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1. 发明授权

US08772323B2 Benzoxazole- and tetrahydrobenzoxazole-substituted pyridazinones as GPR119 agonists 有权
标题翻译：苯并恶唑和四氢苯并恶唑取代的哒嗪酮作为GPR119激动剂
公开(公告)号：US08772323B2
公开(公告)日：2014-07-08
申请号：US13696094
申请日：2011-05-06
申请人： Matthias Grauert , Remko Bakker , Steffen Breitfelder , Frank Buettner , Peter Eickelmann , Thomas Fox , Marc Grundl , Thorsten Lehmann-Lintz , Wolfgang Rist
发明人： Matthias Grauert , Remko Bakker , Steffen Breitfelder , Frank Buettner , Peter Eickelmann , Thomas Fox , Marc Grundl , Thorsten Lehmann-Lintz , Wolfgang Rist
IPC分类号： A61K31/423 , C07D263/54
CPC分类号： C07D413/10 , C07D413/04 , C07D413/14 , C07D417/14 , C07D453/02 , C07D498/04
摘要： The present invention relates to pyridazinone derivatives of general formula I, wherein the groups A, G and R1 are as defined in the application, the tautomers thereof, stereoisomers thereof, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.
摘要翻译：本发明涉及通式I的哒嗪酮衍生物，其中基团A，G和R 1如本申请中所定义，其互变异构体，其立体异构体，其混合物及其盐具有有价值的药理学性质，特异性结合GPR119受体并调节其活性。

2. 发明申请

US20130172323A1 PYRIDAZINONES AS GPR119 AGONISTS 有权
标题翻译： PYRIDAZINONES作为GPR119激动剂
公开(公告)号：US20130172323A1
公开(公告)日：2013-07-04
申请号：US13696094
申请日：2011-05-06
申请人： Matthias Grauert , Remko Bakker , Steffen Breitfelder , Frank Buettner , Peter Eickelmann , Thomas Fox , Marc Grundl , Thorsten Lehmann-Lintz , Wolfgang Rist
发明人： Matthias Grauert , Remko Bakker , Steffen Breitfelder , Frank Buettner , Peter Eickelmann , Thomas Fox , Marc Grundl , Thorsten Lehmann-Lintz , Wolfgang Rist
IPC分类号： C07D413/10 , C07D498/04 , C07D417/14 , C07D413/14 , C07D453/02
CPC分类号： C07D413/10 , C07D413/04 , C07D413/14 , C07D417/14 , C07D453/02 , C07D498/04
摘要： The present invention relates to pyridazinone derivatives of general formula I, wherein the groups A, G and R1 are as defined in the application, the tautomers thereof, stereoisomers thereof, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.
摘要翻译：本发明涉及通式I的哒嗪酮衍生物，其中基团A，G和R 1如本申请中所定义，其互变异构体，其立体异构体，其混合物及其盐具有有价值的药理学性质，特异性结合GPR119受体并调节其活性。

3. 发明授权

US09550888B2 Low viscosity filler composition of boron nitride particles of spherical geometry and process 有权
标题翻译：球形几何和工艺的氮化硼颗粒的低粘度填料组成
公开(公告)号：US09550888B2
公开(公告)日：2017-01-24
申请号：US10652283
申请日：2003-08-29
申请人： David Lodyga , Joseph W. Tereshko , Ajit Sane , Thomas Fox
发明人： David Lodyga , Joseph W. Tereshko , Ajit Sane , Thomas Fox
IPC分类号： C08K9/08
CPC分类号： C08K9/08
摘要： A low viscosity filler boron nitride agglomerate particles having a generally spherical shape bound together by an organic binder and to a process for producing a BN powder composition of spherically shaped boron nitride agglomerated particles having a treated surface layer which controls its viscosity.
摘要翻译：具有通过有机粘合剂结合在一起的通常为球形的低粘度填充剂氮化硼聚集体颗粒以及用于制备具有控制其粘度的经处理的表面层的球形氮化硼凝聚颗粒的BN粉末组合物的方法。

