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1. 发明授权

US4839388A Prostacyclins and pharmaceuticals containing the same 失效
标题翻译：前列环素和含有相同的药物
公开(公告)号：US4839388A
公开(公告)日：1989-06-13
申请号：US060870
申请日：1987-05-18
申请人： Masakatsu Sibasaki , Mikiko Sodeoka , Katsuhiko Iseki , Masaki Shinoda , Chiyoko Aoki , Yosio Hayasi , Toshiji Kanayama
发明人： Masakatsu Sibasaki , Mikiko Sodeoka , Katsuhiko Iseki , Masaki Shinoda , Chiyoko Aoki , Yosio Hayasi , Toshiji Kanayama
IPC分类号： C07C59/125 , A61K31/557 , A61K31/695 , A61P1/04 , A61P7/02 , A61P9/08 , A61P9/12 , C07C51/00 , C07C59/46 , C07C59/54 , C07C59/62 , C07C59/64 , C07C59/72 , C07C67/00 , C07C69/03 , C07C69/708 , C07C69/732 , C07C69/734 , C07C231/00 , C07C235/06 , C07C235/30 , C07C235/34 , C07C405/00 , C07D295/18 , C07F7/18
CPC分类号： C07C405/0083
摘要： This invention relates to a novel prostacyclin represented by the formula: ##STR1## [wherein R.sup.1 represents --CO.sub.2 R.sup.5 group or --CONR.sup.6 R.sup.7 group; A is(i) --CH.dbd.CH--CH.sub.2 CH.sub.2 -- or(ii) --CH.sub.2 CH.sub.2 --O--CH.sub.2 --;B represents --C.tbd.C-- group; R.sup.2 represents an alkyl group, a cycloalkyl group, an alkenyl group, an alkynyl group, a phenyl group or a phenoxy group;R.sup.3 represents a hydrogen atom, a methyl group or a vinyl group; R.sup.4 represents a hydrogen atom, an acyl group, a tri(1 to 7 carbon atoms)hydrocarbyl-silyl group or a group forming an acetal bond with an oxygen atom of a hydroxy group; a double bond in the substituent represented by A is E or Z, or a mixture thereof; asymmetric center in the substituent represented by R.sup.2 is an R-configuration or S-configuration, or a mixture thereof];and uses in which they are employed as circulation ameliorating pharmaceuticals for blood flow ameliorating, antithrombus and the like, or antiulcer pharmaceuticals.
摘要翻译： PCT No.PCT / JP86 / 00486 Sec。 371日期1987年5月18日 102（e）日期1987年5月18日PCT提交1986年9月18日PCT公布。公开号WO87 / 01696 日本公开号为1987年3月26日。本发明涉及由下式表示的新型前列环素：其中R1表示-CO2R5基或-CONR6R7基; A是（i）-CH = CH-CH 2 CH 2 - 或（ii）-CH 2 CH 2 -O-CH 2 - ; B表示-C3OND C-基团; R2表示烷基，环烷基，烯基，炔基，苯基或苯氧基; R3表示氢原子，甲基或乙烯基; R 4表示氢原子，酰基，三（1〜7个碳原子）烃基 - 甲硅烷基或与羟基的氧原子形成缩醛键的基团。由A表示的取代基中的双键为E或Z，或其混合物; 由R2表示的取代基中的不对称中心是R构型或S-构型，或其混合物]; 以及它们被用作改善血流改善药物的循环改善剂，抗凝血剂等或抗溃疡药物的用途。

