专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4857521A Trialkylsilyl pyridinium cephalosporin antibiotics 失效
标题翻译：三烷基甲硅烷基吡啶鎓头孢菌素抗生素
公开(公告)号：US4857521A
公开(公告)日：1989-08-15
申请号：US6199
申请日：1987-01-23
申请人： Masayasu Kurono , Yutaka Baba , Takahiko Mitani , Masao Onishi , Yasuaki Kondo , Kiichi Sawai
发明人： Masayasu Kurono , Yutaka Baba , Takahiko Mitani , Masao Onishi , Yasuaki Kondo , Kiichi Sawai
IPC分类号： A61K31/695 , A61P31/04 , C07F7/08 , C07F7/18
CPC分类号： C07F7/08 , Y02P20/55
摘要： A cephalosporin derivative represented by the formula ##STR1## wherein R is an organic residue known on .beta.-lactam antibiotics and Q is a radical of ##STR2## dotted-line means a possible double bond, R.sub.1 is hydrogen or monovalent substituent, R.sub.2, R.sub.3 and R.sub.4 are mono-valent substituent, respectively,a salt thereof, a process for the manufacture thereof and a pharmaceutical agent comprising same.
摘要翻译：由式（I）表示的头孢菌素衍生物，其中R是β-内酰胺抗生素已知的有机残基，Q是虚线所示的基团是指可能的双键，R 1是氢或一价取代基， R2，R3和R4分别为一价取代基，其盐，其制备方法和包含其的药剂。

2. 发明授权

US5008416A Organogermanium compound, process for the preparation of same as well as use thereof 失效
标题翻译：有机锗化合物，其制备方法及其用途
公开(公告)号：US5008416A
公开(公告)日：1991-04-16
申请号：US540535
申请日：1990-06-19
申请人： Masayasu Kurono , Yasuaki Kondo , Takahiko Mitani , Yutaka Baba , Kiichi Sawai
发明人： Masayasu Kurono , Yasuaki Kondo , Takahiko Mitani , Yutaka Baba , Kiichi Sawai
IPC分类号： C07F7/30
CPC分类号： C07F7/30
摘要： An organogermanium compound of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are hydrogen atom, alkyl, substituted alkyl, phenyl or substituted phenyl, and R.sub.5 is a radical of ##STR2## n is an integer of 2 or more, and R.sub.6 and R.sub.7 are hydrogen atom, alkyl, substituted alkyl, phenyl or substituted phenyl,a salt of the compound, a processs for the preparation of the compound as well as a use of the compound as an affective ingredient for pharmaceutical preparations.

3. 发明授权

US5279835A Binder-free orally administrable tablet containing 3-oxygermylpropionic acid 失效
标题翻译：无粘合剂的含3-氧基甲基丙酸的口服片剂
公开(公告)号：US5279835A
公开(公告)日：1994-01-18
申请号：US906465
申请日：1992-06-30
申请人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Yasuaki Kondo , Makoto Sato , Yoshiro Ishiwata , Syoji Yokochi , Toshiyuki Kouzaki
发明人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Yasuaki Kondo , Makoto Sato , Yoshiro Ishiwata , Syoji Yokochi , Toshiyuki Kouzaki
IPC分类号： A61K9/20 , A61K31/28 , A61K31/80 , A61K47/02 , A61K47/26 , A61P43/00
CPC分类号： A61K31/80 , A61K31/28 , A61K9/2009 , A61K9/2018
摘要： A 3-oxygermylpropionic acid preparation is provided, which activates the action of 3-oxygermylpropionic acid having the general formula:[(O.sub.1/2).sub.3 GeCH.sub.2 CH.sub.2 COOH]n wherein n=an integer of at least 1 and is readily solubilized and disintegrated in vivo. The present preparation is manufactured by compression-molding at high pressure a composition comprising 3-oxygermylpropionic acid and two or more low-molecular substance of high solubility in water. The low-molecular substances are selected from the group consisting of white sugar, sorbitol, fructose, sucrose, glucose, lactose, mannitol and sodium chloride.
摘要翻译：提供了3-氧基甲基丙酸制剂，其活化具有以下通式的3-氧基甲基丙酸的作用：（（O1 / 2）3GeCH2CH2COOH）n，其中n =至少为1的整数，并且在体内容易溶解和分解。本制剂通过高压压缩成型制备，该组合物包含3-氧基甲基丙酸和两种或更多种在水中的高溶解度的低分子量物质。低分子物质选自白糖，山梨糖醇，果糖，蔗糖，葡萄糖，乳糖，甘露醇和氯化钠。