4. 发明授权

US08648085B2 1, 5-dihydro-pyrazolo (3, 4-D) pyrimidin-4-one derivatives and their use as PDE9A mudulators for the treatment of CNS disorders 有权
标题翻译： 1,5-二氢 - 吡唑并（3,4-D）嘧啶-4-酮衍生物及其用作治疗CNS紊乱的PDE9A混悬剂
公开(公告)号：US08648085B2
公开(公告)日：2014-02-11
申请号：US12744750
申请日：2008-11-27
申请人： Christian Eickmeier , Cornelia Dorner-Ciossek , Dennis Fiegen , Thomas Fox , Klaus Fuchs , Riccardo Giovannini , Niklas Heine , Martin Hendrix , Holger Rosenbrock , Gerhard Schaenzle
发明人： Christian Eickmeier , Cornelia Dorner-Ciossek , Dennis Fiegen , Thomas Fox , Klaus Fuchs , Riccardo Giovannini , Niklas Heine , Martin Hendrix , Holger Rosenbrock , Gerhard Schaenzle
IPC分类号： C07D487/04 , A61K31/519 , A61P25/28 , A61P3/04 , A61P3/10 , A61P25/16
CPC分类号： C07D487/04
摘要： The invention relates to novel substituted pyrazolopyrimidines. Chemically, the compounds are characterized by general Formula (I): with R1 being phenyl or pyridyl, any of which is substituted with 1 to 4, preferably 1 to 3 substituents X; X independently of each other being selected from C2-C6-alky1 or Ci-C6-alkoxy, where C2-C6-alkyl and C1-C6-alkoxy are at least dihalogenated up to perhalogenated. preferably with 2 to 6 halogen substituents, and the halogen atoms being selected from the group of fluoro, chloro and bromo, preferably fluoro; R2 being phenyl or heteroaryl, where phenyl is substituted by 1 to 3 radicals and heteroaryl is optionally substituted by 1 to 3 radicals in each case independently of one another selected from the group of C1-C6-alkyl, C1-C6-alkoxy, hydroxycarbonyl, cyano, trifluoromethyl, amino, nitro, hydroxy, C1-C6-alkylamino, halogen, C6-C10-arylcarbonylamino, C1-C6-alkylcarbonylamino, C1-C6-alkylaminocarbonyl. C1-C6-alkoxycarbonyl, C6-C10-arylaminocarbonyl, heteroarylaminocarbonyl. heteroarylcarbonylamino, C1-C6-alkylsulphonyl-amino, C1-C6-alkylsulphonyl and C1-C6-alkylthio; The new compounds shall be used for the manufacture of medicaments, in particular medicaments for improving, perception, concentration, learning and/or memory in patients in need thereof.
摘要翻译：本发明涉及新的取代吡唑并嘧啶。在化学上，化合物的特征在于通式（I）：其中R 1为苯基或吡啶基，其中任何一个被1至4个，优选1至3个取代基X取代; X独立地选自C 2 -C 6 - 烷基或C 1 -C 6 - 烷氧基，其中C 2 -C 6 - 烷基和C 1 -C 6 - 烷氧基至少被二卤代化为全卤代。优选具有2至6个卤素取代基，并且卤素原子选自氟，氯和溴，优选氟; R 2是苯基或杂芳基，其中苯基被1至3个基团取代，杂芳基任选被1至3个基团取代，各自独立地选自C 1 -C 6 - 烷基，C 1 -C 6 - 烷氧基，羟基羰基氰基，三氟甲基，氨基，硝基，羟基，C 1 -C 6烷基氨基，卤素，C 6 -C 10 - 芳基羰基氨基，C 1 -C 6烷基羰基氨基，C 1 -C 6烷基氨基羰基。 C 1 -C 6 - 烷氧基羰基，C 6 -C 10 - 芳基氨基羰基，杂芳基氨基羰基。杂芳基羰基氨基，C 1 -C 6烷基磺酰基 - 氨基，C 1 -C 6 - 烷基磺酰基和C 1 -C 6烷硫基; 新化合物应用于制造药物，特别是用于改善，感知，集中，学习和/或记忆有需要的患者的药物。

5. 发明申请

US20120058342A1 BORON NITRIDE PARTICLES OF SPHERICAL GEOMETRY AND PROCESS OF MAKING 有权
标题翻译：硼氮化物球形颗粒和制备方法
公开(公告)号：US20120058342A1
公开(公告)日：2012-03-08
申请号：US13173202
申请日：2011-06-30
申请人： David Lodyga , Joseph W. Tereshko , Ajit Sane , Thomas Fox , Paulo Meneghetti
发明人： David Lodyga , Joseph W. Tereshko , Ajit Sane , Thomas Fox , Paulo Meneghetti
IPC分类号： B32B5/16 , C01B21/064
CPC分类号： C04B35/58007 , C01B21/064 , C01B21/0648 , C01P2004/02 , C01P2004/32 , C01P2004/45 , C01P2004/52 , C01P2004/61 , C01P2006/11 , C04B35/62655 , C04B2235/386 , C04B2235/449 , C04B2235/5436 , C08K9/08 , Y10T428/25 , Y10T428/252 , Y10T428/2982 , Y10T428/2991
摘要： A low viscosity filler boron nitride agglomerate particles having a generally spherical shape bound together by an organic binder and to a process for producing a BN powder composition of spherically shaped boron nitride agglomerated particles having a treated surface layer which controls its viscosity.
摘要翻译：具有通过有机粘合剂结合在一起的通常为球形的低粘度填充剂氮化硼聚集体颗粒以及用于制备具有控制其粘度的经处理的表面层的球形氮化硼凝聚颗粒的BN粉末组合物的方法。