2. 发明授权

US4699921A Pharmaceuticals containing prostaglandin I.sub.2 失效
标题翻译：含有前列腺素I2的药物
公开(公告)号：US4699921A
公开(公告)日：1987-10-13
申请号：US763618
申请日：1985-08-08
申请人： Masakatsu Shibasaki , Mikiko Sodeoka , Yuji Ogawa , Toshiaki Mase , Akira Ishibashi , Daijiro Horii , Toshiji Kanayama , Katsuhiko Iseki , Masaki Shinoda , Chiyoko Ishiyama , Yoshio Hayashi
发明人： Masakatsu Shibasaki , Mikiko Sodeoka , Yuji Ogawa , Toshiaki Mase , Akira Ishibashi , Daijiro Horii , Toshiji Kanayama , Katsuhiko Iseki , Masaki Shinoda , Chiyoko Ishiyama , Yoshio Hayashi
IPC分类号： C07C59/46 , A61K31/557 , A61P1/04 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/12 , C07C51/00 , C07C67/00 , C07C69/732 , C07C405/00
CPC分类号： C07C405/0083 , A61K31/557 , Y02P20/55
摘要： Disclosed is a pharmaceutical composition having circulation ameliorating effect and antiulcer effect containing a prostaglandin I.sub.2 analogue represented by the formula shown below or a non-toxic salt or a cyclodextrin inclusion compound thereof as the effective ingredient: ##STR1## wherein R.sup.1 represents a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, a cycloalkyl group having 4 to 7 carbon atoms or a phenyl group, A represents a pentyl group, a cyclopentyl group, a cyclohexyl group, a 1-methyl-3-hexynyl group, a 2-methyl-3-hexynyl group, a 1-methylhexyl group, a 2-phenethyl group, a 1,1-dimethylpentyl group, a 2-methylpentyl group, a 1-cyclohexylethyl group, a 2-methylhexyl group, a 1-methyl-3-pentynyl group or a 2,6-dimethyl-5-heptenyl group; the double bond between the carbon atoms at 4- and 5-positions is E or Z or a mixture thereof; the asymmetric center in the substituent represented by A is in the R-configuration or the S-configuration or a mixture thereof.Pharmaceutical compositions containing, as an active ingredient, prostaglandin I.sub.2 analogues of the present invention have potent platelet aggregation inhibiting effect, blood pressure depressing effect, vasodilative effect and antiulcer effect, and are also low in toxicity.
摘要翻译：本发明公开了一种具有循环改善作用和抗溃疡效果的药物组合物，其含有下述式表示的前列腺素I 2类似物或其无毒性盐或环糊精包合物作为有效成分：其中R 1表示氢原子，碳原子数1〜12的烷基，碳原子数4〜7的环烷基或苯基，A表示戊基，环戊基，环己基，1-甲基-3-己炔基，2 1-甲基-3-己炔基，1-甲基己基，2-苯乙基，1,1-二甲基戊基，2-甲基戊基，1-环己基乙基，2-甲基己基，1-甲基 -3-戊炔基或2,6-二甲基-5-庚烯基; 4-和5-位的碳原子之间的双键是E或Z或它们的混合物; 由A表示的取代基中的不对称中心是R构型或S-构型或其混合物。含有本发明的前列腺素I2类似物作为活性成分的药物组合物具有有效的血小板聚集抑制作用，降血压作用，血管扩张作用和抗溃疡作用，毒性也低。

