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1. 发明申请

US20090105314A1 Pharmaceutical Agent 审中-公开
标题翻译：药剂
公开(公告)号：US20090105314A1
公开(公告)日：2009-04-23
申请号：US12227359
申请日：2007-05-14
申请人： Masayuki Ii , Hideyasu Matsuda , Kouji Mouri
发明人： Masayuki Ii , Hideyasu Matsuda , Kouji Mouri
IPC分类号： A61K31/24 , A61K31/4192 , A61K31/4196 , A61K31/428 , A61P9/00
CPC分类号： A61K31/215
摘要： The present invention provides an agent for the prophylaxis or treatment of complications after coronary-artery bypass surgery or cardiac diseases, autoimmune diseases, central nervous system diseases, inflammatory diseases, sepsis, severe sepsis or septic shock in a patient who undergoes coronary-artery bypass surgery, which comprises a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a compound represented by the formula (II): wherein each symbol is as defined in the specification, or a salt thereof or a prodrug thereof, and an agent for the prophylaxis or treatment of sepsis and the like, as well as complications after coronary-artery bypass surgery, which is prepared for administration of ethyl (6R)-6-[(2-chloro-4-fluoroanilino)sulfonyl]-1-cyclohexene-1-carboxylate or a salt thereof or a prodrug thereof in a specific dose at a specific administration time.
摘要翻译：本发明提供了用于预防或治疗冠状动脉旁路手术后并发症的药物或心脏疾病，自身免疫性疾病，中枢神经系统疾病，炎性疾病，败血症，严重脓毒症或败血症休克的患者。手术，其包含由式（I）表示的化合物：其中每个符号如说明书中所定义，或由式（II）表示的化合物：其中每个符号如说明书中所定义，或其盐或其前药，以及用于预防或治疗败血症等的试剂以及冠状动脉搭桥手术后的并发症，其制备用于给予（6R）-6 - [（2-氯-4- 氟苯胺基）磺酰基] -1-环己烯-1-羧酸酯或其盐或其前药在特定给药时间内以特定剂量。

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