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1. 发明授权

US4034003A 15-Cycloalkyl-prostaglandins 失效
标题翻译： 15-环烷基 - 前列腺素
公开(公告)号：US4034003A
公开(公告)日：1977-07-05
申请号：US566147
申请日：1975-04-08
申请人： Masaki Hayashi , Seiji Kori , Hajimu Miyake , Takashi Yamato , Hisashi Suga
发明人： Masaki Hayashi , Seiji Kori , Hajimu Miyake , Takashi Yamato , Hisashi Suga
IPC分类号： C07C405/00 , C07D307/935 , C07D309/12 , C07F9/40 , C07C177/00
CPC分类号： C07D307/935 , C07C405/00 , C07C405/0016 , C07D309/12 , C07F9/4018 , Y10S514/822 , Y10S514/962
摘要： 15-Cycloalkyl-prostaglandins of the formula:- ##STR1## wherein A represents a grouping of the formula:- ##STR2## X represents ethylene of cis-vinylene, Y represents ethylene or trans-vinylene, B represents ethylene or trans-vinylene, R represents hydrogen or alkyl of 1 through 4 carbon atoms, R.sup.1 represents cycloalkyl of 4 through 7 carbon atoms, and R.sup.2 represents hydrogen or alkyl of 1 through 12 carbon atoms, are new compounds possessing the useful pharmacological properties typical of prostaglandins; they are of especial interest in the inhibition of blood platelet aggregation.
摘要翻译： 15-环烷基 - 前列腺素，其结构式如下：其中A表示下式的基团：X表示顺式 - 亚乙烯基的亚乙基，Y表示亚乙基或反式亚乙烯基，B表示亚乙基或反式亚乙烯基， R表示氢或1〜4个碳原子的烷基，R1表示4〜7个碳原子的环烷基，R2表示氢或1〜12个碳原子的烷基，是具有典型的前列腺素有用的药理学性质的新化合物; 它们对抑制血小板聚集具有特别的兴趣。

2. 发明授权

US4390548A Trans-.DELTA..sup.2 -pge alkylsulphonyl amides 失效
标题翻译：经DELTA 2-pge烷基磺酰胺
公开(公告)号：US4390548A
公开(公告)日：1983-06-28
申请号：US257102
申请日：1981-04-24
申请人： Takashi Yamato , Hirofumi Endo , Kimiichiro Matsumoto , Hajimu Miyake
发明人： Takashi Yamato , Hirofumi Endo , Kimiichiro Matsumoto , Hajimu Miyake
IPC分类号： A61K31/557 , A61K31/5575 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00 , C07C143/75 , A61K31/18
CPC分类号： C07C405/0041 , C07C405/0033 , Y02P20/55
摘要： Prostaglandin analogues of the formula: ##STR1## (wherein R.sup.1 represents an alkyl group containing from 1 to 4 carbon atoms, R.sup.2 represents a single bond or an alkylene group containing from 1 to 5 carbon atoms, R.sup.3 represents a hydrogen atom, an alkyl or alkoxy group containing from 1 to 8 carbon atoms, a cycloalkyl or cycloalkyloxy group containing from 4 to 7 carbon atoms and being unsubstituted or substituted by at least one alkyl group containing from 1 to 8 carbon atoms, or a phenyl or phenoxy group unsubstituted or substituted by at least one halogen atom, trifluoromethyl group or alkyl group containing from 1 to 4 carbon atoms, R.sup.4 represents a hydrogen atom or a hydroxy-protecting group which may be removed under acidic conditions, X represents an ethylene group or a cis-vinylene group, the double bonds between the carbon atoms in positions 2 and 3 and between the carbon atoms in positions 13 and 14 are both in trans-configuration, and the wavy line attached to the carbon atom in position 15 represents .alpha.- or .beta.-configuration or a mixture thereof, provided that, when R.sup.2 represents a single bond, R.sup.3 does not represent an alkoxy group, a cycloalkoxy group or a phenoxy group) and cyclodextrin clathrates thereof are useful compounds: those in which R.sup.4 represents a hydrogen atom possess selective prostaglandin-like properties.
摘要翻译：具有下式的前列腺素类似物：其中R 1表示含有1至4个碳原子的烷基，R 2表示单键或含有1至5个碳原子的亚烷基，R 3表示氢原子，烷基或含有1至8个碳原子的烷氧基，含有4至7个碳原子的环烷基或环烷氧基，未被取代或被至少一个含有1至8个碳原子的烷基取代，或未取代或取代的苯基或苯氧基通过至少一个卤素原子，三氟甲基或含有1至4个碳原子的烷基，R 4表示氢原子或可在酸性条件下除去的羟基保护基，X表示亚乙基或顺式 - 亚乙烯基位置2和3之间的碳原子之间以及位置13和14之间的碳原子之间的双键都是反式构型，并且连接在p中的碳原子上的波浪线环状15表示α-或β-构型或其混合物，条件是当R 2表示单键时，R 3不表示烷氧基，环烷氧基或苯氧基）和环糊精包合物是有用的化合物：其中R4表示氢原子，具有选择性前列腺素样特性。

