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1. 发明公开

EP2652324A2 ELECTROCHEMICAL ACTUATORS 审中-公开
标题翻译：电化学执行器
公开(公告)号：EP2652324A2
公开(公告)日：2013-10-23
申请号：EP11811450.3
申请日：2011-12-16
申请人： Massachusetts Institute Of Technology , Springleaf Therapeutics Inc.
发明人： CHIANG, Yet-Ming , CHIN, Timothy, E. , CIMA, Michael J. , GYORY, J., Richard
IPC分类号： F03G7/00 , H01M4/02
CPC分类号： H01M14/00 , F03G7/005 , H01M4/131 , H01M4/134 , H01M10/052 , H01M10/058
摘要： Devices and methods for providing electrochemical actuation are described herein. In one embodiment, an actuator device includes an electrochemical cell including a negative electrode and a positive electrode At least a portion of the negative electrode is formed with a material formulated to at least one of intercalate, de-intercalate, alloy with, oxidize, reduce, or plate with a first portion of the positive electrode to an extent different than with a second portion of the positive electrode such that a differential strain is imparted between the first portion and the second portion of the positive electrode and such that at least a portion of the electrochemical cell is displaced. The electrochemical cell includes a portion that is pre-bent along an axis of the electrochemical cell to define a fold axis and the displacement of the at least a portion of the electrochemical cell is maximized along the fold axis.

2. 发明申请

WO2017027376A1 SUBCUTANEOUS DRUG DELIVERY DEVICE WITH MANUAL ACTIVATION AND DEACTIVATION OF DRUG RELEASE 审中-公开
标题翻译：具有手动激活和消除药物释放的少量药物递送装置
公开(公告)号：WO2017027376A1
公开(公告)日：2017-02-16
申请号：PCT/US2016/045774
申请日：2016-08-05
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： CIMA, Michael J.
IPC分类号： A61K9/00 , A61M5/142
CPC分类号： A61K9/0092 , A61K9/0002 , A61K9/0024 , A61M5/14276 , A61M5/1428
摘要： Abstract of the Disclosure Implantable drug delivery devices and methods of making and using the same are provided. The implantable drug delivery devices permit selective activation and deactivation of drug delivery while subcutaneously implanted in a patient without the use of electronic equipment or power. The devices include a bistable member that has two stable states. In a first stable state, the bistable member does not close off a fluidic pathway between a drug reservoir and a drug release aperture, thereby allowing drug release from the device. In a second stable state, the bistable member closes off or narrows the fluidic pathway, thereby reducing or preventing drug release from the device. A patient or another person can reversibly change the bistable member between the first and second stable states by applying pressure on the patient's skin over the site of implantation and/or manipulating the device through the patient's skin at the site of implantation.
摘要翻译：本发明摘要提供了可植入药物递送装置及其制造和使用方法。可植入药物递送装置允许药物递送的选择性激活和失活，同时皮下植入患者体内，而不使用电子设备或电力。这些装置包括具有两个稳定状态的双稳态部件。在第一稳定状态下，双稳态构件不会关闭药物储存器和药物释放孔之间的流体通路，从而允许药物从装置释放。在第二稳定状态下，双稳态构件封闭或缩小流体通路，从而减少或阻止药物从装置释放。患者或另一人可以通过在植入部位通过病人的皮肤在植入部位和/或操纵该装置上的患者皮肤上施加压力来可逆地改变第一和第二稳定状态之间的双稳态部件。

3. 发明申请

WO2015017543A2 SYSTEMS AND METHODS FOR DELIVERING CHEMICAL AND ELECTRICAL STIMULATION ACROSS ONE OR MORE NEURAL CIRCUITS 审中-公开
标题翻译：用于在一个或多个神经电路中传递化学和电刺激的系统和方法
公开(公告)号：WO2015017543A2
公开(公告)日：2015-02-05
申请号：PCT/US2014/048899
申请日：2014-07-30
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： MASI, Byron C. , TIERNEY, Patrick L. , GRAYBIEL, Ann M. , CIMA, Michael J.
IPC分类号： A61N1/04
CPC分类号： A61M25/0043 , A61B5/04001 , A61B5/6877 , A61M2205/054 , A61N1/0488 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0551
摘要： Systems, devices, and methods are provided for delivering chemical and electrical stimulation across one or more neural circuits. The systems, devices, and methods can also be used for sensing and recording specific neural activity. In certain embodiments, a system includes first and second fluid reservoirs, a manifold, and a delivery tube. The manifold may include first and second chambers therein. The first chamber may be in fluid communication with the first reservoir, and the second chamber may be in fluid communication with the second reservoir. The delivery tube may include a first conduit in fluid communication with the first chamber, a second conduit in fluid communication with the second chamber, and a third conduit configured to house an electrode therein. In this manner, a distal tip of the delivery tube is configured to be positionable adjacent to the one or more neural circuits for providing chemical and electrical stimulation thereto.
摘要翻译：系统，设备和方法被提供用于跨一个或多个神经回路传递化学和电刺激。系统，设备和方法也可用于感知和记录特定的神经活动。在某些实施例中，系统包括第一和第二流体储存器，歧管和输送管。歧管可以在其中包括第一和第二腔室。第一室可以与第一储器流体连通，第二室可以与第二储器流体连通。输送管可以包括与第一室流体连通的第一导管，与第二室流体连通的第二导管以及构造成在其中容纳电极的第三导管。以这种方式，输送管的远侧末端被配置成可定位成邻近一个或多个神经回路以用于向其提供化学和电刺激。

