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1. 发明授权

US5637309A Physiologically active substance-prolonged releasing-type pharmaceutical preparation 失效
标题翻译：生理活性物质延长释放型药物制剂
公开(公告)号：US5637309A
公开(公告)日：1997-06-10
申请号：US309152
申请日：1994-09-20
申请人： Masahiro Tajima , Takashi Yoshimoto , Shoji Fukushima , Toshihiko Kaminuma , Ritsuko Ehama , Takaaki Baba , Kazuo Watabe
发明人： Masahiro Tajima , Takashi Yoshimoto , Shoji Fukushima , Toshihiko Kaminuma , Ritsuko Ehama , Takaaki Baba , Kazuo Watabe
IPC分类号： A61K9/20 , A61K9/22 , A61K38/00 , A61K38/22 , C07K14/435 , A61F2/00
CPC分类号： C07K14/43577 , A61K38/225 , A61K9/2013 , A61K9/2027 , A61K9/205 , A61K9/2054 , A61K38/00 , Y10S514/808 , Y10S514/929
摘要： A prolonged releasing pharmaceutical preparation is provided carrying a physiologically active substance, particularly, calcitonin gene-related peptide (CGRP) or a maxadilan (MAX). This pharmaceutical preparation can attain the expected effects by incorporating the physiologically active substance into a combination, as carriers for the physiologically active substance, of a cellulosic polymer and at least one auxiliary component selected from the group consisting of fats and oils, waxes, fatty acids, saccharides and polyacrylate ester derivatives. The pharmaceutical preparation can conveniently be used, in living bodies, particularly as an intrathecal implantation-type preparation.
摘要翻译：提供延长释放的药物制剂，其携带生理活性物质，特别是降钙素基因相关肽（CGRP）或maxadilan（MAX）。这种药物制剂可以通过将生理活性物质并入作为生理活性物质的载体的纤维素聚合物和至少一种选自脂肪和油，蜡，脂肪酸的辅助成分的组合来实现预期的效果，糖和聚丙烯酸酯衍生物。药物制剂可以方便地用于生物体中，特别是鞘内注射型制剂。

2. 发明授权

US5993855A Delayed drug-releasing microspheres 失效
标题翻译：延迟药物释放微球
公开(公告)号：US5993855A
公开(公告)日：1999-11-30
申请号：US710648
申请日：1996-09-18
申请人： Takashi Yoshimoto , Masahiro Tajima , Kazuo Watabe
发明人： Takashi Yoshimoto , Masahiro Tajima , Kazuo Watabe
IPC分类号： A61K9/00 , A61K9/16 , A61K9/52 , A61K38/00 , A61K38/22 , A61K38/23 , A61K47/34 , A61P9/08 , B01J13/12 , A61K9/14
CPC分类号： A61K9/0085 , A61K38/1767 , A61K38/225 , A61K9/1647
摘要： Microspheres prepared by emulsifying an aqueous phase containing a drug and an oil phase containing a biodegradable polymer to form a W/O emulsion, and then mixing and agitating this emulsion with another aqueous phase constituting a continuous phase to form a W/O/W emulsion. These microspheres can release a major portion of the drug after a predetermined period of time has elapsed after their administration to the patient, and are especially suitable for intracerebral implantation.
摘要翻译：通过乳化包含药物的水相和含有可生物降解聚合物的油相以形成W / O乳液制备的微球，然后将该乳液与构成连续相的另一水相混合并搅拌以形成W / O / W乳液。这些微球体在给予患者之后经过预定的时间后能释放大部分药物，特别适用于脑内植入。

