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1. 发明授权

US08367695B2 Condensed tetrahydroquinoline derivative and use thereof for medical purposes 失效
标题翻译：缩合四氢喹啉衍生物及其用于医疗目的的用途
公开(公告)号：US08367695B2
公开(公告)日：2013-02-05
申请号：US12523031
申请日：2008-01-15
申请人： Masahiro Eda , Tomoko Kuroda , Keiichi Aritomo , Yoshiyuki Aoki , Satoshi Kaneko
发明人： Masahiro Eda , Tomoko Kuroda , Keiichi Aritomo , Yoshiyuki Aoki , Satoshi Kaneko
IPC分类号： A61K31/435 , A61K31/4355
CPC分类号： C07D519/00 , C07D221/16 , C07D401/04 , C07D409/04 , C07D413/04 , C07D471/04 , C07D491/04 , C07D495/04
摘要： The problem of the present invention is to provide a compound having a GR selective binding activity, which shows less action on other nuclear receptors such as progesterone receptor (PR), mineralocorticoid receptor (MR) and the like. The present invention provides a condensed tetrahydroquinoline compound represented by the following formula (I) wherein each symbol is as defined in the present specification, or a pharmaceutically acceptable salt thereof or a hydrate thereof.
摘要翻译：本发明的问题是提供具有GR选择性结合活性的化合物，其对其它核受体如孕酮受体（PR），盐皮质激素受体（MR）等显示较少的作用。本发明提供由下式（I）表示的缩合四氢喹啉化合物，其中各符号如本说明书中所定义，或其药学上可接受的盐或其水合物。

2. 发明申请

US20100063055A1 CONDENSED TETRAHYDROQUINOLINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES 失效
标题翻译：浓缩四氢喹啉衍生物及其用于医疗用途
公开(公告)号：US20100063055A1
公开(公告)日：2010-03-11
申请号：US12523031
申请日：2008-01-15
申请人： Masahiro Eda , Tomoko Kuroda , Keiichi Aritomo , Yoshiyuki Aoki , Satoshi Kaneko
发明人： Masahiro Eda , Tomoko Kuroda , Keiichi Aritomo , Yoshiyuki Aoki , Satoshi Kaneko
IPC分类号： A61K31/473 , C07D221/16 , C07D413/10 , C07D401/10 , C07D471/04 , C07D487/04 , A61K31/4741 , A61K31/4985 , A61P25/00 , A61P25/22 , A61P25/24
CPC分类号： C07D519/00 , C07D221/16 , C07D401/04 , C07D409/04 , C07D413/04 , C07D471/04 , C07D491/04 , C07D495/04
摘要： The problem of the present invention is to provide a compound having a GR selective binding activity, which shows less action on other nuclear receptors such as progesterone receptor (PR), mineralocorticoid receptor (MR) and the like. The present invention provides a condensed tetrahydroquinoline compound represented by the following formula (I) wherein each symbol is as defined in the present specification, or a pharmaceutically acceptable salt thereof or a hydrate thereof.
摘要翻译：本发明的问题是提供具有GR选择性结合活性的化合物，其对其它核受体如孕酮受体（PR），盐皮质激素受体（MR）等显示较少的作用。本发明提供由下式（I）表示的缩合四氢喹啉化合物，其中各符号如本说明书中所定义，或其药学上可接受的盐或其水合物。

3. 发明申请

US20080167307A1 Carboxylic Acid Derivative Containing Thiazole Ring and Pharmaceutical Use Thereof 失效
标题翻译：含有噻唑环的羧酸衍生物及其药物用途
公开(公告)号：US20080167307A1
公开(公告)日：2008-07-10
申请号：US11667006
申请日：2005-11-04
申请人： Takashi Tozawa , Osamu Tsuruta , Hiroshi Kitajima , Yoshiyuki Aoki , Naoko Ando , Hiroki Tamakawa
发明人： Takashi Tozawa , Osamu Tsuruta , Hiroshi Kitajima , Yoshiyuki Aoki , Naoko Ando , Hiroki Tamakawa
IPC分类号： A61K31/5377 , C07D277/20 , C07D295/00 , C07D213/02 , C07D239/24 , A61K31/506 , A61K31/496 , A61K31/435 , A61P9/00 , A61K31/498 , A61K31/4523 , A61K31/501 , C07D237/06 , C07D221/00 , C07D241/36 , A61K31/426
CPC分类号： C07D277/36
摘要： According to the present invention, a compound represented by the following formula (I) having a superior PPARα agonist action and concurrently showing a hypolipidemic action can be provided, and further, a compound useful as a synthetic intermediate for the compound can be provided.
摘要翻译：根据本发明，可以提供具有优异的PPARααA激动剂作用并同时显示降血脂作用的下式（I）表示的化合物，此外，可用作合成中间体可以提供化合物。

