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1. 发明申请

US20150050371A1 Extract Formulations of Rhodamnia Cinerea And Uses Thereof 审中-公开
标题翻译：提取红景天的制剂及其用途
公开(公告)号：US20150050371A1
公开(公告)日：2015-02-19
申请号：US14382237
申请日：2012-03-09
申请人： Matthias Gehling , Bärbel Köpcke , Thomas Küper , Kathrin Reinhardt , Peter Reinemer , Annie George , Sasikala Chinnappan , Mazria Haslina Md Akir
发明人： Matthias Gehling , Bärbel Köpcke , Thomas Küper , Kathrin Reinhardt , Peter Reinemer , Annie George , Sasikala Chinnappan , Mazria Haslina Md Akir
IPC分类号： A61K36/61 , A23L1/30 , A61K45/06
CPC分类号： A61K36/61 , A23L33/105 , A23V2002/00 , A61K45/06 , A61K2236/33
摘要： The present invention primarily relates to the use of certain extract formulations of Rhodamnia cinerea as defined herein as alpha-amylase inhibitors and as actives for the therapeutic (including prophylactic) treatment of a carbohydrate metabolic disorder or of a disease attendant on hyperglycemia, preferably selected from the group consisting of prediabetes, obesity, hyperlipemia, arteriosclerosis, arteriolosclerosis, atherosclerosis, diabetes, postprandial hyperglycemia, and metabolic syndrome. The present invention also relates to corresponding methods. The invention further relates to specific extract formulations obtainable from Rhodamnia cinerea and to compositions, in particular orally consumable compositions, comprising an effective amount of such an extract formulation.
摘要翻译：本发明主要涉及本文定义的灰葡萄糖苷的某些提取物制剂在α-淀粉酶抑制剂中的用途，以及用于治疗（包括预防）治疗碳水化合物代谢紊乱或伴随高血糖症的疾病的活性物质，优选选自由糖尿病前期，肥胖，高脂血症，动脉硬化，动脉硬化，动脉粥样硬化，糖尿病，餐后高血糖症和代谢综合征组成的组。本发明还涉及相应的方法。本发明还涉及可从灰葡萄球菌获得的特定提取物制剂以及包含有效量的这种提取物制剂的组合物，特别是口服消耗品组合物。

2. 发明申请

US20100267823A1 AURONES AS SELECTIVE PDE INHIBITORS AND THEIR USE IN NEUROLOGICAL CONDITIONS AND DISORDERS 审中-公开
标题翻译：作为选择性PDE抑制剂的神经元及其在神经病学和病症中的使用
公开(公告)号：US20100267823A1
公开(公告)日：2010-10-21
申请号：US12749060
申请日：2010-03-29
申请人： Annie George D/O V.K. George , Bärbel Köpcke , Ernst Roemer , Jens Bitzer , Joerg Gruenwald , Matthias Gehling , Philipp Wabnitz , Tengku Shahrir bin Tengku Adnan , Torsten Grothe
发明人： Annie George D/O V.K. George , Bärbel Köpcke , Ernst Roemer , Jens Bitzer , Joerg Gruenwald , Matthias Gehling , Philipp Wabnitz , Tengku Shahrir bin Tengku Adnan , Torsten Grothe
IPC分类号： A61K31/343 , C07D307/83 , A61P25/00 , A61P25/24 , A61P25/22 , A61P25/18
CPC分类号： C07D307/83 , C07D407/04
摘要： The invention relates to aurones and extracts comprising them useful in the prophylactic and/or therapeutic treatment of an animal (including a human) with a phosphodiesterase (PDE) dependent disease or condition of the central nervous system, as well as methods, uses and other inventions related thereto.
摘要翻译：本发明涉及包含它们可用于预防和/或治疗具有磷酸二酯酶（PDE）依赖性疾病或中枢神经系统病症的动物（包括人）以及方法，用途和其它与此相关的发明。

