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1. 发明授权

US5789590A Double cone-like crystal form of 2-amino-6-chloropurine and preparation 失效
标题翻译：双锥形晶体形式的2-氨基-6-氯嘌呤及其制备方法
公开(公告)号：US5789590A
公开(公告)日：1998-08-04
申请号：US741223
申请日：1996-10-29
申请人： Masatoshi Sakai , Masaki Fujiwara , Toshio Nakamatsu
发明人： Masatoshi Sakai , Masaki Fujiwara , Toshio Nakamatsu
IPC分类号： C07D473/40
CPC分类号： C07D473/40
摘要： The present invention is directed to a method for preparing 2-amino-6-chloropurine having a double cone-like crystal form, comprising the steps of: (A) suspending 2-amino-6-chloropurine having an acicular or irregular-shaped crystal form in a liquid consisting essentially of water having a pH of from 3 to 10; and (B) heating the resulting suspension at a temperature of from 70.degree. to 100.degree. C. to complete the double cone-like crystal form conversion.
摘要翻译：本发明涉及一种制备具有双锥状晶体形式的2-氨基-6-氯嘌呤的方法，包括以下步骤：（A）悬浮具有针状或不规则形状晶体的2-氨基-6-氯嘌呤在基本上由pH为3至10的水组成的液体中形成; 和（B）在70℃至100℃的温度下加热得到的悬浮液以完成双锥状晶体形式的转化。

2. 发明授权

US06187921B1 2-amino-6-chloropurine and method for preparing the same 失效
标题翻译： 2-氨基-6-氯嘌呤及其制备方法
公开(公告)号：US06187921B1
公开(公告)日：2001-02-13
申请号：US09104192
申请日：1998-06-25
申请人： Masatoshi Sakai , Masaki Fujiwara , Toshio Nakamatsu
发明人： Masatoshi Sakai , Masaki Fujiwara , Toshio Nakamatsu
IPC分类号： C07D47340
CPC分类号： C07D473/40
摘要： 2-Amino-6-chloropurine having a double cone-like crystal form.
摘要翻译：具有双锥状晶体形式的2-氨基-6-氯嘌呤

3. 发明授权

US09223209B2 Sulfonamide-containing photoresist compositions and methods of use 有权
标题翻译：含磺酰胺的光致抗蚀剂组合物和使用方法
公开(公告)号：US09223209B2
公开(公告)日：2015-12-29
申请号：US12709346
申请日：2010-02-19
申请人： Daniel Paul Sanders , Masaki Fujiwara , Yoshiharu Terui
发明人： Daniel Paul Sanders , Masaki Fujiwara , Yoshiharu Terui
IPC分类号： G03F7/039 , G03F7/20 , G03F7/004 , G03F7/11 , G03F7/32
CPC分类号： G03F7/0046 , G03F7/0392 , G03F7/0397 , G03F7/11 , G03F7/2041 , G03F7/322 , G03F7/325
摘要： Provided are sulfonamide-containing photoresist compositions for use in lithographic processes that have improved properties for high resolution, low blur imaging. Also provided are alcohol-soluble photoresists for resist-on-resist applications. The sulfonamide-containing photoresist compositions of the present invention include positive-tone photoresist compositions that have sulfonamide-substituted repeat units with branched linking group as shown in Formula (I):
摘要翻译：提供了用于光刻工艺的含磺酰胺的光致抗蚀剂组合物，其具有用于高分辨率，低模糊成像的改进的性质。还提供了用于抗蚀剂抗蚀剂应用的醇溶性光致抗蚀剂。本发明的含磺酰胺的光致抗蚀剂组合物包括具有如式（I）所示的具有支链连接基团的磺酰胺取代的重复单元的正色调光致抗蚀剂组合物：

