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1. 发明申请

US20070036717A1 Chemoradiotherapy with TS-1/camptothecins 审中-公开
标题翻译：化疗放疗与TS-1 /喜树碱
公开(公告)号：US20070036717A1
公开(公告)日：2007-02-15
申请号：US11498098
申请日：2006-08-03
申请人： Masahiko Watanabe , Takeo Sato
发明人： Masahiko Watanabe , Takeo Sato
IPC分类号： A61K51/00 , A61K31/4745
CPC分类号： A61K41/0038 , A61K31/4745 , A61K45/06
摘要： An antitumor agent for chemoradiotherapy of rectal cancer comprising a combination of TS-1 (a combination drug of tegafur, gimeracil, and oteracil potassium at a 1:0.4:1 molar ratio) and CPT-11 (irinotecan hydrochloride). The antitumor agent of the invention can achieve marked tumor volume reduction without causing major side effects, especially by coadministering it with preoperative radiation therapy. The volume of even large tumors that are refractory to surgical resection can be reduced by coadministering the antitumor agent of the invention with preoperative radiation therapy, making the subsequent surgical resection of the tumor easier.
摘要翻译：包括TS-1（替加氟组合药物，吉马斯特和1：0.4：1摩尔比的奥特拉西钾）和CPT-11（盐酸伊立替康）的组合的直肠癌放化疗用抗肿瘤剂。本发明的抗肿瘤剂可以显着降低肿瘤体积，而不会引起重大副作用，特别是通过术前放射治疗联合使用。通过用术前放射治疗联合本发明的抗肿瘤药物可以减少手术切除难治的甚至大肿瘤的体积，使随后的肿瘤手术切除更容易。

2. 发明申请

US20140328754A1 RADIOACTIVE METAL-LABELED ANTI-CADHERIN ANTIBODY 审中-公开
标题翻译：放射性金属标签抗体CAD抗体
公开(公告)号：US20140328754A1
公开(公告)日：2014-11-06
申请号：US14307589
申请日：2014-06-18
申请人： Akihiro HINO , Akio Nagano , Masahiko Watanabe , Tadasi Matsuura , Hirokazu Satoh , Fumiko Nomura , Katsuyuki Mitomo
发明人： Akihiro HINO , Akio Nagano , Masahiko Watanabe , Tadasi Matsuura , Hirokazu Satoh , Fumiko Nomura , Katsuyuki Mitomo
IPC分类号： A61K51/10
CPC分类号： A61K51/1027 , A61K51/1093 , A61K51/1096 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K16/46 , C07K2317/24 , C12N15/02 , C12N15/85
摘要： A radioactive metal-labeled anti-cadherin antibody which is obtained by binding a radioactive metallic element to an anti-cadherin antibody via a metal-chelating reagent.
摘要翻译：通过金属螯合剂将放射性金属元素与抗钙粘蛋白抗体结合而获得的放射性金属标记抗钙粘蛋白抗体。

3. 发明授权

US08727526B2 Inkjet printing apparatus 有权
标题翻译：喷墨打印设备
公开(公告)号：US08727526B2
公开(公告)日：2014-05-20
申请号：US13090681
申请日：2011-04-20
申请人： Kosuke Yamamoto , Tetsuya Saito , Yoshiaki Suzuki , Koji Furusawa , Hiroshi Tajika , Masahiko Watanabe , Atsuhiko Masuyama , Atsushi Miyahara , Masashi Ito , Fumie Kameyama
发明人： Kosuke Yamamoto , Tetsuya Saito , Yoshiaki Suzuki , Koji Furusawa , Hiroshi Tajika , Masahiko Watanabe , Atsuhiko Masuyama , Atsushi Miyahara , Masashi Ito , Fumie Kameyama
IPC分类号： B41J29/38 , B41J2/01 , B41J11/00 , B41J11/42 , B41J29/393 , B41J2/045 , B41J11/06
CPC分类号： B41J11/0015 , B41J2/04563 , B41J3/60 , B41J11/002 , B41J11/007 , B41J11/06 , B41J11/42 , B41J13/0045 , B41J29/393
摘要： In an inkjet printing apparatus capable of automatic duplex printing, time required to fix ink is shortened and throughput is improved without producing uneven fixing. The inkjet printing apparatus includes a printing unit that prints onto a sheet, a fixing unit that heats a sheet printed by the printing unit, a conveying unit that conveys a sheet with respect to the printing unit and the fixing unit, and a controller that controls the conveying unit such that a printing region of a sheet printed on the first side by the printing unit passes through the fixing unit, and afterwards, the conveyance direction of the sheet is reversed in order to print on the second side and the printing region once again passes through the fixing unit. The controller variably controls the conveyance speed of the sheet when the printing region once again passes through the fixing unit.
摘要翻译：在能够进行自动双面打印的喷墨打印装置中，缩短油墨固化所需的时间，并且不会产生不均匀的固定而提高生产量。喷墨打印设备包括打印在纸张上的打印单元，加热由打印单元打印的纸张的定影单元，相对于打印单元和定影单元传送纸张的输送单元，以及控制器所述输送单元使得由所述印刷单元印刷在所述第一侧上的印张的印刷区域通过所述定影单元，然后将所述纸张的输送方向反转以便在所述第二面和所述印刷区域上打印一次再次通过定影单元。当打印区域再次通过定影单元时，控制器可变地控制纸张的输送速度。

