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1. 发明申请

US20080125452A1 Indolopyridines,Benzofuranopyridines and Benzothienopyridines 审中-公开
标题翻译：吲哚并吡啶类，苯并呋喃并吡啶类和苯并噻吩并吡啶类
公开(公告)号：US20080125452A1
公开(公告)日：2008-05-29
申请号：US11795762
申请日：2006-01-26
申请人： Matthias Vennemann , Thomas Bar , Jurgen Braunger , Petra Gimmnich , Thomas Beckers , Mathias Schmidt , Thomas Ciossek , Sandra Nappe
发明人： Matthias Vennemann , Thomas Bar , Jurgen Braunger , Petra Gimmnich , Thomas Beckers , Mathias Schmidt , Thomas Ciossek , Sandra Nappe
IPC分类号： A61K31/4745 , C07D491/14 , C07D498/14 , C07D487/14
CPC分类号： C07D471/14 , C07D491/14 , C07D495/14
摘要： Compounds of a certain formula (I), in which R1, R2, R3, R4, R5 and X have the meanings indicated in the description, are novel effective compounds with anti-proliferative and/or apoptosis inducing activity.
摘要翻译：其中R1，R2，R3，R4，R5和X具有说明书中所示含义的某种式（I）的化合物是具有抗增殖和/或凋亡诱导活性的新型有效化合物。

2. 发明授权

US07879853B2 4,6-disubstituted pyrimidines and their use as protein kinase inhibitors 失效
标题翻译： 4,6-二取代嘧啶及其作为蛋白激酶抑制剂的用途
公开(公告)号：US07879853B2
公开(公告)日：2011-02-01
申请号：US11630352
申请日：2005-06-28
申请人： Josef Stadlwieser , Thomas Baer , Thomas Maier , Thomas Beckers , Thomas Ciossek , Armin Zuelch , Ulrich Graedler
发明人： Josef Stadlwieser , Thomas Baer , Thomas Maier , Thomas Beckers , Thomas Ciossek , Armin Zuelch , Ulrich Graedler
IPC分类号： C07D405/04 , A61K31/506
CPC分类号： C07D405/04 , C07D239/42 , C07D401/04 , C07D405/14 , C07D409/04
摘要： The invention relates to novel pyrimidine derivatives of Formula (1) which are efficacious inhibitors of protein kinases, in particular of one or more isoforms of the protein kinase B/Akt.
摘要翻译：本发明涉及式（1）的新型嘧啶衍生物，其是蛋白激酶，特别是蛋白激酶B / Akt的一种或多种同工型的有效抑制剂。

3. 发明授权

US07745446B2 Pyrazolo[1,5-c]pyrimidines 有权
标题翻译：吡唑并[1,5-c]嘧啶
公开(公告)号：US07745446B2
公开(公告)日：2010-06-29
申请号：US11661111
申请日：2005-09-05
申请人： Thomas Maier , Armin Zuelch , Thomas Ciossek , Thomas Baer , Thomas Beckers
发明人： Thomas Maier , Armin Zuelch , Thomas Ciossek , Thomas Baer , Thomas Beckers
IPC分类号： C07D487/04 , A61K31/519 , A61P35/04 , A61P35/02
CPC分类号： C07D487/04
摘要： Compounds of a certain formula I in which R1, R2, R3 and R4 have the meanings indicated in the description are novel compounds expected to be useful in the therapy of (hyper)proliferative diseases and/or disorders responsive to induction of apoptosis.
摘要翻译：其中R 1，R 2，R 3和R 4具有本说明书所述含义的某种式I的化合物是预期可用于治疗对于诱导凋亡有反应的（超）增殖性疾病和/或病症的新化合物。

