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1. 发明授权

US4844905A Granule remaining in stomach 失效
标题翻译：颗粒留在胃里
公开(公告)号：US4844905A
公开(公告)日：1989-07-04
申请号：US13832
申请日：1987-02-12
申请人： Masaki Ichikawa , Sumio Watanabe , Yasuo Miyake
发明人： Masaki Ichikawa , Sumio Watanabe , Yasuo Miyake
IPC分类号： A61K49/00 , A61K9/00 , A61K9/46 , A61K9/50 , A61K9/52 , A61K9/54
CPC分类号： A61K9/0065 , A61K9/0007 , A61K9/5073 , A61K9/5078
摘要： A granule of drug to remain in the stomach comprises a core comprising a pharmaceutically effective ingredient, a foaming layer coated on said core and an expansive film coated on said layer.
摘要翻译：保留在胃中的药物颗粒包括包含药学有效成分的核心，涂覆在所述核心上的发泡层和涂覆在所述层上的膨胀膜。

2. 发明授权

US5120719A Conjugate of prostaglandin and polysaccharide 失效
标题翻译：前列腺素和多糖的结合
公开(公告)号：US5120719A
公开(公告)日：1992-06-09
申请号：US437463
申请日：1989-11-15
申请人： Kiyoshi Iwamoto , Masahiro Kawahara , Sumio Watanabe , Yasuo Miyake , Fumio Sagami
发明人： Kiyoshi Iwamoto , Masahiro Kawahara , Sumio Watanabe , Yasuo Miyake , Fumio Sagami
IPC分类号： C08B31/04 , A61K31/557 , A61K31/715 , A61K47/48 , A61P43/00 , C07C405/00 , C08B37/00
CPC分类号： A61K47/4823 , A61K31/557
摘要： A conjugate formed by the covalent bonding of a prostaglandin or a similar compound thereto and a polysaccharide. The prostaglandin is selected from prostaglandin E1, prostaglandin E2, prostaglandin F2.alpha., prostaglandin I2, carbacycline and iloprost and the polysaccharide is selected from pluran, amylose, amylopectin, cellulose, dextran and hydroxyethylated starch.

3. 发明授权

US5030455A Sustained-release drug preparation 失效
标题翻译：持续释放药物制剂
公开(公告)号：US5030455A
公开(公告)日：1991-07-09
申请号：US396838
申请日：1989-08-22
申请人： Hidenobu Andoh , Sumio Watanabe , Yasuo Miyake
发明人： Hidenobu Andoh , Sumio Watanabe , Yasuo Miyake
IPC分类号： A61K9/16 , A61K9/20 , A61K9/22 , A61K9/26 , A61K31/135 , A61K31/52 , A61K31/55 , A61K47/00 , A61K47/14 , A61K47/26 , A61K47/44
CPC分类号： A61K9/2013 , A61K47/44
摘要： A sustained-release drug preparation comprises a water-soluble drug, a lipidic substance and an oil as its essential components. The drug level in the blood is sustained at a preferable concentation for a long period of time.

4. 发明授权

US5576021A Sustained-release multi-granule tablet 失效
标题翻译：持续释放多颗粒片剂
公开(公告)号：US5576021A
公开(公告)日：1996-11-19
申请号：US275240
申请日：1994-07-15
申请人： Hidenobu Andoh , Sumio Watanabe , Yasuo Miyake
发明人： Hidenobu Andoh , Sumio Watanabe , Yasuo Miyake
IPC分类号： A61K9/20 , A61K9/22 , A61K9/26 , A61K31/551
CPC分类号： A61K9/2081 , A61K31/551 , Y10S514/96 , Y10S514/961 , Y10S514/965
摘要： A sustained-release multi-granule tablet is obtained by compressing sustained-release granules, which contains an active substance, and a formulation adjuvant. Each of the granules has been coated in advance with a layer of the formulation adjuvant and/or a layer of a mixture of the formulation adjuvant and the active substance. The tablet releases an active substance at a suitable velocity into the digestion tract, resulting in that the variability in the absorption of the drug in each patient and among individual patients is minimized to achieve maximum bioavailability.
摘要翻译：通过压缩含有活性物质的缓释颗粒和制剂佐剂获得缓释多颗粒片剂。预先用制剂佐剂层和/或制剂佐剂和活性物质的混合物层预先涂覆每种颗粒。片剂以适当的速度将活性物质释放到消化道中，导致每个患者和个体患者中药物的吸收变化最小化以达到最大生物利用度。

