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1. 发明申请

US20050025813A1 Keratin layer improving laminated sheet 审中-公开
标题翻译：角质层改善层压板
公开(公告)号：US20050025813A1
公开(公告)日：2005-02-03
申请号：US10903834
申请日：2004-07-30
申请人： Masaru Hoshi , Yasunari Takanashi , Kaname Nakahara , Norikazu Sato , Kyoko Hashino , Kanae Morishita
发明人： Masaru Hoshi , Yasunari Takanashi , Kaname Nakahara , Norikazu Sato , Kyoko Hashino , Kanae Morishita
IPC分类号： A61F13/02 , A61K8/02 , A61K8/03 , A61K8/30 , A61K8/34 , A61K8/40 , A61K8/42 , A61K8/72 , A61K9/70 , A61Q19/00
CPC分类号： A61Q19/00 , A61K8/0208 , A61K8/345 , A61K8/42 , A61Q19/007
摘要： Disclosed is a keratin layer improving laminated sheet comprising a fixing adhesive sheet having an adhesive layer on an adhesive sheet substrate and a moisture retaining pad having a moisturizing agent-containing polymer layer on a pad substrate, said moisture retaining pad being fixed to the fixing adhesive sheet in such a manner that the pad substrate of the moisture retaining pad is in contact with the adhesive layer of the fixing adhesive sheet, wherein in 100% by weight of the moisturizing agent-containing polymer layer, glycerol as a moisturizing agent is contained in an amount of 25 to 55% by weight and moisturizing agents including glycerol are contained in a total amount of 30 to 60% by weight.
摘要翻译：公开了一种角质层改进层压片，其包括在粘合片基材上具有粘合剂层的固定粘合片和在衬垫基底上具有含保湿剂的聚合物层的保湿垫，所述保湿垫固定到固定粘合剂片状物，使得保湿垫的衬垫基片与固定粘合片的粘合剂层接触，其中在100重量％的含保湿剂聚合物层中含有作为保湿剂的甘油含量为25〜55重量％，含有甘油的保湿剂的含量为30〜60重量％。

2. 发明授权

US08168851B2 Adhesive skin patch sheet 有权
标题翻译：胶粘皮肤贴片
公开(公告)号：US08168851B2
公开(公告)日：2012-05-01
申请号：US12289923
申请日：2008-11-06
申请人： Kaname Nakahara , Atsuko Kameshima
发明人： Kaname Nakahara , Atsuko Kameshima
IPC分类号： A61F13/00
CPC分类号： A61F13/023
摘要： An adhesive skin patch sheet comprises a support, a pressure-sensitive adhesive layer and a release sheet laminated in that order, the release sheet is divided by a cut line into a small first release sheet and a large second release sheet, the cut line is formed so as to be convex only from the second release sheet toward the first release sheet.
摘要翻译：粘合性皮肤贴片包括依次层叠的支持体，粘合剂层和剥离片，剥离片由切割线分割成小的第一剥离片和大的第二剥离片，切断线为形成为仅从第二剥离片向第一剥离片凸起。

3. 发明授权

US06733785B1 Moisture-sensitive preparation of percutaneous absorption type 失效
标题翻译：经皮吸收型水分敏感性制剂
公开(公告)号：US06733785B1
公开(公告)日：2004-05-11
申请号：US09762615
申请日：2001-02-08
申请人： Kaname Nakahara , Toshinobu Seki
发明人： Kaname Nakahara , Toshinobu Seki
IPC分类号： A61K914
CPC分类号： A61K9/7084 , A61K31/137 , A61K31/455 , A61K31/506
摘要： The invention relates to a percutaneous absorption preparation which comprises a supporting body, a medicine storage layer, a permeation controlling film, a layer of an adhesive and a release liner and which is featured in that the above-mentioned permeation controlling film is plasticized by moisture volatilized from the skin at the time of application of the preparation.
摘要翻译：本发明涉及一种经皮吸收制剂，其包括支撑体，药物储存层，渗透控制膜，粘合剂层和剥离衬垫，其特征在于，上述渗透控制膜通过水分增塑在制剂应用时皮肤挥发。

4. 发明授权

US08071126B2 Percutaneous absorption type patch 有权
标题翻译：经皮吸收型贴片
公开(公告)号：US08071126B2
公开(公告)日：2011-12-06
申请号：US12666435
申请日：2008-03-19
申请人： Toru Sekiguchi , Kaname Nakahara , Toru Watanabe
发明人： Toru Sekiguchi , Kaname Nakahara , Toru Watanabe
IPC分类号： A61F13/00 , A61F13/02 , A61F15/00 , B23B9/00
CPC分类号： A61K9/703 , A61F2013/00646 , A61K9/7038 , A61K9/7084 , A61L15/44 , A61L15/58 , A61L2300/256 , A61L2300/406 , A61L2300/41 , A61L2300/428 , A61L2300/608 , A61M35/006 , Y10T428/1495
摘要： A percutaneous absorption type patch adapted to be applied to a skin surface of a patient. The percutaneous absorption type patch comprises: a stratum-corneum release member constituted from a sheet-like first supporting substrate and a pressure-sensitive adhesive layer laminated on the first supporting member; a medicinal-components administration member constituted from a sheet-like second supporting substrate, a medicinal-components retention layer laminated on the second supporting substrate, and a protect layer laminated on the medicinal-components retention layer; and a sheet-like handling member interposed between the stratum-corneum release member and the medicinal-components administration member. An edge portion of the handling member is coupled to or integrated with both the first supporting substrate and the protect layer. Operations of peeling the stratum-corneum release member from the skin surface of the patient and peeling the protect layer from the medicinal-components retention layer are carried out at a time by pulling the handling member toward an operating direction.
摘要翻译：适合施用于患者皮肤表面的经皮吸收型贴剂。经皮吸收型贴片包括：由片状第一支撑基板和层叠在第一支撑部件上的压敏粘合剂层构成的角质层释放部件; 由片状第二支撑基板，层叠在第二支撑基板上的药物保持层和层叠在药剂保持层上的保护层构成的药物成分给药部件，以及插入在角质层释放构件和药物成分给药构件之间的片状处理构件。处理构件的边缘部分与第一支撑衬底和保护层两者耦合或一体化。通过沿着操作方向拉动处理构件，一次执行从患者皮肤表面剥离角质层释放构件并从保护层剥离保护层的操作。

