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1. 发明申请

US20070264318A1 Compositions for the treatment and prevention of eyelid swelling 有权
标题翻译：用于治疗和预防眼睑肿胀的组合物
公开(公告)号：US20070264318A1
公开(公告)日：2007-11-15
申请号：US11796278
申请日：2007-04-26
申请人： Matthew Chapin , Mark Abelson , Keith Lane , Akimitsu Makino
发明人： Matthew Chapin , Mark Abelson , Keith Lane , Akimitsu Makino
IPC分类号： A61K31/70 , A61K31/045 , A61K33/14
CPC分类号： A61K31/40 , A61K9/0048 , A61K31/045 , A61K31/047 , A61K31/137 , A61K31/70 , A61K31/7016 , A61K33/14
摘要： The invention features topical formulations comprising an osmotically active agent and/or a vasoconstrictor and/or an astringent agent for the treatment and prevention of eyelid swelling, and methods of use thereof.
摘要翻译：本发明的特征在于包含用于治疗和预防眼睑肿胀的渗透活性剂和/或血管收缩剂和/或收敛剂的局部制剂及其使用方法。

2. 发明申请

US20080039398A1 Formulations and methods for treating dry eye 审中-公开
标题翻译：治疗干眼症的制剂和方法
公开(公告)号：US20080039398A1
公开(公告)日：2008-02-14
申请号：US11890030
申请日：2007-08-02
申请人： George Ousler , Matthew Chapin , Mark Abelson
发明人： George Ousler , Matthew Chapin , Mark Abelson
IPC分类号： A61K38/00 , A61K31/01 , A61K31/045 , A61K31/21 , A61P27/04 , A61K31/40 , A61K31/715 , A61K31/717
CPC分类号： A61K31/01 , A61K31/045 , A61K31/21 , A61K31/40 , A61K31/715 , A61K31/717
摘要： The present invention provides compositions for treating and/or preventing signs and symptoms associated with dry eye and/or ocular irritation, and methods of use thereof. Such compositions are provided in novel ophthalmic formulations that are comfortable upon instillation in the eye.
摘要翻译：本发明提供用于治疗和/或预防与眼睛和/或眼睛刺激相关的体征和症状的组合物及其使用方法。这些组合物提供在眼睛滴注中舒适的新型眼用制剂中。

3. 发明申请

US20070299124A1 Formulations and methods for treating dry eye 审中-公开
标题翻译：治疗干眼症的制剂和方法
公开(公告)号：US20070299124A1
公开(公告)日：2007-12-27
申请号：US11807147
申请日：2007-05-24
申请人： George Ousler , Matthew Chapin , Mark Abelson
发明人： George Ousler , Matthew Chapin , Mark Abelson
IPC分类号： A61K31/407 , A61K31/165 , A61K31/192 , A61K31/196 , A61P27/04 , A61P29/00 , A61P27/02 , A61K31/381 , A61K31/405
CPC分类号： A61K31/165 , A61K31/192 , A61K31/196 , A61K31/381 , A61K31/407
摘要： The present invention provides compositions for treating and/or preventing signs and symptoms associated with dry eye and/or ocular irritation, and methods of use thereof. Such compositions are provided in novel ophthalmic formulations that are comfortable upon instillation in the eye.
摘要翻译：本发明提供用于治疗和/或预防与眼睛和/或眼睛刺激相关的体征和症状的组合物及其使用方法。这些组合物提供在眼睛滴注中舒适的新型眼用制剂中。

4. 发明申请

US20060270592A1 Use of neurotransmitters and neuropeptides for the treatment of dry eye diseases and related conditions 审中-公开
标题翻译：使用神经递质和神经肽治疗干眼病和相关病症
公开(公告)号：US20060270592A1
公开(公告)日：2006-11-30
申请号：US11295165
申请日：2005-12-06
申请人： George Ousler , Matthew Chapin , Mark Abelson
发明人： George Ousler , Matthew Chapin , Mark Abelson
IPC分类号： A61K38/22 , A61K31/4172 , A61K31/198 , A61K31/137 , A61K31/195
CPC分类号： A61K38/1709 , A61K9/0048 , A61K31/137 , A61K31/198 , A61K31/4172 , A61K38/22 , A61K38/33 , A61K45/06 , A61K2300/00
摘要： The invention further features novel methods and compositions for treating and preventing dry eye by administration of neurotransmitters and/or neuropeptides, optionally in formulation with various other agents, as well as kits for the use of such novel formulations and methods.
摘要翻译：本发明还涉及用于通过施用神经递质和/或神经肽，任选地与各种其它试剂配制来治疗和预防干眼症的新型方法和组合物，以及用于使用这种新型制剂和方法的试剂盒。