3. 发明授权

US4443478A Prostaglandin analogues 失效
标题翻译：前列腺素类似物
公开(公告)号：US4443478A
公开(公告)日：1984-04-17
申请号：US392676
申请日：1982-06-28
申请人： Takashi Muryobayashi , Hajimu Miyake , Takashi Yamato
发明人： Takashi Muryobayashi , Hajimu Miyake , Takashi Yamato
IPC分类号： C07C405/00 , C07C177/00 , A61K31/215
CPC分类号： C07C405/0025 , C07C405/00 , Y10S514/824 , Y10S514/826 , Y10S514/866 , Y10S514/926 , Y10S514/927
摘要： Prostaglandin E.sub.1 analogues of general formula: ##STR1## [wherein R.sup.1 represents a bond or a straight- or branched-chain alkylene group containing from 1 to 5 carbon atom(s), and R.sup.2 represents a hydrogen atom, a straight- or branched-chain alkyl group containing from 1 to 8 carbon atom(s), a cycloalkyl group containing from 4 to 7 carbon atoms in the ring and unsubstituted or substituted by at least one stright- or branched-chain alkyl group containing from 1 to 8 carbon atom(s) or a phenyl or phenoxy group unsubstituted or substituted by at least one halogen atoms, trifluoromethyl group or straight- or branched-chain alkyl group containing from 1 to 4 carbon atom(s), with the proviso that, when R.sup.1 represents a bond, R.sup.2 does not represent a phenoxy group,] possess inhibitory activity or gastric ulceration and cytoprotective activity.
摘要翻译：前列腺素E1类似物，通式为：其中R1表示含有1〜5个碳原子的键或直链或支链亚烷基，R2表示氢原子，直链或支链的亚烷基，含有1至8个碳原子的链烷基，在环中含有4至7个碳原子的环烷基，未被取代或被至少一个含有1至8个碳原子的支链或支链烷基取代或未被取代或被至少一个卤素原子，三氟甲基或含有1至4个碳原子的直链或支链烷基取代的苯基或苯氧基，条件是当R 1表示键，R2不代表苯氧基，]具有抑制活性或胃溃疡和细胞保护活性。

4. 发明授权

US09157924B2 Analyzing apparatus 有权
标题翻译：分析仪器
公开(公告)号：US09157924B2
公开(公告)日：2015-10-13
申请号：US12870494
申请日：2010-08-27
申请人： Takashi Yamato , Hiroshi Kurono
发明人： Takashi Yamato , Hiroshi Kurono
IPC分类号： G01N35/00 , G01N35/10 , G01N35/04
CPC分类号： G01N35/1004 , G01N35/1002 , G01N35/1011 , G01N2035/00673 , G01N2035/00801 , G01N2035/0443 , G01N2035/0465 , Y10T436/11 , Y10T436/111666
摘要： A specimen analyzing apparatus for measuring a specimen by using a reagent which has a dispensing mechanism which includes a dispensing tube for suctioning and discharging liquid; a reagent container holder from which a reagent container is removable when the reagent container is in a container removal area; a receiving section for receiving a replacement command for a replacement of the reagent; and a controller for controlling the dispensing mechanism so as to retreat the dispensing tube from the container removal area when the replacement command has been received by the receiving section. Also, a control method for a specimen analyzing apparatus.
摘要翻译：一种用于通过使用具有分配机构的试剂来测量样本的样本分析装置，所述分配机构包括用于抽吸和排出液体的分配管; 试剂容器保持器，当试剂容器处于容器移除区域时，试剂容器可以从其移除; 接收部分，用于接收替换所述试剂的替换命令; 以及控制器，用于控制分配机构，以便当接收部分接收到替换命令时，将分配管从容器移除区域撤回。另外，也可以是用于检体分析装置的控制方法。

