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1. 发明授权

US5639862A Deletion muteins of hst-1 失效
标题翻译： hst-1的缺失突变蛋白
公开(公告)号：US5639862A
公开(公告)日：1997-06-17
申请号：US446198
申请日：1995-05-19
申请人： Masaaki Terada , Hiromi Sakamoto , Teruhiko Yoshida , Koichi Igarashi , Yoshio Kozai
发明人： Masaaki Terada , Hiromi Sakamoto , Teruhiko Yoshida , Koichi Igarashi , Yoshio Kozai
IPC分类号： C07K14/50 , C07K14/82 , C12N15/12 , C12N15/16 , C07K14/475 , C07K14/495
CPC分类号： C07K14/50 , C07K14/82
摘要： A deletion type mutein of heparin-binding secretory transforming factor (hst-1) possesses excellent cell growth promoting activity and is stable. The present mutein can therefore be used as a therapeutic medicine such as a healing promoter for burns, wounds, surgical injuries etc.
摘要翻译：肝素结合分泌转化因子（hst-1）的缺失型突变蛋白具有优异的细胞生长促进活性，稳定。因此，本发明的突变蛋白可用作治疗药物，例如用于烧伤，伤口，手术伤害等的治疗促进剂。

2. 发明授权

US6013784A Nucleic acids encoding HST 2 muteins 失效
标题翻译：核酸编码HST 2突变蛋白
公开(公告)号：US6013784A
公开(公告)日：2000-01-11
申请号：US902233
申请日：1997-07-29
申请人： Koji Yoshimura , Kaori Ishimaru , Koichi Igarashi , Masaaki Terada
发明人： Koji Yoshimura , Kaori Ishimaru , Koichi Igarashi , Masaaki Terada
IPC分类号： A61K38/00 , C07K14/50 , C12N15/16 , C12N5/10 , C12N15/12 , C12N15/63
CPC分类号： C07K14/50 , A61K38/00
摘要： The present invention provides a polypeptide represented by the following amino acid sequence:(Met)n=X=Leu=Ala=Gly=Glu=Ile=Ala=Gly=Val=Asn - Trp=Glu=Ser - Gly=Tyr=Leu=Val=Gly=Ile=Lys=Arg=Gln=Arg=Arg - Leu=Tyr=Cys=Asn - Val=Gly=Ile=Gly=Phe=His=Leu=Gln=Val=Leu=Pro - Asp=Gly=Arg=Ile - Ser=Gly=Thr=His=Glu=Glu=Asn=Pro=Tyr=Ser=Leu - Leu=Glu=Ile=Ser - Thr=Val=Glu=Arg=Gly=Val=Val=Ser=Leu=Phe=Gly - Val=Arg=Ser=Ala - Leu=Phe=Val=Ala=Met=Asn=Ser=Lys=Gly=Arg=Leu - Tyr=Ala=Thr=Pro - Ser=Phe=Gin=Glu=Glu=Cys=Lys=Phe=Arg=Glu=Thr Leu=Leu=Pro=Asn - Asn=Tyr=Asn=Ala=Tyr=Glu=Ser=Asp=Leu=Tyr=Gln - Gly=Thr=Tyr=Ile - Ala=Leu=Ser=Lys=Tyr=Gly=Arg=Val=Lys=Arg=Gly - Ser=Lys=Val=Ser - Pro=Ile=Met=Thr=Val=Thr=His=Phe=Leu=Pro=Arg=Ile wherein n is 0 or 1 and X represents Pro Ala Gly Thr Arg Ala Asn Asn Thr Leu Leu Asp Ser Arg Gly Trp Gly Thr Leu Leu Ser Arg Ser Arg Ala Gly or a fragment thereof (n=0: SEQ ID NO: 1, n=1: SEQ ID NO: 2), a recombinant DNA coding for the polypeptide, a vector containing the recombinant DNA, the preparation of a transformant carrying the vector, and the production of the polypeptide with the transformant.
摘要翻译：本发明提供由以下氨基酸序列表示的多肽： - （Met）n = X = Leu = Ala = Gly = Glu = Ile = Ala = Gly = Val = Asn-Trp = Glu = Ser- Tyr = Leu = Val = Gly = Ile = Lys = Arg = Gln = Arg = Arg-Leu = Tyr = Cys = Asn-Val = Gly = Ile = Gly = Phe = His = Leu = Gln = Val = Leu = Pro-Asp = Gly = Arg = Ile-Ser = Gly = Thr = His = Glu = Glu = Asn = Pro = Tyr = Ser = Leu-Leu = Glu = Ile = Ser- Arg = Gly = Val = Val = Ser = Leu = Phe = Gly-Val = Arg = Ser = Ala-Leu = Phe = Val = Ala = Met = Asn = Ser = Lys = Gly = = Ala = Thr = Pro-Ser = Phe = Gin = Glu = Glu = Cys = Lys = Phe = Arg = Glu = Thr- Leu = Leu = Pro = Asn -Asn = Tyr = Asn = Ala = Tyr = Glu = Ser = Asp = Leu = Tyr = Gln-Gly = Thr = Tyr = Ile-Ala = Leu = Ser = Lys = Tyr = Gly = Arg = Val = Lys = Arg = Gly-Ser = = Ser-Pro = Ile = Met = Thr = Val = Thr = His = Phe = Leu = Pro = Arg = Ile-其中n为0或1，X表示Pro Ala Gly Thr Arg Ala Asn Asn Thr Leu Leu Asp Ser Arg Gly Trp Gly Thr Leu Leu Ser Arg Ser Arg Ala Gly或其片段（n = 0：SEQ ID NO：1，n = 1：SEQ ID NO：2），编码多肽的重组DNA ide，含有重组DNA的载体，携带载体的转化体的制备以及与转化体的多肽的产生。

