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1. 发明申请

US20080293818A1 Regulator of Physiological Function of Ghrelin and Use Thereof 审中-公开
标题翻译： Ghrelin生理功能调节因子及其用途
公开(公告)号：US20080293818A1
公开(公告)日：2008-11-27
申请号：US11628743
申请日：2005-04-19
申请人： Masayasu Kojima , Yoshihiro Nishi , Kenji Kanagawa , Keiichi Abe , Reiko Izumi , Junichi Nakamura
发明人： Masayasu Kojima , Yoshihiro Nishi , Kenji Kanagawa , Keiichi Abe , Reiko Izumi , Junichi Nakamura
IPC分类号： A61K31/20 , A61P1/00
CPC分类号： A61K31/19 , A23L33/12 , A23V2002/00 , A61K31/20 , A61K31/22 , A61K31/23 , A23V2200/326 , A23V2200/306 , A23V2250/186
摘要： A regulator for regulating physiological functions, such as activity of increasing an intracellular calcium ion concentration, activity of promoting growth hormone secretion, activity of promoting eating, regulatory activity relating to fat accumulation, activity of ameliorating heart function and activity of stimulating gastric acid secretion, of ghrelin, which regulator comprises a fatty acid of carbon number 2-35 or its derivative, and use thereof.
摘要翻译：用于调节生理功能的调节剂，例如增加细胞内钙离子浓度的活性，促进生长激素分泌的活性，促进饮食的活性，与脂肪蓄积有关的调节活性，改善心脏功能的活性和刺激胃酸分泌的活性，的生长素释放肽，其调节剂包含碳数为2-35的脂肪酸或其衍生物及其用途。

2. 发明申请

US20050257587A1 Profile element pipe for hydraulic bulging, hydraulic bulging device using the element pipe, hydraulic bulging method using the element pipe, and hydraulically bulged product 审中-公开
标题翻译：用于液压膨胀的轮廓元件管，使用元件管的液压膨胀装置，使用元件管的液压膨胀法和液压膨胀产品
公开(公告)号：US20050257587A1
公开(公告)日：2005-11-24
申请号：US11123196
申请日：2005-05-06
申请人： Atsushi Tomizawa , Masayasu Kojima
发明人： Atsushi Tomizawa , Masayasu Kojima
IPC分类号： B21D26/033 , B21D26/045 , B21D26/02
CPC分类号： B21D26/033 , B21D26/045
摘要： A profile element pipe for hydraulic bulging of the present invention has a peripheral length with an outer diameter gradually increasing or decreasing from one axial side toward the other thereof and has a parallel part formed on at least one end thereof. According to a bulging device and a bulging method using this profile element pipe, for example, even when a profile steel pipe having a cross sectional shape varying in the axial direction as in a tapered pipe is hydraulically bulged, a bulging in which an internal pressure loading and an shaft pressing are combined with each other can be performed to provide a larger expansion ratio than a conventional case and a joining and socket connection thereof to the other part can also be easily performed.
摘要翻译：本发明的液压膨胀用轮廓元件管具有从一个轴向侧朝向另一个的外径逐渐增大或减小的圆周长度，并且在其至少一端形成有平行部。根据使用该型材元件管的凸起装置和膨胀方法，例如即使在锥形管中具有沿轴向方向变化的截面形状的型材钢管是液压膨胀的，也可以是膨胀，其中内压可以进行加载和轴压相结合以提供比常规壳体更大的膨胀比，并且也可以容易地进行与另一部分的接合和插座连接。

3. 发明授权

US09573986B2 Modified ghrelin peptides 有权
标题翻译：改良的生长素释放肽
公开(公告)号：US09573986B2
公开(公告)日：2017-02-21
申请号：US12728495
申请日：2010-03-22
申请人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
发明人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
IPC分类号： A61K9/00 , C07K14/47 , C07K14/575 , C07K14/46 , C07K14/465 , A61K38/00 , A61K47/42 , A61K48/00
CPC分类号： C07K14/575 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K48/00 , C07K14/461 , C07K14/463 , C07K14/465 , C07K14/47 , C07K14/4702
摘要： The present invention provides a peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供诱导生长激素分泌的肽型化合物，其具有增加细胞内钙离子浓度的活性，其中至少一个氨基酸被修饰的氨基酸和/或非氨基酸化合物代替，或其药学上可接受的盐。