5. 发明授权

US5093200A Multilayer sustained release granule 失效
标题翻译：多层可持续发布GRANULE
公开(公告)号：US5093200A
公开(公告)日：1992-03-03
申请号：US253367
申请日：1988-09-30
申请人： Sumio Watanabe , Ichiro Yamakawa , Hidenobu Ando , Nobutaka Noda , Yasuo Miyake
发明人： Sumio Watanabe , Ichiro Yamakawa , Hidenobu Ando , Nobutaka Noda , Yasuo Miyake
IPC分类号： A61K9/56 , A61K9/16 , A61K9/22 , A61K9/24 , A61K9/50 , A61K9/54
CPC分类号： A61K9/5078 , Y10T428/2984 , Y10T428/2985 , Y10T428/2989 , Y10T428/2991 , Y10T428/2998
摘要： A multilayer granule of the invention comprises a core, a slow-release layer, a rapid-release layer to be provided outer of said slow-release layer and a film layer containing a metal stearate and being deposited between the slow-release layer and the rapid-release layer. A pharmacologically effective component is kept to discharge for long.
摘要翻译：本发明的多层颗粒包括芯，缓释层，提供在所述缓释层外部的快速释放层和含有金属硬脂酸盐的膜层，并沉积在缓释层和缓释层之间快速释放层。药理学有效成分长时间保持放电。

6. 发明授权

US5624683A Sustained-release multi-granule tablet 失效
标题翻译：持续释放多颗粒片剂
公开(公告)号：US5624683A
公开(公告)日：1997-04-29
申请号：US192603
申请日：1994-02-07
申请人： Hidenobu Andoh , Sumio Watanabe , Yasuo Miyake
发明人： Hidenobu Andoh , Sumio Watanabe , Yasuo Miyake
IPC分类号： A61K9/20 , A61K9/22 , A61K9/26 , A61K31/551
CPC分类号： A61K9/2081 , A61K31/551 , Y10S514/96 , Y10S514/961 , Y10S514/965
摘要： A sustained-release multi-granule tablet is obtained by compressing sustained-release granules, which contains a basis, and a formulation adjuvant. Each of the granules has been coated in advance with a layer of the formulation adjuvant and/or a layer of a mixture of the formulation adjuvant and the basis. The tablet releases an active substance at a suitable velocity into the digestion tract, resulting in that the inbalance in the absorption of the drug in each patient and among individual patients is minimized to achieve maximum bioavailability.
摘要翻译：通过压缩含有基础的缓释颗粒和制剂佐剂获得缓释多颗粒片剂。预先将各颗粒剂用制剂佐剂层和/或制剂佐剂和基质的混合物层进行包衣。片剂以适当的速度将活性物质释放到消化道中，导致每个患者和个体患者中药物吸收的不平衡被最小化以达到最大生物利用度。

7. 发明授权

US5425943A Modified tPA-containing injection composition having increased solubility 失效
标题翻译：改进的含tPA的注射组合物具有增加的溶解度
公开(公告)号：US5425943A
公开(公告)日：1995-06-20
申请号：US900796
申请日：1992-06-22
申请人： Masahiro Kawahara , Yuichiro Hayashi , Naoki Asakawa , Sumio Watanabe , Yasuo Miyake
发明人： Masahiro Kawahara , Yuichiro Hayashi , Naoki Asakawa , Sumio Watanabe , Yasuo Miyake
IPC分类号： A61K38/46 , A61K9/08 , A61K38/49 , A61K47/00 , A61K47/18 , A61K38/48 , C12N9/50 , C12N9/64
CPC分类号： A61K9/0019 , A61K38/49 , A61K47/183
摘要： An injection composition comprises a pharmacologically effective amount of a modified tPA, 47.5 mM or more of an amino acid or a salt thereof and is improved in view of stability and solubility.
摘要翻译：注射组合物包含药理学上有效量的修饰的tPA，47.5mM或更多的氨基酸或其盐，并且从稳定性和溶解性的观点来看是有改进的。

