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1. 发明申请

US20050131004A1 Hydronopol derivatives as agonists on human ORL1 receptors 有权
标题翻译：水诺酮衍生物作为人类ORL1受体的激动剂
公开(公告)号：US20050131004A1
公开(公告)日：2005-06-16
申请号：US11007255
申请日：2004-12-09
申请人： Matthias Mentzel , Dania Reiche , Reinhard Bruckner , Samuel David , Bartholomeus Van Steen , Uwe Schon , Daniel Jasserand , Ulf Preuschoff
发明人： Matthias Mentzel , Dania Reiche , Reinhard Bruckner , Samuel David , Bartholomeus Van Steen , Uwe Schon , Daniel Jasserand , Ulf Preuschoff
IPC分类号： A61K31/438 , A61K31/4747 , A61P9/06 , A61P9/12 , A61P29/00 , C07D221/00 , C07D233/00 , C07D471/10 , C07D487/08
CPC分类号： C07D471/10
摘要： The invention relates to a group of hydronopol derivatives which are agonists on human ORL1 (nociceptin) receptors. The invention also relates to the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at least one of these novel hydronopol derivatives as an active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which ORL1 receptors are involved. The invention relates to compounds of the general formula (1) wherein the symbols have the meanings as given in the description.
摘要翻译：本发明涉及作为人类ORL1（伤害感受素）受体的激动剂的一组水诺酮衍生物。本发明还涉及这些化合物的制备，含有药理学活性量的这些新型水葫芦醇衍生物中的至少一种作为活性成分的药物组合物，以及这些药物组合物用于治疗其中涉及ORL1受体。本发明涉及通式（1）的化合物，其中符号具有说明书中给出的含义。

2. 发明申请

US20070219214A1 Dual NK2/NK3-antagonists, pharmaceutical compositions comprising them, and processes for their preparation 审中-公开
标题翻译：双NK2 / NK3拮抗剂，包含它们的药物组合物及其制备方法
公开(公告)号：US20070219214A1
公开(公告)日：2007-09-20
申请号：US11700788
申请日：2007-02-01
申请人： Daniel Jasserand , Matthias Mentzel , Janis Jaunzems , Werner Benson , Uwe Schon , Pieter Smid , Ulf Preuschoff , Michael Firnges , Holger Sann , Reinhard Brueckner , Martinus Adolfs , Amos Attali , Dania Reiche , Andrew McCreary
发明人： Daniel Jasserand , Matthias Mentzel , Janis Jaunzems , Werner Benson , Uwe Schon , Pieter Smid , Ulf Preuschoff , Michael Firnges , Holger Sann , Reinhard Brueckner , Martinus Adolfs , Amos Attali , Dania Reiche , Andrew McCreary
IPC分类号： A61K31/495 , A61K31/445 , C07D211/26 , C07D241/04
CPC分类号： C07D211/26 , C07D211/62 , C07D211/66 , C07D241/04 , C07D295/15 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： Dual NK2/NK3-antagonists corresponding to formula I: and physiologically compatible salts of such compounds in which X and R1 to R5 have specific defined meanings, pharmaceutical compositions containing such compounds, methods of using such compounds to treat or inhibit disorders mediated by tachykinin receptors, and a process for preparing such compounds.
摘要翻译：对应于式I的双NK2 / NK3拮抗剂：其中X和R 1至R 5具有特定定义的化合物的生理上相容的盐，含有这些化合物的药物组合物，使用这些化合物治疗或抑制由速激肽受体介导的疾病的方法，以及这种化合物的制备方法。