4. 发明授权

US4870062A Organo-platinum complex and use thereof as anti-tumor agent 失效
标题翻译：有机铂复合物及其用作抗肿瘤剂
公开(公告)号：US4870062A
公开(公告)日：1989-09-26
申请号：US183575
申请日：1988-04-19
申请人： Masayasu Kurono , Ryoichi Unno , Yukiharu Matsumoto , Yasuaki Kondo , Takahiko Mitani , Takahito Jomori , Hisashi Michishita , Kiichi Sawai
发明人： Masayasu Kurono , Ryoichi Unno , Yukiharu Matsumoto , Yasuaki Kondo , Takahiko Mitani , Takahito Jomori , Hisashi Michishita , Kiichi Sawai
IPC分类号： A61K31/28 , A61K31/282 , A61K31/55 , A61P35/00 , C07F15/00
CPC分类号： C07F15/0093
摘要： A removable rating plug for a circuit breaker provides an active variable impedance in series with a reference resistor between the sensing terminals of the circuit breaker trip circuit to adjust the sensing voltage produced in response to the input current received from current monitors in the protected circuit. The active variable impedance, which is energized by the input current, includes a high gain transistor amplifier, preferably a Darlington transistor, controlled by an operational amplifier. A control circuit includes a pair of reference diodes which match the forward drop across the Darlington transistor when full on, in series with a reference voltage selection circuit which applies a reference voltage to the non-inverting input of the operational amplifier. The voltage at the connection between the Darlington transistor and the reference resistor is fed back to the inverting input of the operational amplifier so that the gain of the amplifier, and therefore the variable impedance in series with the reference resistor, varies with the reference voltage.

5. 发明授权

US5356880A Glycyrrhetinic acid derivatives 失效
标题翻译：甘草次酸衍生物
公开(公告)号：US5356880A
公开(公告)日：1994-10-18
申请号：US889709
申请日：1992-05-28
申请人： Masayasu Kurono , Yoshiro Ishiwata , Syoji Yokochi , Kyoichi Asano , Takahiko Mitani , Takuji Kakigami , Noriyuki Iwata , Kougaku Isogawa , Yutaka Baba , Hiroyuki Ohwaki , Kiichi Sawai , Hiromoto Kimura , Masato Fukushima , Ryoichi Unno , Tamaki Ohtuka
发明人： Masayasu Kurono , Yoshiro Ishiwata , Syoji Yokochi , Kyoichi Asano , Takahiko Mitani , Takuji Kakigami , Noriyuki Iwata , Kougaku Isogawa , Yutaka Baba , Hiroyuki Ohwaki , Kiichi Sawai , Hiromoto Kimura , Masato Fukushima , Ryoichi Unno , Tamaki Ohtuka
IPC分类号： C07C61/35 , C07C62/38 , C07C323/41 , C07D295/185 , C07H15/256 , C07J63/00 , A61K31/58 , C07J43/00
CPC分类号： C07D295/185 , C07C323/41 , C07C61/35 , C07C62/38 , C07H15/256 , C07J63/008 , C07C2103/52
摘要： The invention provides a novel glycoside which contains as the aglycon a 4-(substituted phenyl)piperazine-1-yl derivative of glycyrrhetinic acid and 11-deoxo-glycyrrhetinic acid or their derivative as well as a composition for the treatment of virus infection, which contains these compounds as a main active component.
摘要翻译：本发明提供了一种新颖的糖苷，其含有作为糖苷配基的甘草次酸和11-脱氧甘草次酸或其衍生物的4-（取代苯基）哌嗪-1-基衍生物以及用于治疗病毒感染的组合物，其中含有这些化合物作为主要活性组分。