4. 发明授权

US08940138B2 Biosensor system, sensor chip, and method of measuring analyte concentration in blood sample 有权
标题翻译：生物传感器系统，传感器芯片和测量血液样品中分析物浓度的方法
公开(公告)号：US08940138B2
公开(公告)日：2015-01-27
申请号：US12935803
申请日：2009-04-02
申请人： Masaki Fujiwara
发明人： Masaki Fujiwara
IPC分类号： C12Q1/00 , C12Q1/26 , C12M1/34 , G01N27/327 , A61B5/15 , A61B5/145
CPC分类号： G01N27/3273 , C12Q1/26 , G01N27/3274
摘要： The present biosensor system prevents a measurement error caused by the temperature of the environment in use. A biosensor system 100 includes a measuring instrument 101 having an operation part 306, and a sensor chip 200 insertable into and removable from the measuring instrument 101 and which accepts a blood sample. The sensor chip 200 includes a measurement part 41 that acquires Data a related to the concentration of an analyte in a blood sample based on the amount of electric current that flows in the sample due to a reaction in which an oxidoreductase with the analyte used as a substrate is involved, and a measurement part 42 that acquires, from the sample, Data b for temperature correction of Data a. The operation part 306 determines the concentration of the analyte in the sample, corrected according to the temperature of the sample based on Data a and Data b.
摘要翻译：本生物传感器系统防止由使用环境的温度引起的测量误差。生物传感器系统100包括具有操作部306的测量仪器101和可插入测量仪器101并可从测量仪器101移除并且接受血液样本的传感器芯片200。传感器芯片200包括测量部分41，该测量部分41基于由于其中使用分析物的氧化还原酶的反应而在样品中流动的电流量来获取与血液样品中的分析物的浓度相关的Data a 涉及基板;以及测量部42，其从该样本获取用于Data a的温度校正的Data b。操作部306根据数据a和数据b，根据样本的温度来确定样品中分析物的浓度。

5. 发明授权

US08859292B2 Method for measuring temperature of biological sample, method for measuring concentration of biological sample, sensor chip and biosensor system 有权
标题翻译：生物样品温度测定方法，生物样品浓度测定方法，传感器芯片和生物传感器系统
公开(公告)号：US08859292B2
公开(公告)日：2014-10-14
申请号：US13144790
申请日：2010-01-28
申请人： Masaki Fujiwara
发明人： Masaki Fujiwara
IPC分类号： G01N27/416 , C12Q1/54 , G01N27/327
CPC分类号： G01N27/3274 , B01L3/502 , B01L2200/147 , B01L2300/0645 , B01L2400/0406 , C12Q1/004 , C12Q1/006 , C12Q1/54 , G01K7/00 , G01N27/26 , G01N27/28 , G01N27/327 , G01N27/3272 , G01N27/3273 , G01N27/416 , Y10T436/144444
摘要： A sensor chip is configured to measure the temperature of a blood sample and includes a capillary section and an electrode unit. The capillary section allows the blood sample to be introduced therein. The electrode unit is configured to measure the temperature of the blood sample and includes a working electrode and a counter electrode. The working electrode and the counter electrode respectively include a reaction reagent layer containing an electrolyte. Further, the electrode unit is configured to receive a predetermined voltage to be applied in measuring the temperature of the blood sample for allowing a result of the measurement to be less affected by increase and reduction in a glucose concentration and the like.
摘要翻译：传感器芯片被配置为测量血液样本的温度，并且包括毛细管部分和电极单元。毛细管部分允许将血液样品引入其中。电极单元被配置为测量血液样本的温度，并且包括工作电极和对电极。工作电极和对电极分别包含含有电解质的反应试剂层。此外，电极单元被配置为在测量血液样本的温度时接受预定的电压，以允许测量结果受葡萄糖浓度的增加和降低等的影响较小。

