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1. 发明授权

US07803638B2 Fluorescent label 有权
标题翻译：荧光标签
公开(公告)号：US07803638B2
公开(公告)日：2010-09-28
申请号：US11379617
申请日：2006-04-21
申请人： Masami Sugiyama
发明人： Masami Sugiyama
IPC分类号： G01N33/533 , G01N33/53 , G01N21/76
CPC分类号： G01N33/582 , Y10S436/80 , Y10T436/17 , Y10T436/18
摘要： The present invention relates to a fluorescent label characterized by containing a hydrophilic polymer having an anionic group, a polyether derivative, and a phosphor, in which the phosphor is bound to the hydrophilic polymer via the polyether derivative, and also relates to a fluorescently labeled recognition substance labeled with the fluorescent label, and an immunoassay method using the recognition substance.
摘要翻译：本发明涉及一种荧光标记，其特征在于含有具有阴离子基团的亲水性聚合物，聚醚衍生物和荧光体，其中荧光体通过聚醚衍生物与亲水性聚合物结合，并且还涉及荧光标记的识别用荧光标记标记的物质和使用识别物质的免疫测定法。

2. 发明申请

US20060240479A1 Fluorescent Label 有权
标题翻译：荧光标签
公开(公告)号：US20060240479A1
公开(公告)日：2006-10-26
申请号：US11379617
申请日：2006-04-21
申请人： Masami Sugiyama
发明人： Masami Sugiyama
IPC分类号： G01N33/53 , C08K5/34
CPC分类号： G01N33/582 , Y10S436/80 , Y10T436/17 , Y10T436/18
摘要： The present invention relates to a fluorescent label characterized by containing a hydrophilic polymer having an anionic group, a polyether derivative, and a phosphor, in which the phosphor is bound to the hydrophilic polymer via the polyether derivative, and also relates to a fluorescently labeled recognition substance labeled with the fluorescent label, and an immunoassay method using the recognition substance.
摘要翻译：本发明涉及一种荧光标记，其特征在于含有具有阴离子基团的亲水性聚合物，聚醚衍生物和荧光体，其中荧光体通过聚醚衍生物与亲水性聚合物结合，并且还涉及荧光标记的识别用荧光标记标记的物质和使用识别物质的免疫测定法。

3. 发明授权

US06251618B1 Color developing method, enzyme immunoassay using the color developing method, and immunochromatography incorporating the enzyme immunoassay 有权
标题翻译：彩色显影法，使用彩色显影法的酶免疫测定法和含有酶免疫测定法的免疫层析法
公开(公告)号：US06251618B1
公开(公告)日：2001-06-26
申请号：US09417220
申请日：1999-10-13
申请人： Masami Sugiyama , Mamoru Miyazaki , Yoshihiro Ashihara
发明人： Masami Sugiyama , Mamoru Miyazaki , Yoshihiro Ashihara
IPC分类号： G01N33543
CPC分类号： G01N33/581 , Y10S435/962
摘要： Disclosed are a color developing method utilizing the reaction of an indolyl derivative with an enzyme in the presence of a specific free radical compound and/or a specific chelate compound, and an enzyme immunoassay using the color developing method.
摘要翻译：公开了利用吲哚基衍生物与酶在特定自由基化合物和/或特定螯合物的存在下的反应的彩色显影方法，以及使用彩色显影法的酶免疫测定法。

4. 发明授权

US5432609A Two-dimensional colorimeter 失效
标题翻译：二维色度计
公开(公告)号：US5432609A
公开(公告)日：1995-07-11
申请号：US177843
申请日：1994-01-05
申请人： Masami Sugiyama , Takao Sakai
发明人： Masami Sugiyama , Takao Sakai
IPC分类号： G01J3/36 , G01J3/51
CPC分类号： G01J3/51 , G01J3/36 , G01J3/524 , G01J3/465 , G01J3/513
摘要： A two-dimensional colorimeter focuses light through a beam splitter onto a rotary filter so that a first light receiving element can receive light from multiple points on a sample. A rotating filter can provide multiple measurements based upon different wavelengths of light. A portion of the light from the beam splitter also contacts a spectral sensor which separates the light from a particular point into primary wavelength elements which are converted into electrical signals. Based upon these primary wavelength elements, the first signals from the light receiving element are corrected. As a result, the measurement of chromaticity of multiple points on a sample can be performed accurately using a device of simple construction.
摘要翻译：二维色度计将光束通过分束器聚焦到旋转滤光器上，使得第一光接收元件可以接收来自样品上多个点的光。旋转滤波器可以基于不同波长的光提供多个测量。来自分束器的光的一部分还接触光谱传感器，光谱传感器将光从特定点分离成主要波长元件，其被转换成电信号。基于这些主波长元件，来自光接收元件的第一信号被校正。结果，可以使用简单结构的装置来精确地进行样品上多个点的色度测量。

