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1. 发明授权

US5254347A Controlled release pharmaceutical preparation and method for producing the same 失效
标题翻译：控制释放药物制剂及其制备方法
公开(公告)号：US5254347A
公开(公告)日：1993-10-19
申请号：US729841
申请日：1991-07-12
申请人： Masayoshi Samejima , Kazuo Noda , Yoshiyuki Hirakawa , Hiroyuki Yoshino
发明人： Masayoshi Samejima , Kazuo Noda , Yoshiyuki Hirakawa , Hiroyuki Yoshino
IPC分类号： A61K9/28 , A61K9/50 , A61K9/16
CPC分类号： A61K9/2866 , A61K9/5078
摘要： Disclosed is a controlled release pharmaceutical preparation, comprising a core containing a pharmaceutically active ingredient, and a porous film of a hydrophobic polymeric substance or a hydrophobic polymeric substance and a hydrophilic polymeric substance, the core being coated with the porous film. Disclosed is also a method for producing the same. The controlled release pharmaceutical preparation of this invention posseses a desired dissolution rate by controlling the porosity of the porous film.
摘要翻译：公开了一种控释药物制剂，其包含含有药物活性成分的核心和疏水聚合物质或疏水性聚合物质和亲水性聚合物质的多孔膜，所述核心被多孔膜涂覆。也公开了其制造方法。通过控制多孔膜的孔隙率，本发明的控释药物制剂具有所需的溶出速率。

2. 发明授权

US5068112A Controlled release pharmaceutical preparation and method for producing the same 失效
标题翻译：控制释放药物制备及其生产方法
公开(公告)号：US5068112A
公开(公告)日：1991-11-26
申请号：US329408
申请日：1989-03-24
申请人： Masayoshi Samejima , Kazuo Noda , Yoshiyuki Hirakawa , Hiroyuki Yoshino
发明人： Masayoshi Samejima , Kazuo Noda , Yoshiyuki Hirakawa , Hiroyuki Yoshino
IPC分类号： A61K9/22 , A61K9/28 , A61K9/32 , A61K9/36 , A61K9/50 , A61K9/52
CPC分类号： A61K9/5078 , A61K9/2866
摘要： Disclosed is a controlled release pharmaceutical preparation, comprising a core containing a pharmaceutically active ingredient, and a porous film of a hydrophobic polymeric substance or a hydrophobic polymeric substance and a hydrophilic polymeric substance, the core being coated with the porous film. Disclosed is also a method for producing the same. The controlled release pharmaceutical preparation of this invention posseses a desired dissolution rate by controlling the porosity of the porous film.

3. 发明授权

US5320853A Controlled release formulation for pharmaceutical compounds 失效
标题翻译：药物化合物的控制释放制剂
公开(公告)号：US5320853A
公开(公告)日：1994-06-14
申请号：US995309
申请日：1992-12-22
申请人： Kazuo Noda , Yoshiyuki Hirakawa , Hiroyuki Yoshino , David D. MacLaren , Paul F. Skultety , John R. Lefler , Greg M. Beck
发明人： Kazuo Noda , Yoshiyuki Hirakawa , Hiroyuki Yoshino , David D. MacLaren , Paul F. Skultety , John R. Lefler , Greg M. Beck
IPC分类号： A61K9/52 , A61K9/50 , A61K9/54 , A61K9/58 , A61K31/554 , A61K47/12 , A61K47/20 , A61P9/12 , A61K9/24
CPC分类号： A61K9/5078
摘要： Controlled release pharmaceutical beads are provided having a multi-layered core and a multi-layered periphery. The core contains at least (A) an inner portion having a suitable organic acid and (B) a sustainably-acid-releasing coating thereover. The periphery contains at least (A) an inner portion having a mixture of at least (i) a pharmaceutical compound and (ii) a surface-active agent, and (B) a sustainably-drug-releasing exterior coating.
摘要翻译：提供具有多层芯和多层外围的控释药物珠粒。核心至少包含（A）具有合适的有机酸的内部部分和（B）其上可持续发酸的涂层。外围至少包含（A）具有至少（i）药物化合物和（ii）表面活性剂的混合物的内部部分，和（B）可持续释放药物的外部涂层。

