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1. 发明申请

US20160363641A1 MRI Coil for Use During an Interventional Procedure 审中-公开
标题翻译： MRI线圈在介入程序中使用
公开(公告)号：US20160363641A1
公开(公告)日：2016-12-15
申请号：US15183201
申请日：2016-06-15
申请人： Matthew Finnerty , Arne Hengerer , Volker Matschl , Gregory Weisberg , Tsinghua Zheng
发明人： Matthew Finnerty , Arne Hengerer , Volker Matschl , Gregory Weisberg , Tsinghua Zheng
IPC分类号： G01R33/3415 , G01R33/34
CPC分类号： G01R33/3415 , G01R33/34007 , G01R33/3678
摘要： In order to provide interventional access during an image-guided interventional procedure, while increasing the signal-to-noise ratio for generated images compared to a single loop coil, a local coil includes a single coil element disposed around an opening through the local coil and two coil elements positioned on opposite sides of the single coil element. The opening provides access for an interventional tool used during the image-guided interventional procedure.
摘要翻译：为了在图像引导的介入过程期间提供介入通路，与单个环形线圈相比，在增加所产生的图像的信噪比的同时，局部线圈包括设置在通过局部线圈的开口周围的单个线圈元件，两个线圈元件位于单个线圈元件的相对侧上。该开放提供了在图像引导介入程序期间使用的介入工具的访问。

2. 发明授权

US10353026B2 MRI coil for use during an interventional procedure 有权
公开(公告)号：US10353026B2
公开(公告)日：2019-07-16
申请号：US15183201
申请日：2016-06-15
申请人： Matthew Finnerty , Arne Hengerer , Volker Matschl , Gregory Weisberg , Tsinghua Zheng
发明人： Matthew Finnerty , Arne Hengerer , Volker Matschl , Gregory Weisberg , Tsinghua Zheng
IPC分类号： G01V3/00 , G01R33/3415 , G01R33/34 , G01R33/36
摘要： In order to provide interventional access during an image-guided interventional procedure, while increasing the signal-to-noise ratio for generated images compared to a single loop coil, a local coil includes a single coil element disposed around an opening through the local coil and two coil elements positioned on opposite sides of the single coil element. The opening provides access for an interventional tool used during the image-guided interventional procedure.

3. 发明申请

US20160324424A1 DETERMINING TEMPERATURE WITH THE AID OF AN INTERVENTION APPARATUS 审中-公开
标题翻译：通过干预装置确定温度
公开(公告)号：US20160324424A1
公开(公告)日：2016-11-10
申请号：US15146976
申请日：2016-05-05
申请人： Arne Hengerer , Volker Matschl , Martin Requardt , Rainer Schneider
发明人： Arne Hengerer , Volker Matschl , Martin Requardt , Rainer Schneider
IPC分类号： A61B5/01 , G01K13/00 , A61B18/14 , A61B5/055 , A61B5/06 , A61B34/20 , G01R33/28 , A61B5/00
CPC分类号： A61B5/01 , A61B5/055 , A61B5/061 , A61B5/6847 , A61B5/704 , A61B5/7425 , A61B18/1492 , A61B34/20 , A61B2018/00351 , A61B2018/00577 , A61B2018/00791 , A61B2018/0212 , A61B2034/2051 , A61B2505/05 , G01K7/36 , G01K13/002 , G01K2213/00 , G01R33/286 , G01R33/287 , G01R33/4804
摘要： System and methods are provided for determining temperature with the aid of an intervention apparatus. A reference temperature at a detection location inside the examination object is detected using a reference temperature measuring unit. A relative temperature distribution in a measuring volume, having a spatial position in relation to the detection location of the reference temperature that is known, is detected using a temperature distribution measuring unit. An evaluation unit ascertains an absolute temperature distribution using the reference temperature and the relative temperature distribution.
摘要翻译：提供了借助于介入装置来确定温度的系统和方法。使用参考温度测量单元检测检查对象内的检测位置处的基准温度。使用温度分布测量单元检测测量体积中具有相对于已知的参考温度的检测位置的空间位置的相对温度分布。评估单元使用参考温度和相对温度分布来确定绝对温度分布。