6. 发明授权

US5260056A Composition for enhancing biosynthesis of interferon 失效
标题翻译：用于增强干扰素生物合成的组合物
公开(公告)号：US5260056A
公开(公告)日：1993-11-09
申请号：US640750
申请日：1991-01-14
申请人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Naohisa Ninomiya , Yoshiro Ishiwata , Syoji Yokochi , Kyoichi Asano , Kaneo Yamada , Masashi Taki , Takashi Meguro , Mikio Minamitani , Takao Matumoto , Yuichi Shiokawa
发明人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Naohisa Ninomiya , Yoshiro Ishiwata , Syoji Yokochi , Kyoichi Asano , Kaneo Yamada , Masashi Taki , Takashi Meguro , Mikio Minamitani , Takao Matumoto , Yuichi Shiokawa
IPC分类号： A61K31/28 , A61K31/70 , A61K37/66 , A61K31/79 , A61K59/16
CPC分类号： A61K31/28 , A61K31/70
摘要： An organic germanium compound to be effectively used for curing AIDS or making AIDS asymtomatic in various forms is expressed by the following rational formula: ##STR1## wherein n is an integer of 1 or 2 or more, is in the form of a white acicular or needle crystal, shows a solubility of 1.570/100 ml in water at 25.degree. C. and exhibits a melting (decomposition) point of 240.degree. C.
摘要翻译：有效地用于治疗AIDS或以各种形式产生AIDS的有机锗化合物由以下有理式表示：其中n为1或2或更大的整数，为白色针状或针状结晶，在25℃的水中的溶解度为1.570 / 100ml，熔点（分解）为240℃。

7. 发明授权

US5180739A Use of 3-oxygermylpropionic acid to treat and prevent diabetes-dependent type of autoimmune diseases 失效
标题翻译：使用3-甲氧基丙酸治疗并预防糖尿病依赖型自身免疫性疾病
公开(公告)号：US5180739A
公开(公告)日：1993-01-19
申请号：US659649
申请日：1991-02-23
申请人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Masanori Nagabuchi , Keizo Anzai
发明人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Masanori Nagabuchi , Keizo Anzai
IPC分类号： A61K31/28 , A61K31/80 , A61P3/08 , A61P3/10 , A61P37/00
CPC分类号： A61K31/28 , A61K31/80
摘要： A pharmaceutical composition is used to treat and prevent a diabetes-dependent type of autoimmune diseases, said pharmaceutical composition comprising a therapeutically effective amount of 3-oxygermylpropionic acid represented by the following formula:[(O.sub.1/2).sub.3 GeCH.sub.2 CH.sub.2 CO.sub.2 H].sub.nwherein n stands for an integer of 1 or more, optionally with an activating carrier.

8. 发明授权

US5432261A Motlin-like polypeptide and use thereof 失效
标题翻译： Motlin样多肽及其用途
公开(公告)号：US5432261A
公开(公告)日：1995-07-11
申请号：US943992
申请日：1992-09-11
申请人： Masayasu Kurono , Takahiko Mitani , Haruo Takahashi , Kenichi Tanaka , Katsuya Fujimura , Yuji Hayashi , Yohei Kobayashi , Kiichi Sawai
发明人： Masayasu Kurono , Takahiko Mitani , Haruo Takahashi , Kenichi Tanaka , Katsuya Fujimura , Yuji Hayashi , Yohei Kobayashi , Kiichi Sawai
IPC分类号： A61K38/00 , C07K14/63 , C12N15/16 , C07K14/00
CPC分类号： C07K14/63 , A61K38/00 , C07K2319/02
摘要： A pharmaceutical composition for stimulating peristaltic contraction in the intestinal canal which contains a pharmaceutically acceptable carrier or excipient and an effective amount of a polypeptide, or a salt thereof, having a pharmacological activity similar to motilin. The polypeptide has the formula B.sub.1 -Z.sub.1 -A.sub.1 -Z.sub.2 -B.sub.2 -Thr-B.sub.3 -A.sub.2 -Glu-Z.sub.3 -C-Arg-X'-Gln-Glu-Lys-Glu-Arg-D-Lys-Gly-E-Y, with Z.sub.1,Z.sub.2 and Z.sub.3 each being an amino acid residue having a hydrophobic side-chain, A.sub.1 and A.sub.2 each being an amino acid residue such as Pro, Gly, Asn and Ser, B.sub.1, B.sub.2 and B.sub.3 are each an amino acid residue having a side-chain with an aromatic ring, C is Gln, Glu or Asp, D is Asn, Glu or Asp, X' is an amino acid residue other than Met, E is Gln, Lys or Arg, and Y is homoserine, homoserine-lactone or a peptide chain having amino acid residues not exceeding 10 and containing homoserine or homoserine-lactone at the C-terminal where the first amino acid of said peptide chain is other than Lys, Arg or Pro.
摘要翻译：一种用于刺激肠道蠕动收缩的药物组合物，其含有药学上可接受的载体或赋形剂和有效量的具有与胃动素相似的药理活性的多肽或其盐。该多肽具有式B1-Z1-A1-Z2-B2-Thr-B3-A2-Glu-Z3-C-Arg-X'-Gln-Glu-Lys-Glu-Arg-D-Lys-Gly-EY， Z 1，Z 2和Z 3各自为具有疏水侧链的氨基酸残基，A1和A2各自为氨基酸残基，例如Pro，Gly，Asn和Ser，B1，B2和B3各自为具有具有芳环的侧链，C是Gln，Glu或Asp，D是Asn，Glu或Asp，X'是Met以外的氨基酸残基，E是Gln，Lys或Arg，Y是高丝氨酸，高丝氨酸 β-内酯或氨基酸残基不超过10的肽链，并且在所述肽链的第一个氨基酸不是Lys，Arg或Pro的C末端含有高丝氨酸或高丝氨酸 - 内酯。