6. 发明申请

US20060123759A1 Conditioning roller drive 有权
标题翻译：调节辊驱动
公开(公告)号：US20060123759A1
公开(公告)日：2006-06-15
申请号：US11043433
申请日：2005-01-27
申请人： Thomas Fox , John Enns , Geoffrey Snider , James Dunn
发明人： Thomas Fox , John Enns , Geoffrey Snider , James Dunn
IPC分类号： G05G15/00
CPC分类号： A01D82/02
摘要： A forage conditioner for conditioning cut crop material from a forage harvester includes a fixed bottom fluted roller carried in end housings and a top fluted roller which is pivotally mounted on the housings by a linkage pivotal relative to the housing about an axis lying in a plane at right angles to the roller axes so that the top roller is liftable from crushing position against the bias of a spring extending along the top roller. Rotation of the bottom roller is transferred to the top roller through a gear train which includes two idler gears each mounted on a respective arm with the arms constrained to move symmetrically relative to the rollers by intermeshing teeth on the arms so as to control the angular timing of the rollers to ensure accurate intermeshing of the flutes.
摘要翻译：用于从饲料收割机调节切割作物材料的饲料调节器包括承载在端部壳体中的固定底部带槽辊和顶部带槽辊，其通过相对于壳体枢转地枢转地安装在壳体上的连接件围绕位于与滚子轴线成直角，使得顶部辊可以克服沿着顶部辊子延伸的弹簧的偏压而从破碎位置提升。下辊的旋转通过齿轮系传递到顶辊，该齿轮系包括两个惰轮，每个惰轮分别安装在相应的臂上，其中臂被限制为相对于辊对称地移动，通过相互啮合在臂上的齿，以便控制角定时的滚子，以确保凹槽的精确啮合。

7. 发明申请

US20060010344A1 System and method for predictive processor failure recovery 有权
标题翻译：用于预测处理器故障恢复的系统和方法
公开(公告)号：US20060010344A1
公开(公告)日：2006-01-12
申请号：US10888391
申请日：2004-07-09
申请人： Edward Zorek , Thomas Fox , Eric Kern , Michael Rollins , William Schwartz
发明人： Edward Zorek , Thomas Fox , Eric Kern , Michael Rollins , William Schwartz
IPC分类号： G06F11/00
CPC分类号： G06F11/2043 , G06F11/2025 , G06F11/2028 , G06F11/203 , G06F11/2035
摘要： A system, method, and computer program product for reporting and recovering from an internal processor error in a multiprocessor system supporting system management mode. In accordance with the method of the present invention one or more replacement agents are allocated such as during system startup within the multiprocessor system. Machine specific error-reporting registers are monitored for one or more active processor agents during system operation. In response to detecting a faulty agent via the monitoring, a system management interrupt (SMI) request is issued to one or both the faulty agent and a selected replacement agent. In response to receiving the SMI request, the operating state of the faulty agent is copied to the selected replacement agent in system management mode. Operating system processing is then resumed using the replacement agent.
摘要翻译：用于在支持系统管理模式的多处理器系统中从内部处理器错误报告和恢复的系统，方法和计算机程序产品。根据本发明的方法，一个或多个替换代理被分配，例如在系统启动期间在多处理器系统内。在系统操作期间，对一个或多个活动处理器代理监视机器特定的错误报告寄存器。响应于通过监视检测故障代理，系统管理中断（SMI）请求被发送给故障代理和所选替换代理的一个或两个。响应于接收到SMI请求，故障代理的操作状态将以系统管理模式复制到选定的替换代理。然后使用更换代理恢复操作系统处理。