4. 发明申请

US20110184153A1 MODIFIED GHERLIN PEPTIDES 有权
标题翻译：改良的GHERLIN PEPTIDES
公开(公告)号：US20110184153A1
公开(公告)日：2011-07-28
申请号：US13076844
申请日：2011-03-31
申请人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
发明人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
IPC分类号： C07K16/18
CPC分类号： C07K14/575 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K48/00 , C07K14/461 , C07K14/463 , C07K14/465 , C07K14/47 , C07K14/4702
摘要： The present invention provides a novel peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了诱导生长激素分泌的新型肽型化合物，其具有增加细胞内钙离子浓度的活性，其中至少一个氨基酸被修饰的氨基酸和/或非氨基酸替代化合物或其药学上可接受的盐。

5. 发明授权

US07827839B2 Profile element pipe for hydraulic bulging, hydraulic bulging device using the element pipe, hydraulic bulging method using the element pipe, and hydraulically bulged product 有权
标题翻译：用于液压膨胀的轮廓元件管，使用元件管的液压膨胀装置，使用元件管的液压膨胀法和液压膨胀产品
公开(公告)号：US07827839B2
公开(公告)日：2010-11-09
申请号：US12003389
申请日：2007-12-21
申请人： Atsushi Tomizawa , Masayasu Kojima
发明人： Atsushi Tomizawa , Masayasu Kojima
IPC分类号： B21D39/08
CPC分类号： B21D26/045 , B21D26/033 , B21D26/047 , Y10T29/49805
摘要： According to a bulging device and a bulging method using a profile element pipe, for example, even when a profile steel pipe having a cross sectional shape varying in the axial direction as in a tapered pipe is hydraulically bulged, a bulging in which an internal pressure loading and an axial pressing are combined with each other can be performed to provide a larger expansion ratio than a conventional case and a joining and socket connection thereof to the other part can also be easily performed.
摘要翻译：根据使用型材元件管的凸起装置和凸起方法，例如即使在具有如锥形管中的轴向上的横截面形状变化的型材钢管是液压地隆起的情况下，也可以是膨胀，可以进行加载和轴向挤压相结合以提供比常规壳体更大的膨胀比，并且也可以容易地进行与另一部分的接合和插座连接。

6. 发明授权

US6009913A Lubricant surface-treated steel pipe for hydroforming use 失效
标题翻译：用于液压成型的润滑剂表面处理钢管
公开(公告)号：US6009913A
公开(公告)日：2000-01-04
申请号：US964915
申请日：1997-11-05
申请人： Masayasu Kojima , Kenji Ikisima , Ken Tomiyasu
发明人： Masayasu Kojima , Kenji Ikisima , Ken Tomiyasu
IPC分类号： B05D7/14 , C10M107/28 , C10M107/32 , C10M107/44 , C10M111/04 , C10M177/00 , F16L57/06 , F16L58/10 , F16L9/147
CPC分类号： F16L58/1072 , B05D7/146 , C10M107/28 , C10M107/32 , C10M107/44 , C10M111/04 , C10M177/00 , F16L57/06 , F16L58/1054 , C10M2205/022 , C10M2205/14 , C10M2207/125 , C10M2207/126 , C10M2207/129 , C10M2209/00 , C10M2209/02 , C10M2209/08 , C10M2209/084 , C10M2209/0845 , C10M2209/0863 , C10M2209/10 , C10M2209/101 , C10M2209/1013 , C10M2209/1023 , C10M2211/06 , C10M2213/02 , C10M2213/062 , C10M2217/0403 , C10M2217/0415 , C10M2217/0425 , C10M2217/0435 , C10M2217/044 , C10M2217/0443 , C10M2217/045 , C10M2217/0453 , C10M2217/0465 , C10N2210/00 , C10N2210/01 , C10N2210/02 , C10N2240/401 , C10N2250/121
摘要： A lubricant surface-treated steel pipe for hydroforming use in which at least its outer surface is coated with a lubricating organic resin to a thickness of 0.5 .mu.m to 100 .mu.m. The surface-treated steel pipe provides excellent prevention of galling and excellent lubrication in hydroforming. Also, hydroforming can be started immediately after the surface-treated steel pipe is cut into short pieces.
摘要翻译：一种用于液压成形用途的润滑剂表面处理钢管，其中至少其外表面涂覆有润滑有机树脂至0.5μm至100μm的厚度。表面处理钢管在液压成形中提供优异的防磨损和优异的润滑。此外，在将表面处理钢管切割成短片之后，可以立即开始液压成型。