5. 发明授权

US4419445A Method for determining the activity of cholinesterases 失效
标题翻译：确定胆碱酯酶活性的方法
公开(公告)号：US4419445A
公开(公告)日：1983-12-06
申请号：US360723
申请日：1982-03-22
申请人： Yasushi Kasahara , Yoshihiro Ashihara , Masami Sugiyama , Takahiro Harada
发明人： Yasushi Kasahara , Yoshihiro Ashihara , Masami Sugiyama , Takahiro Harada
IPC分类号： G01N33/50 , C12Q1/46 , C12Q1/26
CPC分类号： C12Q1/46 , C12Q2334/00
摘要： A method for determining the activity of cholinesterase comprising the steps of:mixing a solution containing p-methoxybenzoate demethylmonooxygenase, nicotinamide adenine dinucleotide reduced form (NADH) and p-methoxybenzoyl choline cation having the following formula: ##STR1## with a liquid containing cholinesterase, measuring the decrease in absorbance of light by NADH, which is based on a consumption of NADH, and calculating the activity of cholinesterase therefrom.
摘要翻译：一种确定胆碱酯酶活性的方法，包括以下步骤：将含有对甲氧基苯甲酸甲酯脱甲基单加氧酶，烟酰胺腺嘌呤二核苷酸还原形式（NADH）和具有下式的对甲氧基苯甲酰胆碱阳离子的溶液与含有胆碱酯酶的液体混合，测量基于NADH消耗的NADH对光的吸光度的降低，并计算其中胆碱酯酶的活性。

6. 发明授权

US4205918A Color balance indicating device 失效
标题翻译：色平衡指示装置
公开(公告)号：US4205918A
公开(公告)日：1980-06-03
申请号：US881177
申请日：1978-02-27
申请人： Tohru Kisanuki , Masami Sugiyama , Takeshi Kosaka
发明人： Tohru Kisanuki , Masami Sugiyama , Takeshi Kosaka
IPC分类号： G01J3/51 , G03B27/72 , G03B27/73 , G01J3/50
CPC分类号： G01J3/51 , G03B27/72
摘要： A hand-carriable, compact color meter for indicating proper amount of adjustment of color compensation filters interposed in the light path of a color printer for the compensation of color balance of the light illuminating a film or the slide set on the printer. The color meter includes an indicating lamp, a photocell to be exposed to the light passing through the film or slide, a plurality of optical color filters selectively disposed in front of the photocell to provide the photocell with spectral sensitivities corresponding to the spectral sensitivity of the printing paper, a plurality of fixed or variable resistors selectable in correspondence to the selection of the color filter, and an electric circuit for actuating the indicating lamp in accordance with the relationship between the output of the light measuring circuit and a reference voltage commensurate with the selected one of the resistors. In a preferred embodiment, the color meter further includes a combination of a variable resistor and a filter for determination of exposure time.
摘要翻译：一种手提式紧凑型色表，用于指示插入彩色打印机光路中的适当量的色彩补偿滤光片的调整，以补偿照亮胶片或设置在打印机上的幻灯片的光的色彩平衡。色度计包括指示灯，要暴露于穿过膜或载玻片的光的光电池，选择性地设置在光电管前面的多个光学滤色器，以向光电池提供与光电池的光谱灵敏度相对应的光谱灵敏度打印纸，对应于滤色器的选择可选择的多个固定或可变电阻器，以及用于根据光测量电路的输出与与该测量电路相当的参考电压之间的关系致动指示灯的电路选择一个电阻。在优选实施例中，色度计还包括可变电阻器和用于确定曝光时间的滤光器的组合。

7. 发明申请

US20090081696A1 LUMINESCENCE ENHANCER AND USE THEREOF 审中-公开
标题翻译：发光增强剂及其用途
公开(公告)号：US20090081696A1
公开(公告)日：2009-03-26
申请号：US12277359
申请日：2008-11-25
申请人： Masami Sugiyama
发明人： Masami Sugiyama
IPC分类号： G01N33/53 , C08F210/02 , C08F112/06 , C08F226/06
CPC分类号： G01N33/582 , C08F212/14 , C08F212/36 , C08F220/06 , C08F226/06 , C09K11/06 , C09K11/07 , C09K2211/1007 , C09K2211/1088 , G01N21/76 , G01N33/52 , G01N33/532 , G01N2333/916
摘要： An object of the present invention is to provide a luminescence enhancer by which a luminescence such as chemiluminescence can be enhanced with higher sensitivity and the luminescence can be continued over a prolonged period of time. That is, the present invention provides a luminescence enhancer containing a heteropolymer as an active ingredient, a method for measuring the luminescence using a luminescent substrate and said luminescence enhancer, and a method for analyzing a substance to be measured in a specimen wherein the specimen, an antigen and/or antibody corresponding to a substance to be measured, an antigen and/or antibody labeled-form with an activator and a luminescent substrate are reacted in the presence of said luminescence enhancer to measure the luminescence.
摘要翻译：本发明的目的是提供一种发光增强剂，通过该发光增强剂可以以更高的灵敏度增强诸如化学发光的发光，并且可以在长时间内持续发光。也就是说，本发明提供含有异源聚合物作为有效成分的发光增强剂，使用发光底物和所述发光增强剂测定发光的方法，以及在试样中分析待测物质的方法，与待测物质相对应的抗原和/或抗体，用激活剂和发光底物标记形式的抗原和/或抗体在所述发光增强剂存在下反应以测量发光。

