragments thereof. The invention also provides kits for producing, screening and selecting multispecific antibodies. Finally, the invention provides multispecific antibodies, and antigen-binding fragments thereof, produced by the methods provided herein.
摘要翻译：本发明涉及在真核细胞中表达多特异性抗体的高效方法。本发明进一步涉及一种生产免疫球蛋白重链和轻链文库的方法，特别是使用三分子重组方法在真核细胞中表达。本发明还提供了选择和筛选多特异性抗体及其抗原结合片段的方法。本发明还提供用于产生，筛选和选择多特异性抗体的试剂盒。最后，本发明提供了通过本文提供的方法产生的多特异性抗体及其抗原结合片段。

9. 发明授权

US06706477B2 Methods for producing polynucleotide libraries in vaccinia virus 有权
标题翻译：用于在痘苗病毒中产生多核苷酸文库的方法
公开(公告)号：US06706477B2
公开(公告)日：2004-03-16
申请号：US09822250
申请日：2001-04-02
申请人： Maurice Zauderer
发明人： Maurice Zauderer
IPC分类号： C12Q168
CPC分类号： C12N15/1086 , C12N15/1034
摘要： The present invention relates to novel methods for the identification of antigens recognized by cytotoxic T cells (CTLs) and specific for human tumors, cancers, and infected cells, and the use of such antigens in immunogenic compositions or vaccines to induce regression of tumors, cancers, or infections in mammals, including humans. The invention encompasses methods for induction and isolation of cytotoxic T cells specific for human tumors, cancers and infected cells, and for improved selection of genes that encode the target antigens recognized by these specific T cells. The invention also relates to differential display methods that improve resolution of, and that reduce the frequency of false positives of DNA fragments that are differentially expressed in tumorous, cancerous, or infected tissues versus normal tissues. The invention further relates to the engineering of recombinant viruses as expression vectors for tumor, cancer, or infected cell-specific antigens.
摘要翻译：本发明涉及用于鉴定由细胞毒性T细胞（CTL）识别并且对人肿瘤，癌症和感染细胞特异性的抗原的新方法，以及在免疫原性组合物或疫苗中使用这些抗原诱导肿瘤，癌症消退，或哺乳动物，包括人类的感染。本发明包括用于诱导和分离对人肿瘤，癌症和感染细胞特异性的细胞毒性T细胞的方法，以及改进编码由这些特异性T细胞识别的靶抗原的基因的选择。本发明还涉及差异显示方法，其提高在肿瘤，癌性或感染组织中与正常组织差异表达的DNA片段的分离度并降低其误差的频率。本发明还涉及重组病毒作为肿瘤，癌症或感染的细胞特异性抗原的表达载体的工程。

10. 发明申请

US20140227296A1 MODIFIED GLYCOLIPIDS AND METHODS OF MAKING AND USING THE SAME 有权
标题翻译：改性甘氨酸及其制备方法和使用方法
公开(公告)号：US20140227296A1
公开(公告)日：2014-08-14
申请号：US13803972
申请日：2013-03-14
申请人： Steven A. Porcelli , Maurice Zauderer
发明人： Steven A. Porcelli , Maurice Zauderer
IPC分类号： A61K47/48 , C07H15/18
CPC分类号： A61K39/39 , A61K39/0011 , A61K47/646 , A61K2039/505 , A61K2039/55572 , A61K2039/572 , A61K2039/575 , C07H15/10 , C07H15/18 , C07K14/70539 , C07K16/30 , C07K2317/622 , C07K2319/30
摘要： The invention is directed to compositions and methods related to proteins that are physically associated with ceramide-like glycolipids for use as activators of NKT cells. The compositions and methods of the present invention are useful for the prevention and treatment of diseases.
摘要翻译：本发明涉及与用作NKT细胞的激活剂的神经酰胺样糖脂物理相关的蛋白质相关的组合物和方法。本发明的组合物和方法可用于预防和治疗疾病。

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