6. 发明授权

US08480869B2 Method of measuring hematocrit (Hct), sensor used in the method, and measuring device 有权
标题翻译：测量血细胞比容（Hct），方法中使用的传感器和测量装置的方法
公开(公告)号：US08480869B2
公开(公告)日：2013-07-09
申请号：US13279787
申请日：2011-10-24
申请人： Masaki Fujiwara , Teppei Shinno , Shin Ikeda
发明人： Masaki Fujiwara , Teppei Shinno , Shin Ikeda
IPC分类号： G01N27/327
CPC分类号： G01N27/3274
摘要： The present invention provides a method of electrochemically measuring a hematocrit (Hct) value using a sensor, capable of achieving excellent measurement accuracy and reliability and also provides a sensor used in the method. The method of electrochemically measuring a hematocrit (Hct) value of blood include: providing an electrode system having a working electrode (11) and a counter electrode (12), in which a redox substance is provided on the counter electrode (12) but not on the working electrode (11); supplying blood to the electrode system; applying a voltage to the electrode system in this state to cause an oxidation current or a reduction current to flow between the working electrode (11) and the counter electrode (12); detecting the oxidation current or the reduction current; and determining a Hct value based on a value of the detected current.
摘要翻译：本发明提供一种使用传感器电化学测量血细胞比容（Hct）值的方法，其能够实现优异的测量精度和可靠性，并且还提供了该方法中使用的传感器。电化学测量血液血细胞比容（Hct）值的方法包括：提供具有工作电极（11）和对电极（12）的电极系统，其中在对电极（12）上设置氧化还原物质在工作电极（11）上; 向电极系统供应血液; 在该状态下向电极系统施加电压，使得氧化电流或还原电流在工作电极（11）和对电极（12）之间流动。检测氧化电流或还原电流; 以及基于检测到的电流的值确定Hct值。

7. 发明授权

US08444576B2 Blood test apparatus having blood sensor 有权
标题翻译：具有血液传感器的血液检查装置
公开(公告)号：US08444576B2
公开(公告)日：2013-05-21
申请号：US13237157
申请日：2011-09-20
申请人： Masaki Fujiwara , Yoshinori Amano
发明人： Masaki Fujiwara , Yoshinori Amano
IPC分类号： A61B5/00 , A61B5/151 , A61B5/157
CPC分类号： A61B5/157 , A61B5/14532 , A61B5/14535 , A61B5/1486 , A61B5/150022 , A61B5/150099 , A61B5/15019 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150519 , A61B5/15087 , A61B5/15117 , A61B5/1513 , A61B5/1519 , A61B2562/0295
摘要： A blood test apparatus has a housing, a blood sensor, and a plurality of connectors. The blood sensor has a plurality of connection terminals that are electrically connected with each electrode of the electrode system; and a reference terminal that serves as a reference. The plurality of connectors are configured to connect to the plurality of connection terminals and the reference terminal of the blood sensor attached at a predetermined position in the blood test apparatus, respectively. And also, relations between the reference terminal and each of the plurality of connection terminals are measured to identify the reference terminal automatically.
摘要翻译：血液检查装置具有壳体，血液传感器和多个连接器。血液传感器具有与电极系统的每个电极电连接的多个连接端子; 以及作为参考的参考端子。多个连接器被配置为分别连接到血液检查装置中的预定位置处的多个连接端子和血液传感器的参考端子。并且，还测量参考终端与多个连接终端中的每一个之间的关系以自动识别参考终端。

8. 发明授权

US08207351B2 Cyclic carbonyl compounds with pendant carbonate groups, preparations thereof, and polymers therefrom 失效
标题翻译：具有侧碳酸酯基团的环状羰基化合物，其制备物及其聚合物
公开(公告)号：US08207351B2
公开(公告)日：2012-06-26
申请号：US12770877
申请日：2010-04-30
申请人： Masaki Fujiwara , James Lupton Hedrick , Daniel Paul Sanders , Manabu Yasumoto
发明人： Masaki Fujiwara , James Lupton Hedrick , Daniel Paul Sanders , Manabu Yasumoto
IPC分类号： C07D263/00
CPC分类号： C07D319/04 , C07D317/36 , C08G64/0233 , C08G64/30 , Y02P20/582
摘要： A one pot method of preparing cyclic carbonyl compounds comprising an active pendant pentafluorophenyl carbonate group is disclosed. The cyclic carbonyl compounds can be polymerized by ring opening methods to form ROP polymers comprising repeat units comprising a side chain pentafluorophenyl carbonate group. Using a suitable nucleophile, the pendant pentafluorophenyl carbonate group can be selectively transformed into a variety of other functional groups before or after the ring opening polymerization.
摘要翻译：公开了一种制备包含活性五氟苯基碳酸酯基团的环状羰基化合物的一锅法。环状羰基化合物可以通过开环方法聚合以形成包含包含侧链五氟苯基碳酸酯基团的重复单元的ROP聚合物。使用合适的亲核试剂，可以在开环聚合之前或之后将五氟苯基碳酸五酯基团选择性地转化成多种其它官能团。