8. 发明授权

US5998156A Color developing method, enzyme immunoassay using the color developing method, and immunochromatography incorporating the enzyme immunoassay 失效
标题翻译：彩色显影法，使用彩色显影法的酶免疫测定法和含有酶免疫测定法的免疫层析法
公开(公告)号：US5998156A
公开(公告)日：1999-12-07
申请号：US104166
申请日：1998-06-25
申请人： Masami Sugiyama , Mamoru Miyazaki , Yoshihiro Ashihara
发明人： Masami Sugiyama , Mamoru Miyazaki , Yoshihiro Ashihara
IPC分类号： G01N33/58 , G01N33/543 , G01N33/576
CPC分类号： G01N33/581 , Y10S435/962
摘要： Disclosed are a color developing method utilizing the reaction of an indolyl derivative with an enzyme in the presence of a specific free radical compound and/or a specific chelate compound, and an enzyme immunoassay using the color developing method.
摘要翻译：公开了利用吲哚基衍生物与酶在特定自由基化合物和/或特定螯合物的存在下的反应的彩色显影方法，以及使用彩色显影法的酶免疫测定法。

9. 发明授权

US5214494A Light sensor with an adjustable spectral characteristic 失效
标题翻译：具有可调光谱特性的光传感器
公开(公告)号：US5214494A
公开(公告)日：1993-05-25
申请号：US754742
申请日：1991-09-04
申请人： Masahito Inaba , Masami Sugiyama
发明人： Masahito Inaba , Masami Sugiyama
IPC分类号： G01J3/26 , G01J1/04 , G01J1/42 , G01J3/12 , G01J3/51 , G02B5/28 , G02B7/00
CPC分类号： G02B26/007 , G01J1/04 , G01J1/0403 , G01J1/0437 , G01J1/0448 , G01J1/0474 , G02B5/28 , G01J1/0266 , G01J1/0492 , G01J1/4257 , G01J2003/1243
摘要： A light sensor comprises optical filters, an interference filter and a photoelectric converting element which receives and photoelectrically converts light which has passed through the optical filters and the interference filter. An incident angle of the incident light on the interference filter can be changed so as to realize a desirable spectral sensitivity in a combination of the optical filters, the interference filter and the photoelectric converting element. The incident angle can be changed by a mounting structure that can rotate about an optical axis.
摘要翻译：光传感器包括滤光器，干涉滤光器和光电转换元件，其接收并光电转换已经通过滤光器和干涉滤光器的光。可以改变干涉滤光片上的入射光的入射角，以便在滤光器，干涉滤光器和光电转换元件的组合中实现期望的光谱灵敏度。入射角度可以通过围绕光轴旋转的安装结构来改变。

10. 发明授权

US4634763A Amylase inhibitor and preparation and use thereof 失效
标题翻译：淀粉酶抑制剂及其制备及应用
公开(公告)号：US4634763A
公开(公告)日：1987-01-06
申请号：US428918
申请日：1982-09-30
申请人： Masami Sugiyama , Yasushi Kasahara
发明人： Masami Sugiyama , Yasushi Kasahara
IPC分类号： C12N9/99 , C07K1/22 , C07K14/415 , C12Q1/40 , C07K15/10 , C07K3/20
CPC分类号： C12Q1/40
摘要： A novel amylase inhibitor, obtained from hard wheat and durum wheat by using dye ligand affinity chromatography having an inhibitory activity on human salivary amylase of less than 0.1 of the inhibitory activity on human pancreatic amylase is disclosed which is useful for measuring isoenzymes of amylase in the field of clinical tests.
摘要翻译：公开了一种通过使用对人唾液淀粉酶具有抑制活性的染色配体亲和层析从硬质小麦和硬质小麦获得的新型淀粉酶抑制剂，其对人胰淀粉酶的抑制活性小于0.1，可用于测定淀粉酶的同工酶临床试验领域。

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