3. 发明申请

US20060283197A1 Cooling apparatus used for cryonic preservation, and corresponding operating method 有权
标题翻译：用于冷冻保存的冷却装置及相应的操作方法
公开(公告)号：US20060283197A1
公开(公告)日：2006-12-21
申请号：US10595308
申请日：2004-10-06
申请人： Uwe Schon , Heiko Zimmermann , Gunter Fuhr
发明人： Uwe Schon , Heiko Zimmermann , Gunter Fuhr
IPC分类号： F25B29/00 , F24F3/16 , F17C9/02
CPC分类号： F25D3/10 , A01N1/02 , A01N1/0257 , B01L7/00 , F25D29/001 , F25D2700/12 , G01N1/42
摘要： The invention relates to a cooling apparatus, especially for cryogenically preserving biological samples, comprising a duct (5) for delivering a coolant (3) to a cooling chamber (1), a heater (6) that has an adjustable first heating performance (P2) for heating the coolant (3) delivered to the cooling chamber (1), a first temperature sensor (8-10) for measuring the temperature (T2-T4) in the cooling chamber (1), a second temperature sensor (7) for measuring the temperature (T1) of the coolant (3) delivered to the cooling chamber (1), and a regulator (11) for regulating the temperature. Said regulator (11) is embodied as a multiple regulator which detects several temperatures (T1-T4) as control variables and/or adjusts several heating performances (P1, P2) as manipulated variables. The invention further relates to a corresponding operating method.
摘要翻译：本发明涉及一种特别用于低温保存生物样品的冷却装置，包括用于将冷却剂（3）输送到冷却室（1）的管道（5），具有可调节的第一加热性能的加热器（6） 2），用于加热输送到冷却室（1）的冷却剂（3），用于测量冷却室（1）中的温度（T 2 -T 4）的第一温度传感器（8-10），第二温度传感器（7），用于测量输送到冷却室（1）的冷却剂（3）的温度（T 1）和用于调节温度的调节器（11）。所述调节器（11）被实施为多个调节器，其检测多个温度（T 1 -T 4）作为控制变量和/或调节多个加热性能（P 1，P 2）作为操作变量。本发明还涉及相应的操作方法。

4. 发明申请

US20060156753A1 Device and method for handling a probe 有权
标题翻译：用于处理探头的装置和方法
公开(公告)号：US20060156753A1
公开(公告)日：2006-07-20
申请号：US10564904
申请日：2004-07-19
申请人： Gunter Fuhr , Uwe Schon , Heiko Zimmermann , Young-Joo Oh
发明人： Gunter Fuhr , Uwe Schon , Heiko Zimmermann , Young-Joo Oh
IPC分类号： F24F3/16 , F25D25/00
CPC分类号： G01N1/42 , A01N1/0252 , B25J21/02
摘要： The invention relates to a device and method for handling a probe, in particular, for treating, examining, inserting or extracting a cryoprobe. According to the invention, said probe is surrounded by an ambient gas, during handling, and an air-conditioning device (33) cools, dries and/or at least partially replaces the ambient gas by a protective gas, in order to prevent deterioration of the probe by the ambient gas during handling.
摘要翻译：本发明涉及一种用于处理探头的装置和方法，特别是用于处理，检查，插入或提取冷冻探针。根据本发明，在处理期间，所述探针被环境气体包围，并且空气调节装置（33）通过保护气体冷却，干燥和/或至少部分地替代环境气体，以防止劣化在处理期间由环境气体探测。

5. 发明授权

US5177236A Process for the preparation of 3-chloropropyl-silanes 失效
标题翻译：制备3-氯丙烯 - 硅烷的方法
公开(公告)号：US5177236A
公开(公告)日：1993-01-05
申请号：US893439
申请日：1992-06-04
申请人： Claus-Dietrich Seiler , Willy Hange , Bernhard Lillig , Reinhard Matthes , Uwe Schon
发明人： Claus-Dietrich Seiler , Willy Hange , Bernhard Lillig , Reinhard Matthes , Uwe Schon
IPC分类号： B01J23/42 , C07B61/00 , C07F7/08 , C07F7/12 , C07F7/14
CPC分类号： C07F7/0801 , C07F7/14
摘要： 3-chloropropylsilanes are prepared from hydrogensilanes and allyl chloride, where a stoichiometric excess of allyl chloride is maintained in the condensate of the vapor emitted by the boiling reactant mixture.
摘要翻译： 3-氯丙基硅烷由氢化硅烷和烯丙基氯制备，其中化学计量过量的烯丙基氯保持在由沸腾反应物混合物发射的蒸气的冷凝物中。