5. 发明申请

US20120294763A1 SPECIMEN ANALYZING APPARATUS AND SPECIMEN ANALYZING METHOD 审中-公开
标题翻译：样本分析设备和样本分析方法
公开(公告)号：US20120294763A1
公开(公告)日：2012-11-22
申请号：US13562992
申请日：2012-07-31
申请人： Kazuya FUKUDA , Hiroki Koike , Hironori Katsumi , Takashi Yamato , Masayuki Ikeda , Tsuyoshi Fukuzaki , Daisuke Nakano , Masanori Imazu , Nobuhiro Kitagawa
发明人： Kazuya FUKUDA , Hiroki Koike , Hironori Katsumi , Takashi Yamato , Masayuki Ikeda , Tsuyoshi Fukuzaki , Daisuke Nakano , Masanori Imazu , Nobuhiro Kitagawa
IPC分类号： G01N35/00
CPC分类号： G01N35/1065 , G01N35/00722 , G01N35/0092 , G01N35/025 , G01N35/026 , G01N35/1016 , G01N35/1079 , G01N35/1081 , G01N2035/00752 , G01N2035/00801 , G01N2035/0403 , G01N2035/0444 , G01N2035/1086
摘要： A specimen analyzing apparatus comprising: a detector for detecting component information regarding a component in a specimen contained in each of analyzing containers, the analyzing containers comprising first and second analyzing containers; an analyzing part for analyzing the component information detected by the detector; a transporting device for transporting specimen containers each containing a specimen, the specimen containers comprising first and second specimen containers; an operation mode selector for selecting one of a first operation mode and a second operation mode; a first supplying device for supplying the specimen of a first amount; a second supplying device for supplying the specimen of a second amount grater than the first amount; and a supply controller for controlling the first and second supplying devices in accordance with an operation mode selected by the operation mode selector, is disclosed. A specimen analyzing method is also disclosed.
摘要翻译：一种样本分析装置，包括：检测器，用于检测包含在每个分析容器中的样本中的成分的成分信息，所述分析容器包括第一和第二分析容器; 用于分析由检测器检测到的分量信息的分析部件; 一个运送装置，用于运送每个包含试样的标本容器，该样本容器包括第一和第二标本容器; 操作模式选择器，用于选择第一操作模式和第二操作模式之一; 第一供给装置，其供给第一量的试样; 第二供给装置，其供给比第一量的第二量磨机的试样; 以及用于根据由操作模式选择器选择的操作模式来控制第一和第二供应装置的供应控制器。还公开了一种样本分析方法。

6. 发明授权

US09395380B2 Specimen processing apparatus that determines whether a moveable section was moved when a moving operation had been stopped 有权
标题翻译：判定在移动动作停止时是否移动了移动部的试样处理装置
公开(公告)号：US09395380B2
公开(公告)日：2016-07-19
申请号：US12842566
申请日：2010-07-23
申请人： Takashi Yamato , Hiroshi Kurono
发明人： Takashi Yamato , Hiroshi Kurono
IPC分类号： G01N35/02 , G01N35/00 , G05D3/12 , G01N35/10
CPC分类号： G01N35/025 , G01N35/0092 , G01N35/1011 , G05D3/12 , Y10T436/25
摘要： A specimen processing apparatus comprising: a specimen processing section which includes a movable section and processes a specimen by moving the movable section; and a controller for determining whether the movable section was moved while a specimen processing operation by the specimen processing section was stopped, and controlling the specimen processing section to perform a preparing operation for starting the specimen processing operation based on the determination result, is disclosed. A control method for a specimen processing apparatus is also disclosed.
摘要翻译：一种试样处理装置，包括：试样处理部，其包括可动部，通过移动所述可动部来处理试样; 公开了一种控制器，用于在通过样本处理部分的检体处理操作停止时确定可移动部分是否移动，并且基于该确定结果控制样本处理部分执行用于开始样本处理操作的准备操作。还公开了一种样本处理装置的控制方法。