4. 发明申请

US20070254046A1 Novel Pyrazolopyrimidines 有权
标题翻译：新型吡唑并嘧啶
公开(公告)号：US20070254046A1
公开(公告)日：2007-11-01
申请号：US11661111
申请日：2005-09-05
申请人： Thomas Maier , Armin Zuelch , Thomas Ciossek , Thomas Baer , Thomas Beckers
发明人： Thomas Maier , Armin Zuelch , Thomas Ciossek , Thomas Baer , Thomas Beckers
IPC分类号： A61K33/24 , A61K31/515 , A61K38/00 , A61P35/00 , C07D487/00
CPC分类号： C07D487/04
摘要： Compounds of a certain formula I in which R1, R2, R3 and R4 have the meanings indicated in the description are novel compounds expected to be useful in the therapy of (hyper)proliferative diseases and/or disorders responsive to induction of apoptosis.
摘要翻译：其中R 1，R 2，R 3和R 4具有本说明书所述含义的某种式I的化合物是预期可用于治疗对于诱导凋亡有反应的（超）增殖性疾病和/或病症的新化合物。

5. 发明授权

US07034112B2 Methods for diagnosis and treatment of MDK1 signal transduction disorders 失效
公开(公告)号：US07034112B2
公开(公告)日：2006-04-25
申请号：US10073064
申请日：2002-02-12
申请人： Thomas Ciossek , Axel Ullrich , Birgit Millauer
发明人： Thomas Ciossek , Axel Ullrich , Birgit Millauer
IPC分类号： C07K17/00
CPC分类号： C07K16/40 , A61K38/00 , C07K14/71
摘要： The present invention relates to MDK1 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing.Methods for treatment, diagnosis, and screening are provided for diseases or conditions characterized by an abnormality in a signal transduction disorder. The signal transduction pathway involves an interaction between a MDK1 receptor tyrosine kinase and a receptor for the kinase. The MDK1 receptor tyrosine kinase may be truncated and lack a kinase domain and may be selected from the group consisting of MDK1.T1, MDK1.T2, MDK1.Δ1 and MDK1.Δ2.

6. 发明申请

US20050049212A1 Bestrophin and bestrophin homologous proteins involved in the regulation of energy homeostasis 审中-公开
标题翻译：参与调节能量稳态的Bestrophin和bestrophin同源蛋白
公开(公告)号：US20050049212A1
公开(公告)日：2005-03-03
申请号：US10492032
申请日：2002-10-09
申请人： Arnd Steuernagel , Gunter Bronner , Rudiger Fritsch , Karsten Eulenberg , Thomas Ciossek
发明人： Arnd Steuernagel , Gunter Bronner , Rudiger Fritsch , Karsten Eulenberg , Thomas Ciossek
IPC分类号： A01K67/027 , A61K31/7088 , A61K38/00 , A61K38/17 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/16 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/12 , A61P19/02 , A61P35/00 , C07K14/47 , C12N5/10 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/50 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/1709
摘要： The present invention discloses Bestrophin homologous proteins regulating the energy homeostasis and the metabolism of triglycerides, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders, for example, but not limited to, metabolic diseases such as obesity as well as related disorders such as eating disorder cachexia, diabetes mellitus, hypertension, coronary heart disease, hypercholesterolemia, osteoarthritis, gallstones, cancers of the reproductive organs, and sleep apnea.
摘要翻译：本发明公开了调节甘油三酯的能量稳态和代谢的Bestrophin同源蛋白质，以及鉴定和编码本发明公开的蛋白质的多核苷酸。本发明还涉及这些序列在诊断，研究，预防和治疗疾病和病症中的用途，所述疾病和病症例如但不限于代谢性疾病如肥胖以及相关疾病，例如进食障碍恶病质，糖尿病高血压，冠心病，高胆固醇血症，骨关节炎，胆结石，生殖器官的癌症和睡眠呼吸暂停。

