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1. 发明申请

US20110009471A1 Oligonucleotide analogues and methods utilizing the same 有权
标题翻译：寡核苷酸类似物和利用其的方法
公开(公告)号：US20110009471A1
公开(公告)日：2011-01-13
申请号：US12804500
申请日：2010-07-22
申请人： Masakatsu Kaneko , Koji Morita , Takeshi Imanishi
发明人： Masakatsu Kaneko , Koji Morita , Takeshi Imanishi
IPC分类号： A61K31/7088 , A61K31/7084 , A61P29/00 , A61P17/06 , A61P31/18 , A61P31/22 , A61P31/16 , A61P35/00 , C07H21/04 , C12P19/34 , G01N33/50
CPC分类号： C07H19/10 , C07H19/06 , C07H19/16 , C07H19/20 , Y02P20/55 , Y10T436/143333
摘要： A method for the prevention or treatment in a mammal of a disease preventable or treatable by the pharmacologically useful antisense or antigene activity of an oligonucleotide analogue or a pharmacologically acceptable salt thereof in the body of said mammal, which method comprises administering to said mammal in need of such prevention or treatment a pharmaceutically effective amount of an oligonucleotide analogue comprising two or more nucleoside units, wherein at least one of said nucleoside units is a structure of the formula (2): wherein A is methylene; and B is an unsubstituted purin-9-yl, an unsubstituted 2-oxo-pyrimidin-1-yl or a substituted purin-9-yl; or a pharmacologically acceptable salt thereof.
摘要翻译：一种用于预防或治疗哺乳动物的疾病，其可通过所述哺乳动物体内的寡核苷酸类似物或其药理学上可接受的盐的药理学上有用的反义或反应活性可预防或治疗的疾病，所述方法包括向需要的所述哺乳动物施用这样的预防或治疗药物有效量的包含两个或多个核苷单位的寡核苷酸类似物，其中所述核苷单元中的至少一个是式（2）的结构：其中A是亚甲基; 和B是未取代的嘌呤-9-基，未取代的2-氧代 - 嘧啶-1-基或取代的嘌呤-9-基; 或其药理学上可接受的盐。

2. 发明授权

US07816333B2 Oligonucleotide analogues and methods utilizing the same 有权
标题翻译：寡核苷酸类似物和利用其的方法
公开(公告)号：US07816333B2
公开(公告)日：2010-10-19
申请号：US11881775
申请日：2007-07-27
申请人： Masakatsu Kaneko , Koji Morita , Takeshi Imanishi
发明人： Masakatsu Kaneko , Koji Morita , Takeshi Imanishi
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： C07H19/10 , C07H19/06 , C07H19/16 , C07H19/20 , Y02P20/55 , Y10T436/143333
摘要： A method for the prevention or treatment in a mammal of a disease preventable or treatable by the pharmacologically useful antisense or antigene activity of an oligonucleotide analogue or a pharmacologically acceptable salt thereof in the body of said mammal, which method comprises administering to said mammal in need of such prevention or treatment a pharmaceutically effective amount of an oligonucleotide analogue comprising two or more nucleoside units, wherein at least one of said nucleoside units is a structure of the formula (2): wherein A is methylene; and B is an unsubstituted purin-9-yl, an unsubstituted 2-oxo-pyrimidin-1-yl or a substituted purin-9-yl; or a pharmacologically acceptable salt thereof.
摘要翻译：一种用于预防或治疗哺乳动物的疾病，其可通过所述哺乳动物体内的寡核苷酸类似物或其药理学上可接受的盐的药理学上有用的反义或反应活性可预防或治疗的疾病，所述方法包括向需要的所述哺乳动物施用这样的预防或治疗药物有效量的包含两个或多个核苷单位的寡核苷酸类似物，其中所述核苷单元中的至少一个是式（2）的结构：其中A是亚甲基; 和B是未取代的嘌呤-9-基，未取代的2-氧代 - 嘧啶-1-基或取代的嘌呤-9-基; 或其药理学上可接受的盐。