7. 发明授权

US08234941B2 Specimen analyzing apparatus and specimen analyzing method 有权
标题翻译：标本分析仪器和样本分析方法
公开(公告)号：US08234941B2
公开(公告)日：2012-08-07
申请号：US12607739
申请日：2009-10-28
申请人： Kazuya Fukuda , Hiroki Koike , Hironori Katsumi , Takashi Yamato , Masayuki Ikeda , Tsuyoshi Fukuzaki , Daisuke Nakano , Masanori Imazu , Nobuhiro Kitagawa
发明人： Kazuya Fukuda , Hiroki Koike , Hironori Katsumi , Takashi Yamato , Masayuki Ikeda , Tsuyoshi Fukuzaki , Daisuke Nakano , Masanori Imazu , Nobuhiro Kitagawa
IPC分类号： G01N35/00 , G01N35/02 , G01N35/10
CPC分类号： G01N35/1065 , G01N35/00722 , G01N35/0092 , G01N35/025 , G01N35/026 , G01N35/1016 , G01N35/1079 , G01N35/1081 , G01N2035/00752 , G01N2035/00801 , G01N2035/0403 , G01N2035/0444 , G01N2035/1086
摘要： A specimen analyzing apparatus comprising: a detector for detecting component information regarding a component in a specimen contained in each of analyzing containers, the analyzing containers comprising first and second analyzing containers; an analyzing part for analyzing the component information detected by the detector; a transporting device for transporting specimen containers each containing a specimen, the specimen containers comprising first and second specimen containers; an operation mode selector for selecting one of a first operation mode and a second operation mode; a first supplying device for supplying the specimen of a first amount; a second supplying device for supplying the specimen of a second amount grater than the first amount; and a supply controller for controlling the first and second supplying devices in accordance with an operation mode selected by the operation mode selector, is disclosed. A specimen analyzing method is also disclosed.
摘要翻译：一种样本分析装置，包括：检测器，用于检测包含在每个分析容器中的样本中的成分的成分信息，所述分析容器包括第一和第二分析容器; 用于分析由检测器检测到的分量信息的分析部件; 一个运送装置，用于运送每个包含试样的标本容器，该样本容器包括第一和第二标本容器; 操作模式选择器，用于选择第一操作模式和第二操作模式之一; 第一供给装置，其供给第一量的试样; 第二供给装置，其供给比第一量的第二量磨机的试样; 以及用于根据由操作模式选择器选择的操作模式来控制第一和第二供应装置的供应控制器。还公开了一种样本分析方法。

8. 发明授权

US5587129A Apparatus for automatically analyzing specimen 失效
标题翻译：用于自动分析试样的装置
公开(公告)号：US5587129A
公开(公告)日：1996-12-24
申请号：US530901
申请日：1995-09-20
申请人： Tsuyoshi Kurosaki , Atsuo Tomioka , Takashi Yamato
发明人： Tsuyoshi Kurosaki , Atsuo Tomioka , Takashi Yamato
IPC分类号： B65G47/80 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10
CPC分类号： G01N35/00603 , G01N35/025 , G01N2035/0443 , G01N2035/0444 , G01N2035/0465 , G01N2035/0472 , G01N2035/1076 , G01N35/0099 , G01N35/109 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831 , Y10T436/119163
摘要： An apparatus and a method for automatically analyzing specimens are disclosed. The apparatus includes a sample vial retainer for retaining a sample vial containing a specimen such as blood; a stock vial into which part of the specimen in the sample vial is dispensed; a stock vial retainer for retaining the stock vial; a first dispenser for dispensing the specimen in the sample vial to the stock vial; an assay vial into which part of the specimen in the stock vial is dispensed; an assay vial retainer for retaining a plurality of assay vials; a second dispenser for dispensing the specimen in the stock vial to the assay vial; a reagent container for containing a reagent necessary for an assay; a third dispenser for dispensing the reagent to the assay vial; an assay device for assaying the specimen in the assay vial; an assay vial transporter for transporting the assay vial retained in the assay vial retainer to the assay device; a vial discharger for discharging the assay vial after the assay; and a controller, whereby the specimen once dispensed from the sample vial to the stock vial is dispensed from the stock vial to the assay vial for an assay.
摘要翻译：公开了一种用于自动分析试样的设备和方法。该装置包括用于保持包含诸如血液的样本的样品瓶的样品瓶保持器; 储存样品瓶，其中分配样品瓶中的一部分样品; 用于保持小瓶的储料瓶保持器; 用于将样品瓶中的样品分配到储存小瓶的第一分配器; 分析样品瓶，其中分配储存小瓶中的样品的一部分; 用于保留多个测定小瓶的测定小瓶保持器; 用于将存储小瓶中的样品分配到分析小瓶的第二分配器; 用于容纳测定所必需的试剂的试剂容器; 用于将试剂分配到测定小瓶的第三分配器; 用于测定分析小瓶中的样品的测定装置; 用于将保留在测定小瓶保持器中的测定小瓶运送到测定装置的测定小瓶转运器; 用于在测定后排出测定小瓶的小瓶放出器; 和一个控制器，其中一次从样品瓶分配到储备小瓶的样品从储备小瓶分配到用于测定的测定小瓶。