4. 发明申请

WO2019222187A1 NANOFLUIDIC PERISTALTIC PUMPS AND METHODS OF USE 审中-公开
公开(公告)号：WO2019222187A1
公开(公告)日：2019-11-21
申请号：PCT/US2019/032183
申请日：2019-05-14
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： CIMA, Michael J. , LANGER, Robert , RAMAN, Ritu
IPC分类号： F04B19/00 , F04B43/09 , F04B43/12
摘要： A nanofluidic peristaltic pump includes an elongated tubular member having a first end, an opposed second end, and an elastic wall defining a flow channel extending between the first and second ends; and a series of shape memory alloy actuator wires extending across and at least partially around the outer surface of the elastic wall at spaced positions along the length of the tubular member, wherein the actuator wires are configured to reversibly and directly compress the wall, and thereby constrict regions of the flow channel, upon an electrothermally induced phase transition of the shape memory alloy. With the flow channel at the first end of the tubular member in fluid communication with a fluid source, an electric current is delivered to the actuator wires to sequentially activate and deactivate them and cause fluid to flow through the flow channel from the first end toward the second end.

5. 发明申请

WO2018191607A1 FORMULATIONS, METHODS, AND SYSTEMS FOR TREATING GENITOURINARY CONDITIONS 审中-公开
公开(公告)号：WO2018191607A1
公开(公告)日：2018-10-18
申请号：PCT/US2018/027474
申请日：2018-04-13
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE GENERAL HOSPITAL CORPORATION
发明人： LI, Xiang , CIMA, Michael J. , EISNER, Brian H.
IPC分类号： A61K31/24 , A61K31/415 , A61K31/44
摘要： Provided are formulations and methods for treating one or more genitourinary conditions. The formulations may include a therapeutic agent that includes a calcium channel blocker, a rho kinase inhibitor, or a combination thereof. The methods may include locally administering a therapeutic agent into a ureter. Systems for delivering a therapeutic agent also are provided.

6. 发明申请

WO2018169955A1 SYSTEMS AND METHODS FOR NEURAL DRUG DELIVERY AND MODULATION OF BRAIN ACTIVITY 审中-公开
公开(公告)号：WO2018169955A1
公开(公告)日：2018-09-20
申请号：PCT/US2018/022183
申请日：2018-03-13
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： DAGDEVIREN, Canan , LANGER, Robert , CIMA, Michael J.
IPC分类号： A61M5/32 , A61B5/04 , A61B5/00 , A61N1/05 , A61N1/04 , A61M5/158
CPC分类号： A61M5/158 , A61B5/0084 , A61B5/04001 , A61B5/4064 , A61B5/6868 , A61M5/1723 , A61M5/329 , A61M5/3294 , A61M25/0084 , A61M2005/1588 , A61M2202/04 , A61M2205/02 , A61M2205/051 , A61M2205/054 , A61M2205/3303 , A61M2207/00 , A61M2210/0693 , A61M2230/08 , A61N1/0488 , A61N1/0529
摘要： A neural drug delivery system is disclosed. In an embodiment, the system includes two or more microtubes, each having a distal end, a proximal end, and elongate channel body extending therebetween; an electrode having a distal end, a proximal end, and elongate body extending therebetween; an elongate carrying template supporting the microtubes and the electrode in an aligned stack; and an annular needle having a distal end and a proximal end, and housing the carrying template, the microtubes, and the electrode. The system may include at least one pump fluidically connected to the proximal end(s) of one or more of the microtubes. The pump may be configured to deliver a fluid drug on demand through the elongate channel body and out of the distal end of the microtubes.