5. 发明申请

US20070297981A1 Formulations and methods for treating dry eye 审中-公开
公开(公告)号：US20070297981A1
公开(公告)日：2007-12-27
申请号：US11820461
申请日：2007-06-18
申请人： George Ousler , Matthew Chapin , Mark Abelson
发明人： George Ousler , Matthew Chapin , Mark Abelson
IPC分类号： A61K49/00 , A61K31/133 , A61K31/192 , A61K31/196 , A61K31/381 , A61K31/403 , A61P29/00 , C12N9/99 , A61P27/04 , A61K31/405 , A61K31/717 , A61K31/721 , A61K38/02
CPC分类号： A61K31/045 , A61K9/0048 , A61K31/01 , A61K31/21 , A61K31/40 , A61K31/715 , A61K47/38
摘要： The present invention provides compositions for treating and/or preventing signs and symptoms associated with dry eye and/or ocular irritation, and methods of use thereof. Such compositions are provided in novel ophthalmic formulations that are comfortable upon instillation in the eye.

6. 发明申请

US20070254841A1 Formulations and methods for treating dry eye 审中-公开
标题翻译：治疗干眼症的制剂和方法
公开(公告)号：US20070254841A1
公开(公告)日：2007-11-01
申请号：US11698778
申请日：2007-01-25
申请人： George Ousler , Matthew Chapin , Mark Abelson
发明人： George Ousler , Matthew Chapin , Mark Abelson
IPC分类号： A61K38/00 , A61K31/01 , A61K31/045 , A61K31/21 , A61K31/40 , A61K31/715
CPC分类号： A61K9/0048 , A61K31/00 , A61K31/01 , A61K31/045 , A61K31/192 , A61K31/196 , A61K31/21 , A61K31/381 , A61K31/40 , A61K31/405 , A61K31/407 , A61K31/715 , A61K45/06
摘要： Provided are methods and compositions for treating and preventing dry eye and/or increasing tear film break-up time.
摘要翻译：提供用于治疗和预防干眼症和/或增加泪液破裂时间的方法和组合物。

7. 发明申请

US20050239745A1 Novel topical ophthalmic formulations 审中-公开
标题翻译：新型局部眼用配方
公开(公告)号：US20050239745A1
公开(公告)日：2005-10-27
申请号：US11074000
申请日：2005-03-03
申请人： Mark Abelson , Paulo Gomes , Matthew Chapin
发明人： Mark Abelson , Paulo Gomes , Matthew Chapin
IPC分类号： A61K31/192 , A61K31/205 , A61K31/55 , A61K31/716
CPC分类号： A61K9/0048 , A61K31/192 , A61K31/205 , A61K31/55 , A61K31/716 , A61K45/06 , A61K2300/00
摘要： The invention features novel topical formulations of antiallergenic agents in formulation with various other agents (such as a tear substitute) that provide a comfortable formulation when instilled in the eye and has enhanced efficacy and duration of action. The invention further features novel methods of treating ocular allergy by topical application of antiallergenic agents in formulation with various other agents (such as a tear substitute), as well as kits for the use of such novel formulations and methods.
摘要翻译：本发明的特征在于使用各种其它试剂（例如泪液替代物）配制抗变应性剂的新型局部制剂，其在滴注在眼睛中时提供舒适的制剂并具有增强的作用和作用持续时间。本发明还涉及通过在与各种其它试剂（例如泪液替代物）的配制中局部施用抗变应性剂以及使用这种新型制剂和方法的试剂盒来治疗眼睛变态反应的新方法。

8. 发明授权

US08372814B2 Ophthalmic formulations and uses thereof 有权
标题翻译：眼用制剂及其用途
公开(公告)号：US08372814B2
公开(公告)日：2013-02-12
申请号：US11146652
申请日：2005-06-07
申请人： Mark Abelson , Kirk McMullin
发明人： Mark Abelson , Kirk McMullin
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： A61K31/7036 , A61K31/195 , A61K31/496 , A61K31/573 , A61K31/7034 , A61K33/14 , A61K33/42 , A61K45/06 , A61K2300/00
摘要： Provided by the present invention are compositions or formulations suitable for application to a patient's eyes which utilizes a topical ophthalmically-acceptable formulation comprising a therapeutically-effective amount of an ophthalmically-active antimicrobial agent, and an ophthalmically-active anti-inflammatory or steroidal agent in combination with physiologic levels of serum electrolytes in an ophthalmic formulation for the treatment of changes in the normal eye condition. The invention also includes methods of treating patient's having an ophthalmic disease, injury or disorder, utilizing the compositions or formulations. Also provided are kits comprising the compositions or formulations and a means of applying the compositions or formulation to the patient's eyes.
摘要翻译：本发明提供了适用于患者眼睛的组合物或制剂，其利用局部眼科可接受的制剂，其包含治疗有效量的眼科活性抗微生物剂和眼科活性抗炎或甾族化合物与眼用制剂中的血清电解质的生理水平的组合用于治疗正常眼睛状况的变化。本发明还包括利用组合物或制剂治疗患有眼科疾病，损伤或病症的患者的方法。还提供了包含组合物或制剂的试剂盒以及将组合物或制剂施用于患者眼睛的方法。