4. 发明申请

US20050168690A1 Light control plastic lens, coated sheet-like light control element for the lens production, and a production method for light control plastic lens 有权
标题翻译：光控塑料透镜，用于镜片生产的涂层片状光控元件，以及光控塑料透镜的制造方法
公开(公告)号：US20050168690A1
公开(公告)日：2005-08-04
申请号：US11041337
申请日：2005-01-25
申请人： Ryozo Kawai , Yoshiyuki Aoki , Kyohei Takakuwa , Mitsuhiko Masumoto , Toshizumi Hirota , Motoharu Takeuchi
发明人： Ryozo Kawai , Yoshiyuki Aoki , Kyohei Takakuwa , Mitsuhiko Masumoto , Toshizumi Hirota , Motoharu Takeuchi
IPC分类号： G02C7/02 , B29C39/02 , B29C39/18 , B29C41/20 , B29C45/14 , B29C53/04 , B29C70/70 , B29D11/00 , G02B5/23 , G02B5/30 , G02C7/10 , G02C7/12
CPC分类号： G02C7/12 , B29C39/025 , B29C41/20 , B29C53/04 , B29C70/70 , B29C2791/001 , B29D11/0073 , B29K2105/0002 , G02B5/23 , G02B5/305
摘要： A light control plastic lens, a sheet-like light control element, and a production method for light control plastic lenses are provided. More specifically, a light control plastic lens, such as a high index polarizing property and/or a photochromic plastic lens that is made by cast polymerization is provided. Also provided are a sheet-like light control element for use in the production of the lenses, as well as a production method of such light control plastic lenses. The light control plastic lens has a sheet-like light control element including at least a light control sheet. In particular, the light control plast lens the sheet-like light control element, a curable resin layer laminated on at least one surface of the sheet-like light control element, and a polymerizable lens resin layer laminated at least on the curable resin layer.
摘要翻译：提供了光控塑料透镜，片状光控制元件和用于光控制塑料透镜的制造方法。更具体地，提供了通过浇铸聚合制成的光控塑料透镜，例如高折射率偏振性质和/或光致变色塑料透镜。还提供了用于制造透镜的片状光控制元件以及这种光控塑料透镜的制造方法。光控塑料透镜具有至少包括光控板的片状光控制元件。特别是，光控塑料透镜，片状光控制元件，层压在片状光控制元件的至少一个表面上的可固化树脂层和至少层压在可固化树脂层上的可聚合透镜树脂层。

5. 发明授权

US4347383A Process for producing benzophenone-azines 失效
标题翻译：生产二苯甲酮吖嗪的方法
公开(公告)号：US4347383A
公开(公告)日：1982-08-31
申请号：US147194
申请日：1980-05-06
申请人： Tomiya Isshiki , Tetsuo Tomita , Shuzabu Sakaguchi , Toshiaki Kohzaki , Osamu Aoki , Norio Takeda , Yoshiyuki Aoki
发明人： Tomiya Isshiki , Tetsuo Tomita , Shuzabu Sakaguchi , Toshiaki Kohzaki , Osamu Aoki , Norio Takeda , Yoshiyuki Aoki
IPC分类号： C07C255/67 , C07C109/16
CPC分类号： C07C251/88
摘要： A process for producing a benzophenone-azine which comprises reacting the corresponding benzophenone-imine with molecular oxygen or benzophenone with ammonia and molecular oxygen in the presence of a catalyst selected from the group consisting of metals, metal oxides and alloys of two or more metals, particularly copper or copper alloy-containing catalyst, is disclosed.
摘要翻译：一种二苯甲酮 - 吖嗪的制备方法，其包括使相应的二苯甲酮 - 亚胺与分子氧或二苯甲酮与氨和分子氧在选自金属，金属氧化物和两种或更多种金属的合金的催化剂存在下反应，特别是含铜或含铜合金的催化剂。