7. 发明申请

WO2017096042A1 PH-SENSITIVE POLYMERIC COMPOSITIONS, KITS, AND METHODS 审中-公开
标题翻译： PH敏感性聚合物组合物，试剂盒和方法
公开(公告)号：WO2017096042A1
公开(公告)日：2017-06-08
申请号：PCT/US2016/064420
申请日：2016-12-01
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： EKCHIAN, Gregory James , CIMA, Michael J.
IPC分类号： C08F220/06 , C08F220/34 , C08L33/14 , A61B5/145 , A61B5/1468
CPC分类号： C08F220/34 , A61B5/14507 , A61B5/14539 , A61B5/1468 , A61B5/4848 , C08F220/06 , C08F2800/20 , C08L33/14 , G01N33/84 , C08F2222/1013
摘要： Provided herein are polymeric compositions having a relaxation time that is a function of pH. The polymeric compositions can include an anionic monomer, a cationic monomer, and a crosslinker. The crosslinker may comprise at least one of a diacrylate crosslinker and a dimethacrylate crosslinker. Also provided herein are methods of pH sensing, and methods of forming a polymeric composition. Kits of parts also are provided that include a polymeric composition. The polymeric compositions may be used to determine the pH of one or more biological tissues and/or liquids.
摘要翻译：本文提供了具有作为pH函数的弛豫时间的聚合物组合物。聚合物组合物可以包含阴离子单体，阳离子单体和交联剂。交联剂可以包含二丙烯酸酯交联剂和二甲基丙烯酸酯交联剂中的至少一种。本文还提供了pH感测的方法和形成聚合物组合物的方法。还提供了包含聚合物组合物的成套部件。该聚合物组合物可用于测定一种或多种生物组织和/或液体的pH。

8. 发明申请

WO2019079684A1 MEDICAL PROBES AND METHODS OF USE 审中-公开
公开(公告)号：WO2019079684A1
公开(公告)日：2019-04-25
申请号：PCT/US2018/056654
申请日：2018-10-19
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： CIMA, Michael J. , RAMADI, Khalil Basil , ROUSSEAU, Erin Byrne , COTLER, Max Joseph
IPC分类号： A61B17/34 , A61M5/158
CPC分类号： A61B34/20 , A61B17/3403 , A61B17/3417 , A61B90/10 , A61B2017/3454 , A61B2034/107 , A61M5/158 , A61M2025/0042
摘要： A medical probe for guided insertion into soft tissue, such as the brain, is disclosed. The medical probe may include a flexible, elongated body having a proximal end portion and an opposed distal end portion. The elongated body has a length of at least 1 cm and an outer diameter of 80 µm or less. The distal end portion may comprise a beveled tip such that the distal end portion of the medical probe can be steered independently to a target site in the soft tissue.

9. 发明申请

WO2018161061A1 METHODS AND SYSTEMS FOR QUANTITATIVE MONITORING OF IN VIVO TUMOR OXYGENATION 审中-公开
公开(公告)号：WO2018161061A1
公开(公告)日：2018-09-07
申请号：PCT/US2018/020810
申请日：2018-03-03
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , BRIGHAM AND WOMEN'S HOSPITAL
发明人： EKCHIAN, Gregory James , CIMA, Michael J. , CORMACK, Robert , LEE, Larissa , SCHMIDT, Ehud Jeruham
IPC分类号： A61B5/00 , A61B5/055 , A61B5/145 , G01R33/50 , G01R33/56 , A61B5/1473 , A61N5/10
摘要： An oxygen sensor is provided for measuring a dissolved oxygen concentration when deployed or implanted at a tissue site. The oxygen sensor includes a solid-state contrast agent for oxygen. The oxygen sensor is configured to indicate the dissolved oxygen concentration of a tissue when subjected to a magnetic resonance based method. The oxygen sensor may be used to map tumor oxygenation levels and for adaptive planning in brachytherapy.

10. 发明申请

WO2016196903A1 SYSTEMS AND METHODS FOR REDUCING SCAR FORMATION ABOUT A NEURAL IMPLANT 审中-公开
标题翻译：用于减少关于神经植入物的神经形成的系统和方法
公开(公告)号：WO2016196903A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/035679
申请日：2016-06-03
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： SPENCER, Kevin C. , SY, Jay Christopher , CIMA, Michael J.
IPC分类号： A61N1/05
CPC分类号： A61B5/686 , A61B5/04001 , A61B5/0476 , A61B5/0478 , A61B5/6868 , A61B2562/125 , A61B2562/14 , A61M37/00 , A61N1/0534 , A61N1/0536 , A61N1/0551
摘要： Systems, devices, and methods are provided for reducing scar formation about a neural implant due to brain tissue and neural implant movement. In an embodiment, a neural implant is provided which has a surface coating that matches one or more mechanical properties, such as elastic modulus, of the brain tissue, thereby reduce scar formation about the neural implant due to normal brain micromotion.
摘要翻译：提供了系统，装置和方法，用于减少由于脑组织和神经植入物运动引起的关于神经植入物的瘢痕形成。在一个实施例中，提供神经植入物，其具有匹配脑组织的一个或多个机械性质（例如弹性模量）的表面涂层，从而由于正常的脑微动作而减少关于神经植入物的瘢痕形成。

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