3. 发明授权

US5053526A Pharmaceuticals containing prostaglandin I.sub.2 失效
标题翻译：含有前列腺素I2的药物
公开(公告)号：US5053526A
公开(公告)日：1991-10-01
申请号：US511945
申请日：1990-04-16
申请人： Masakatsu Shibasaki , Mikiko Sodeoka , Yuji Ogawa , Toshiaki Mase , Akira Ishibashi , Daijiro Horii , Toshiji Kanayama , Katsuhiko Iseki , Masaki Shinoda , Chiyoko Ishiyama , Yoshio Hayashi
发明人： Masakatsu Shibasaki , Mikiko Sodeoka , Yuji Ogawa , Toshiaki Mase , Akira Ishibashi , Daijiro Horii , Toshiji Kanayama , Katsuhiko Iseki , Masaki Shinoda , Chiyoko Ishiyama , Yoshio Hayashi
IPC分类号： A61K31/557 , C07C405/00
CPC分类号： C07C405/0083 , A61K31/557
摘要： Disclosed is a pharmaceutical having circulation ameliorating effect and antiulcer effect containing a prostaglandin I.sub.2 analogue represented by the formula shown below or a non-toxic salt of its salt or a cyclodextrin inclusion compound thereof as the effective ingredient: ##STR1## wherein R.sup.1 represents a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, a cycloalkyl group having 4 to 7 carbon atoms or a phenyl group; A represents a pentyl group, a cyclopentyl group, a cyclohexyl group, a 1-methyl-3-hexynyl group, a 2-methyl-3-hexynyl group, a 1-methylhexyl group, a 2-phenethyl group, a 1,1-dimethylpentyl group, a 2-methylpentyl group, a 1-cyclohexylethyl group, a 2-methylhexyl group, a 1-methyl-3-pentynyl group or 1 2,6-dimethyl-5-heptenyl group; the double bond between the carbon atoms at 4- and 5-positions is E or Z or a mixture thereof, the asymmetric center in the substituent represented by A is R-configuration or S-configuration or a mixture thereof.The pharmaceuticals containing, as an active ingredient, prostaglandin I.sub.2 analogues of the present invention have potent platelet aggregation inhibiting effect, blood pressure depressing effect, vasodilative effect and antiulcer effect, and are also low in toxicity.
摘要翻译：本发明公开了一种具有循环改善作用和抗溃疡效果的药物，其含有下述式表示的前列腺素I2类似物或其盐的无毒性盐或其环糊精包合物作为有效成分：其中R1表示氢原子，碳原子数1〜12的烷基，碳原子数4〜7的环烷基或苯基; A表示戊基，环戊基，环己基，1-甲基-3-己炔基，2-甲基-3-己炔基，1-甲基己基，2-苯乙基，1,1 2-甲基戊基，2-甲基戊基，1-环己基乙基，2-甲基己基，1-甲基-3-戊炔基或1,6-二甲基-5-庚烯基; 在4-和5-位碳原子之间的双键是E或Z或其混合物，由A表示的取代基中的不对称中心是R-构型或S-构型或其混合物。含有本发明的前列腺素I2类似物作为活性成分的药物具有有效的血小板聚集抑制作用，降血压作用，血管扩张作用和抗溃疡作用，毒性也低。

