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    • 9. 发明授权
    • N(2-Pyrrolidinylmethyl)meta-sulfonamido-benzamides
    • N(2-吡咯烷基甲基)间 - 磺酰氨基 - 苯甲酰胺
    • US4350635A
    • 1982-09-21
    • US124726
    • 1980-02-26
    • Masaru OgataHiroshi Matsumoto
    • Masaru OgataHiroshi Matsumoto
    • C07D207/09C07D207/14C07D307/14A61K31/40
    • C07D207/14C07D207/09C07D307/14Y10S514/872Y10S514/96
    • Meta-sulfonamido-benzamide derivatives of the formula: ##STR1## wherein R is a hydrogen atom or a lower alkyl, cyano, or lower alkanesulfonyl group;R.sup.1 is a lower alkyl, phenyl, amino, lower alkylamino, di(lower)alkylamino, or C.sub.4 -C.sub.5 alkyleneamino group;R.sup.2 is a hydrogen or halogen atom or a lower alkyl, di(lower)alkylamino, or lower alkoxy group;R.sup.3 is a hydrogen atom or a methyl or methoxy group;R.sup.4 is a hydrogen or halogen atom;R.sup.5 is a lower alkyl, lower alkenyl, C.sub.3 -C.sub.6 cycloalkyl, benzyl, or halogenobenzyl group; andn is 1 or zeroor their acid addition salts, showing pharmacological activity such as anti-emetic or psychotropic activity, are provided via several routes.
    • 亚磺酰氨基 - 苯甲酰胺衍生物,其分子式如下:其中R是氢原子或低级烷基,氰基或低级链烷磺酰基; R 1是低级烷基,苯基,氨基,低级烷基氨基,二(低级)烷基氨基或C 4 -C 5亚烷基氨基; R2是氢或卤素原子或低级烷基,二(低级)烷基氨基或低级烷氧基; R3是氢原子或甲基或甲氧基; R4是氢或卤素原子; R5是低级烷基,低级烯基,C3-C6环烷基,苄基或卤代苄基; 并且n是1或0,或者它们的酸加成盐,显示药理活性,如抗呕吐或精神活性,通过几种途径提供。
    • 10. 发明授权
    • Meta-sulfonamido-benzamide derivatives
    • 亚磺酰氨基 - 苯甲酰胺衍生物
    • US4330472A
    • 1982-05-18
    • US162793
    • 1980-06-25
    • Masaru OgataHiroshi Matsumoto
    • Masaru OgataHiroshi Matsumoto
    • C07D207/09C07D207/14C07D307/14C07D207/08
    • C07D207/14C07D207/09C07D307/14Y10S514/872Y10S514/96
    • Meta-sulfonamido-benzamide derivatives of the formula: ##STR1## [wherein R is a hydrogen atom or a lower alkyl, cyano, or lower alkanesulfonyl group;R.sup.1 is a lower alkyl, phenyl, amino, lower alkylamino, di(lower)alkylamino, or C.sub.4 -C.sub.5 alkyleneamino group;R.sup.2 is a hydrogen or halogen atom or a lower alkyl, di(lower)alkylamino, or lower alkoxy group;R.sup.3 is a hydrogen atom or a methyl or methoxy group;R.sup.4 is a hydrogen or halogen atom;R.sup.5 is a lower alkyl, lower alkenyl, C.sub.3 -C.sub.6 cycloalkyl, benzyl, or halogenobenzyl group; and n is 1 or zero]or their acid addition salts, showing pharmacological activity such as anti-emetic or psychotropic activity, are provided via several routes.
    • 下式的亚磺酰氨基 - 苯甲酰胺衍生物:其中R是氢原子或低级烷基,氰基或低级链烷磺酰基; R 1是低级烷基,苯基,氨基,低级烷基氨基,二(低级)烷基氨基或C 4 -C 5亚烷基氨基; R2是氢或卤素原子或低级烷基,二(低级)烷基氨基或低级烷氧基; R3是氢原子或甲基或甲氧基; R4是氢或卤素原子; R5是低级烷基,低级烯基,C3-C6环烷基,苄基或卤代苄基; 并且n为1或0]或其酸性加成盐,显示出药理活性,如抗呕吐或精神活性,通过多种途径提供。