3. 发明申请

US20090149404A1 Oligonucleotide analogues and methods utilizing the same 有权
标题翻译：寡核苷酸类似物和利用其的方法
公开(公告)号：US20090149404A1
公开(公告)日：2009-06-11
申请号：US11881775
申请日：2007-07-27
申请人： Masakatsu Kaneko , Koji Morita , Takeshi Imanishi
发明人： Masakatsu Kaneko , Koji Morita , Takeshi Imanishi
IPC分类号： A61K31/7084 , C12Q1/68 , C07H21/00
CPC分类号： C07H19/10 , C07H19/06 , C07H19/16 , C07H19/20 , Y02P20/55 , Y10T436/143333
摘要： A method for the prevention or treatment in a mammal of a disease preventable or treatable by the pharmacologically useful antisense or antigene activity of an oligonucleotide analogue or a pharmacologically acceptable salt thereof in the body of said mammal, which method comprises administering to said mammal in need of such prevention or treatment a pharmaceutically effective amount of an oligonucleotide analogue comprising two or more nucleoside units, wherein at least one of said nucleoside units is a structure of the formula (2): wherein A is methylene; and B is an unsubstituted purin-9-yl, an unsubstituted 2-oxo-pyrimidin-1-yl or a substituted purin-9-yl; or a pharmacologically acceptable salt thereof.
摘要翻译：一种用于预防或治疗哺乳动物的疾病，其可通过所述哺乳动物体内的寡核苷酸类似物或其药理学上可接受的盐的药理学上有用的反义或反应活性可预防或治疗的疾病，所述方法包括向需要的所述哺乳动物施用这样的预防或治疗药物有效量的包含两个或多个核苷单位的寡核苷酸类似物，其中所述核苷单元中的至少一个是式（2）的结构：其中A是亚甲基; 和B是未取代的嘌呤-9-基，未取代的2-氧代 - 嘧啶-1-基或取代的嘌呤-9-基; 或其药理学上可接受的盐。

4. 发明授权

US08957201B2 Oligonucleotide analogues and methods utilizing the same 有权
公开(公告)号：US08957201B2
公开(公告)日：2015-02-17
申请号：US12804500
申请日：2010-07-22
申请人： Masakatsu Kaneko , Koji Morita , Takeshi Imanishi
发明人： Masakatsu Kaneko , Koji Morita , Takeshi Imanishi
IPC分类号： C07H19/00 , C07H19/048
CPC分类号： C07H19/10 , C07H19/06 , C07H19/16 , C07H19/20 , Y02P20/55 , Y10T436/143333
摘要： A method for the prevention or treatment in a mammal of a disease preventable or treatable by the pharmacologically useful antisense or antigene activity of an oligonucleotide analogue or a pharmacologically acceptable salt thereof in the body of said mammal, which method comprises administering to said mammal in need of such prevention or treatment a pharmaceutically effective amount of an oligonucleotide analogue comprising two or more nucleoside units, wherein at least one of said nucleoside units is a structure of the formula (2): wherein A is methylene; and B is an unsubstituted purin-9-yl, an unsubstituted 2-oxo-pyrimidin-1-yl or a substituted purin-9-yl; or a pharmacologically acceptable salt thereof.

5. 发明授权

US07335765B2 Nucleoside and oligonucleotide analogues 有权
标题翻译：核苷和寡核苷酸类似物
公开(公告)号：US07335765B2
公开(公告)日：2008-02-26
申请号：US09925673
申请日：2001-08-09
申请人： Masakatsu Kaneko , Koji Morita , Takeshi Imanishi
发明人： Masakatsu Kaneko , Koji Morita , Takeshi Imanishi
IPC分类号： C07H19/00 , C07H21/00 , C07H19/06 , C70H19/16
CPC分类号： C07H19/10 , C07H19/06 , C07H19/16 , C07H19/20 , Y02P20/55 , Y10T436/143333
摘要： A compound of the formula (1): wherein R1 and R2 are the same or different and represent a hydrogen atom, a hydroxyl protecting group, a phosphate group, or —P(R3)R4, wherein R3 and R4 are the same or different and represent a hydroxyl group, an amino group, an alkoxy group having from 1 to 4 carbon atoms, a cyanoalkoxy group having from 1 to 5 carbon atoms or an amino group substituted by an alkyl group having from 1 to 4 carbon atoms; A represents an alkylene group having from 1 to 4 carbon atoms and B represents a purin-9-yl group, a 2-oxo-pyrimidin-1-yl group, a substituted purin-9-yl group or a substituted 2-oxo-pyrimidin-1-yl group having a substituent α selected from the group consisting of a hydroxyl group which may be protected, an alkoxy group having from 1 to 4 carbon atoms, a mercapto group which may be protected, an alkylthio group having from 1 to 4 carbon atoms, an alkoxy group having from 1 to 4 carbon atoms, an amino group which may be protected, a mono- or di-alkylamino group which may be substituted by an alkyl group having from 1 to 4 carbon atoms, an alkyl group having from 1 to 4 carbon atoms and a halogen atom; or a salt thereof.
摘要翻译：式（1）的化合物：其中R 1和R 2相同或不同，表示氢原子，羟基保护基，磷酸基或 -P（R 3）R 4，其中R 3和R 4相同或不同，表示羟基，氨基，具有1至4个碳原子的烷氧基，具有1至5个碳原子的氰基烷氧基或被具有1至4个碳原子的烷基取代的氨基; A表示具有1至4个碳原子的亚烷基，B表示嘌呤-9-基，2-氧代 - 嘧啶-1-基，取代的嘌呤-9-基或取代的2-氧代 - 具有选自可被保护的羟基，具有1至4个碳原子的烷氧基，可被保护的巯基的取代基的嘧啶-1-基，具有1至4个碳原子的烷硫基， 4个碳原子，具有1至4个碳原子的烷氧基，可被保护的氨基，可以被具有1至4个碳原子的烷基取代的一烷基或二烷基氨基，烷基具有1至4个碳原子和卤素原子; 或其盐。