3. 发明申请

US20070299032A1 Method and Composition for Thickening Hair 审中-公开
标题翻译：增稠头发的方法和组成
公开(公告)号：US20070299032A1
公开(公告)日：2007-12-27
申请号：US10578507
申请日：2004-11-10
申请人： Ritsuko Ehama , Masato Iino , Yosuke Nakazawa , Masahiro Tajima , Masashi Ogou , Seiji Arase
发明人： Ritsuko Ehama , Masato Iino , Yosuke Nakazawa , Masahiro Tajima , Masashi Ogou , Seiji Arase
IPC分类号： A61K31/7076 , A61P17/14 , C12Q1/68
CPC分类号： G01N33/5008 , A61K8/606 , A61Q5/00 , A61Q7/00 , G01N2333/475 , G01N2500/10
摘要： The present invention provides a method for maintaining and promoting hair thickening by increasing the expression of keratinocyte growth factor (FGF-7) in hair follicle cells, and preferably dermal papilla cells, a composition for increasing expression of FGF-7 that contains adenosine and/or a derivative thereof, and particularly, an external scalp preparation for maintaining and promoting hair thickening.
摘要翻译：本发明提供一种通过增加毛囊细胞中角质形成细胞生长因子（FGF-7）的表达并优选皮肤乳头细胞来维持和促进毛发增稠的方法，用于增加含有腺苷和/ 或其衍生物，特别是用于保持和促进毛发增厚的外用头皮制剂。

4. 发明授权

US5612454A Process for purification of polypeptide using a buchner funnel 失效
标题翻译：使用布氏漏斗纯化多肽的方法
公开(公告)号：US5612454A
公开(公告)日：1997-03-18
申请号：US776272
申请日：1991-11-29
申请人： Toshihiko Kaminuma , Toshii Iida , Masahiro Tajima
发明人： Toshihiko Kaminuma , Toshii Iida , Masahiro Tajima
IPC分类号： C07K1/16 , C07K1/36 , A61K38/00 , A61K38/02 , C07K1/00 , C07K5/00
CPC分类号： C07K1/16 , C07K1/36
摘要： An improved process for purifying a polypeptide using a packing material for reversed phase high performance liquid chromatography is provided. A process for purifying a polypeptide characterized in that an aqueous solution containing polypeptide obtained by pre-treating a polypeptide produced by a wide variety of cells to a predetermined state is adjusted to a specific pH value, to remove impurities, and is then treated with a packing material for reversed phase high performance liquid chromatography.
摘要翻译： PCT No.PCT / JP91 / 00421 Sec。 371日期：1991年11月29日 102（e）1991年11月29日PCT PCT 1991年3月29日PCT。公开号WO91 / 15502 日期1991年10月17日提供了一种使用反相高效液相色谱法的填充材料纯化多肽的改进方法。一种纯化多肽的方法，其特征在于，将通过将由多种细胞产生的多肽预处理至预定状态而获得的含有多肽的水溶液调节至特定的pH值以除去杂质，然后用用于反相高效液相色谱的包装材料。