8. 发明授权

US08827581B2 Printer and method of controlling printer 有权
标题翻译：打印机和打印机控制方法
公开(公告)号：US08827581B2
公开(公告)日：2014-09-09
申请号：US13477695
申请日：2012-05-22
申请人： Masahiro Tsuchiya , Tetsuhiro Ishikawa , Sumio Watanabe , Masaru Kihara , Yukihiro Mori
发明人： Masahiro Tsuchiya , Tetsuhiro Ishikawa , Sumio Watanabe , Masaru Kihara , Yukihiro Mori
IPC分类号： B65H35/04 , B41J15/04 , B41J11/70 , B41J2/32 , B41J13/10
CPC分类号： B41J15/04 , B41J2/32 , B41J11/70 , B41J13/106 , B65H35/006 , B65H2301/51256 , B65H2301/5151 , B65H2301/51532 , B65H2402/41 , B65H2801/12
摘要： A printer includes a printing part configured to perform printing on rolled recording paper, a presenter unit configured to convey the recording paper for up to a predetermined length, and a cutter part configured to cut the recording paper subjected to the printing and conveyed for up to the predetermined length, wherein the presenter unit is removably attached to a printer body part including the printing part and the presenter unit.
摘要翻译：打印机包括被配置为在卷纸上执行打印的打印部件，被配置为将记录纸传送达预定长度的演示单元和被配置为将经过打印的记录纸切割直到所述预定长度，其中所述演示单元可移除地附接到包括所述打印部分和所述演示者单元的打印机主体部分。

9. 发明授权

US08550733B2 Printing apparatus with sealed gear drive mechanism 有权
标题翻译：具有密封齿轮传动机构的印刷设备
公开(公告)号：US08550733B2
公开(公告)日：2013-10-08
申请号：US12068127
申请日：2008-02-01
申请人： Yukihiro Mori , Sumio Watanabe
发明人： Yukihiro Mori , Sumio Watanabe
IPC分类号： B41J11/04 , B41J11/70 , B41J29/02
CPC分类号： B41J15/042 , B26D1/385 , B41J11/70
摘要： A printing apparatus having shorter length in the longitudinal direction and a dust-protecting feature is disclosed. The printer includes a main frame, a subframe assembly, first and second pulse motors each have a reduction gear drive mechanism, a thermal head, a platen roller, a rotary blade, and a stationary blade. The first motor for driving the platen roller and the second motor for driving the rotary blade are disposed between two side plates provided one on each end of the main frame. The reduction gear drive mechanisms are substantially sealed and disposed inside the corresponding side plates. Two pulleys and a timing belt are provided outside each of the side plates.
摘要翻译：公开了一种在纵向具有较短长度和防尘特征的打印设备。打印机包括主框架，子框架组件，第一和第二脉冲电机，每个具有减速齿轮驱动机构，热头，压纸辊，旋转刀片和固定刀片。用于驱动压纸辊的第一电动机和用于驱动旋转刀片的第二电动机设置在设置在主框架的每个端部上的两个侧板之间。减速齿轮驱动机构基本上被密封并设置在相应的侧板内。在每个侧板的外侧设置有两个滑轮和同步皮带。

10. 发明授权

US07362346B2 Printer apparatus 有权
标题翻译：打印机装置
公开(公告)号：US07362346B2
公开(公告)日：2008-04-22
申请号：US11299627
申请日：2005-12-13
申请人： Sumio Watanabe , Fumio Sakurai , Yukihiro Mori , Masahiro Tsuchiya
发明人： Sumio Watanabe , Fumio Sakurai , Yukihiro Mori , Masahiro Tsuchiya
IPC分类号： B41J29/00
CPC分类号： B41J2/32 , B41J3/4075 , B41J15/042 , B41J29/02 , B41J29/13 , B41J29/38
摘要： A printer apparatus is disclosed that includes a printer unit, a first chassis, and a second chassis that is arranged to open/close through rotation. The printer unit includes a thermal head, a first module having a motor, and a second module having a platen roller and a rotating body. The first chassis includes a heat sensitive paper roll accommodating portion and a mount portion to which the first module is mounted. The second chassis includes mount portions to which the second module and a printed paper roll shaft are mounted, a printed paper roll accommodating portion, and a rotation transmitting mechanism. When the second chassis is closed, the heat sensitive paper roll accommodating portion is closed, the second module is coupled to the first module, the rotating body is rotated by the motor, and the shaft is rotated by the motor via the rotating body and the rotation transmitting mechanism.
摘要翻译：公开了一种打印机装置，其包括打印机单元，第一机箱和布置成通过旋转打开/关闭的第二机箱。打印机单元包括热敏头，具有电动机的第一模块和具有压纸辊和旋转体的第二模块。第一底架包括热敏纸卷容纳部分和安装第一模块的安装部分。第二底盘包括安装第二模块和打印纸辊轴的安装部分，打印纸卷容纳部分和旋转传递机构。当第二底盘关闭时，热敏纸卷容纳部分关闭，第二模块联接到第一模块，旋转体由电动机旋转，并且轴通过旋转体由电动机旋转，并且旋转传递机构。

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