6. 发明授权

US07872795B2 Laminated body for optical purposes that includes a melanin-containing layer and an optical product which includes the laminate 有权
标题翻译：用于光学目的的层压体包括含黑色素层和包括层压体的光学产品
公开(公告)号：US07872795B2
公开(公告)日：2011-01-18
申请号：US11710398
申请日：2007-02-26
申请人： Ryozo Kawai , Yoshiyuki Aoki , Eiko Aoki, legal representative , Masahiko Namiki , Mitsuo Miura
发明人： Ryozo Kawai , Yoshiyuki Aoki , Masahiko Namiki , Mitsuo Miura
IPC分类号： G02B5/22 , G02C7/10
CPC分类号： B32B27/28 , B32B27/08 , B32B27/18 , B32B27/306 , B32B27/308 , B32B27/365 , B32B27/40 , B32B2250/24 , B32B2307/40 , B32B2307/412 , B32B2307/42 , B32B2551/00 , B32B2605/006 , C08F220/28 , C08G18/10 , C08G18/6446 , G02B1/04 , G02B5/23 , G02B5/3033 , G02C7/102 , G02C7/108 , G02C7/12 , G02C2202/16 , C08L75/04 , C08L33/10 , C08L33/08
摘要： A laminated body of the present invention includes a melanin-containing layer, wherein the melanin-containing layer is formed by curing a composition that includes at least a melanin, a polymerizable monomer, and a urethane-derived composition. The composition for the laminated body of the present invention is used for producing the laminated body and includes at least a melanin, a polymerizable monomer, and a urethane-derived composition. The optical product of the present invention is formed including the laminated body.
摘要翻译：本发明的层叠体包含黑色素含有层，其中含黑色素的层通过固化至少含有黑色素，可聚合单体和氨基甲酸酯衍生组合物的组合物而形成。本发明的层叠体用组合物用于层压体的制造，至少含有黑色素，聚合性单体和氨基甲酸酯衍生物。本发明的光学产品形成为包括层叠体。

7. 发明授权

US6031194A Slide switch with self cleaning structure including grooves in rectangular substrate 失效
标题翻译：具有自清洁结构的滑动开关，包括矩形基板中的凹槽
公开(公告)号：US6031194A
公开(公告)日：2000-02-29
申请号：US91903
申请日：1998-06-26
申请人： Yoshiyuki Aoki
发明人： Yoshiyuki Aoki
IPC分类号： H01H15/02 , H01H1/60
CPC分类号： H01H1/60 , H01H15/02 , H01H2001/406
摘要： A slide switch that can remove foreign particles, such as metallic dust, from its ground terminals. When the movable contact slides toward a stroke end, the power source contact first passes through an end section of the power source terminal before disengaging the terminal. At that instant, arcs are generated between the contact and the terminal. Arcs produce metallic dust, carbide particles, etc. that adhere to the insulator and terminals creating buildup and obstructing the sliding path of the contacts. The switch is provided with a discharge hole and arc gaps along the sliding path of the contacts to eliminate the arc buildup. The contacts carry the metallic dust and carbide particles while sliding so that the dust and particles drop into the discharge hole or arc gap.
摘要翻译： PCT No.PCT / JP96 / 03826 Sec。 371日期：1998年6月26日 102（e）日期1998年6月26日PCT 1996年12月24日PCT公布。出版物WO97 / 24743 日期1997年7月10日一种可从其接地端子除去异物等金属粉尘的滑动开关。当可动触点向行程端滑动时，电源触点首先在断开端子之前通过电源端子的端部。在该瞬间，触点和端子之间产生弧。电弧产生粘附到绝缘体和端子的金属粉尘，碳化物颗粒等，从而产生积聚并阻碍触点的滑动路径。开关设置有沿着触头的滑动路径的排出孔和电弧间隙，以消除电弧积聚。触点在滑动时携带金属粉尘和碳化物颗粒，使灰尘和颗粒落入排放孔或电弧间隙。

8. 发明授权

US4239741A Process for producing hydrazine sulfate 失效
标题翻译：硫酸肼生产方法
公开(公告)号：US4239741A
公开(公告)日：1980-12-16
申请号：US955166
申请日：1978-10-27
申请人： Tomiya Isshiki , Tetsuo Tomita , Toshiaki Kozaki , Osamu Aoki , Mitsuo Abe , Norio Takeda , Mitsuo Miura , Yoshiyuki Aoki , Takao Kondo , Kaoru Tsuyuki
发明人： Tomiya Isshiki , Tetsuo Tomita , Toshiaki Kozaki , Osamu Aoki , Mitsuo Abe , Norio Takeda , Mitsuo Miura , Yoshiyuki Aoki , Takao Kondo , Kaoru Tsuyuki
IPC分类号： C01B21/16 , C01B21/54
CPC分类号： C01B21/16
摘要： Hydrazine sulfate having a relatively large particle diameter and a high purity is produced by hydrolysis of benzophenoneazines by sulfuric acid having a concentration of 75% by weight or less in an amount of 1.1 times by mole or more the stoichiometric amount in a very high conversion and a high yield with less operational loss.
摘要翻译：通过以非常高的转化率使化学计量量为1.1倍摩尔以上的浓度为75重量％以下的硫酸水解二苯甲酮酮而产生具有较大粒径且高纯度的硫酸肼，产量高，运营损失少。