4. 发明授权

US4810805A (2-chloro-3-oxo-1-alkenyl)bicyclo(3.3.0)octane derivative 失效
标题翻译：（2-氯-3-氧代-1-烯基）双环（3.3.0）辛烷衍生物
公开(公告)号：US4810805A
公开(公告)日：1989-03-07
申请号：US943484
申请日：1986-12-19
申请人： Masakatsu Shibasaki , Katsuhiko Iseki , Masaki Shinoda , Chiyoko Aoki , Yoshio Hayashi
发明人： Masakatsu Shibasaki , Katsuhiko Iseki , Masaki Shinoda , Chiyoko Aoki , Yoshio Hayashi
IPC分类号： C07F9/38 , C07C67/343 , C07C69/738 , C07C405/00 , C07F9/40 , C07D309/12
CPC分类号： C07C405/0083
摘要： There are disclosed a (2-chloro-3-oxo-1-alkenyl)-bicyclo[3.3.0 octene derivative represented by the formula: ##STR1## wherein R.sup.1 represents --CH.sub.2 CH.sub.2 CH.sub.2 COOR.sup.5, --CH.sub.2 CH.sub.2 --O--CH.sub.2 COOR.sup.5, --CH.dbd.CHCH.sub.2 COOR.sup.5 or --CH.sub.2 CH.sub.2 C.tbd.C--COOR.sup.5 group where R.sup.5 in the groups represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; R.sup.2 represents a hydrogen atom, an acyl group having 1 to 7 carbon atoms, a tri(1 to 7 carbon atoms)-hydrocarbylsilyl group or a group forming an acetal bonding with an oxygen atom of a hydroxy group; R.sup.3 represents a straight or branched alkyl group having 3 to 10 carbon atoms, a cycloalkyl group having 4 to 7 carbon atoms, which may be substituted by at least one alkyl group having 1 to 4 carbon atoms, a straight or branched alkenyl group having 3 to 12 carbom atoms, a straight or branched alkynyl group having 3 to 8 carbon atoms, a phenyl group or a phenoxy group which may have substituents, an alkoxy group having 1 to 6 carbon atoms or an alkyl group substituted by a cycloalkyl group having 5 to 8 carbon atoms, and a process for preparing the same which comprises reacting an aldehyde represented by the formula: ##STR2## wherein R.sup.1 and R.sup.2 have the same meanings as defined above, with kotophosphonate represented by the formula: ##STR3## wherein R.sup.3 has the same meaning as defined above and R.sup.4 represents an alkyl group having 1 to 10 carbon atoms, in the presence of a base.
摘要翻译：公开了由下式表示的（2-氯-3-氧代-1-烯基） - 二环[3.3.0辛烯衍生物：其中R 1表示-CH 2 CH 2 CH 2 COOR 5，-CH 2 CH 2 -O-CH 2 COOR 5，-CH = CHCH 2 COOR 5 或-CH 2 CH 2 C 3 CON COROR 5基团，其中基团中的R 5表示氢原子或具有1至6个碳原子的烷基; R2表示氢原子，碳原子数1〜7的酰基，三（1〜7个碳原子） - 烃基甲硅烷基或与羟基形成缩醛键的基团。 R3表示可以被至少一个具有1至4个碳原子的烷基取代的具有3至10个碳原子的直链或支链烷基，具有4至7个碳原子的环烷基，具有3个碳原子的直链或支链烯基至12个碳原子，具有3至8个碳原子的直链或支链炔基，可具有取代基的苯基或苯氧基，具有1至6个碳原子的烷氧基或被具有5个环烷基的环烷基取代的烷基至8个碳原子，及其制备方法，其包括使由下式表示的醛：其中R 1和R 2具有与上述相同的含义，与下式表示的焦磷酸酯反应：其中R 3具有在碱的存在下，与上述定义相同，R 4表示具有1至10个碳原子的烷基。

5. 发明授权

US4668677A 4-phenylphthalazine derivatives, their preparation and their use as pharmaceuticals 失效
标题翻译： 4-苯基酞嗪衍生物，它们的制备及其作为药物的用途
公开(公告)号：US4668677A
公开(公告)日：1987-05-26
申请号：US722304
申请日：1985-04-11
申请人： Yasuhiro Morinaka , Katsuhiko Iseki , Toshiji Kanayama , Toshiaki Watanabe , Hiroyoshi Nishi
发明人： Yasuhiro Morinaka , Katsuhiko Iseki , Toshiji Kanayama , Toshiaki Watanabe , Hiroyoshi Nishi
IPC分类号： A61K31/50 , A61K31/502 , A61P7/02 , A61P9/00 , C07D237/34 , C07D237/30
CPC分类号： C07D237/34
摘要： Certain new 1-alkylamino-4-phenylphthalazine derivatives, 1-neopentylamino-4-phenylphthalazine and 1-(1-ethylpropylamino)-4-phenylphthalazine, having prominent activity to ameliorate circulatory disorders and prepared from the corresponding phthalazinones.
摘要翻译：某些新的1-烷基氨基-4-苯基酞嗪衍生物，1-新戊基氨基-4-苯基酞嗪和1-（1-乙基丙基氨基）-4-苯基酞嗪，具有改善循环障碍并由相应的2,3-二氮杂萘酮制备的活性。