6. 发明授权

US4983611A 3-sulfonyl-3,7-diazabicyclo[3,3,1]nonane intermediates and pharmaceutical method 失效
标题翻译： 3-磺酰基-3,7-二氮杂双环[3,3,1]壬烷中间体和药物方法
公开(公告)号：US4983611A
公开(公告)日：1991-01-08
申请号：US401749
申请日：1989-09-25
申请人： Uwe Schon , Wolfgang Kehrbach , Klaus-Ullrich Wolf
发明人： Uwe Schon , Wolfgang Kehrbach , Klaus-Ullrich Wolf
IPC分类号： A61K31/435 , A61P1/14 , C07D471/08 , C07D471/10
CPC分类号： C07D471/08 , C07D471/10
摘要： 3-sulfonyl-3,7-diazabicyclo[3,3,1]nonane compounds corresponding to the formula: ##STR1## wherein R.sup.1 is alkyl, cycloalkylalkyl or benzyl,R.sup.2 is hydrogen or lower alkyl,R.sup.3 is hydrogen or lower alkyl orR.sup.2 and R.sup.3 together form an alkylene chain, andR.sup.4 represents lower alkyl, thienyl, halogen substituted thienyl or a --(CH.sub.2).sub.n --R.sup.5 group, wherein n=0-3 andR.sup.5 is an optionally substituted phenyl group.The compounds are pharmacologically active, particularly in influencing the motility of the stomach.

7. 发明授权

US5690431A Guide system for guiding a movable element along a predetermined elongated path 失效
标题翻译：用于沿着预定细长路径引导可移动元件的导向系统
公开(公告)号：US5690431A
公开(公告)日：1997-11-25
申请号：US566793
申请日：1995-12-04
申请人： Uwe Schon
发明人： Uwe Schon
IPC分类号： B23Q11/08 , F16C29/08 , F16C29/12 , F16H25/24 , F16J15/16 , F16C33/74
CPC分类号： B23Q11/085 , F16C29/082 , F16C29/12
摘要： To prevent elongation of a covering tape or ribbon (25) extending over an elongated opening (34) in an elongated base body (2) over which a movable element (3) can slide, the tape or ribbon is retained at preferably both of its ends, by a reverse motion, or one-way lock (50,52). In the simplest form, this reverse-motion lock (50,52) is formed by a leaf spring (63) extending at an acute angle with respect to the tape or ribbon; the tape or ribbon is backed up by bridge-like counter element (54) bridging over the elongated opening (34). If the tape or ribbon stretches, for example due to friction upon movement of the movable element (3) heating, or aging, and the movable element pushes the tape or ribbon in form of a bulge towards a terminal position, it can slide beneath the leaf spring and extend over an end portion of the base body; upon reverse motion of the movable element, the elongated end cannot, however, slip because of the one-way locking feature, thus retaining the tape or ribbon (25) taut against the opening (34) and effecting a good seal to prevent egress of operating fluid, as well as ingress of contamination, such as dirt, extraneous oil or the like.
摘要翻译：为了防止在可移动元件（3）可滑动的细长基体（2）中的细长开口（34）上延伸的覆盖带或带（25）的伸长，带或带优选保持在其两个结束，反向运动或单向锁定（50,52）。在最简单的形式中，该反向运动锁（50,52）由相对于带或带呈锐角延伸的板簧（63）形成; 带或带由桥接在细长开口（34）上方的桥状计数元件（54）支撑。如果带子或带状物例如由于可移动元件（3）的移动时的摩擦而加热或老化，并且可移动元件以朝向终端位置的形式推动带状物或带状物，则它可以在板簧并延伸到基体的端部上; 然而，在可移动元件的反向运动时，细长端不能由于单向锁定特征而滑动，因此将带或带（25）保持紧靠在开口（34）上并且实现良好的密封以防止出口工作流体，以及污染物的进入，例如污物，外来油等。

8. 发明授权

US4912113A 3,7-diazabicyclo(3,3,1)nonane compounds and pharmaceutical compositions containing such compounds 失效
标题翻译： 3,7-二氮杂双环（3,3,1）壬烷化合物和含有这些化合物的药物组合物
公开(公告)号：US4912113A
公开(公告)日：1990-03-27
申请号：US239766
申请日：1988-09-02
申请人： Uwe Schon , Wolfgang Kehrbach , Gerd Buschmann , Ulrich Kuhl , Dieter Ziegler
发明人： Uwe Schon , Wolfgang Kehrbach , Gerd Buschmann , Ulrich Kuhl , Dieter Ziegler
IPC分类号： A61K31/435 , A61P9/00 , A61P9/06 , C07D471/08 , C07D471/10
CPC分类号： C07D471/08 , C07D471/10
摘要： 3,7-Diazabicyclo[3,3,1]nonane compounds having valuable heart rate-affecting pharmacological properties corresponding to the Formula I: ##STR1## wherein R.sup.1 is alkyl, cycloalkylalkyl or benzyl,R.sup.2 is lower alkyl,R.sup.3 is lower alkyl, orR.sup.2 and R.sup.3 together form an alkylene chain, andR.sup.4 represents a benzhydryl group, optionally substituted by halogen, lower alkoxy, lower alkyl, hydroxy or trifluoromethyl, or a cinnamyl group optionally substituted by halogen, lower alkyl, lower alkoxy, hydroxy, nitro or trifluoromethyl.
摘要翻译：对应于式I的具有有价值的心率影响的药理学性质的3,7-二氮杂双环[3,3,1]壬烷化合物：其中R1是烷基，环烷基烷基或苄基，R2是低级烷基，R3是低级烷基，或R 2和R 3一起形成亚烷基链，并且R 4表示任选被卤素，低级烷氧基，低级烷基，羟基或三氟甲基取代的二苯甲基，或任选被卤素，低级烷基，低级烷氧基，羟基，硝基或三氟甲基。