4. 发明授权

US09651639B2 Method and device for determining a change over time in a biomarker in a region to be examined 有权
公开(公告)号：US09651639B2
公开(公告)日：2017-05-16
申请号：US13894623
申请日：2013-05-15
申请人： Björn Heismann , Arne Hengerer , Sebastian Schmidt
发明人： Björn Heismann , Arne Hengerer , Sebastian Schmidt
IPC分类号： G01R33/48 , G01R33/483 , A61B5/055 , G01R33/485 , G01R33/563
CPC分类号： G01R33/485 , A61B5/055 , G01R33/48 , G01R33/4806 , G01R33/483 , G01R33/5616 , G01R33/56366
摘要： A method for determining a change over time in a biomarker in a region to be examined of a patient is provided. The change is determined from magnetic resonance data using a magnetic resonance measuring system with sequences and protocols for measuring the biomarkers by functional resting state connectivity by rsfMRI, perfusion values, magnetic resonance spectra of voxels, or morphometry of organs. A control unit has programs which evaluates the biomarker and a data memory which stores the results of the evaluation and additional data. During a first examination, a quantity result of the biomarkers is determined and stored in the data memory. During a follow-up examination, at least one previous item of the result and additional data from the first examination stored in the data memory are used for determining a quantitative change in the biomarker.

5. 发明申请

US20160073925A1 Obtaining a Three-dimensional Image of a Medical Instrument with a Magnetic Resonance Tomography Device 审中-公开
标题翻译：获得具有磁共振断层成像装置的医疗仪器的三维图像
公开(公告)号：US20160073925A1
公开(公告)日：2016-03-17
申请号：US14837060
申请日：2015-08-27
申请人： David Grodzki , Annemarie Hausotte , Björn Heismann , Arne Hengerer , Mark-Aleksi Keller-Reichenbecher , Sebastian Schmidt
发明人： David Grodzki , Annemarie Hausotte , Björn Heismann , Arne Hengerer , Mark-Aleksi Keller-Reichenbecher , Sebastian Schmidt
IPC分类号： A61B5/06 , A61B5/055 , G06T11/60 , G06T11/00 , G06T7/00 , A61N5/10 , A61B5/00
CPC分类号： G06T11/60 , A61B5/055 , A61B5/064 , A61B34/20 , A61B90/39 , A61N5/1001 , A61N5/1049 , A61N2005/1055 , G01R33/286
摘要： An apparatus is provided for obtaining a spatial instrument image of a medical instrument with a magnetic resonance tomography device, wherein the apparatus includes a medical instrument, a magnetic resonance tomography device, and a computing and control device. The medical instrument includes at least one marker material in at least one region, the marker material having a nuclear spin resonance outside of the proton resonance and wherein the computing and control device is configured to control the magnetic resonance tomography device such that a nuclear spin tomography imaging may be implemented by the magnetic resonance tomography device with the nuclear spin resonance of the at least one marker material in order to obtain a spatial instrument image, and wherein the computing and control device is configured to accept the instrument image. A corresponding medical instrument and a corresponding method are also provided.
摘要翻译：提供一种用于获得具有磁共振断层摄影装置的医疗器械的空间仪器图像的装置，其中所述装置包括医疗器械，磁共振断层摄影装置和计算和控制装置。所述医疗器械在至少一个区域中包括至少一种标记材料，所述标记材料在所述质子共振之外具有核自旋共振，并且其中所述计算和控制装置被配置为控制所述磁共振断层摄影装置，使得核自旋断层扫描成像可以通过具有至少一种标记材料的核自旋共振的磁共振断层摄影装置来实现，以获得空间仪器图像，并且其中计算和控制装置被配置为接受仪器图像。还提供了相应的医疗仪器和相应的方法。