4. 发明授权

US08587805B2 Execution log generation apparatus and method 有权
公开(公告)号：US08587805B2
公开(公告)日：2013-11-19
申请号：US12457515
申请日：2009-06-12
申请人： Akio Kobayashi , Kazumasa Taneike , Masahiko Watanabe
发明人： Akio Kobayashi , Kazumasa Taneike , Masahiko Watanabe
IPC分类号： G06F3/12 , G06Q30/00 , G06Q20/00
CPC分类号： G06F11/3476 , G06Q10/06
摘要： An execution log generation apparatus generates an execution log upon receiving, for each job operation, job operation data indicating content of a job operation performed in a job procedure from a job processing apparatus that performs job processes through job procedures. The execution log generation apparatus includes a definition file holding unit that holds a definition file in which job operations performed in the job procedures are defined along a flow of the job processes and the job procedures, and in which output items to be output as execution logs for the each job operation are listed in a common format; and an execution log output unit that selects, from the definition file, an output item corresponding to a job operation contained in the job operation data, and outputs, as an execution log, the same output item as the selected output item from the job operation data.

5. 发明申请

US20130193844A1 ORGANIC ELECTRO-LUMINESCENCE LIGHT-EMITTING DEVICE AND PRODUCTION METHOD OF THE SAME 有权
标题翻译：有机电致发光元件及其生产方法
公开(公告)号：US20130193844A1
公开(公告)日：2013-08-01
申请号：US13878513
申请日：2011-10-06
申请人： Shigenori Morita , Ryohei Kakiuchi , Takahiro Nakai , Jin Yoshikawa , Masahiko Watanabe , Junichi Nagase
发明人： Shigenori Morita , Ryohei Kakiuchi , Takahiro Nakai , Jin Yoshikawa , Masahiko Watanabe , Junichi Nagase
IPC分类号： H05B33/14
CPC分类号： H05B33/145 , H01L25/048 , H01L51/0097 , H01L51/5203 , H01L51/5253 , H01L51/56 , H01L2251/5338 , H01L2251/566 , H01L2924/0002 , H01L2924/00
摘要： In order to provide an organic electroluminescent light-emitting device with less uneven brightness, which can be manufactured at low cost, a plurality of ribbon-like organic electroluminescent elements are connected to wires, which are connected to electrode terminals for energization at specific locations in a terminal region and mounted on a base material which has a substantially plate-like shape.
摘要翻译：为了提供可以以低成本制造的不均匀亮度的有机电致发光发光器件，多个带状有机电致发光元件连接到导线，导线连接到用于在特定位置处的通电的电极端子端子区域并且安装在基本上具有大致板状的基材上。