7. 发明授权

US08828934B2 Mnk kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism 有权
标题翻译：参与调节能量稳态和细胞器代谢的Mnk激酶同源蛋白
公开(公告)号：US08828934B2
公开(公告)日：2014-09-09
申请号：US13245188
申请日：2011-09-26
申请人： Arnd Steuernagel , Karsten Eulenberg , Guenter Broenner , Thomas Ciossek , Bettina Rudolph , Dorothea Rudolph , Funmi Belgore , Stefan Jaekel , Christoph Meyer
发明人： Arnd Steuernagel , Karsten Eulenberg , Guenter Broenner , Thomas Ciossek , Bettina Rudolph , Dorothea Rudolph , Funmi Belgore , Stefan Jaekel , Christoph Meyer
IPC分类号： A61K38/45 , C12N9/12 , A61K38/00
CPC分类号： C12N9/1205 , A61K38/45 , Y10S514/909
摘要： This invention relates to the use of nucleic acid sequences of the MAP kinase-interacting kinase (Mnk) gene family and amino acid sequences encoded thereby, and to using these sequences or effectors of Mnk nucleic acids or polypeptides, particularly Mnk kinase inhibitors and activators, in the diagnosis and treatment of diseases and disorders related to body-weight regulation and thermogenesis. One aspect of the disclosure encompasses methods of identifying an animal or human having an elevated probability of having or developing a pancreatic malfunction, the method comprising: (a) obtaining a biological sample from an animal or human subject; and (b) determining from the biological sample whether the subject has a genetic variant of an Mnk2 and/or Mnk1 gene or a homolog thereof, or an expression product of said Mnk2 and/or Mnk1 gene or homolog thereof, wherein said genetic variant is associated with an elevated probability of having or developing a pancreatic malfunction.
摘要翻译：本发明涉及MAP激酶相互作用激酶（Mnk）基因家族的核酸序列及其编码的氨基酸序列的用途，以及使用Mnk核酸或多肽，特别是Mnk激酶抑制剂和激活剂的这些序列或效应物，在与体重调节和产热相关的疾病和病症的诊断和治疗中。本公开的一个方面包括识别具有升高的胰腺功能障碍或发展中的可能性的动物或人的方法，所述方法包括：（a）从动物或人类受试者获得生物样品; 和（b）从生物样品中确定受试者是否具有Mnk2和/或Mnk1基因的遗传变体或其同源物，或所述Mnk2和/或Mnk1基因的表达产物或其同源物，其中所述遗传变异体为与胰腺功能障碍的发生概率相关。

8. 发明授权

US07404952B2 Protein disulfide isomerase and ABC transporter homologous proteins involved in the regulation of energy homeostasis 失效
标题翻译：蛋白二硫键异构酶和ABC转运蛋白同源蛋白参与能量稳态调节
公开(公告)号：US07404952B2
公开(公告)日：2008-07-29
申请号：US11567079
申请日：2006-12-05
申请人： Karsten Eulenberg , Gunter Bronner , Thomas Ciossek , Thomas Hader , Arnd Steuernagel
发明人： Karsten Eulenberg , Gunter Bronner , Thomas Ciossek , Thomas Hader , Arnd Steuernagel
IPC分类号： A61K38/71 , C12N9/10 , C07K1/00
CPC分类号： A61K31/70 , A61K38/52 , C07K14/705 , C07K2319/00 , C12N9/90 , C12Y503/04001
摘要： The present invention discloses three novel proteins regulating the energy homeostasis and the metabolism of triglycerides, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to vectors, host cells, antibodies, and recombinant methods for producing the polypeptides and polynucleotides of the invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders related to body-weight regulation, for example, but not limited to, metabolic diseases such as obesity, as well as related disorders such as adipositas, eating disorders, wasting syndromes (cachexia), pancreatic dysfunctions (such as diabetes mellitus), hypertension, pancreatic dysfunctions, arteriosclerosis, coronary artery disease (CAD), coronary heart disease, hypercholesterolemia, dyslipidemia, osteoarthritis, gallstones, cancer, e.g. cancers of the reproductive organs, sleep apnea, and others.
摘要翻译：本发明公开了三种调节甘油三酯的能量稳态和代谢的新型蛋白质，以及鉴定和编码本发明公开的蛋白质的多核苷酸。本发明还涉及用于产生本发明的多肽和多核苷酸的载体，宿主细胞，抗体和重组方法。本发明还涉及这些序列用于诊断，研究，预防和治疗与体重调节相关的疾病和病症的用途，例如但不限于代谢性疾病如肥胖症以及相关疾病胰腺功能障碍（例如糖尿病），高血压，胰腺功能障碍，动脉硬化，冠状动脉疾病（CAD），冠心病，高胆固醇血症，血脂异常，骨关节炎，胆结石，癌症，糖尿病，例如生殖器官的癌症，睡眠呼吸暂停等。