6. 发明授权

US07314923B2 Nucleoside and oligonucleotide analogues 有权
标题翻译：核苷和寡核苷酸类似物
公开(公告)号：US07314923B2
公开(公告)日：2008-01-01
申请号：US10430705
申请日：2003-05-05
申请人： Masakatsu Kaneko , Koji Morita , Takeshi Imanishi
发明人： Masakatsu Kaneko , Koji Morita , Takeshi Imanishi
IPC分类号： C07H21/02 , C07H21/04 , A61K31/70 , A01N43/04
CPC分类号： C07H19/10 , C07H19/06 , C07H19/16 , C07H19/20 , Y02P20/55 , Y10T436/143333
摘要： A probe for a gene or a primer for starting amplification comprising an oligonucleotide analogue comprising two or more nucleoside units, wherein at least one of the nucleoside units is a structure of the formula (2): wherein A represents a C1-C4 alkylene group, and B is an unsubstituted purin-9-yl group, an unsubstituted 2-oxo-pyrimidin-1-yl-group, a substituted purin-9-yl-group or a substituted 2-oxo-pyrimidin-1-yl group. Also a method for preventing or treating a disease preventable or treatable by the antisense or antigene activity of an oligonucleotide by administering the oligonucleotide analogue.
摘要翻译：用于开始扩增的基因或引物的探针，其包含包含两个或多个核苷单元的寡核苷酸类似物，其中所述核苷单元中的至少一个是式（2）的结构：其中A表示C 1' C 1 -C 4亚烷基，B是未取代的嘌呤-9-基，未取代的2-氧代 - 嘧啶-1-基，取代的嘌呤-9-基 - 基团或取代的2-氧代 - 嘧啶-1-基。也是通过施用寡核苷酸类似物来预防或治疗可通过寡核苷酸的反义或反义活性预防或治疗的疾病的方法。

7. 发明授权

US07994145B2 Bicyclonucleoside analogues 失效
标题翻译：双环核苷类似物
公开(公告)号：US07994145B2
公开(公告)日：2011-08-09
申请号：US11700361
申请日：2007-01-31
申请人： Takeshi Imanishi , Satoshi Obika
发明人： Takeshi Imanishi , Satoshi Obika
IPC分类号： A61K48/00 , C07H21/02
CPC分类号： C07H19/06 , C07H19/16 , C07H21/00 , Y02P20/55
摘要： Oligonucleotide analogues which have anti-sense or anti-gene activity, as well as in vivo stability, or pharmaceutically acceptable salts thereof. The oligonucleotide analogues have one or more structural units represented by the following formula (1a): provided that when the oligonucleotide has two or more structural units of formula (1a), each B is the same or different, wherein B represents a purin-9-yl group or a 2-oxo-1,2-dihydropyrimidin-1-yl group.
摘要翻译：具有反义或抗基因活性的寡核苷酸类似物，以及体内稳定性或其药学上可接受的盐。寡核苷酸类似物具有一个或多个由下式（1a）表示的结构单元：条件是当寡核苷酸具有两个或更多个式（1a）的结构单元时，每个B相同或不同，其中B表示嘌呤-9 - 基或2-氧代-1,2-二氢嘧啶-1-基。