9. 发明授权

US5428015A Vasoactive intestinal polypeptide analogues and use thereof 失效
标题翻译：血管活性肠多肽类似物及其用途
公开(公告)号：US5428015A
公开(公告)日：1995-06-27
申请号：US201092
申请日：1994-02-24
申请人： Masayasu Kurono , Takahiko Mitani , Haruo Takahashi , Kiichi Sawai
发明人： Masayasu Kurono , Takahiko Mitani , Haruo Takahashi , Kiichi Sawai
IPC分类号： A61K38/00 , C07K14/575 , C07K7/08
CPC分类号： C07K14/57563 , A61K38/00
摘要： Vasoactive intestinal polypeptide (VIP) analogues and use thereof are disclosed. The VIP analogues are shown by the formula ofHis-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-X-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-Ywherein X is a residue of amino acid other than methionine (Met); and Y is homoserine, homoserine-lactone, amidized homoserine, a residue reacted homoserine-lactone with a primary alkyl amine having carbon atoms not exceeding 20, or an optional polypeptide chain and containing an amidized homoserine at C-terminal.Each of the VIP analogues is employed as an effective ingredient for various medicines and a hair tonic, and more particularly curing an asthma and impotence.
摘要翻译：公开了血管活性肠肽（VIP）类似物及其用途。 VIP类似物以His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-X-Ala-Val-Lys-Lys -Tyr-Leu-Asn-Ser-Ile-Leu-Asn-Y其中X是甲硫氨酸以外的氨基酸残基（Met）; 并且Y是高丝氨酸，高丝氨酸 - 内酯，酰胺化高丝氨酸，残基与高丝氨酸 - 内酯与碳原子数不超过20的伯烷基胺反应，或任选的多肽链，并且在C-末端含有酰胺化的高丝氨酸。每种VIP类似物被用作各种药物和头发补品的有效成分，更特别地治疗哮喘和阳。。

10. 发明授权

US5211956A Pharmaceutical compositions containing phytic acid or its salts 失效
标题翻译：含有植物酸或其盐的药物组合物
公开(公告)号：US5211956A
公开(公告)日：1993-05-18
申请号：US346852
申请日：1989-05-03
申请人： Kiichi Sawai , Masayasu Kurono , Hiromoto Asai , Takahiko Mitani , Naohisa Ninomiya
发明人： Kiichi Sawai , Masayasu Kurono , Hiromoto Asai , Takahiko Mitani , Naohisa Ninomiya
IPC分类号： A61K31/66
CPC分类号： A61K31/66
摘要： Pharmaceutical compositions for oral administration used for the treatment and prevention of hyperlipemia, obesity and obesity-related diseases contain phytic acid or its salt as a pharmaceutically effective component.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式