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1. 发明授权

US08313920B2 High-throughput assay for evaluating dipeptidyl peptidase I activity 有权
标题翻译：用于评估二肽基肽酶I活性的高通量测定
公开(公告)号：US08313920B2
公开(公告)日：2012-11-20
申请号：US12603372
申请日：2009-10-21
申请人： Matthew Olson , Matthew Todd
发明人： Matthew Olson , Matthew Todd
IPC分类号： C12Q1/37 , A61K38/00
CPC分类号： C12Q1/37 , C07K5/06026 , C12N9/6483 , C12Y304/23004 , G01N2333/948 , G01N2500/02
摘要： A method of screening a compound which modulates dipeptidyl peptidase I (DPPI) activities comprises the steps of adding a peptide substrate of DPPI to a reaction mixture which comprises DPPI and a compound, wherein the peptide substrate of DPPI has at least 3 amino acids and binds to a binding site of DPPI in addition to the S1-S2 site; and measuring the molecular weight of the substrate, wherein a change in the molecular weight of the substrate is indicative of the presence of DPPI activity.
摘要翻译：筛选调节二肽基肽酶I（DPPI）活性的化合物的方法包括以下步骤：将DPPI的肽底物加入到包含DPPI和化合物的反应混合物中，其中DPPI的肽底物具有至少3个氨基酸并且结合除了S1-S2位点之外，还与DPPI的结合位点; 并测量底物的分子量，其中底物分子量的变化表明存在DPPI活性。

2. 发明申请

US20100136594A1 HIGH-THROUGHPUT ASSAY FOR EVALUATING DIPEPTIDYL PEPTIDASE I ACTIVITY 有权
标题翻译：用于评估DIPEPTIDYL PEPTIDASE I活性的高通量测定
公开(公告)号：US20100136594A1
公开(公告)日：2010-06-03
申请号：US12603372
申请日：2009-10-21
申请人： Matthew Olson , Matthew Todd
发明人： Matthew Olson , Matthew Todd
IPC分类号： C12Q1/37 , C12N9/48
CPC分类号： C12Q1/37 , C07K5/06026 , C12N9/6483 , C12Y304/23004 , G01N2333/948 , G01N2500/02
摘要： A method of screening a compound which modulates dipeptidyl peptidase I (DPPI) activities comprises the steps of adding a peptide substrate of DPPI to a reaction mixture which comprises DPPI and a compound, wherein the peptide substrate of DPPI has at least 3 amino acids and binds to a binding site of DPPI in addition to the S1-S2 site; and measuring the molecular weight of the substrate, wherein a change in the molecular weight of the substrate is indicative of the presence of DPPI activity.
摘要翻译：筛选调节二肽基肽酶I（DPPI）活性的化合物的方法包括以下步骤：将DPPI的肽底物加入到包含DPPI和化合物的反应混合物中，其中DPPI的肽底物具有至少3个氨基酸并且结合除了S1-S2位点之外，还与DPPI的结合位点; 并测量底物的分子量，其中底物分子量的变化表明存在DPPI活性。

3. 发明申请

US20090229160A1 Weapon Ball Stock With Integrated Weapon Orientation 审中-公开
标题翻译：武器球库存与综合武器导向
公开(公告)号：US20090229160A1
公开(公告)日：2009-09-17
申请号：US12309019
申请日：2005-02-14
申请人： William Elliott , Matthew Olson , James Kilham
发明人： William Elliott , Matthew Olson , James Kilham
IPC分类号： F41C23/12 , F41C23/04
CPC分类号： F41A23/04 , F41A23/18 , F41C23/20 , F41C33/001
摘要： A weapon ball-and-socket-based weapon mounting system for removably attaching a to the body of a user. A ball stock adapted to be attached to a weapon at one end and configured with a substantially ball-shaped ball element on the other end replaced the conventional weapon butt stock. The ball stock mates with a body-supported socket adapted to receive the ball element by clicking in to the socket. The user is able to articulate the weapon into a rest position as well as rotating it through a full range of elevation and sweeping orientations.
摘要翻译：一种用于可拆卸地附接到使用者身体的武器基于球 - 插座的武器安装系统。适于在一端附接到武器并且在另一端上配置有基本上球形的球形元件的球杆替换了常规武器对接物料。球杆与身体支撑的插座配合，适用于通过点击插座来接收球形元件。用户能够将武器表达为静止位置，并将其旋转通过全范围的仰角和扫掠方向。