7. 发明授权

US5973134A Rat CNP complementary DNA and precursor protein 失效
标题翻译：大鼠CNP互补DNA和前体蛋白
公开(公告)号：US5973134A
公开(公告)日：1999-10-26
申请号：US757606
申请日：1991-09-11
申请人： Hisayuki Matsuo , Masayasu Kojima , Kenji Kangawa , Naoto Minamito
发明人： Hisayuki Matsuo , Masayasu Kojima , Kenji Kangawa , Naoto Minamito
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61P7/10 , A61P9/12 , C07H21/04 , C07K14/00 , C07K14/575 , C07K14/58 , C12N15/12 , C12P21/02 , C07H17/00
CPC分类号： C07K14/58 , A61K38/00
摘要： A cDNA coding for a rat derived CNP (rCNP: C-type natriuretic pepteide), and a rat derived CNP precursor protein and derivatives thereof are disclosed.The rat derived CNP precursor is represented by the following amino acid sequence.Met His Leu Ser Gln Leu Ile Ala Cys Ala Leu Leu Leu Ala Leu Leu Ser Leu Arg Pro Ser Glu Ala Lys Pro Gly Thr Pro Pro Lys Val Pro Arg Thr Pro Pro Gly Glu Glu Leu Ala Glu Pro Gln Ala Ala Gly Gly Asn Gln Lys Lys Gly Asp Lys Thr Pro Gly Gly Gly Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg Leu Leu Arg Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu His Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Gly Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly CysThe rCNP precursor and its derivatives are novel and have natriuretic and hypotensive activities.
摘要翻译：公开了编码大鼠衍生的CNP（rCNP：C型利尿钠蛋白酶）的cDNA和大鼠衍生的CNP前体蛋白及其衍生物。大鼠衍生的CNP前体由以下氨基酸序列表示。 Met His Leu Ser Gln Leu Ile Ala Cys Ala Leu Leu Leu Ala Leu Leu Ser Leu Arg Pro Ser Glu Ala Lys Pro Gly Thr Pro Pro Lys Val Pro Arg Thr Pro Pro Gly Glu Glu Leu Ala Glu Pro Gln Ala Ala Gly Gly Asn Gln Lys Lys Gly Asp Lys Thr Pro Gly Gly Gly Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg Leu Leu Arg Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu His Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Gly Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys rCNP前体及其衍生物是新颖的，具有钠尿和降血压活性。

8. 发明申请

US20130172251A1 MODIFIED GHRELIN PEPTIDES 审中-公开
标题翻译：改性GHRELIN肽
公开(公告)号：US20130172251A1
公开(公告)日：2013-07-04
申请号：US13494673
申请日：2012-06-12
申请人： Kenji KANGAWA , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
发明人： Kenji KANGAWA , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
IPC分类号： C07K14/575
CPC分类号： C07K14/575 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K48/00 , C07K14/461 , C07K14/463 , C07K14/465 , C07K14/47 , C07K14/4702
摘要： The present invention provides a novel peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了诱导生长激素分泌的新型肽型化合物，其具有增加细胞内钙离子浓度的活性，其中至少一个氨基酸被修饰的氨基酸和/或非氨基酸替代化合物或其药学上可接受的盐。