5. 发明申请

US20110251561A1 TRANSDERMAL ADMINISTRATION DEVICE 审中-公开
标题翻译：超导管理设备
公开(公告)号：US20110251561A1
公开(公告)日：2011-10-13
申请号：US13055378
申请日：2009-07-27
申请人： Akinori Inou , Masahiro Takigawa , Toru Sekiguchi , Kaname Nakahara , Toru Watanabe
发明人： Akinori Inou , Masahiro Takigawa , Toru Sekiguchi , Kaname Nakahara , Toru Watanabe
IPC分类号： A61M5/00 , A61M5/32
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/0046
摘要： The transdermal administration device of the present invention includes: a device body including a needle form body, which includes a plurality of microneedles formed on a surface thereof and is provided with a fluid passage hole through the front surface to a back surface thereof, and a medical fluid filling section for providing a medical fluid to the back surface of the needle form body; a stratum corneum peeling system; and a connection section for connecting the device body and the stratum corneum peeling system, where the stratum corneum peeling system is connected to the device body by the connection section such that the microneedles of the needle form body of the device body are positioned in an area of a skin surface in which a stratum corneum is peeled by the stratum corneum peeling system.
摘要翻译：本发明的透皮给药装置包括：装置主体，其包括针形体，其包括在其表面上形成的多个微针，并且在其前表面的后表面上设置有流体通道孔，药液填充部，用于向针形体的后表面提供医用流体; 角质层剥离系统; 以及用于连接装置主体和角质层剥离系统的连接部分，其中角质层剥离系统通过连接部分连接到装置主体，使得装置主体的针形体的微针位于一个区域的皮肤表面，其中角质层被角质层剥离系统剥离。

6. 发明申请

US20100189751A1 PERCUTANEOUS ABSORPTION TYPE PATCH 有权
标题翻译： PERCUTANEOUS吸收型PATCH
公开(公告)号：US20100189751A1
公开(公告)日：2010-07-29
申请号：US12666435
申请日：2008-03-19
申请人： Toru Sekiguchi , Kaname Nakahara , Toru Watanabe
发明人： Toru Sekiguchi , Kaname Nakahara , Toru Watanabe
IPC分类号： A61K9/70
CPC分类号： A61K9/703 , A61F2013/00646 , A61K9/7038 , A61K9/7084 , A61L15/44 , A61L15/58 , A61L2300/256 , A61L2300/406 , A61L2300/41 , A61L2300/428 , A61L2300/608 , A61M35/006 , Y10T428/1495
摘要： A percutaneous absorption type patch adapted to be applied to a skin surface of a patient. The percutaneous absorption type patch comprises: a stratum-corneum release member constituted from a sheet-like first supporting substrate and a pressure-sensitive adhesive layer laminated on the first supporting member; a medicinal-components administration member constituted from a sheet-like second supporting substrate, a medicinal-components retention layer laminated on the second supporting substrate, and a protect layer laminated on the medicinal-components retention layer; and a sheet-like handling member interposed between the stratum-corneum release member and the medicinal-components administration member. An edge portion of the handling member is coupled to or integrated with both the first supporting substrate and the protect layer. Operations of peeling the stratum-corneum release member from the skin surface of the patient and peeling the protect layer from the medicinal-components retention layer are carried out at a time by pulling the handling member toward an operating direction.
摘要翻译：适合施用于患者皮肤表面的经皮吸收型贴剂。经皮吸收型贴片包括：由片状第一支撑基板和层叠在第一支撑部件上的压敏粘合剂层构成的角质层释放部件; 由片状第二支撑基板，层叠在第二支撑基板上的药物保持层和层叠在药剂保持层上的保护层构成的药物成分给药部件，以及插入在角质层释放构件和药物成分给药构件之间的片状处理构件。处理构件的边缘部分与第一支撑衬底和保护层两者耦合或一体化。通过沿着操作方向拉动处理构件，一次执行从患者皮肤表面剥离角质层释放构件并从保护层剥离保护层的操作。

7. 发明申请

US20090124953A1 Adhesive skin patch sheet 有权
标题翻译：胶粘皮肤贴片
公开(公告)号：US20090124953A1
公开(公告)日：2009-05-14
申请号：US12289923
申请日：2008-11-06
申请人： Kaname Nakahara , Atsuko Kameshima
发明人： Kaname Nakahara , Atsuko Kameshima
IPC分类号： A61F13/02
CPC分类号： A61F13/023
摘要： A adhesive skin patch sheet comprises a support, a pressure-sensitive adhesive layer and a release sheet laminated in that order, the release sheet is divided by a cut line into a small first release sheet and a large second release sheet, the cut line is formed so as to be convex only from the second release sheet toward the first release sheet.
摘要翻译：粘合性皮肤贴片包括依次层叠的支持体，粘合剂层和剥离片，剥离片由切割线分割成小的第一剥离片和大的第二剥离片，切断线为形成为仅从第二剥离片向第一剥离片凸起。

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