5. 发明授权

US6156555A Method of preparing an enzyme participating in C-terminal amidation 失效
标题翻译：制备参与C-末端酰胺化的酶的方法
公开(公告)号：US6156555A
公开(公告)日：2000-12-05
申请号：US172120
申请日：1998-10-14
申请人： Toshii Iida , Toshihiko Kaminuma , Yuka Fuse , Masahiro Tajima , Mitsuo Yanagi , Hiroshi Okamoto , Jiro Kishimoto , Ohji Ifuku , Ichiro Kato
发明人： Toshii Iida , Toshihiko Kaminuma , Yuka Fuse , Masahiro Tajima , Mitsuo Yanagi , Hiroshi Okamoto , Jiro Kishimoto , Ohji Ifuku , Ichiro Kato
IPC分类号： C07K1/107 , C12N9/02 , C12N15/53 , C12N15/60 , C12N9/48 , C12N9/14 , C12N9/78 , C12N9/80 , C12N15/00
CPC分类号： C12N9/0071 , C07K1/107 , C12Y114/17003 , Y10S435/814 , Y10S435/815
摘要： A purified enzyme-I is obtained that participates in C-terminal amidation by acting on a peptide C-terminal glycine adduct to form a peptide C-terminal .alpha.-hydroxyglycine adduct. The enzyme has an optimum pH of about 5 to 7, an optimum temperature of 25 to 40.degree. C. and a molecular weight of about 25 kDa or about 36 kDa, and metal ions and ascorbic acid act as a cofactor. A purified enzyme-II is obtained that participates in C-terminal amidation by acting on the peptide C-terminal .alpha.-hydroxyglycine adduct to produce a C-terminal amidated compound. The enzyme has an optimum pH of about 5 to 6, an optimum temperature of 15 to 35.degree. C. and a molecular weight of about 40 kDa or about 43 kDa. Enzyme-I does not act on the peptide C-terminal .alpha.-hydroxyglycine adduct and enzyme-II does not act on the peptide C-terminal glycine adduct. The enzymes may be purified from a biological material such as horse serum by affinity chromatography using a peptide C-terminal glycine adduct as a ligand. The enzymes may also be obtained from host cells transformed with a plasmid containing a cDNA coding for the enzymes. Assay of activity of the enzymes is carried out by measuring the C-terminal .alpha.-hydroxyglycine adduct or the C-terminal amidated compound that has been isolated such as by high performance liquid chromatography with the use of an acetonitrile-containing buffer.
摘要翻译：获得通过作用于肽C-末端甘氨酸加合物以形成肽C末端α-羟基甘氨酸加合物参与C-末端酰胺化的纯化的酶I. 酶的最佳pH为约5至7，最适温度为25至40℃，分子量为约25kDa或约36kDa，金属离子和抗坏血酸用作辅因子。获得了通过作用于肽C-末端α-羟基甘氨酸加合物参与C-末端酰胺化产生C末端酰胺化合物的纯化的酶-II。酶的最佳pH为约5至6，最适温度为15至35℃，分子量为约40kDa或约43kDa。酶-I不对肽C-端α-羟基甘氨酸加合物起作用，酶-II不对肽C-末端甘氨酸加合物起作用。可以使用肽C-末端甘氨酸加合物作为配体通过亲和层析从生物材料如马血清中纯化酶。酶也可以从用含有编码酶的cDNA的质粒转化的宿主细胞获得。酶的活性测定是通过使用含有乙腈的缓冲液，通过高分辨液相色谱法测定已分离的C末端α-羟基甘氨酸加成物或C末端酰胺化合物进行的。

6. 发明授权

US5871995A Purified enzymes participating in C-terminal amidation 失效
标题翻译：纯化酶参与C-末端酰胺化
公开(公告)号：US5871995A
公开(公告)日：1999-02-16
申请号：US070301
申请日：1991-05-24
申请人： Toshii Iida , Toshihiko Kaminuma , Yuka Fuse , Masahiro Tajima , Mitsuo Yanagi , Hiroshi Okamoto , Jiro Kishimoto , Ohji Ifuku , Ichiro Kato
发明人： Toshii Iida , Toshihiko Kaminuma , Yuka Fuse , Masahiro Tajima , Mitsuo Yanagi , Hiroshi Okamoto , Jiro Kishimoto , Ohji Ifuku , Ichiro Kato
IPC分类号： C07K1/107 , C12N9/02 , C12N15/53 , C12N15/60 , C12N9/48 , C12N9/14 , C12N9/78 , C12N9/80
CPC分类号： C12N9/0071 , C07K1/107 , C12Y114/17003 , Y10S435/814 , Y10S435/815
摘要： A purified enzyme-I is obtained that participates in C-terminal amidation by acting on a peptide C-terminal glycine adduct to form a peptide C-terminal .alpha.-hydroxyglycine adduct. The enzyme has an optimum pH of about 5 to 7, an optimum temperature of 25.degree. to 40.degree. C. and a molecular weight of about 25 kDa or about 36 kDa, and metal ions and ascorbic acid act as a cofactor. A purified enzyme-II is obtained that participates in C-terminal amidation by acting on a peptide C-terminal .alpha.-hydroxyglycine adduct to produce a C-terminal amidated compound. The enzyme has an optimum pH of about 5 to 6, an optimum temperature of 15.degree. to 35.degree. C. and a molecular weight of about 40 kDa or about 43 kDa. Enzyme-I does not act on the peptide C-terminal .alpha.-hydroxyglycine adduct and enzyme-II does not act on the peptide C-terminal glycine adduct. The enzymes may be purified from a biological material such as horse serum by affinity chromatography using a peptide C-terminal glycine adduct as a ligand. The enzymes may also be obtained from host cells transformed with a plasmid containing a cDNA coding for the enzymes. Assay of activity of the enzymes is carried out by measuring adduct (II) or the compound (III) that has been isolated such as by high performance liquid chromatography with the use of an acetonitrile-containing buffer.
摘要翻译： PCT No.PCT / JP90 / 01036 Sec。 371日期1991年5月24日 102（e）日期1991年5月24日PCT提交1990年4月12日PCT公布。公开号WO91 / 02790 日期1991年3月7日获得通过作用于肽C-末端甘氨酸加合物以形成肽C-末端α-羟基甘氨酸加合物参与C-末端酰胺化的纯化的酶-I。酶的最佳pH为约5至7，最适温度为25至40℃，分子量为约25kDa或约36kDa，金属离子和抗坏血酸用作辅因子。获得了通过作用于肽C-末端α-羟基甘氨酸加合物以产生C末端酰胺化合物而参与C-末端酰胺化的纯化的酶-II。酶的最佳pH为约5至6，最适温度为15-35℃，分子量为约40kDa或约43kDa。酶-I不对肽C-端α-羟基甘氨酸加合物起作用，酶-II不对肽C-末端甘氨酸加合物起作用。可以使用肽C-末端甘氨酸加合物作为配体通过亲和层析从生物材料如马血清中纯化酶。酶也可以从用含有编码酶的cDNA的质粒转化的宿主细胞获得。酶的活性测定是通过使用含乙腈的缓冲液测定加成物（II）或分离的化合物（III），例如通过高效液相色谱法进行的。