4. 发明授权

US07563905B2 Triazole derivatives and method of using the same to treat HIV infections 失效
标题翻译：三唑衍生物及其使用方法治疗HIV感染
公开(公告)号：US07563905B2
公开(公告)日：2009-07-21
申请号：US11076960
申请日：2005-03-11
申请人： Matthew Olson , Martin Di Grandi
发明人： Matthew Olson , Martin Di Grandi
IPC分类号： C07D249/08
CPC分类号： C07D409/04 , C07D249/12 , C07D401/04 , C07D405/04
摘要： The present invention is directed to compounds of formula (I): wherein R1, R2 and R3 are independently selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aryl and heteroaryl and X1 and X2 are independently a bond or an linker group of 1 to 6 atoms and may be optional substituted or oxidized, or a prodrug, a pharmaceutically acceptable salt or a pharmaceutically active metabolite thereof. The invention is also directed to methods of using the same for treating HIV infections, or AIDs or preventing viral replication.
摘要翻译：本发明涉及式（I）化合物：其中R 1，R 2和R 3独立地选自烷基，烯基，炔基，环烷基，芳基和杂芳基，X 1和X 2独立地是键或连接基团 1至6个原子，并且可以是任选的取代或氧化的，或其前药，药学上可接受的盐或其药物活性代谢物。本发明还涉及使用该方法治疗HIV感染或AID或预防病毒复制的方法。

5. 发明申请

US20050203176A1 Carbamates as HIV anti-viral agents 审中-公开
标题翻译：氨基甲酸酯作为HIV抗病毒剂
公开(公告)号：US20050203176A1
公开(公告)日：2005-09-15
申请号：US11076929
申请日：2005-03-11
申请人： Matthew Olson , Martin Grandi , Amarnauth Prashad
发明人： Matthew Olson , Martin Grandi , Amarnauth Prashad
IPC分类号： A61K31/325 , C07C333/20 , C07C333/24
CPC分类号： C07C333/20 , C07C333/24
摘要： The present invention relates to carbamate derivatives having RNase H, polymerase and/or HIV reverse transcriptase modulatory, and particularly, inhibitory activity. Included in the invention are the carbamate derivatives, compositions containing the derivatives, methods of synthesis of the derivatives, screening methods to identify the derivatives, and methods of treatment using the carbamate derivatives, including the treatment of HIV, AIDS and retrovirus-associated cancer.
摘要翻译：本发明涉及具有RNA酶H，聚合酶和/或HIV逆转录酶调节的氨基甲酸酯衍生物，特别涉及抑制活性。本发明包括氨基甲酸酯衍生物，含有衍生物的组合物，衍生物的合成方法，鉴定衍生物的筛选方法以及使用氨基甲酸酯衍生物的治疗方法，包括治疗HIV，AIDS和逆转录病毒相关癌症。

6. 发明授权

US06349166B1 Adhesive system for a fiber optic gyroscope sensing coil 有权
标题翻译：用于光纤陀螺仪感应线圈的粘合系统
公开(公告)号：US06349166B1
公开(公告)日：2002-02-19
申请号：US09222260
申请日：1998-12-28
申请人： Andrew Kaliszek , Matthew Olson
发明人： Andrew Kaliszek , Matthew Olson
IPC分类号： G02B616
CPC分类号： G02B6/4457 , G01C19/722
摘要： An adhesive system for use in minimizing the negative environmental influences on a fiber optic gyroscope comprises a free-standing substantially cylindrical sensing coil 12 having an inner coil surface, a rigid substantially cylindrical coil-supporting structure or hub 10 having a cylindrical wall and an outer surface, a plurality of grooves 16 formed into the hub's outer surface, a plurality of slots 24 formed into the outer surface of hub 10 and an adhesive 14 affixing hub 10 to coil 12. Adhesive 14 may be injected into manifolds 18 located in the cylindrical wall of hub 10, travel through the slots 24 into a gap existing between coil 12 and hub 10. Excess adhesive 14 may flow into grooves 16. Different orientations and sizes of grooves 16 and slots 24, different types and amounts of adhesive 14, and different thicknesses of adhesive between the coil 12 and hub 10 may be used to achieve suitable adhesion. The adhesive system may further include a stress buffer 22 and an additional adhesive 20 to further minimize environmental influences on coil 12. Specifically, a first adhesive 14 affixes the inner surface of buffer 22 to the outer surface of hub 10. A second adhesive 20 affixes the outer surface of buffer 22 to the inner surface of coil 12.
摘要翻译：用于最小化对光纤陀螺仪的负面环境影响的粘合剂系统包括具有内部线圈表面的独立的大致圆柱形的感测线圈12，具有圆柱形壁和外部线圈支撑结构的刚性大致圆柱形的线圈支撑结构或轮毂10 表面，形成在毂的外表面中的多个槽16，形成在轮毂10的外表面中的多个槽24和将轮毂10固定到线圈12的粘合剂14.粘合剂14可以被注入到位于圆柱体轮毂10的壁穿过狭槽24进入线圈12和轮毂10之间的间隙中。过多的粘合剂14可能流入凹槽16.凹槽16和狭槽24的不同取向和尺寸，不同类型和数量的粘合剂14和可以使用线圈12和轮毂10之间的不同厚度的粘合剂来实现合适的粘附。粘合剂系统还可以包括应力缓冲器22和附加粘合剂20，以进一步最小化对线圈12的环境影响。具体地，第一粘合剂14将缓冲器22的内表面固定到轮毂10的外表面。第二粘合剂20固定缓冲器22的外表面到线圈12的内表面。

