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1. 发明申请

US20100216164A1 MAMMALIAN PRICKLE GENE 审中-公开
公开(公告)号：US20100216164A1
公开(公告)日：2010-08-26
申请号：US12392063
申请日：2009-02-24
申请人： Masakazu Takeuchi , Keiko Sato , Yoshimasa Sakamoto , Maki Tawarada , Toshihisa Ohtsuka
发明人： Masakazu Takeuchi , Keiko Sato , Yoshimasa Sakamoto , Maki Tawarada , Toshihisa Ohtsuka
IPC分类号： G01N33/567
CPC分类号： C07K14/47
摘要： The present invention provides the mPrickle gene which encodes a protein present in mammalian PSD fractions. The mPrickle protein is localized in synapses, and binds to the scaffold protein PSD-95. Precipitation of endogenous mPrickle using an anti-mPrickle antibody results in the coprecipitation of NMDA receptors, and thus, mPrickle can be used in drug delivery systems that target NMDA receptors. NMDA receptors are closely related to learning and memory, and are also suggested to be involved in mental disorders. Thus, in the future, mPrickle is expected to be applicable to the diagnosis and/or treatment of neurodegenerative diseases associated with learning/memory, such as mental deterioration and dementia.
摘要翻译：本发明提供编码哺乳动物PSD级分中存在的蛋白质的mPrickle基因。 mPrickle蛋白定位在突触中，并结合到支架蛋白PSD-95。使用抗mPrickle抗体沉淀内源性mPrickle导致NMDA受体的共沉淀，因此，mPrickle可用于靶向NMDA受体的药物递送系统。 NMDA受体与学习记忆密切相关，也被认为与精神障碍有关。因此，将来，mPrickle预期适用于与学习/记忆相关的神经变性疾病的诊断和/或治疗，例如精神恶化和痴呆。

2. 发明申请

US20060292669A1 Mammalian prickle gene 审中-公开
标题翻译：哺乳动物刺刺基因
公开(公告)号：US20060292669A1
公开(公告)日：2006-12-28
申请号：US10536586
申请日：2003-11-28
申请人： Masakazu Takeuchi , Keiko Sato , Yoshimasa Sakamoto , Maki Tawarada , Toshihisa Ohtsuka
发明人： Masakazu Takeuchi , Keiko Sato , Yoshimasa Sakamoto , Maki Tawarada , Toshihisa Ohtsuka
IPC分类号： C07K14/705 , C07K16/28 , C07H21/04 , C12P21/06
CPC分类号： C07K14/47
摘要： The present invention provides the mPrickle gene which encodes a protein present in mammalian PSD fractions. The mPrickle protein is localized in synapses, and binds to the scaffold protein PSD-95. Precipitation of endogenous mPrickle using an anti-mPrickle antibody results in the coprecipitation of NMDA receptors, and thus, mPrickle can be used in drug delivery systems that target NMDA receptors. NMDA receptors are closely related to learning and memory, and are also suggested to be involved in mental disorders. Thus, in the future, mPrickle is expected to be applicable to the diagnosis and/or treatment of neurodegenerative diseases associated with learning/memory, such as mental deterioration and dementia.
摘要翻译：本发明提供编码哺乳动物PSD级分中存在的蛋白质的mPrickle基因。 mPrickle蛋白定位在突触中，并结合到支架蛋白PSD-95。使用抗mPrickle抗体沉淀内源性mPrickle导致NMDA受体的共沉淀，因此，mPrickle可用于靶向NMDA受体的药物递送系统。 NMDA受体与学习记忆密切相关，也被认为与精神障碍有关。因此，将来，mPrickle预期适用于与学习/记忆相关的神经变性疾病的诊断和/或治疗，例如精神恶化和痴呆。

3. 发明授权

US08317600B2 Game device 有权
标题翻译：游戏设备
公开(公告)号：US08317600B2
公开(公告)日：2012-11-27
申请号：US12679229
申请日：2008-09-19
申请人： Manabu Hazama , Keiko Sato , Yasumi Takase , Naohiro Yamamoto , Kota Wakasa , Takashi Nishibori
发明人： Manabu Hazama , Keiko Sato , Yasumi Takase , Naohiro Yamamoto , Kota Wakasa , Takashi Nishibori
IPC分类号： A63F9/24
CPC分类号： A63F13/67 , A63F13/10 , A63F13/69 , A63F2300/6027
摘要： A game device of a computer game includes plural unit games, each of which can be completed when a requirement for completion is satisfied. The game device includes: a rule storage unit for storing rules of the computer game, in which the rules include rules stipulating the requirement for completion of each of the plural unit games and rules stipulating a content of play of each of the plural unit games; a difficulty changer for rewriting a rule stored in the rule storage unit so as to change a level of difficulty for completion of at least one unit game among the plural unit games; and a play processor for conducting a unit game selection process for enabling a player to select one from among the plural unit games, a play execution process for executing play of the selected unit game in accordance with the rule stipulating the content of play stored in the rule storage unit, and a decision process for deciding whether or not the unit game is completed on the basis of the rule stipulating the requirement for completion stored in the rule storage unit.
摘要翻译：计算机游戏的游戏装置包括多个单元游戏，当满足完成要求时，可以完成每个单元游戏。游戏装置包括：规则存储单元，用于存储计算机游戏的规则，其中规则包括规定完成多个单元游戏中的每一个的规则的规则和规定多个单元游戏中的每一个游戏的内容的规则; 用于重写存储在规则存储单元中的规则以改变在多个单元游戏中完成至少一个单元游戏的难度级别的难点改变器; 以及播放处理器，用于进行单元游戏选择处理，用于使玩家能够从多个单元游戏中选择一个，用于根据规定游戏内容的规则执行所选择的单元游戏的播放的播放执行处理规则存储单元，以及用于基于规定存储在规则存储单元中的完成要求的规则来决定单元游戏是否完成的决定处理。