6. 发明申请

US20110201650A1 CYCLOHEXANE DERIVATIVE AND PHARMACEUTICAL USE THEREOF 有权
标题翻译：环己烷衍生物和药物用途
公开(公告)号：US20110201650A1
公开(公告)日：2011-08-18
申请号：US13126901
申请日：2009-10-30
申请人： Yasuhiro Morita , Katsuhiko Iseki , Yuji Sugawara , Hideyuki Tsutsui , Shunsuke Iwano , Naoki Izumimoto , Tadamasa Arai , Hidetoshi Noda , Chihiro Yoshida
发明人： Yasuhiro Morita , Katsuhiko Iseki , Yuji Sugawara , Hideyuki Tsutsui , Shunsuke Iwano , Naoki Izumimoto , Tadamasa Arai , Hidetoshi Noda , Chihiro Yoshida
IPC分类号： A61K31/4439 , C07D231/12 , A61K31/415 , C07D401/04 , C07D263/32 , A61K31/421 , C07D277/30 , A61K31/426 , A61P25/04
CPC分类号： A61K31/415 , A61K31/421 , A61K31/426 , A61K31/4439 , C07D231/12 , C07D263/32 , C07D277/24 , C07D401/04
摘要： A compound has a strong analgesic action against both nociceptive pain and neuropathic pain and has less side effects, and is medically useful. The compound includes cyclohexane derivatives represented by the following compound, or pharmaceutically acceptable salts thereof or prodrugs thereof.
摘要翻译：化合物对伤害性疼痛和神经性疼痛均具有强烈的镇痛作用，副作用较小，在医学上有用。该化合物包括由以下化合物表示的环己烷衍生物，或其药学上可接受的盐或其前药。

7. 发明授权

US07309743B2 Fluorine-containing elastomer and composition thereof for crosslinking 有权
标题翻译：含氟弹性体及其组合物用于交联
公开(公告)号：US07309743B2
公开(公告)日：2007-12-18
申请号：US10726604
申请日：2003-12-04
申请人： Kazuyoshi Kawasaki , Masaki Irie , Katsuhiko Iseki , Tsuyoshi Itagaki , Tsuyoshi Noguchi , Takafumi Yamato , Mitsuru Kishine
发明人： Kazuyoshi Kawasaki , Masaki Irie , Katsuhiko Iseki , Tsuyoshi Itagaki , Tsuyoshi Noguchi , Takafumi Yamato , Mitsuru Kishine
IPC分类号： C08L27/12 , C08F8/00
CPC分类号： C08L27/12 , C08F8/00 , C08F8/30 , C08F2800/10 , C08F2810/20 , C08K5/18 , C08K5/29 , C08K5/32 , C08F216/1408
摘要： To provide a novel crosslinking system of fluorine-containing elastomer giving a crosslinked product particularly having improved mechanical strength and compression set at high temperature. A fluorine-containing rubber composition comprising a fluorine-containing elastomer having carboxyl group and/or alkoxycarbonyl group at an end of a trunk chain and/or branched chain as a crosslinkable group.
摘要翻译：提供一种含氟弹性体的新型交联体系，得到交联产物，特别是在高温下具有改进的机械强度和压缩永久变形。一种含氟橡胶组合物，其包含在作为可交联基团的树脂链和/或支链末端具有羧基和/或烷氧基羰基的含氟弹性体。