7. 发明申请

US20150348170A1 METHODS AND SYSTEMS FOR FACILITATING ENTERTAINMENT MEDIA LISTINGS USING UNIQUE USER IDENTIFIERS 审中-公开
标题翻译：使用独特的用户识别器促进娱乐媒体列表的方法和系统
公开(公告)号：US20150348170A1
公开(公告)日：2015-12-03
申请号：US14288270
申请日：2014-05-27
申请人： Christopher Alan Wilber , Matthew Olson , Imad Jabbour , Vipul Govil
发明人： Christopher Alan Wilber , Matthew Olson , Imad Jabbour , Vipul Govil
IPC分类号： G06Q30/06 , G06F17/24 , G06F17/30 , G06Q30/02
CPC分类号： G06Q30/0635 , G06Q30/0255
摘要： Systems and methods are presented for facilitating entertainment media listings using unique user identifiers. In some embodiments, a computer-implemented method is presented. The method may include accessing a unique user identifier of a user, the unique user identifier associated with at least one form of entertainment media, the unique user identifier including a user history of at least one form of the entertainment media accessed by the user. The method may also include transmitting first information for displaying an offer to conduct a consumer transaction of a product associated with the at least one form of entertainment media, wherein displaying the offer is based on the user history within the accessed unique user identifier.
摘要翻译：介绍了使用独特的用户标识符来促进娱乐媒体列表的系统和方法。在一些实施例中，呈现计算机实现的方法。该方法可以包括访问用户的唯一用户标识符，与至少一种形式的娱乐媒体相关联的唯一用户标识符，唯一用户标识符包括由用户访问的娱乐媒体的至少一种形式的用户历史。该方法还可以包括发送用于显示提供的第一信息以进行与至少一种娱乐媒体形式相关联的产品的消费者交易，其中，显示提供是基于所访问的唯一用户标识符内的用户历史。

8. 发明申请

US20140129612A1 METHODS, APPARATUS, AND SYSTEM FOR MOBILE PIGGYBACKING 有权
标题翻译：方法，装置和移动电话系统
公开(公告)号：US20140129612A1
公开(公告)日：2014-05-08
申请号：US14075582
申请日：2013-11-08
申请人： Scot Fraser Hamilton , Ladd Van Tol , Luke Shardlow , Jonathan David Chard , Matthew Olson
发明人： Scot Fraser Hamilton , Ladd Van Tol , Luke Shardlow , Jonathan David Chard , Matthew Olson
IPC分类号： H04L29/08
CPC分类号： H04W4/50 , G06F3/1454 , G09G2370/022 , G09G2370/027 , H04L67/025 , H04L67/38 , H04W76/10
摘要： Methods, systems, and apparatus for providing assistance to a user of a mobile application are described. A request for assistance from the user is detected and a request is issued to a remote device for establishment of a remote assistance session. Information describing a state of the mobile device is periodically transmitted to the remote device and one or more commands may be received from the remote device. The commands may be executed on the mobile device.
摘要翻译：描述了用于向移动应用的用户提供帮助的方法，系统和装置。检测到来自用户的帮助的请求，并且向远程设备发出请求以建立远程协助会话。描述移动设备的状态的信息被周期地发送到远程设备，并且可以从远程设备接收一个或多个命令。命令可以在移动设备上执行。