6. 发明授权

US08529615B2 Element that can be fixed in a blood vessel and is provided with biomarkers 失效
标题翻译：可固定在血管中并具有生物标志物的元件
公开(公告)号：US08529615B2
公开(公告)日：2013-09-10
申请号：US13042532
申请日：2011-03-08
申请人： Arne Hengerer
发明人： Arne Hengerer
IPC分类号： A61F2/06
CPC分类号： A61B5/055 , A61B5/0515 , A61B5/6846 , A61B90/39 , A61F2/86 , A61F2250/0067 , A61L31/16 , A61L31/18 , A61L2300/602 , A61L2300/80 , A61L2400/12
摘要： An element is disclosed that can be fixed in a blood vessel of a living being has a base body to which a first substance and/or a second substance is/are applied at least in parts. In at least one embodiment, the first substance is determined in such a way that it can be detected from outside of the body of the living being by way of a first non-invasive detection method and reacts with at least one first biochemical substance that is released by the living being into the blood vessel during a first pathological condition of the living being, with the result that the quantity of first substance applied to the base body is reduced. The second substance is determined in such a way that it binds at least one second biochemical substance that is released by the living being into the blood vessel during a second pathological condition of the living being and the presence of the bound substance can be detected from outside of the body of the living being by way of a second non-invasive detection method.
摘要翻译：公开了一种能够固定在生物体的血管中的元件，其具有至少部分地施加有第一物质和/或第二物质的基体。在至少一个实施方案中，第一物质以这样的方式确定：其可以通过第一非侵入性检测方法从生物体内从外部检测，并与至少一种第一生化物质反应在生命的第一病态下，由生物释放到血管中，结果是施加到基体的第一物质的量减少。第二物质以这样的方式确定，即在活体的第二病理状态期间，将生物释放的至少一种第二生化物质结合到血管中，并且可以从外部检测结合物质的存在通过第二种非侵入性检测方法来检测生命体。

7. 发明申请

US20110224533A1 Element That Can Be Fixed In A Blood Vessel And Is Provided With Biomarkers 失效
标题翻译：可以在血管中固定的元素，并且具有生物标志物
公开(公告)号：US20110224533A1
公开(公告)日：2011-09-15
申请号：US13042532
申请日：2011-03-08
申请人： Arne Hengerer
发明人： Arne Hengerer
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/0515 , A61B5/6846 , A61B90/39 , A61F2/86 , A61F2250/0067 , A61L31/16 , A61L31/18 , A61L2300/602 , A61L2300/80 , A61L2400/12
摘要： An element is disclosed that can be fixed in a blood vessel of a living being has a base body to which a first substance and/or a second substance is/are applied at least in parts. In at least one embodiment, the first substance is determined in such a way that it can be detected from outside of the body of the living being by way of a first non-invasive detection method and reacts with at least one first biochemical substance that is released by the living being into the blood vessel during a first pathological condition of the living being, with the result that the quantity of first substance applied to the base body is reduced. The second substance is determined in such a way that it binds at least one second biochemical substance that is released by the living being into the blood vessel during a second pathological condition of the living being and the presence of the bound substance can be detected from outside of the body of the living being by way of a second non-invasive detection method.
摘要翻译：公开了一种能够固定在生物体的血管中的元件，其具有至少部分地施加有第一物质和/或第二物质的基体。在至少一个实施方案中，第一物质以这样的方式确定：其可以通过第一非侵入性检测方法从生物体内从外部检测，并与至少一种第一生化物质反应在生命的第一病态下，由生物释放到血管中，结果是施加到基体的第一物质的量减少。第二物质以这样的方式确定，即在活体的第二病理状态期间，将生物释放的至少一种第二生化物质结合到血管中，并且可以从外部检测结合物质的存在通过第二种非侵入性检测方法来检测生命体。

8. 发明申请

US20090312618A1 ENDOSCOPIC DEVICE WITH BIOCHIP SENSOR 审中-公开
标题翻译：具有生物传感器的内窥镜装置
公开(公告)号：US20090312618A1
公开(公告)日：2009-12-17
申请号：US12295062
申请日：2007-03-27
申请人： Arne Hengerer , Rainer Kuth
发明人： Arne Hengerer , Rainer Kuth
IPC分类号： A61B5/05 , A61B6/00
CPC分类号： A61B5/073 , A61B1/00087 , A61B1/00158 , A61B1/00193 , A61B1/041 , A61B1/0676 , A61B1/0684 , A61B5/062 , A61B5/4839 , A61B5/6882 , A61B34/73
摘要： A device for performing minimally invasive procedures in vivo has an endoscope body that carries at least one sensor or actuator and at least one magnetic element allowing the body to be freely navigated in the body of a patient by an extracorporeally applied magnetic field. the body carries at least one biochip sensor with capture molecules for detection of biological molecules in samples. A processing and analyzing unit in the body is connected to the biochip sensor for optical or electrical evaluation of the samples.
摘要翻译：用于在体内执行微创程序的装置具有携带至少一个传感器或致动器的内窥镜主体和允许身体通过体外施加的磁场自由地导航到患者体内的至少一个磁性元件。身体携带至少一个具有捕获分子的生物芯片传感器，用于检测样品中的生物分子。身体中的处理和分析单元连接到生物芯片传感器，用于样品的光学或电学评估。