9. 发明授权

US08206318B2 Blood test apparatus 有权
标题翻译：血液检测仪
公开(公告)号：US08206318B2
公开(公告)日：2012-06-26
申请号：US12293626
申请日：2007-03-22
申请人： Motonori Uchiyama , Masaki Fujiwara , Toshihiro Akiyama , Yoshinori Amano
发明人： Motonori Uchiyama , Masaki Fujiwara , Toshihiro Akiyama , Yoshinori Amano
IPC分类号： A61B5/00
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150099 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150519 , A61B5/150954 , A61B5/15113 , A61B5/15117 , A61B5/15134 , A61B5/15138 , A61B5/1519
摘要： It is intended to provide a means of easily removing a portion of blood bleeding from pierced skin, which has not been taken into a blood sensor but remained on the skin, in a blood test with the use of a blood test apparatus. By using this means, it becomes unnecessary in the blood test to separately prepare a paper sheet, etc. for wiping off. More specifically speaking, a blood test apparatus wherein a blood sensor is provided within a blood sensor unit detachable to the blood test apparatus body and the blood sensor unit has a part to be in contact with the skin in the test and an absorption means. It is favorable that the part to be in contact with the skin in the test serves as the absorption means.
摘要翻译：本发明旨在提供一种在使用血液检查装置的血液检查中，能够容易地除去未被吸入血液传感器而残留在皮肤上的被刺穿的皮肤的一部分血液渗出的手段。通过使用这种方式，在血液检查中不需要分别制作用于擦除的纸张等。更具体地说，一种血液检查装置，其中血液传感器设置在可与血液检查装置主体分离的血液传感器单元内，并且血液传感器单元具有在测试中与皮肤接触的部分和吸收装置。在试验中与皮肤接触的部分作为吸收手段是有利的。

10. 发明申请

US20120037506A1 METHOD OF MEASURING HEMATOCRIT (Hct), SENSOR USED IN THE METHOD, AND MEASURING DEVICE 有权
标题翻译：测量HEMATOCRIT（Hct）的方法，方法中使用的传感器和测量装置
公开(公告)号：US20120037506A1
公开(公告)日：2012-02-16
申请号：US13279787
申请日：2011-10-24
申请人： Masaki Fujiwara , Teppei Shinno , Shin Ikeda
发明人： Masaki Fujiwara , Teppei Shinno , Shin Ikeda
IPC分类号： G01N27/327 , G01N33/50
CPC分类号： G01N27/3274
摘要： The present invention provides a method of electrochemically measuring a hematocrit (Hct) value using a sensor, capable of achieving excellent measurement accuracy and reliability and also provides a sensor used in the method. The method of electrochemically measuring a hematocrit (Hct) value of blood include: providing an electrode system having a working electrode (11) and a counter electrode (12), in which a redox substance is provided on the counter electrode (12) but not on the working electrode (11); supplying blood to the electrode system; applying a voltage to the electrode system in this state to cause an oxidation current or a reduction current to flow between the working electrode (11) and the counter electrode (12); detecting the oxidation current or the reduction current; and determining a Hct value based on a value of the detected current.
摘要翻译：本发明提供一种使用传感器电化学测量血细胞比容（Hct）值的方法，其能够实现优异的测量精度和可靠性，并且还提供了该方法中使用的传感器。电化学测量血液血细胞比容（Hct）值的方法包括：提供具有工作电极（11）和对电极（12）的电极系统，其中在对电极（12）上设置氧化还原物质在工作电极（11）上; 向电极系统供应血液; 在该状态下向电极系统施加电压，使得氧化电流或还原电流在工作电极（11）和对电极（12）之间流动。检测氧化电流或还原电流; 以及基于检测到的电流的值确定Hct值。

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