9. 发明授权

US07553967B2 1,2-Dihydroquinoline derivatives and method for using the same to treat HIV infections 失效
标题翻译： 1,2-二氢喹啉衍生物及其用于治疗HIV感染的方法
公开(公告)号：US07553967B2
公开(公告)日：2009-06-30
申请号：US11076936
申请日：2005-03-11
申请人： Matthew Olson , Martin Di Grandi , Amarnauth Prashad
发明人： Matthew Olson , Martin Di Grandi , Amarnauth Prashad
IPC分类号： C07D215/38
CPC分类号： C07D215/48 , C07D215/08
摘要： The present invention is directed to compound of formula (A): wherein R1 is selected from (a) alkyl, alkenyl, alkynyl, cycloalkyl, aryl, and heteroaryl, or (b) CN and —C(NR10R11)═N—R12, R2 is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aryl and heteroaryl, R3-R12 are as described within the specification, and A is O, NR9 or S, or a prodrug, a pharmaceutically acceptable salt or a pharmaceutically active metabolite thereof, provided that R1 is not alkyl when R2 is pyridine, provided that at least one of R3-R8 is not H or F when A is O, R1 is (b) and R2 is a phenyl ring, a phenyl ring substituted at the para position with halo, —CN, —OCH3, —CF3 or —CO2CH3, a quinoline or an ethylene substituted with a phenyl ring or a 3,4-methylenedioxyphenyl moiety, provided that R4 is not methyl when R3 and R5-R8 are H, A is O, R1 is (b) and R2 is 4-chlorophenyl, and provided that R6 is not Cl when R3-R5 and R7-R8 are H, R1 is CN and R2 is phenyl. This invention is also directed to methods of using the same for treating HIV infections, or AIDS, or preventing replication.
摘要翻译：本发明涉及式（A）的化合物：其中R1选自（a）烷基，烯基，炔基，环烷基，芳基和杂芳基，或（b）CN和-C（NR10R11）-N-R12， R 2选自烷基，烯基，炔基，环烷基，芳基和杂芳基，R 3 -R 12如说明书中所述，A是O，NR 9或S，或前药，药学上可接受的盐或药学上可接受的盐条件是当R 2为吡啶时R 1不为烷基，条件是当A为O时，R 3 -R 8中的至少一个不为H或F，R 1为（b）且R 2为苯环，苯环取代在具有卤素的对位，-CN，-OCH 3，-CF 3或-CO 2 CH 3，喹啉或被苯环或3,4-亚甲二氧基苯基部分取代的亚乙基，条件是当R 3和R 5 -R 8 是H，A是O，R 1是（b），R 2是4-氯苯基，条件是当R 3 -R 5和R 7 -R 8是H时，R 6不是Cl，R 1是CN，R 2是苯基。本发明还涉及使用该方法治疗HIV感染或AIDS或预防复制的方法。

10. 发明授权

US09045930B2 Electric circuit with speed control and diode separation for use with an electrically actuatable mechanism 有权
标题翻译：具有速度控制和二极管分离的电路，用于可电动启动机构
公开(公告)号：US09045930B2
公开(公告)日：2015-06-02
申请号：US13090456
申请日：2011-04-20
申请人： Matthew Olson , Paul Kubinski , Romell Alaman
发明人： Matthew Olson , Paul Kubinski , Romell Alaman
IPC分类号： E05F15/00
CPC分类号： E05F15/50 , E05F15/53 , E05F15/565 , E05Y2400/36 , E05Y2400/40 , E05Y2400/452 , E05Y2900/51 , Y10T307/76
摘要： An electric circuit with speed control and diode separation for use with an electrically actuatable mechanism. An operator input provides a signal to a controller of the electric circuit. The controller causes a MOSFET relay to provide a voltage to the electrically actuatable mechanism. The relay is adapted to vary the voltage in response to pulse width modified signals from the controller.
摘要翻译：具有速度控制和二极管分离的电路，可与电致动机构一起使用。操作员输入向电路的控制器提供信号。控制器使MOSFET继电器向电致动机构提供电压。继电器适于响应于来自控制器的脉冲宽度修改信号来改变电压。

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