9. 发明申请

US20080260642A1 Bacteriophage-Based Contrast Agents, the Use Thereof and a Method for the Production Thereof 审中-公开
标题翻译：基于噬菌体的对比剂，其用途及其生产方法
公开(公告)号：US20080260642A1
公开(公告)日：2008-10-23
申请号：US11885040
申请日：2006-02-22
申请人： Arne Hengerer
发明人： Arne Hengerer
IPC分类号： A61K49/06 , C12N15/00 , A61K35/66 , C12P21/06 , A61K49/00 , A61K49/04
CPC分类号： C40B40/02 , C12N15/1037
摘要： Bacteriophage-based contrast agents and a method for the production thereof are disclosed. The bacteriophages, in at least one embodiment, contain a first fusion protein comprising a phage-surface protein and a ligand specific for an identifiable target structure and a second fusion protein comprising a phage-surface protein and a peptide binding a signal generating molecule.
摘要翻译：公开了基于噬菌体的造影剂及其生产方法。噬菌体在至少一个实施方案中包含第一融合蛋白，其包含噬菌体表面蛋白和对于可识别的靶结构特异性的配体，以及包含噬菌体表面蛋白和结合信号产生分子的肽的第二融合蛋白。

10. 发明申请

US20080132782A1 Combined MR-ultrasound (US) coil for prostate-, cevix- and rectum cancer imaging diagnostics 审中-公开
标题翻译：联合MR超声（US）线圈用于前列腺癌，头颈癌和直肠癌成像诊断
公开(公告)号：US20080132782A1
公开(公告)日：2008-06-05
申请号：US11045619
申请日：2005-01-27
申请人： Bogdan von Rueckmann , Ralph Gareus , Wilhelm Durr , Ralph Weissleder , Arne Hengerer
发明人： Bogdan von Rueckmann , Ralph Gareus , Wilhelm Durr , Ralph Weissleder , Arne Hengerer
IPC分类号： A61B5/055 , A61B8/00
CPC分类号： A61B8/12 , A61B8/4416
摘要： We present, in exemplary embodiments of the present invention, a system combining anatomical imaging technologies (e.g., MR) with molecular imaging technologies (e.g., ultrasound). The system can be used for a variety of applications, including, but not limited to, (1) cancer diagnosis and staging; (2) image guidance; and (3) radiation therapy planning. Image guidance may include guiding a biopsy. For example, a prostatectomy potentially has severe side effects, such as impotence and incontinence. Thus, a histologically-confirmed diagnosis, such as one provided from a biopsy, may prevent unnecessary prostatectomy. Image guidance may also include guiding minimal invasive therapy, such as brachytherapy focused ultrasound. The present invention may be used to plan radiation therapy, for example, by detecting, and thus sparing, healthy tissue from radiation exposure.
摘要翻译：我们在本发明的示例性实施例中呈现将解剖成像技术（例如，MR）与分子成像技术（例如超声）组合的系统。该系统可用于各种应用，包括但不限于（1）癌症诊断和分期; （2）图像指导; 和（3）放射治疗计划。图像指导可能包括指导活检。例如，前列腺切除术可能具有严重的副作用，例如阳ence和失禁。因此，组织学确诊的诊断，例如从活组织检查提供的诊断可以防止不必要的前列腺切除术。图像引导还可以包括引导最小侵入性治疗，例如近距离放射治疗聚焦超声。本发明可以用于计划放射治疗，例如通过从辐射暴露中检测健康组织并因此节省健康组织。

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