8. 发明申请

US20120270906A1 CYCLOHEXANE DERIVATIVE AND PHARMACEUTICAL USE THEREOF 有权
标题翻译：环己烷衍生物和药物用途
公开(公告)号：US20120270906A1
公开(公告)日：2012-10-25
申请号：US13534093
申请日：2012-06-27
申请人： Yasuhiro Morita , Katsuhiko Iseki , Yuji Sugawara , Hideyuki Tsutsui , Shunsuke Iwano , Naoki Izumimoto , Tadamasa Arai , Hidetoshi Noda , Chihiro Yoshida
发明人： Yasuhiro Morita , Katsuhiko Iseki , Yuji Sugawara , Hideyuki Tsutsui , Shunsuke Iwano , Naoki Izumimoto , Tadamasa Arai , Hidetoshi Noda , Chihiro Yoshida
IPC分类号： A61K31/415 , A61P29/00 , A61K31/426 , A61K31/4439 , A61K31/421
CPC分类号： A61K31/415 , A61K31/421 , A61K31/426 , A61K31/4439 , C07D231/12 , C07D263/32 , C07D277/24 , C07D401/04
摘要： A method relieves both nociceptive pain and neuropathic pain and has fewer side effects. The compound includes cyclohexane derivatives represented by the following compound, or pharmaceutically acceptable salts thereof or prodrugs thereof.
摘要翻译：一种方法减轻伤害性疼痛和神经性疼痛，副作用较小。该化合物包括由以下化合物表示的环己烷衍生物，或其药学上可接受的盐或其前药。

9. 发明授权

US06191233B1 Fluorinated triallyl isocyanurates, vulcanizable elastomer compositions containing the same, and method for vulcanization 失效
标题翻译：氟化三烯丙基异氰脲酸酯，含有它们的可硫化弹性体组合物和硫化方法
公开(公告)号：US06191233B1
公开(公告)日：2001-02-20
申请号：US09202919
申请日：1998-12-23
申请人： Mitsuru Kishine , Yutaka Ueta , Yoshiko Mori , Satoshi Oishi , Katsuhiko Iseki , Yasuji Iwasaki
发明人： Mitsuru Kishine , Yutaka Ueta , Yoshiko Mori , Satoshi Oishi , Katsuhiko Iseki , Yasuji Iwasaki
IPC分类号： C08F22606
CPC分类号： C07D251/32 , C08K5/34924 , C08L21/00 , C08L27/18 , C08L27/16
摘要： A fluorine-containing triallyl isocyanurate of the formula [I]: wherein at least one of X and Y is a fluorine atom, and the other is a hydrogen atom or a fluorine atom, exhibits good curing properties even when it is used as a crosslinking aid for elastomers which are required to have good heat resistance, such as in particular, fluororubbers, and provides cured materials having good mechanical properties and heat resistance.
摘要翻译：式[I]的含氟三烯丙基异氰脲酸酯：其中X和Y中的至少一个是氟原子，另一个是氢原子或氟原子，即使用作交联剂也表现出良好的固化性能有助于具有良好耐热性的弹性体，特别是氟橡胶，并提供具有良好机械性能和耐热性的固化材料。

10. 发明授权

US5210237A Vitamin D.sub.3 analogues 失效
标题翻译：维生素D3类似物
公开(公告)号：US5210237A
公开(公告)日：1993-05-11
申请号：US750307
申请日：1991-08-27
申请人： Yoshiro Kobayashi , Katsuhiko Iseki , Tadabumi Nagai , Yoko Tanaka , Nobuo Ikekawa
发明人： Yoshiro Kobayashi , Katsuhiko Iseki , Tadabumi Nagai , Yoko Tanaka , Nobuo Ikekawa
IPC分类号： A61K31/59 , A61P35/00 , C07C401/00 , C07F7/18
CPC分类号： C07C401/00 , C07F7/1856 , Y02P20/55
摘要： Vitamin D.sub.3 analogues of the formula: ##STR1## wherein R.sup.1 is hydrogen atom and R.sup.2 is hydroxy, or R.sup.1 is hydroxy and R.sup.2 is hydrogen atom, X is hydrogen atom, hydroxy or a hydroxy protected by a hydroxy-protecting group, and R.sup.3 is hydrogen atom or a hydroxy-protecting group, which have vitamin D.sub.3 -like activities such as activity of controlling calcium metabolism and tumor cell differentiation-inducing activity.

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