4. 发明授权

US5395628A Controlled release succinic acid microcapsules coated with aqueous acrylics 失效
标题翻译：控释琥珀酸微胶囊涂有丙烯酸水溶液
公开(公告)号：US5395628A
公开(公告)日：1995-03-07
申请号：US870195
申请日：1992-04-13
申请人： Kazuo Noda , Yoshiyuki Hirakawa , Hiroyuki Yoshino , Shinji Narisawa
发明人： Kazuo Noda , Yoshiyuki Hirakawa , Hiroyuki Yoshino , Shinji Narisawa
IPC分类号： A61K9/58 , A61K9/28 , A61K9/50 , A61K9/52 , A61K9/54 , A61K47/32
CPC分类号： A61K9/5078
摘要： A controlled release pharmaceutical preparation comprising (a) a core containing a pharmaceutically active substance and an organic acid, and (b) a coating film formed on the surface of the core by aqueous coating of a water-insoluble and water-slightly permeable acrylic polymer containing a trimethylammonium-ethyl group, which exhibits well controlled dissolution and release of the pharmaceutically active substance when administered and can maintain the desired blood level of the active substance for a long period of time, and a method for producing the preparation.
摘要翻译：一种控释药物制剂，其包含（a）含有药物活性物质和有机酸的核心，和（b）通过水不溶性和水 - 微透性丙烯酸类聚合物的水性涂层形成在芯的表面上的涂膜其含有三甲基铵 - 乙基，其在施用时表现出良好控制的药物活性物质的溶解和释放，并且可以长时间保持活性物质的期望血液水平，以及制备该制剂的方法。

5. 发明授权

US5725880A Pharmaceutical preparation controlled to release medicinal active ingredient at targeted site in intestinal tract 失效
标题翻译：控制药物制剂以在肠道的目标部位释放药用活性成分
公开(公告)号：US5725880A
公开(公告)日：1998-03-10
申请号：US402052
申请日：1995-03-10
申请人： Yoshiyuki Hirakawa , Hiroyuki Yoshino , Eiji Fukui , Tami Hanamori
发明人： Yoshiyuki Hirakawa , Hiroyuki Yoshino , Eiji Fukui , Tami Hanamori
IPC分类号： A61K9/32 , A61K9/28 , A61K9/36 , A61K45/00 , A61K47/12 , A61K47/32 , A61K47/38 , A61K9/42
CPC分类号： A61K9/2846 , A61K9/2866
摘要： A pharmaceutical preparation for oral administration which is controlled to release a medicinal active ingredient at a targeted site in the intestinal tract comprising (a) a core containing a medicinal active ingredient and (b) a press-coated layer comprising an enteric polymer, said layer being provided around the core. In the pharmaceutical preparation of the present invention, the medicinal active ingredient is not released during residence in the stomach and, after discharged from the stomach, until reaching a targeted site in the intestine, and thereafter is quickly released, so that the medicinal active ingredient is efficiently delivered to the targeted site in the intestinal tract.
摘要翻译：一种用于口服给药的药物制剂，其被控制以在肠道中的靶位点上释放药物活性成分，其包含（a）含有药用活性成分的核心和（b）包含肠溶性聚合物的加压包衣层，所述层围绕核心提供。在本发明的药物制剂中，药物活性成分在胃停留期间不释放，并且在从胃排出后直到达到肠内的目标部位，然后迅速释放，使得药用活性成分有效地输送到肠道中的目标部位。

6. 发明授权

US5614220A Pharmaceutical preparation controlled to release medicinal active ingredient at targeted site in intestinal tract 失效
标题翻译：控制药物制剂以在肠道的目标部位释放药用活性成分
公开(公告)号：US5614220A
公开(公告)日：1997-03-25
申请号：US385982
申请日：1995-02-09
申请人： Yoshiyuki Hirakawa , Hiroyuki Yoshino , Katsuji Uemura , Eiji Fukui , Tami Hanamori
发明人： Yoshiyuki Hirakawa , Hiroyuki Yoshino , Katsuji Uemura , Eiji Fukui , Tami Hanamori
IPC分类号： A61K9/58 , A61K9/28 , A61K9/36 , A61K45/00 , A61K47/32 , A61K47/38
CPC分类号： A61K9/2886
摘要： A pharmaceutical preparation for oral administration comprising(a) a core containing a medicinal active ingredient,(b) a press-coated layer comprising a pH-independently water-soluble polymer, said layer being provided around the core and(c) a film comprising an enteric polymer, said film being provided around the press-coated layer. In the pharmaceutical preparation of the present invention, the medicinal active ingredient is not released during residence in the stomach and, after forwarded from the stomach, until reaching a targeted site in the intestine, and thereafter is quickly released, so that the medicinal active ingredient is efficiently delivered to the targeted site in the intestinal tract.
摘要翻译：一种用于口服给药的药物制剂，其包含（a）含有药用活性成分的核心，（b）包含pH独立的水溶性聚合物的压制涂层，所述层围绕所述芯设置，（c）包含肠溶性聚合物，所述膜设置在压制涂层周围。在本发明的药物制剂中，药物活性成分在胃停留期间不会释放，并且在从胃部转移到达肠道的目标部位之后不被释放，然后迅速释放，使得药物活性成分有效地输送到肠道中的目标部位。