9. 发明申请

US20090317616A1 PROCESS FOR PRODUCING MELANIN, MELANIN PRODUCED BY THE PROCESS, FUNCTIONAL FILM CONTAINING THE MELANIN, AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：生产MELANIN的方法，由该方法生产的MELANIN，含有MELANIN的功能膜及其生产方法
公开(公告)号：US20090317616A1
公开(公告)日：2009-12-24
申请号：US11995621
申请日：2006-07-14
申请人： Ryozo Kawai , Yoshiyuki Aoki , Eiko Aoki , Kyohei Takakuwa , Masahiko Namiki
发明人： Ryozo Kawai , Yoshiyuki Aoki , Eiko Aoki , Kyohei Takakuwa , Masahiko Namiki
IPC分类号： C08L29/04 , C04B14/00
CPC分类号： C09B59/00 , C09B67/0097 , C09B69/104 , G02B5/208 , G02B5/3033
摘要： The present invention provides a melanin that is excellent in coloring a functional film, and in reproducibility and stability during storage, and a method for its production. Also, the invention provides a functional film containing a melanin and its method for production. Specifically, it provides a functional film containing a melanin of which the alteration is improved and which is excellent in the property for protecting eyes from ultraviolet rays, and in its method for production.The method for producing a melanin of the present invention, comprises, at least, under controlled conditions, a step for an oxidative reaction wherein a melanin precursor is continuously oxidized while the mole ratio of the melanin precursor relative to the oxidative agent is maintained at a constant ratio, and a step for precipitation wherein a melanin is precipitated by acidifying a reaction solution after the step for an oxidative reaction.
摘要翻译：本发明提供了对功能性膜着色，保存时的再现性和稳定性优异的黑色素及其制造方法。另外，本发明提供含有黑色素的功能性膜及其制造方法。具体地说，提供了含有黑色素的功能性膜，其变化得到改善，并且在保护眼睛免受紫外线的性质方面优异，并且在其生产方法中。本发明的黑色素的制备方法至少在受控条件下，包括氧化反应的步骤，其中黑色素前体被连续氧化，而黑色素前体相对于氧化剂的摩尔比保持在恒定比例和沉淀步骤，其中通过在氧化反应步骤之后使反应溶液酸化而使黑色素沉淀。

10. 发明授权

US07381128B2 Operating device of air conditioner for vehicle 有权
标题翻译：车用空调机操作装置
公开(公告)号：US07381128B2
公开(公告)日：2008-06-03
申请号：US10947336
申请日：2004-09-23
申请人： Satoshi Ogawa , Tomoyuki Shibata , Yoshiyuki Aoki
发明人： Satoshi Ogawa , Tomoyuki Shibata , Yoshiyuki Aoki
IPC分类号： B60H1/00 , G05G1/10 , F16H35/18
CPC分类号： G05G1/105 , B60H1/0065 , Y10T74/2084
摘要： A gear portion is provided on the inner peripheral surface of a dial, and a large diameter portion of a main driving gear is mated with the gear portion. A driven gear is mated with a small diameter portion of the main driving gear, and the state of an air conditioner is switched based on the moving operation of a cable through the gear portion, the main driving gear and the driven gear in the rotating operation of the dial. With this structure, it is not necessary to provide a rotary shaft as a member for transmitting an operating force to the central part or the dial. Consequently, it is possible to maintain a space in the central part of the dial. Thus, restrictions can be decreased in the case in which a knob is to be arranged.
摘要翻译：齿轮部设置在表盘的内周面上，主驱动齿轮的大直径部与齿轮部配合。从动齿轮与主驱动齿轮的小直径部分配合，并且基于电缆通过齿轮部分，主驱动齿轮和从动齿轮在旋转操作中的移动操作来切换空调器的状态的表盘。利用这种结构，不需要将旋转轴设置为用于将操作力传递到中心部分或表盘的部件。因此，可以在表盘的中心部分保持空间。因此，在要布置旋钮的情况下可以减少限制。

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