6. 发明申请

US20110281349A1 Insect Desiccation Resistance Genes and Uses Thereof 有权
标题翻译：昆虫抗病基因及其用途
公开(公告)号：US20110281349A1
公开(公告)日：2011-11-17
申请号：US13103806
申请日：2011-05-09
申请人： Takahiro Kikawada , Takashi Okuda , Masahiko Watanabe , Kazuei Mita , Keiko Kadono
发明人： Takahiro Kikawada , Takashi Okuda , Masahiko Watanabe , Kazuei Mita , Keiko Kadono
IPC分类号： C12N5/10 , C12N15/63 , C07H21/04
CPC分类号： C07K14/43563
摘要： An objective of the present invention is to provide polynucleotides encoding insect desiccation resistance proteins, and uses thereof cDNA libraries were produced from Polypedilum vanderplanki larvae in a desiccated state, a P. vanderplanki EST database was constructed, and genes encoding LEA proteins were isolated. This resulted in the successful isolation of three types of novel gene encoding LEA-like proteins (PvLEA1, PvLEA2, and PvLEA3.) When secondary structure predictions and motif searches were performed on the proteins deduced from each of the genes, all three proteins had α-helix-rich structures and LEA_4 motifs, which are characteristic of LEA proteins. Moreover, the recombinant proteins synthesized from PvLEA1, 2 and 3 genes were heat soluble even when boiling, so that PvLEA1, 2 and 3 proteins have highly hydrophilic property as well as plant LEA proteins. Therefore, the three isolated genes were found to be novel P. vanderplanki-derived LEA genes. Furthermore, introduction of these PvLEA 1, 2 and 3 genes into animal cells successfully conferred desiccation resistance to the cells. The present invention provides the first example of LEA genes isolated from insects.
摘要翻译：本发明的目的在于提供编码昆虫抗干扰性蛋白质的多核苷酸及其使用方法，从干燥状态的Polypedilum vanderplanki幼虫生产cDNA文库，构建P.vanderplanki EST数据库，分离编码LEA蛋白质的基因。这导致了三种类型的编码LEA样蛋白的新基因（PvLEA1，PvLEA2和PvLEA3）的成功分离。当对从每个基因推导的蛋白进行二级结构预测和基序搜索时，所有三种蛋白都具有α 富含螺旋的结构和LEA_4基序，是LEA蛋白的特征。此外，由PvLEA1,2和3基因合成的重组蛋白即使在沸腾时也是热溶性的，因此PvLEA1,2和3蛋白具有高亲水性以及植物LEA蛋白。因此，发现三个分离的基因是新的P. vanderplanki衍生的LEA基因。此外，将这些PvLEA 1,2和3基因引入动物细胞成功地赋予细胞干燥抗性。本发明提供了从昆虫分离的LEA基因的第一个实例。

7. 发明授权

US07544761B2 Polythiourethane 失效
标题翻译：聚硫氨酯
公开(公告)号：US07544761B2
公开(公告)日：2009-06-09
申请号：US11587362
申请日：2005-04-28
申请人： Masanori Watanabe , Masahiko Watanabe , Atsushi Morikami , Takafumi Hirakawa
发明人： Masanori Watanabe , Masahiko Watanabe , Atsushi Morikami , Takafumi Hirakawa
IPC分类号： C08G63/00 , C08G63/02
CPC分类号： C08G75/28 , C08G18/4676 , G02B1/04 , C08L75/04
摘要： Disclosed is a polythiourethane having a high refractive index and low dispersion which is obtained through a reaction between a polythiol component containing one or more polythiocarbonate polythiol (preferably one having a —(CO—S—R—S)— structure (wherein R represents a divalent hydrocarbon group) and a number average molecular weight of 200-2,500) and a polyisocyanate component containing a polyisocyanate and/or a polyisothiocyanate. This polythiourethane is useful for plastic lenses, prisms, optical fibers, substrates for information recording, colored filters, infrared absorbing filters and the like.
摘要翻译：公开了通过含有一种或多种聚硫代碳酸酯多硫醇（优选具有 - （CO-SRS） - 结构（其中R表示二价烃基）的多硫醇组分的多硫醇组分之间的反应获得的具有高折射率和低分散性的聚硫氨酯，数均分子量为200-2,500）和含有多异氰酸酯和/或多异氰酸酯的多异氰酸酯组分。该聚硫氨酯可用于塑料透镜，棱镜，光纤，信息记录用基板，彩色滤光片，红外吸收滤光片等。