7. 发明授权

US09032229B2 Information processing device with sleep control processing, control method and non-transitory computer readable recording medium 有权
标题翻译：具有睡眠控制处理的信息处理装置，控制方法和非暂时性计算机可读记录介质
公开(公告)号：US09032229B2
公开(公告)日：2015-05-12
申请号：US13393516
申请日：2010-10-29
申请人： Mitsutaka Iwai , Tetsuji Ohtsuki , Kazuma Minami , Hiroyuki Yoshino
发明人： Mitsutaka Iwai , Tetsuji Ohtsuki , Kazuma Minami , Hiroyuki Yoshino
IPC分类号： G06F1/32 , G06F9/48
CPC分类号： G06F1/3203 , G06F1/3206 , G06F9/4893 , Y02D10/24
摘要： An information processing device (1) includes a main CPU (2) and a sub CPU (3). The main CPU (2) is provided with a function of managing schedules of task processing and idle processing and executes sleep control which reduces power consumption of the main CPU (2) as the idle processing when the task processing is not executed. The sub CPU (3) measures elapsed time during which the sleep control is executed, detects an interrupt event occurring during the sleep control, and notifies the elapsed time until the interrupt event occurs to the main CPU (2). The main CPU (2) terminates the sleep control in accordance with the notification of the elapsed time and reflects the elapsed time in the schedule. As a result, inconsistency of a timer caused by the sleep control can be solved, and the information processing device which can use a scheduler correctly even if the sleep control is executed is provided.
摘要翻译：信息处理装置（1）包括主CPU（2）和副CPU（3）。主CPU（2）具有管理任务处理和空闲处理的时间表的功能，并且执行睡眠控制，当不执行任务处理时，执行休眠控制，这降低了作为空闲处理的主CPU（2）的功耗。子CPU（3）测量执行睡眠控制的经过时间，检测在睡眠控制期间发生的中断事件，并通知直到中断事件发生到主CPU（2）的经过时间。主CPU（2）根据经过时间的通知终止睡眠控制，并反映出时间表中的经过时间。结果，可以解决由睡眠控制引起的定时器的不一致性，并且提供即使执行了睡眠控制也能够正确使用调度器的信息处理设备。

8. 发明授权

US08900628B2 Hard capsule and method for producing same 有权
标题翻译：硬胶囊及其制造方法
公开(公告)号：US08900628B2
公开(公告)日：2014-12-02
申请号：US13581022
申请日：2011-02-25
申请人： Toshiaki Moriuchi , Akane Kojo , Yusuke Hayashi , Hiroyuki Yoshino
发明人： Toshiaki Moriuchi , Akane Kojo , Yusuke Hayashi , Hiroyuki Yoshino
IPC分类号： A61K9/48 , A61J3/07
CPC分类号： A61J3/077 , A61K9/4816 , A61K9/4891
摘要： This invention provides a hard capsule that has excellent stability even when filled with a solvent for dissolving poorly soluble drugs, and that also achieves reduction in disintegration time, thereby ensuring excellent solubility.Specifically, the hard capsule of the present invention has a film comprising: (A) a polymer or copolymer obtained by polymerizing or copolymerizing, in the presence of polyvinyl alcohol and/or a derivative thereof, at least one polymerizable vinyl monomer represented by Formula (1): H2C═C(R1)—COOR2 (1) wherein R1 represents hydrogen or methyl, and R2 represents hydrogen or alkyl having 1 to 4 carbon atoms; and (B) native gellan gum.
摘要翻译：本发明提供一种即使填充溶解难溶性药物的溶剂也具有优异的稳定性的硬胶囊，并且还实现崩解时间的降低，从而确保优异的溶解性。具体地说，本发明的硬胶囊具有：（A）在聚乙烯醇和/或其衍生物的存在下聚合或共聚至少一种由式（ 1）：H 2 C = C（R 1）-COOR 2（1）其中R 1表示氢或甲基，R 2表示氢或具有1至4个碳原子的烷基; 和（B）天然绞兰胶。