9. 发明申请

US20070185048A1 Protein Disulfide Isomerase and ABC Transporter Homologous Proteins Involved in the Regulation of Energy Homeostasis 失效
标题翻译：蛋白二硫化物异构酶和ABC转运蛋白同源蛋白参与能量稳态调节
公开(公告)号：US20070185048A1
公开(公告)日：2007-08-09
申请号：US11567079
申请日：2006-12-05
申请人： Karsten Eulenberg , Gunter Bronner , Thomas Ciossek , Thomas Hader , Arnd Steuernagel
发明人： Karsten Eulenberg , Gunter Bronner , Thomas Ciossek , Thomas Hader , Arnd Steuernagel
IPC分类号： A61K48/00 , A01K67/027 , C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/90
CPC分类号： A61K31/70 , A61K38/52 , C07K14/705 , C07K2319/00 , C12N9/90 , C12Y503/04001
摘要： The present invention discloses three novel proteins regulating the energy homeostasis and the metabolism of triglycerides, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to vectors, host cells, antibodies, and recombinant methods for producing the polypeptides and polynucleotides of the invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders related to body-weight regulation, for example, but not limited to, metabolic diseases such as obesity, as well as related disorders such as adipositas, eating disorders, wasting syndromes (cachexia), pancreatic dysfunctions (such as diabetes mellitus), hypertension, pancreatic dysfunctions, arteriosclerosis, coronary artery disease (CAD), coronary heart disease, hypercholesterolemia, dyslipidemia, osteoarthritis, gallstones, cancer, e.g. cancers of the reproductive organs, sleep apnea, and others.
摘要翻译：本发明公开了三种调节甘油三酯的能量稳态和代谢的新型蛋白质，以及鉴定和编码本发明公开的蛋白质的多核苷酸。本发明还涉及用于产生本发明的多肽和多核苷酸的载体，宿主细胞，抗体和重组方法。本发明还涉及这些序列用于诊断，研究，预防和治疗与体重调节相关的疾病和病症的用途，例如但不限于代谢性疾病如肥胖症以及相关疾病胰腺功能障碍（例如糖尿病），高血压，胰腺功能障碍，动脉硬化，冠状动脉疾病（CAD），冠心病，高胆固醇血症，血脂异常，骨关节炎，胆结石，癌症，糖尿病，例如生殖器官的癌症，睡眠呼吸暂停等。

10. 发明授权

US06361984B1 MDK1 polypeptides 失效
标题翻译： MDK1多肽
公开(公告)号：US06361984B1
公开(公告)日：2002-03-26
申请号：US08438265
申请日：1995-05-09
申请人： Thomas Ciossek , Axel Ullrich , Birgit Millauer
发明人： Thomas Ciossek , Axel Ullrich , Birgit Millauer
IPC分类号： C12N900
CPC分类号： C07K16/40 , A61K38/00 , C07K14/71
摘要： The present invention relates to MDK1 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for diseases or conditions characterized by an abnormality in a signal transduction disorder. The signal transduction pathway involves an interaction between a MDK1 receptor tyrosine kinase and a receptor for the kinase. The MDK1 receptor tyrosine kinase may be truncated and lack a kinase domain and may be selected from the group consisting of MDK1.T1, MDK1.T2, MDK1.&Dgr;1 and MDK1.&Dgr;2.
摘要翻译：本发明涉及MDK1多肽，编码这种多肽的核酸，含有这种核酸的细胞，组织和动物，这种多肽的抗体，利用这些多肽的测定法，以及与上述所有方法有关的方法。治疗，诊断和为特征为信号转导障碍异常的疾病或病症提供筛查。信号转导途径涉及MDK1受体酪氨酸激酶与激酶受体之间的相互作用。 MDK1受体酪氨酸激酶可能被截短并缺少激酶结构域，并且可以选自MDK1.T1，MDK1.T2，MDK1.DELTA1和MDK1.DELTA2。

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