3. 发明申请

US20100267822A1 AURONES AS ESTROGEN RECEPTOR MODULATORS AND THEIR USE IN SEX HORMONE DEPENDENT DISEASES 审中-公开
标题翻译：作为雌激素受体调节剂的神经元及其在性别依赖性疾病中的应用
公开(公告)号：US20100267822A1
公开(公告)日：2010-10-21
申请号：US12749024
申请日：2010-03-29
申请人： Annie George D/O V.K. George , Bärbel Köpcke , Ernst Roemer , Jens Bitzer , Joachim Hans , Joerg Gruenwald , Matthias Gehling , Philipp Wabnitz , Tengku Shahrir bin Tengku Adnan , Torsten Grothe
发明人： Annie George D/O V.K. George , Bärbel Köpcke , Ernst Roemer , Jens Bitzer , Joachim Hans , Joerg Gruenwald , Matthias Gehling , Philipp Wabnitz , Tengku Shahrir bin Tengku Adnan , Torsten Grothe
IPC分类号： A61K31/343 , C07D307/83 , A61P25/00 , A61P25/24 , A61P25/28 , A61P27/02 , A61P9/12 , A61P19/08 , A61P35/00 , A61P9/00 , A61P15/00 , A61P5/30
CPC分类号： C07D307/83 , C07D407/04
摘要： The invention relates to aurones and extracts comprising them useful in the prophylactic and/or therapeutic treatment of an animal (including a human) with an estrogen receptor (ER) related disease or condition of the animal or human body, as well as methods, uses and other inventions related thereto.
摘要翻译：本发明涉及包含它们可用于预防和/或治疗具有雌激素受体（ER）相关疾病或动物或人体的病症的动物（包括人））的赭色和提取物以及方法，用途和其他有关的发明。

4. 发明申请

US20140178444A1 LONG CHAIN GLYCOLIPIDS USEFUL TO AVOID PERISHING OR MICROBIAL CONTAMINATION OF MATERIALS 审中-公开
标题翻译：长链甘露糖苷有助于避免物质的微生物污染或微生物污染
公开(公告)号：US20140178444A1
公开(公告)日：2014-06-26
申请号：US14124429
申请日：2012-06-06
申请人： Marc Stadler , Jens Bitzer , Bärbel Köpcke , Kathrin Reinhardt , Jana Moldenhauer
发明人： Marc Stadler , Jens Bitzer , Bärbel Köpcke , Kathrin Reinhardt , Jana Moldenhauer
IPC分类号： A01N43/16 , A61Q5/02 , A23L2/44 , C07H15/04 , A61K8/33
CPC分类号： A01N43/16 , A01N63/04 , A23B4/20 , A23B5/14 , A23B7/154 , A23B9/26 , A23L2/44 , A61K8/33 , A61K8/365 , A61K8/37 , A61K8/99 , A61Q5/02 , A61Q17/005 , C07H15/04 , C12P19/44
摘要： The invention relates to the use of, and methods of use employing, certain glycolipid compounds as defined in detail below and having preservative or antimicrobial properties, novel compounds of the glycolipid class, and related invention embodiments.The compounds have the formula I wherein m is 3 to 5, n is 2 to 5, o is 0 or 1 and p is 3 to 17, with the proviso that the sum m+n+o+p is not less than 14; and R is a carbohydrate moiety bound via one of its carbon atoms to the binding oxygen, and/or a physiologically, especially pharmaceutically or nutraceutically or cosmetically, acceptable salt thereof, or an ester thereof, as such or in the form of a composition, where the compound may be present in open chain form and/or in the form of a lactone (FIG. 1).
摘要翻译：本发明涉及使用以下详细定义的具有防腐或抗微生物性质的某些糖脂化合物的使用和使用方法，糖脂类的新型化合物和相关的发明实施方案。化合物具有式I，其中m为3至5，n为2至5，o为0或1，p为3至17，条件是和m + n + o + p不小于14; 并且R是通过其碳原子之一与结合氧结合的碳水化合物部分，和/或其生理学上，特别是其药学上或药学上可接受的盐或其酯，或者以组合物的形式，其中化合物可以以开链形式和/或以内酯的形式存在（图1）。