9. 发明授权

US08836199B2 Power generation unit, secondary cell, and electronic apparatus 有权
标题翻译：发电单元，二次电池和电子设备
公开(公告)号：US08836199B2
公开(公告)日：2014-09-16
申请号：US13619796
申请日：2012-09-14
申请人： Noritaka Ide , Kunio Tabata , Atsushi Oshima , Hiroyuki Yoshino
发明人： Noritaka Ide , Kunio Tabata , Atsushi Oshima , Hiroyuki Yoshino
IPC分类号： H02N2/18 , H01L41/113
CPC分类号： H02N2/181 , H01L41/1136 , H02N2/188
摘要： A power generation unit includes a deforming member adapted to repeatedly deform a piezoelectric element, a pair of electrodes provided to the piezoelectric element, an inductor disposed between the pair of electrodes, and constituting a resonant circuit together with a capacitive component of the piezoelectric element, a first switch connected in series to the inductor, a member adapted to detect a timing at which a deformation direction of the deforming member is switched, a full bridge rectifier adapted to rectify a current output from the pair of electrodes, a capacitor connected to the full bridge rectifier, and adapted to store a current supplied from the full bridge rectifier, a second switch connected between either one of the pair of electrodes and the capacitor, and a control circuit adapted to operate the first switch and the second switch.
摘要翻译：发电单元包括适于使压电元件反复变形的变形构件，设置在压电元件上的一对电极，设置在该对电极之间的电感器，并与压电元件的电容部件一起构成谐振电路，与电感器串联连接的第一开关，适于检测变形构件的变形方向切换的定时的构件，适于整流来自该对电极的电流输出的全桥整流器，连接到电感器的电容器全桥整流器，并且适于存储从全桥整流器提供的电流，连接在该对电极中的任一个与电容器之间的第二开关以及适于操作第一开关和第二开关的控制电路。

10. 发明申请

US20120022169A1 HARD CAPSULE 审中-公开
标题翻译：硬胶囊
公开(公告)号：US20120022169A1
公开(公告)日：2012-01-26
申请号：US13258703
申请日：2010-04-02
申请人： Toshiaki Moriuchi , Makoto Taguchi , Akane Kojo , Hiroyuki Yoshino , Yoshinobu Fukumori , Yusuke Hayashi
发明人： Toshiaki Moriuchi , Makoto Taguchi , Akane Kojo , Hiroyuki Yoshino , Yoshinobu Fukumori , Yusuke Hayashi
IPC分类号： A61K47/32 , A61K47/38
CPC分类号： A61K9/4866 , A61K9/4816
摘要： The present invention provides a hard capsule that exhibits excellent stability even when filled with a solvent for dissolving a poorly soluble drug, and that achieves improved moldability and drying rate. As such a hard capsule, the present invention provides a hard capsule having a film containing (A) a polymer or copolymer obtained by polymerizing or copolymerizing at least one polymerizable vinyl monomer represented by Formula (1): H2C═C(R1)—COOR2 (1) wherein R1 represents hydrogen or methyl, and R2 represents hydrogen or alkyl having 1 to 4 carbon atoms, in the presence of polyvinyl alcohol and/or a derivative thereof, and (B) at least one water-soluble polymer selected from the group consisting of cellulose polymers, dextrin, and polyvinylpyrrolidone.
摘要翻译：本发明提供即使在溶解难溶性药物的溶剂的情况下也显示出优异的稳定性的硬胶囊，并且能够提高成型性和干燥率。作为这样的硬胶囊，本发明提供一种具有含有（A）通过使至少一种由式（1）表示的可聚合乙烯基单体聚合或共聚得到的聚合物或共聚物的膜的硬胶囊：H 2C≡C（R 1）-COOR 2 （1）其中R 1表示氢或甲基，R 2表示氢或具有1至4个碳原子的烷基，在聚乙烯醇和/或其衍生物的存在下，和（B）至少一种选自以下的水溶性聚合物：由纤维素聚合物，糊精和聚乙烯吡咯烷酮组成的组。

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