8. 发明授权

US06337141B1 Swash-plate of swash-plate type compressor 失效
标题翻译：斜盘式压缩机斜盘
公开(公告)号：US06337141B1
公开(公告)日：2002-01-08
申请号：US09464775
申请日：1999-12-16
申请人： Toyokazu Yamada , Soo-Myung Hong , Masanori Akiduki , Takashi Kokubo , Hiroaki Kayukawa , Hideki Mizutani , Manabu Sugiura , Takeshi Imanishi
发明人： Toyokazu Yamada , Soo-Myung Hong , Masanori Akiduki , Takashi Kokubo , Hiroaki Kayukawa , Hideki Mizutani , Manabu Sugiura , Takeshi Imanishi
IPC分类号： C23C406
CPC分类号： C23C4/06 , C23C4/04 , F04B27/086 , F04B27/1054 , F05C2201/021 , F05C2201/903 , F05C2203/06 , F05C2253/12 , Y10S428/937 , Y10T428/12063 , Y10T428/12139 , Y10T428/12167 , Y10T428/12174 , Y10T428/1275 , Y10T428/12757 , Y10T428/12764
摘要： The seizure resistance of an Al-based flame-sprayed layer formed on the swash plate of a swash-plate type comressor is increased to such a level comparable to that of a flame-sprayed bronze layer. The Al-based flame-sprayed layer of the present invention contains: from 12 to 60% of Si and granular Si particles dispersed in the matrix thereof, and at least one dispersing phase of graphite carbon, amorphous carbon and carbon, the crystallizing degree of which is between the graphite carbon and amorphous carbon, and MoS2.
摘要翻译：形成在旋转斜盘式压缩机的旋转斜盘上的Al系火焰喷涂层的耐发泡性提高到与火焰喷镀的青铜层相当的水平。本发明的Al系火焰喷涂层含有12〜60％的分散在基体中的Si和粒状Si粒子，以及石墨碳，无定形碳和碳的至少一种分散相，其结晶度为在石墨碳和无定形碳之间，和MoS2。

9. 发明授权

US6043060A Nucleotide analogues 失效
标题翻译：核苷酸类似物
公开(公告)号：US6043060A
公开(公告)日：2000-03-28
申请号：US308367
申请日：1999-05-18
申请人： Takeshi Imanishi
发明人： Takeshi Imanishi
IPC分类号： C07H19/10 , C07H19/20 , C07H21/00 , C12N15/113
CPC分类号： C12N15/113 , C07H19/10 , C07H19/20 , C07H21/00 , C12N2310/3231
摘要： An oligonucleotide analog or an antisense molecule, which is minimally hydrolyzable with an enzyme in vivo, has a high sense strand binding ability, and is easily synthesized, is provided. It is an oligo- or polynucleotide analog containing one or more monomer units being nucleotide analogs of the general formula: ##STR1## where B may be identical or different, and is a pyrimidine or purine nucleic acid base, or a derivative thereof.
摘要翻译： PCT No.PCT / JP97 / 04187 Sec。 371日期1999年5月18日 102（e）日期1999年5月18日PCT 1997年11月18日PCT公布。公开号WO98 / 22489 日期1998年5月28日在体内用酶最低限度地水解的寡核苷酸类似物或反义分子具有高有义链结合能力，容易合成。它是含有一个或多个单体单元的寡核苷酸或多核苷酸类似物，其是通式的核苷酸类似物：其中B可以相同或不同，并且是嘧啶或嘌呤核酸碱基或其衍生物。

10. 发明申请

US20070270370A1 Novel bicyclonucleoside analogues 失效
标题翻译：新型双环核苷类似物
公开(公告)号：US20070270370A1
公开(公告)日：2007-11-22
申请号：US11700361
申请日：2007-01-31
申请人： Takeshi Imanishi , Satoshi Obika
发明人： Takeshi Imanishi , Satoshi Obika
IPC分类号： A61K31/7088 , A61P17/00 , A61P17/06 , A61P31/04 , A61P31/12 , A61P31/16 , A61P31/18 , A61P35/00 , A61P43/00 , C07H21/00
CPC分类号： C07H19/06 , C07H19/16 , C07H21/00 , Y02P20/55
摘要： Oligonucleotide analogues which have anti-sense or anti-gene activity, as well as in vivo stability, or pharmaceutically acceptable salts thereof. The oligonucleotide analogues have one or more structural units represented by the following formula (1a): provided that when the oligonucleotide has two or more structural units of formula (1a), each B is the same or different, wherein B represents a purin-9-yl group or a 2-oxo-1,2-dihydropyrimidin-1-yl group.
摘要翻译：具有反义或抗基因活性的寡核苷酸类似物，以及体内稳定性或其药学上可接受的盐。寡核苷酸类似物具有一个或多个由下式（1a）表示的结构单元：条件是当寡核苷酸具有两个或更多个式（1a）的结构单元时，每个B相同或不同，其中B表示嘌呤-9 - 基或2-氧代-1,2-二氢嘧啶-1-基。

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