7. 发明申请

US20070298134A1 Composition and Method for Scalp and Hair Treatment 审中-公开
标题翻译：头皮和头发处理的组成和方法
公开(公告)号：US20070298134A1
公开(公告)日：2007-12-27
申请号：US11794120
申请日：2005-12-28
申请人： Masato Iino , Satoshi Yamaki , Satoshi Nakanishi , Masahiro Tajima , Ryuji Ueno
发明人： Masato Iino , Satoshi Yamaki , Satoshi Nakanishi , Masahiro Tajima , Ryuji Ueno
IPC分类号： A61K36/534 , A61Q5/00 , A61Q7/00
CPC分类号： C07D319/06 , A61K8/365 , A61K8/37 , A61K8/4973 , A61K8/498 , A61K9/0014 , A61K9/06 , A61K47/10 , A61Q5/006 , A61Q7/00 , C07C69/734 , C07D317/30
摘要： Provided is a composition for scalp and hair treatment, comprising a menthol derivative and a prostaglandin compound having two hetero atoms at the 15 position. The composition of the present invention is effective not only for preventing dandruff and itchy scalp but also for preventing or treating hair loss, baldness, or hair thinness.
摘要翻译：本发明提供一种用于头皮和头发处理的组合物，其包含薄荷醇衍生物和在15位具有两个杂原子的前列腺素化合物。本发明的组合物不仅对防止头皮屑和瘙痒的头皮也有效，而且对于防止或治疗脱发，秃发或毛发变薄是有效的。

8. 发明申请

US20140212441A1 PHARMACEUTICAL COMPOSITION FOR INFLAMMATORY DISEASES, ALLERGIC DISEASES AND AUTOIMMUNE DISEASES 审中-公开
标题翻译：用于炎症性疾病，过敏性疾病和自发性疾病的药物组合物
公开(公告)号：US20140212441A1
公开(公告)日：2014-07-31
申请号：US14128257
申请日：2012-06-20
申请人： Yukihiko Mashima , Masahiro Tajima , Reiko Tabuchi
发明人： Yukihiko Mashima , Masahiro Tajima , Reiko Tabuchi
IPC分类号： A61K39/00
CPC分类号： A61K39/0005 , A61K31/5575 , A61K31/5585 , C07D317/20 , C07D319/06
摘要： The present invention relates to methods and pharmaceutical compositions for immunosuppression by using the fatty acid derivative represented by formula (I). The present invention further relates to methods and pharmaceutical compositions for treating inflammatory diseases, allergic diseases and autoimmune diseases by using said fatty acid derivative.
摘要翻译：本发明涉及通过使用由式（I）表示的脂肪酸衍生物的免疫抑制的方法和药物组合物。本发明还涉及通过使用所述脂肪酸衍生物治疗炎性疾病，过敏性疾病和自身免疫疾病的方法和药物组合物。