9. 发明授权

US08584473B2 Cooling apparatus used for cryonic preservation, and corresponding operating method 有权
标题翻译：用于冷冻保存的冷却装置及相应的操作方法
公开(公告)号：US08584473B2
公开(公告)日：2013-11-19
申请号：US10595308
申请日：2004-10-06
申请人： Uwe Schon , Heiko Zimmermann , Gunter Fuhr
发明人： Uwe Schon , Heiko Zimmermann , Gunter Fuhr
IPC分类号： F17C9/02
CPC分类号： F25D3/10 , A01N1/02 , A01N1/0257 , B01L7/00 , F25D29/001 , F25D2700/12 , G01N1/42
摘要： The invention relates to a cooling apparatus, especially for cryogenically preserving biological samples, comprising a duct (5) for delivering a coolant (3) to a cooling chamber (1), a heater (6) that has an adjustable first heating performance (P2) for heating the coolant (3) delivered to the cooling chamber (1), a first temperature sensor (8-10) for measuring the temperature (T2-T4) in the cooling chamber (1), a second temperature sensor (7) for measuring the temperature (T1) of the coolant (3) delivered to the cooling chamber (1), and a regulator (11) for regulating the temperature. Said regulator (11) is embodied as a multiple regulator which detects several temperatures (T1-T4) as control variables and/or adjusts several heating performances (P1, P2) as manipulated variables. The invention further relates to a corresponding operating method.
摘要翻译：本发明涉及一种特别用于低温保存生物样品的冷却装置，包括用于将冷却剂（3）输送到冷却室（1）的管道（5），具有可调节的第一加热性能的加热器（6））用于加热输送到冷却室（1）的冷却剂（3），用于测量冷却室（1）中的温度（T2-T4）的第一温度传感器（8-10），第二温度传感器（7）用于测量输送到冷却室（1）的冷却剂（3）的温度（T1）和用于调节温度的调节器（11）。所述调节器（11）被实施为多个调节器，其将几个温度（T1-T4）作为控制变量检测和/或调节多个加热性能（P1，P2）作为操作变量。本发明还涉及相应的操作方法。

10. 发明授权

US07328937B2 Boot of a motor vehicle 有权
标题翻译：引导汽车
公开(公告)号：US07328937B2
公开(公告)日：2008-02-12
申请号：US10538366
申请日：2003-11-17
申请人： Ferdinand Gaiser , Jens Hantusch , Thomas Remmen , Klaus Riehle , Uwe Schon
发明人： Ferdinand Gaiser , Jens Hantusch , Thomas Remmen , Klaus Riehle , Uwe Schon
IPC分类号： B60R27/00
CPC分类号： B60R5/04 , B60P7/0815 , B60R21/00 , B60R2021/0011
摘要： The invention relates to a trunk of a motor vehicle, having a goods rail (14) which is oriented approximately in the direction of the longitudinal axis (L) of the vehicle and is intended for fixing goods to be transported. In the event of a rear impact, penetration into a seat region arranged in front of the trunk is prevented by reducing the effective of the goods rail (14), by the goods rail (14) being composed of at least two partial rails (15, 16). According to the invention, the separating plane (17) between the partial rails (15, 16) runs in an obliquely inclined manner.
摘要翻译：本发明涉及一种机动车辆的行李箱，其具有大致沿着车辆的纵向轴线（L）的方向定向的货物轨道（14），并且用于固定要运输的货物。在后部碰撞的情况下，通过由至少两个部分轨道（15）组成的货物轨道（14）来减少货物轨道（14）的有效性来防止穿过位于行李箱前方的座椅区域，16）。根据本发明，部分导轨（15,16）之间的分离平面（17）以倾斜的方式延伸。

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