9. 发明授权

US08748402B2 Ophthalmic formulations and uses thereof 有权
标题翻译：眼用制剂及其用途
公开(公告)号：US08748402B2
公开(公告)日：2014-06-10
申请号：US13369452
申请日：2012-02-09
申请人： Mark Abelson , Kirk McMullin , Angel Padilla
发明人： Mark Abelson , Kirk McMullin , Angel Padilla
IPC分类号： A01N43/04 , A61K31/70 , A61K9/48
CPC分类号： A61K9/48 , A61K9/0012 , A61K9/0048 , A61K9/10 , A61K31/195 , A61K31/496 , A61K31/573 , A61K31/7034 , A61K31/7036 , A61K33/14 , A61K33/42 , A61K45/06 , A61K47/00 , A61K2300/00
摘要： Provided by the present invention are compositions or formulations suitable for application to a patient's eyes which utilizes a topical ophthalmically-acceptable formulation comprising a therapeutically-effective amount of an ophthalmically-active antimicrobial agent, and an ophthalmically-active anti-inflammatory or steroidal agent in combination with physiologic levels of serum electrolytes in an ophthalmic formulation for the treatment of changes in the normal eye condition. The invention also includes methods of treating patient's having an ophthalmic disease, injury or disorder, utilizing the compositions or formulations. Also provided are kits comprising the compositions or formulations and a means of applying the compositions or formulation to the patient's eyes.
摘要翻译：本发明提供了适用于患者眼睛的组合物或制剂，其利用局部眼科可接受的制剂，其包含治疗有效量的眼科活性抗微生物剂和眼科活性抗炎或甾族化合物与眼用制剂中的血清电解质的生理水平的组合用于治疗正常眼睛状况的变化。本发明还包括利用组合物或制剂治疗患有眼科疾病，损伤或病症的患者的方法。还提供了包含组合物或制剂的试剂盒以及将组合物或制剂施用于患者眼睛的方法。

10. 发明申请

US20120195972A1 OPHTHALMIC FORMULATIONS AND USES THEREOF 有权
标题翻译：眼底配方及其用途
公开(公告)号：US20120195972A1
公开(公告)日：2012-08-02
申请号：US13369452
申请日：2012-02-09
申请人： Mark Abelson , Kirk McMullin , Angel Padilla
发明人： Mark Abelson , Kirk McMullin , Angel Padilla
IPC分类号： A61K33/42 , A61P41/00 , A61P27/06 , B65D69/00 , A61P37/00 , A61P31/12 , A61P31/04 , A61P27/02 , A61P29/00
CPC分类号： A61K9/48 , A61K9/0012 , A61K9/0048 , A61K9/10 , A61K31/195 , A61K31/496 , A61K31/573 , A61K31/7034 , A61K31/7036 , A61K33/14 , A61K33/42 , A61K45/06 , A61K47/00 , A61K2300/00
摘要： Provided by the present invention are compositions or formulations suitable for application to a patient's eyes which utilizes a topical ophthalmically-acceptable formulation comprising a therapeutically-effective amount of an ophthalmically-active antimicrobial agent, and an ophthalmically-active anti-inflammatory or steroidal agent in combination with physiologic levels of serum electrolytes in an ophthalmic formulation for the treatment of changes in the normal eye condition. The invention also includes methods of treating patient's having an ophthalmic disease, injury or disorder, utilizing the compositions or formulations. Also provided are kits comprising the compositions or formulations and a means of applying the compositions or formulation to the patient's eyes.
摘要翻译：本发明提供了适用于患者眼睛的组合物或制剂，其利用局部眼科可接受的制剂，其包含治疗有效量的眼科活性抗微生物剂和眼科活性抗炎或甾族化合物与眼用制剂中的血清电解质的生理水平的组合用于治疗正常眼睛状况的变化。本发明还包括利用组合物或制剂治疗患有眼科疾病，损伤或病症的患者的方法。还提供了包含组合物或制剂的试剂盒以及将组合物或制剂施用于患者眼睛的方法。

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