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    • 2. 发明授权
    • 4-Benzazonine derivatives and process for preparation thereof
    • 4-苯并氮杂衍生物及其制备方法
    • US4008219A
    • 1977-02-15
    • US467520
    • 1974-05-06
    • Masao IkedaShigeo MiyamotoThutomu NozawaAkira KurobeOsamu Futsukaichi
    • Masao IkedaShigeo MiyamotoThutomu NozawaAkira KurobeOsamu Futsukaichi
    • C07D223/14C07D225/06
    • C07D223/14C07D225/06
    • Novel 4-Benzazonine derivatives and their salts, and processes for the preparation thereof are disclosed. These 4-benzazonine derivatives are represented by the following general formula: ##STR1## wherein R stands for --H, --OH or a lower alkoxy group such as --OCH.sub.3, R.sub.1 designates --H or a lower alkyl group such as --CH.sub.3 and --CH.sub.2 CH.sub.3, R.sub.2 indicates --H or a lower alkyl group such as --CH.sub.3, R.sub.3 stands for --H, a linear or branched, saturated or unsaturated alkyl group having 1 to 4 carbon atoms, a mono- or di-hydroxy lower alkyl group such as --CH.sub.2 OH and ##STR2## a saturated cyclic hydrocarbon group having 3 to 6 carbon atoms or a substituted or unsubstituted aromatic hydrocarbon group having 6 to 8 carbon atoms, and R.sub.4 designates --H, --OH or = O. These compounds have medicinal effects, especially therapeutic activities on the central nervous system, such as analgesic, antitussive and sedative activities.
    • 公开了新的4-苯并氮杂衍生物及其盐,以及其制备方法。 这些4-苯并氮杂衍生物由以下通式表示:其中R代表-H,-OH或低级烷氧基,例如-OCH 3,R 1表示-H或低级烷基如-CH 3和 - CH 2 CH 3,R 2表示-H或低级烷基如-CH 3,R 3表示-H,直链或支链,饱和或不饱和的具有1至4个碳原子的烷基,一或二羟基低级烷基如 作为-CH 2 OH和具有3〜6个碳原子的饱和环状烃基或具有6〜8个碳原子的取代或未取代的芳香族烃基,R4表示-H,-OH或= O.这些化合物具有药效 特别是中枢神经系统的治疗活动,如止痛,镇咳和镇静活动。