8. 发明申请

US20090111176A1 Trehalose transporter gene and method of introducing trehalose into cells 有权
标题翻译：海藻糖转运蛋白基因和将海藻糖引入细胞的方法
公开(公告)号：US20090111176A1
公开(公告)日：2009-04-30
申请号：US12073457
申请日：2008-03-05
申请人： Takahiro Kikawada , Takashi Okuda , Masahiko Watanabe , Ayako Saito , Yasushi Kanamori , Yuichi Nakahara
发明人： Takahiro Kikawada , Takashi Okuda , Masahiko Watanabe , Ayako Saito , Yasushi Kanamori , Yuichi Nakahara
IPC分类号： C12N5/06 , C12N15/11 , C07K14/00 , C12N15/00
CPC分类号： C07K14/43563 , C07K14/43577
摘要： There are provided trehalose transporter gene and a method of introducing trehalose into cells by using the gene. Candidates for the trehalose transporter genes were searched in P. vanderplanki EST, resulting in being obtained cDNA designated as Tret1. Tret1 encodes a 504 amino acid protein with 12 trans-membrane structures. Tret1 expression was induced by desiccation stress and predominant in the fat body. Functional expression of TRET1 in Xenopus oocytes showed that transport activity was specific for trehalose and independent of extracellular pH and electrochemical membrane potential. The direction of transport of TRET1 was reversible depending on the concentration gradient of trehalose. Apparent Km and Vmax of TRET1 for trehalose were extraordinarily high values. These results indicate that TRET1 is a facilitated, high-capacity trehalose-specific transporter. Tret1 is widespread in insects. Furthermore, TRET1 conferred trehalose permeability upon cells including those of vertebrates as well as insects.
摘要翻译：提供海藻糖转运蛋白基因和通过使用该基因将海藻糖引入细胞的方法。在P. vanderplanki EST中搜索海藻糖转运蛋白基因的候选物，得到获得的命名为Tret1的cDNA。 Tret1编码具有12个跨膜结构的504个氨基酸的蛋白质。 Tret1表达由干燥应激诱导，在脂肪体中占优势。非洲爪蟾卵母细胞中TRET1的功能表达显示，转运活性对海藻糖是特异性的，独立于细胞外pH和电化学膜电位。根据海藻糖的浓度梯度，TRET1的转运方向是可逆的。 TRET1对于海藻糖的表观Km和Vmax是非常高的值。这些结果表明TRET1是一种促进的高容量海藻糖特异性转运蛋白。 Tret1在昆虫中广泛存在。此外，TRET1在包括脊椎动物以及昆虫的细胞中赋予海藻糖通透性。

9. 发明申请

US20090056655A1 VARIABLE VALVE TIMING CONTROL APPARATUS OF INTERNAL COMBUSTION ENGINE AND COOLING DEVICE FOR THE SAME 审中-公开
标题翻译：内燃机的可变阀定时控制装置及其冷却装置
公开(公告)号：US20090056655A1
公开(公告)日：2009-03-05
申请号：US12178360
申请日：2008-07-23
申请人： Yoshiyuki KOBAYASHI , Masahiko Watanabe , Atsushi Yamanaka
发明人： Yoshiyuki KOBAYASHI , Masahiko Watanabe , Atsushi Yamanaka
IPC分类号： F01L1/344
CPC分类号： F01L1/352 , F01L1/344 , F01L2001/3522
摘要： A variable valve timing control apparatus of an internal combustion engine includes a phase change mechanism configured to control engine valve timing by changing a relative angular phase between a timing sprocket and a camshaft by braking torque application via an electromagnetic brake. A flow control valve is arranged downstream of an oil supply passage that supplies cooling oil into an inside of the phase change mechanism. The flow control valve includes a valve element configured to control a flow rate of the oil supplied into the inside of the phase change mechanism, by changing an opening area of a valve bore communicating the oil supply passage by way of an advancing/retreating motion of the valve element in the valve bore, and a temperature-sensitive member configured to create the advancing/retreating motion of the valve element responsively to a temperature of the oil.
摘要翻译：内燃机的可变气门正时控制装置包括：相变机构，其被配置为通过经由电磁制动器的制动转矩施加来改变正时链轮和凸轮轴之间的相对角相位来控制发动机气门正时。流量控制阀配置在向相变机构的内部供给冷却油的供油路的下游侧。流量控制阀包括：阀元件，其被配置为通过改变连通供油通道的阀孔的开口面积，通过前进/后退运动来控制供给到相变机构内部的油的流量阀孔中的阀元件以及响应于油的温度而产生阀元件的前进/后退运动的温度敏感元件。

10. 发明授权

US07441524B2 Valve timing control apparatus for internal combustion engine and control method thereof 失效
标题翻译：内燃机气门正时控制装置及其控制方法
公开(公告)号：US07441524B2
公开(公告)日：2008-10-28
申请号：US11083179
申请日：2005-03-18
申请人： Naoki Okamoto , Masahiko Watanabe , Yoshiyuki Kobayashi
发明人： Naoki Okamoto , Masahiko Watanabe , Yoshiyuki Kobayashi
IPC分类号： F01L1/34
CPC分类号： F01L1/344
摘要： In a structure with a variable valve timing mechanism which varies an opening-and-closing timing of an intake valve and/or an exhaust valve due to a rotational phase of a camshaft with respect to a crankshaft of an internal combustion engine being varied, the rotational phase is detected in an arbitrary timing regardless of a rotational period of the camshaft, and the variable valve timing mechanism is controlled on the basis of the detected rotational phase.
摘要翻译：在具有可变气门正时机构的结构中，其可改变由于凸轮轴相对于内燃机的曲轴的转动相位而改变的进气门和/或排气门的打开和关闭正时，因此，无论凸轮轴的转动周期如何，在任意的定时检测转动相位，根据检测的转动相位来控制可变气门正时机构。

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