4. 外观设计

USD565658S1 Cap for a marking pen 有权
公开(公告)号：USD565658S1
公开(公告)日：2008-04-01
申请号：US29260515
申请日：2006-05-25
申请人： Keiko Sato
设计人： Keiko Sato

5. 发明授权

US08777742B2 Game device, control method for a game device, and non-transitory information storage medium 有权
标题翻译：游戏装置，游戏装置的控制方法以及非暂时信息存储介质
公开(公告)号：US08777742B2
公开(公告)日：2014-07-15
申请号：US13309299
申请日：2011-12-01
申请人： Keiko Sato
发明人： Keiko Sato
IPC分类号： A63F13/02
CPC分类号： A63F13/428 , A63F13/213 , A63F13/44 , A63F13/814 , A63F2300/1087 , A63F2300/1093 , A63F2300/61 , A63F2300/638 , A63F2300/8047
摘要： A game device in which a first comparison unit compares an exemplary model posture (posture that is supposed to be adopted by a player) at a reference time and a posture of the player indicated by posture data acquired by a posture data acquiring unit at a compared time. A second comparison unit executes at least one of: a comparison between a different posture from the exemplary model posture at the reference time and the posture of the player indicated by the posture data acquired at the compared time; and a comparison between the exemplary model posture at the reference time and a different posture from the posture of the player indicated by the posture data acquired at the compared time. An output control unit causes an output based on a comparison between results from the first and second comparison units.
摘要翻译：一种游戏装置，其中第一比较单元比较在参考时间的示例性模型姿势（应该由玩家采用的姿势）和由比较的姿势数据获取单元获取的姿势数据所指示的玩家的姿势时间。第二比较单元执行以下中的至少一个：与参考时间的示例性模型姿势不同的姿势与在比较时间获取的姿势数据所指示的玩家的姿势之间的比较; 以及在参考时间的示例性模型姿势与与在比较时间获取的姿势数据所指示的玩家的姿势不同的姿势之间的比较。输出控制单元基于来自第一和第二比较单元的结果之间的比较来产生输出。

6. 发明申请

US20050238779A1 Low-calorie beverages and sweetener composition with improved palatability 审中-公开
标题翻译：低热量饮料和甜味剂组合物具有改善的适口性
公开(公告)号：US20050238779A1
公开(公告)日：2005-10-27
申请号：US11114019
申请日：2005-04-26
申请人： Naoko Isoya , Keiko Sato , Yasuyuki Tomiyama
发明人： Naoko Isoya , Keiko Sato , Yasuyuki Tomiyama
IPC分类号： A23L2/00 , A23L27/30 , A23L1/236
CPC分类号： A23L2/60 , A23L27/30 , A23L27/37 , A23V2002/00 , A23V2250/264 , A23V2250/242 , A23V2250/032 , A23V2200/332 , A23V2250/2482 , A23V2250/606
摘要： The invention described herein provide beverages which have excellent palatability and are limited in calorie content and a sweetener composition having the same characteristics, which contain sucralose and acesulfame K.
摘要翻译：本文描述的本发明提供了具有优异适口性并且热量含量受限的饮料和具有相同特征的甜味剂组合物，其含有三氯蔗糖和乙酰磺胺酸钾。