5. 发明授权

US09453016B2 Terpenoid spiro ketal compounds with LXR agonists activity, their use and formulations with them 有权
标题翻译：具有LXR激动剂活性的萜类螺旋酮缩酮化合物，它们的用途和配方
公开(公告)号：US09453016B2
公开(公告)日：2016-09-27
申请号：US13994447
申请日：2011-12-08
申请人： Torsten Grothe , Marc Stadler , Bärbel Köpcke , Ernst Roemer , Jens Bitzer , Philipp Wabnitz , Thomas Küper
发明人： Torsten Grothe , Marc Stadler , Bärbel Köpcke , Ernst Roemer , Jens Bitzer , Philipp Wabnitz , Thomas Küper
IPC分类号： A61K31/35 , C07D493/00 , C07D471/10 , A61K31/56 , A61K31/58 , A61K36/07
CPC分类号： C07D471/10 , A61K31/56 , A61K31/58 , A61K36/07
摘要： The invention relates to compositions and methods (with regard to animals and humans) for utilizing an extract and/or one or more natural spiro triterpenoids and derivatives thereof alone or as a supplement. Certain materials utilized are from the blazeispirol family, obtainable from Agaricus species. Treatments include the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to the modulation of Liver X receptor, as well as corresponding methods of treatment, the manufacture of a pharmaceutical and nutraceutical formulation for said treatment. The invention also relates to the use of the extract and compound(s) in the treatment or in the preparation of a medicament (e.g. a nutraceutical) for the prophylactic and/or therapeutic treatments, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations described herein which are useful in prophylactic and therapeutic treatments. They can also be used for non-therapeutic, e.g. cosmetic, purposes.
摘要翻译：本发明涉及用于单独使用提取物和/或一种或多种天然螺三萜类化合物及其衍生物或作为补充剂的组合物和方法（关于动物和人）。使用的某些材料来自于可从姬松茸（Agaricus）物种获得的烟草系列。治疗包括对对肝X受体的调节作出响应的疾病，病症或病状的预防和/或治疗性治疗，以及相应的治疗方法，制备用于所述治疗的药物和营养制剂。本发明还涉及提取物和化合物在治疗或制备用于预防和/或治疗性治疗的药物（例如营养药物）以及其制备中的用途。它还涉及可用于预防和治疗性治疗的本文所述的药物或营养制剂。它们也可以用于非治疗性的，例如，化妆品，用途。

6. 发明申请

US20130338219A1 Terpenoid Spiro Ketal Compounds with LXR Agonists Activity, Their Use and Formulations with Them 有权
标题翻译：萜类螺旋酮化合物与LXR激动剂的活性，它们的用途和配方
公开(公告)号：US20130338219A1
公开(公告)日：2013-12-19
申请号：US13994447
申请日：2011-12-08
申请人： Torsten Grothe , Marc Stadler , Bärbel Köpcke , Ernst Roemer , Jens Bitzer , Philipp Wabnitz , Thomas Küper
发明人： Torsten Grothe , Marc Stadler , Bärbel Köpcke , Ernst Roemer , Jens Bitzer , Philipp Wabnitz , Thomas Küper
IPC分类号： C07D471/10
CPC分类号： C07D471/10 , A61K31/56 , A61K31/58 , A61K36/07
摘要： The invention relates to compositions and methods (with regard to animals and humans) for utilizing an extract and/or one or more natural spiro triterpenoids and derivatives thereof alone or as a supplement. Certain materials utilized are from the blazeispirol family, obtainable from Agaricus species. Treatments include the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to the modulation of Liver X receptor, as well as corresponding methods of treatment, the manufacture of a pharmaceutical and nutraceutical formulation for said treatment. The invention also relates to the use of the extract and compound(s) in the treatment or in the preparation of a medicament (e.g. a nutraceutical) for the prophylactic and/or therapeutic treatments, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations described herein which are useful in prophylactic and therapeutic treatments. They can also be used for non-therapeutic, e.g. cosmetic, purposes.
摘要翻译：本发明涉及用于单独使用提取物和/或一种或多种天然螺三萜类化合物及其衍生物或作为补充剂的组合物和方法（关于动物和人）。使用的某些材料来自于可从姬松茸（Agaricus）物种获得的烟草系列。治疗包括对对肝X受体的调节作出响应的疾病，病症或病状的预防和/或治疗性治疗，以及相应的治疗方法，制备用于所述治疗的药物和营养制剂。本发明还涉及提取物和化合物在治疗或制备用于预防和/或治疗性治疗的药物（例如营养药物）以及其制备中的用途。它还涉及可用于预防和治疗性治疗的本文所述的药物或营养制剂。它们也可以用于非治疗性的，例如，化妆品，用途。

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