9. 发明申请

US20080178650A1 Profile element pipe for hydraulic bulging, hydraulic bulging device using the element pipe, hydraulic bulging method using the element pipe, and hydraulically bulged product 有权
标题翻译：用于液压膨胀的轮廓元件管，使用元件管的液压膨胀装置，使用元件管的液压膨胀法和液压膨胀产品
公开(公告)号：US20080178650A1
公开(公告)日：2008-07-31
申请号：US12003389
申请日：2007-12-21
申请人： Atsushi Tomizawa , Masayasu Kojima
发明人： Atsushi Tomizawa , Masayasu Kojima
IPC分类号： B21D26/02
CPC分类号： B21D26/045 , B21D26/033 , B21D26/047 , Y10T29/49805
摘要： According to a bulging device and a bulging method using a profile element pipe, for example, even when a profile steel pipe having a cross sectional shape varying in the axial direction as in a tapered pipe is hydraulically bulged, a bulging in which an internal pressure loading and an axial pressing are combined with each other can be performed to provide a larger expansion ratio than a conventional case and a joining and socket connection thereof to the other part can also be easily performed.
摘要翻译：根据使用型材元件管的凸起装置和凸起方法，例如即使在具有如锥形管中的轴向上的横截面形状变化的型材钢管是液压地隆起的情况下，也可以是膨胀，可以进行加载和轴向挤压相结合以提供比常规壳体更大的膨胀比，并且也可以容易地进行与另一部分的接合和插座连接。

10. 发明授权

US06722009B2 Metallic sheet hydroforming method, forming die, and formed part 有权
标题翻译：金属板液压成型法，成型模具及成型件
公开(公告)号：US06722009B2
公开(公告)日：2004-04-20
申请号：US10141074
申请日：2002-05-09
申请人： Masayasu Kojima , Mitsutoshi Uchida
发明人： Masayasu Kojima , Mitsutoshi Uchida
IPC分类号： B23P1700
CPC分类号： B21D26/021 , B21D26/023 , B21D26/059 , Y10T29/49375 , Y10T29/49805 , Y10T29/49893 , Y10T29/49941
摘要： A sheet hydroforming method is disclosed wherein two stacked metallic sheets are clamped between a pair of upper and lower dies 10, 11 and a fluid is introduced and pressurized between mating surfaces of the metallic sheets, causing the metallic sheets to bulge into a space defined by die cavities 10b and 11b. A thru-hole 11d for introducing the fluid is formed in one of the dies so as to lead to a holding surface of the die, while a pierced hole for introducing the fluid is formed in one of the metallic sheets in a portion of the one metallic sheet which portion is in contact with a holding surface 10a (10b) of one of the dies, the pierced hole being positioned with the thru-hole 11d, then the fluid is introduced in a pressurized state between mating surfaces of the metallic sheets from the thru-hole through the pierced hole, thereby causing the metallic sheets to bulge. According to this method, a pressurized fluid can be introduced between the mating surfaces of blanks easily without leakage of the fluid. Not only the efficiency of the sheet hydroforming method but also the dent resistance of a formed part can be improved.
摘要翻译：公开了一种片材液压成形方法，其中两个堆叠的金属板被夹在一对上模具和下模具10,11之间，并且在金属板材的配合表面之间引入和加压流体，导致金属板件膨胀到由模腔10b和11b。在一个模具中形成用于引入流体的通孔11d，以导致模具的保持表面，同时在一个金属片中的一个中形成用于引入流体的穿孔，金属片与其中一个模具的保持表面10a（10b）接触，穿孔与通孔11d定位，然后将流体以金属片的配合表面之间的加压状态引入通孔穿过穿孔，从而使金属片膨胀。根据该方法，加压流体可以容易地在坯料的配合表面之间引入，而不会泄漏流体。不仅可以提高片材液压成形方法的效率，而且可以提高成形部件的耐凹陷性。

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