7. 发明申请

US20110076704A1 Method for diagnosing alzheimer's disease using serum glycoprotein as biomarker 失效
标题翻译：使用血清糖蛋白作为生物标志物诊断阿尔茨海默病的方法
公开(公告)号：US20110076704A1
公开(公告)日：2011-03-31
申请号：US11920167
申请日：2006-05-11
申请人： Shinobu Kitazume , Ritsuko Oka , Yasuhiro Hashimoto , Yuji Sato , Tamao Endo , Makoto Higuchi , Hiroyuki Arai , Takaomi Saido , Keiko Sato
发明人： Shinobu Kitazume , Ritsuko Oka , Yasuhiro Hashimoto , Yuji Sato , Tamao Endo , Makoto Higuchi , Hiroyuki Arai , Takaomi Saido , Keiko Sato
IPC分类号： G01N33/53 , C07K14/42 , C07K16/18
CPC分类号： G01N33/6896 , G01N2800/2821
摘要： It is an object of the present invention to detect a change in the metabolism of a glycoprotein having an α2,6-sialyl residue, which is contained in blood, so as to provide an agent and a method for diagnosing sporadic Alzheimer's disease. The present invention provides an agent for diagnosing Alzheimer's disease, which comprises lectin used for detecting an α2,6-sialyl residue-containing glycoprotein.
摘要翻译：本发明的目的是检测血液中含有的具有α2,6-唾液酰残基的糖蛋白的代谢变化，从而提供用于诊断散发性阿尔茨海默病的药剂和方法。本发明提供了用于诊断阿尔茨海默病的药剂，其包含用于检测含有α2,6-唾液酸残基的糖蛋白的凝集素。

8. 发明申请

US20050238786A1 Low-calorie beverages with improved flavor 审中-公开
标题翻译：具有改善风味的低热量饮料
公开(公告)号：US20050238786A1
公开(公告)日：2005-10-27
申请号：US10942937
申请日：2004-09-17
申请人： Naoko Isoya , Keiko Sato , Yasuyuki Tomiyama
发明人： Naoko Isoya , Keiko Sato , Yasuyuki Tomiyama
IPC分类号： A23L2/00 , A23L2/38 , A23L2/56 , A23L2/60 , A23G3/30
CPC分类号： A23L2/60 , A23V2002/00 , A23V2250/2482 , A23V2250/264 , A23V2200/15
摘要： The invention described herein improves the suppression or the control of a flavor in sucralose-containing beverages by incorporating aspartame into the beverage. Thus the present invention provides a low-calorie beverage, containing at least one flavoring ingredient, aspartame and sucralose, where the aspartame:sucralose weight ratio is from 1:1 to 10:1.
摘要翻译：本文所述的发明通过将阿斯巴甜纳入饮料来改善抑制或控制含三氯蔗糖的饮料中的风味。因此，本发明提供了含有至少一种调味成分，阿斯巴甜和三氯蔗糖的低热量饮料，其中阿斯巴甜：三氯蔗糖的重量比为1:1至10:1。

9. 发明申请

US20100234096A1 GAME DEVICE 有权
标题翻译：游戏设备
公开(公告)号：US20100234096A1
公开(公告)日：2010-09-16
申请号：US12679229
申请日：2008-09-19
申请人： Manabu Hazama , Keiko Sato , Yasumi Takase , Naohiro Yamamoto , Kota Wakasa , Takashi Nishibori
发明人： Manabu Hazama , Keiko Sato , Yasumi Takase , Naohiro Yamamoto , Kota Wakasa , Takashi Nishibori
IPC分类号： A63F9/24
CPC分类号： A63F13/67 , A63F13/10 , A63F13/69 , A63F2300/6027
摘要： A game device of a computer game includes plural unit games, each of which can be completed when a requirement for completion is satisfied. The game device includes: a rule storage unit for storing rules of the computer game, in which the rules include rules stipulating the requirement for completion of each of the plural unit games and rules stipulating a content of play of each of the plural unit games; a difficulty changer for rewriting a rule stored in the rule storage unit so as to change a level of difficulty for completion of at least one unit game among the plural unit games; and a play processor for conducting a unit game selection process for enabling a player to select one from among the plural unit games, a play execution process for executing play of the selected unit game in accordance with the rule stipulating the content of play stored in the rule storage unit, and a decision process for deciding whether or not the unit game is completed on the basis of the rule stipulating the requirement for completion stored in the rule storage unit.
摘要翻译：计算机游戏的游戏装置包括多个单元游戏，当满足完成要求时，可以完成每个单元游戏。游戏装置包括：规则存储单元，用于存储计算机游戏的规则，其中规则包括规定完成多个单元游戏中的每一个的规则的规则和规定多个单元游戏中的每一个游戏的内容的规则; 用于重写存储在规则存储单元中的规则以改变在多个单元游戏中完成至少一个单元游戏的难度级别的难点改变器; 以及播放处理器，用于进行单元游戏选择处理，用于使玩家能够从多个单元游戏中选择一个，用于根据规定游戏内容的规则执行所选择的单元游戏的播放的播放执行处理规则存储单元，以及用于基于规定存储在规则存储单元中的完成要求的规则来决定单元游戏是否完成的决定处理。

10. 外观设计

USD567290S1 Cap for a marking pen 有权
公开(公告)号：USD567290S1
公开(公告)日：2008-04-22
申请号：US29260513
申请日：2006-05-25
申请人： Keiko Sato
设计人： Keiko Sato

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