9. 发明申请

US20080064723A1 Anti-Hair Graying Agent 审中-公开
标题翻译：防发灰剂
公开(公告)号：US20080064723A1
公开(公告)日：2008-03-13
申请号：US11665214
申请日：2005-10-13
申请人： Ritsuro Ideta , Yosuke Nakazawa , Haruhi Iwaki , Akihiro Ishino , Masahiro Tajima
发明人： Ritsuro Ideta , Yosuke Nakazawa , Haruhi Iwaki , Akihiro Ishino , Masahiro Tajima
IPC分类号： A61K31/13 , A61K31/195 , A61K31/445 , A61P17/00
CPC分类号： A61K8/4926 , A61K8/44 , A61K31/133 , A61K31/196 , A61K31/215 , A61K31/445 , A61K31/4465 , A61Q5/10
摘要： An anti-hair graying agent containing, as an active ingredient, a substance having a superior anti-hair graying action, for example, aminocyclohexane carboxylic acid, aminocyclohexane carboxylic acid esters such as aminocyclohexane carboxylic acid ethyl ester, aminocyclohexane derivatives such as aminocyclohexanol, and piperidinecarboxylic acid, piperidinecarboxylic acid esters such as piperidinecarboxylic acid ethyl ester, and piperidine derivatives such as hydroxypiperidine is provided.
摘要翻译：作为活性成分，含有优异的防毛发作用的物质，例如氨基环己烷羧酸，氨基环己烷羧酸酯如氨基环己烷羧酸乙酯，氨基环己烷衍生物如氨基环己醇的抗头发变灰剂和哌啶羧酸，哌啶羧酸酯如哌啶羧酸乙酯和哌啶衍生物如羟基哌啶。

10. 发明申请

US20050176822A1 Phenylacetonitrile derivatives and hair tonics and external preparations for skin containing the derivatives 审中-公开
标题翻译：苯乙腈衍生物和头发滋养物以及含有衍生物的皮肤外用制剂
公开(公告)号：US20050176822A1
公开(公告)日：2005-08-11
申请号：US10509246
申请日：2003-03-28
申请人： Naoto Hanyu , Koji Kobayashi , Masahiro Tajima , Akihiro Ishino
发明人： Naoto Hanyu , Koji Kobayashi , Masahiro Tajima , Akihiro Ishino
IPC分类号： A61K8/40 , A61K8/41 , A61P17/14 , A61Q7/00 , A61Q19/00 , C07C255/42 , C07C255/43 , A61K31/277
CPC分类号： A61Q19/00 , A61K8/40 , A61K8/41 , A61Q7/00 , C07C255/42 , C07C255/43
摘要： A hair growth promoting composition comprising, as an effective ingredient, a phenylacetonitrile derivative or a pharmacologically acceptable salt thereof expressed by the following Formula (I): wherein each of R1 and R2 is hydrogen atom, a C1-10 alkyl group, a C2-10 alkenyl group or C2-10 acyl group, or NR1R2 may be a heterocycle having 3-7 members; R3 is a C1-5 alkyl group; and each of R4, R5 and R6 is hydrogen atom or a C1-4 alkoxy group. The present invention provides a hair growth promoting composition having excellent effects on promoting hair regrowth, preventing or inhibiting hair loss, and the like in human by compounding above-specified phenylacetonitrile derivative as a effective ingredient thereto.
摘要翻译：一种毛发生长促进组合物，其包含由下式（I）表示的苯乙腈衍生物或其药理学上可接受的盐作为有效成分：其中R 1和R 2各自表示， SUP>是氢原子，C 1-10烷基，C 2-10链烯基或C 2-10酰基，或NR 1 R 2可以是具有3-7个成员的杂环; R 3是C 1-5烷基; R 4，R 5和R 6中的每一个为氢原子或C 1-4烷氧基。本发明提供一种通过将上述规定的苯乙腈衍生物作为有效成分配合而具有对促进毛发再生，预防或抑制脱发等的效果的毛发生长促进组合物。

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