8. 发明申请

US20060002512A1 X-ray reflector exhibiting taper, method of making same, narrow band x-ray filters including same, devices including such filters, multispectral x-ray production via unispectral filter, and multispectral x-ray production via multispectral filter 失效
标题翻译：具有锥形的X射线反射器，其制造方法，包括其的窄带x射线滤光器，包括这种滤光片的装置，通过单光谱滤光器的多光谱X射线生成，以及通过多光谱滤光器的多光谱X射线生成
公开(公告)号：US20060002512A1
公开(公告)日：2006-01-05
申请号：US11139655
申请日：2005-05-31
申请人： Yong Cho , Thomas Fox
发明人： Yong Cho , Thomas Fox
IPC分类号： G21K1/06
CPC分类号： A61B6/032 , A61B6/4014 , A61B6/4035 , A61B6/482 , B82Y10/00 , G21K1/062 , G21K1/10 , G21K2201/067
摘要： An x-ray reflector may include: a substrate; a first layer formed on the substrate, the first layer including a relatively higher-Z material, where Z represents the atomic number; and a second layer formed on the first layer, the second layer including a relatively lower-Z material; at least one of the first layer and the second layer exhibiting a taper in an axial direction extending between a first end of the substrate and a second end of the substrate.
摘要翻译： x射线反射器可以包括：基底; 形成在所述基板上的第一层，所述第一层包括相对较高的Z材料，其中Z表示原子序数; 以及形成在所述第一层上的第二层，所述第二层包括相对较低的Z材料; 第一层和第二层中的至少一层在基板的第一端和基板的第二端之间呈轴向延伸。

9. 发明授权

US06713088B2 Low viscosity filler composition of boron nitride particles of spherical geometry and process 有权
标题翻译：球形几何和工艺的氮化硼颗粒的低粘度填料组成
公开(公告)号：US06713088B2
公开(公告)日：2004-03-30
申请号：US09754154
申请日：2001-01-03
申请人： David Lodyga , Joseph W. Tereshko , Ajit Sane , Thomas Fox
发明人： David Lodyga , Joseph W. Tereshko , Ajit Sane , Thomas Fox
IPC分类号： A61K914
CPC分类号： C08K9/08
摘要： A low viscosity filler boron nitride agglomerate particles having a generally spherical shape bound together by an organic binder and to a process for producing a BN powder composition of spherically shaped boron nitride agglomerated particles having a treated surface layer which controls its viscosity.
摘要翻译：具有通过有机粘合剂结合在一起的通常为球形的低粘度填充剂氮化硼聚集体颗粒以及用于制备具有控制其粘度的经处理的表面层的球形氮化硼凝聚颗粒的BN粉末组合物的方法。

10. 发明授权

US09115142B2 Heterocycle-substituted piperazino-dihydrothienopyrimidines 有权
标题翻译：杂环取代的哌嗪子基 - 二氢噻吩并嘧啶
公开(公告)号：US09115142B2
公开(公告)日：2015-08-25
申请号：US14134367
申请日：2013-12-19
申请人： Pascale Pouzet , Ralf Anderskewitz , Horst Dollinger , Dennis Fiegen , Thomas Fox , Rolf Goeggel , Christoph Hoenke , Domnic Martyres , Peter Nickolaus , Klaus Klinder
发明人： Pascale Pouzet , Ralf Anderskewitz , Horst Dollinger , Dennis Fiegen , Thomas Fox , Rolf Goeggel , Christoph Hoenke , Domnic Martyres , Peter Nickolaus , Klaus Klinder
IPC分类号： C07D495/04 , A61K31/519 , C07D519/00
CPC分类号： C07D495/04 , A61K31/519 , A61K2300/00
摘要： Dihydrothienopyrimidinesulphoxides of formula 1 wherein X is SO or SO2, R1 is H or C1-6-alkyl, R2 is H or an organic group as disclosed herein, and R3 is an optionally substituted, mono- or bicyclic, unsaturated, partially saturated or saturated heterocycle or an optionally substituted, mono- or bicyclic heteroaryl, and the pharmacologically acceptable salts thereof, as well as pharmaceutical compositions which contain these compounds. These dihydrothienopyrimidinesulphoxides are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system, or cancers.
摘要翻译：式1的二氢噻吩并嘧啶亚砜，其中X是SO或SO 2，R 1是H或C 1-6 - 烷基，R 2是H或如本文所公开的有机基团，并且R 3是任选取代的单或双环不饱和的，部分饱和的或饱和的杂环或任选取代的单环或双环杂芳基及其药理学上可接受的盐，以及含有这些化合物的药物组合物。这些二氢噻吩并嘧啶亚砜适用于治疗呼吸道或胃肠道疾病，关节，皮肤或眼睛的炎性疾病，外周或中枢神经系统疾病或癌症。

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