9. 发明授权

US08545760B2 Specimen analyzing method and specimen analyzing apparatus 有权
公开(公告)号：US08545760B2
公开(公告)日：2013-10-01
申请号：US11905328
申请日：2007-09-28
申请人： Norimasa Yamamoto , Takashi Yamato , Naohiko Matsuo , Satoshi Iguchi
发明人： Norimasa Yamamoto , Takashi Yamato , Naohiko Matsuo , Satoshi Iguchi
IPC分类号： G01N21/00
CPC分类号： G01N35/00594 , G01N21/0332 , G01N21/17 , G01N21/31 , G01N21/59 , G01N33/5302 , G01N33/86 , G01N35/00603 , G01N35/025 , G01N2035/00465 , G01N2201/0231 , G01N2201/062 , Y10S436/815 , Y10S436/817 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/146666
摘要： A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.

10. 发明授权

US07850921B2 Dispenser, reagent dispenser and sample analyzer 有权
标题翻译：分配器，试剂分配器和样品分析仪
公开(公告)号：US07850921B2
公开(公告)日：2010-12-14
申请号：US11893919
申请日：2007-08-17
申请人： Satoshi Iguchi , Takashi Yamato , Nobuhiro Kitagawa , Akio Toyoda
发明人： Satoshi Iguchi , Takashi Yamato , Nobuhiro Kitagawa , Akio Toyoda
IPC分类号： B01L3/02 , G01N21/00 , G01N31/00 , G01N33/00 , G01N1/22
CPC分类号： G01N35/1009 , G01N35/025 , G01N35/1002 , G01N2035/00425 , G05D23/1919 , G05D23/24
摘要： The present invention is to present a dispenser which is capable of heating a liquid to an approximately constant temperature in the same time regardless of an aspiration amount of the liquid. The dispenser comprises a liquid holder for holding a liquid; aspiration amount information obtaining means for obtaining aspiration amount information indicating an aspiration amount of the liquid; an aspiration-discharge part for aspirating the aspiration amount of the liquid indicated by the obtained aspiration amount information into the liquid holder and discharging the liquid from the liquid holder; a heater for heating the liquid held by the liquid holder; a temperature sensor for detecting a temperature of the liquid held by the liquid holder; target temperature determining means for determining a target temperature of the liquid based on the aspiration amount of the liquid indicated by the obtained aspiration amount information; and controlling means for controlling the heater so as to conform the temperature detected by the temperature sensor to the target temperature.
摘要翻译：本发明是提供一种分配器，其能够在液体的吸入量无论在同一时间内将液体加热到近似恒定的温度。分配器包括用于保持液体的液体保持器; 抽吸量信息获取装置，用于获得指示液体抽吸量的抽吸量信息; 抽吸排出部，用于将由所获取的吸液量信息指示的液体的吸入量吸入液体保持器并从液体保持器排出液体; 用于加热由液体保持器保持的液体的加热器; 用于检测由液体保持器保持的液体的温度的温度传感器; 目标温度确定装置，用于基于由所获得的抽吸量信息指示的液体的抽吸量来确定液体的目标温度; 以及用于控制加热器以使温度传感器检测的温度与目标温度一致的控制装置。

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