3. 发明授权

US5679550A Hst-2 muteins, pharmaceutical compositions and kits comprising same, and preparation of same 失效
标题翻译： Hst-2突变蛋白，药物组合物和包含其的试剂盒及其制备方法
公开(公告)号：US5679550A
公开(公告)日：1997-10-21
申请号：US551171
申请日：1995-10-31
申请人： Koji Yoshimura , Kaori Ishimaru , Koichi Igarashi , Masaaki Terada
发明人： Koji Yoshimura , Kaori Ishimaru , Koichi Igarashi , Masaaki Terada
IPC分类号： A61K38/00 , C07K14/50 , C12N15/16 , A61K38/17 , C07K14/435 , C12N15/12
CPC分类号： C07K14/50 , A61K38/00
摘要： The present invention provides a polypeptide represented by the following amino acid sequence: ##STR1## wherein n is 0 or 1 and X represents Pro Ala Gly Thr Arg Ala Asn Asn Thr Leu Leu Asp Ser Arg Gly Trp Gly Thr Leu Leu Ser Arg Ser Arg Ala Gly or a fragment thereof (n=0: SEQ ID NO:1, n=1: SEQ ID NO:2), a recombinant DNA coding for the polypeptide, a vector containing the recombinant DNA, the preparation of a transformant carrying the vector, and the production of the polypeptide with the transformant. The use of this peptide in pharmaceutical compositions is also provided.
摘要翻译：本发明提供由下述氨基酸序列所表示的多肽：（MET）N XLeuAlaGlyGluIleAlaGlyValAsnTrpGluSer GlyTyrLeuValGlyIleLysArgGlnArgArgLeuTyrCysAsn ValGlyIleGlyPheHisLeuGlnValLeuProAspGlyArgIle SerGlyThrHisGluGluAsnProTyrSerLeuLeuGluIleSer ThrValGluArgGlyValValSerLeuPheGlyValArgSerAla LeuPheValAlaMetAsnSerLysGlyArgLeuTyrAlaThrPro SerPheGlnGluGluCysLysPheArgGluThrLeuLeuProAsn AsnTyrAsnAlaTyrGluSerAspLeuTyrGlnGlyThrTyrIle AlaLeuSerLysTyrGlyArgValLysArgGlySerLysValSer ProIleMetThrValThrHisPheLeuProArgIle其中n是0或1，X表示临丙氨酸甘氨酸苏氨酸精氨酸丙氨酸天冬酰胺天冬酰胺苏氨酸亮氨酸亮氨酸天冬氨酸丝氨酸 Arg Gly Trp Gly Thr Leu Leu Ser Arg Ser Arg Ala Gly或其片段（n = 0：SEQ ID NO：1，n = 1：SEQ ID NO：2），编码该多肽的重组DNA，含有重组DNA，携带载体的转化体的制备以及与转化体的多肽的产生。还提供了在药物组合物中使用该肽。

4. 发明授权

US5711095A Hydraulic working machine having a projecting portion 失效
标题翻译：液压作业机具有突出部分
公开(公告)号：US5711095A
公开(公告)日：1998-01-27
申请号：US645713
申请日：1996-05-14
申请人： Kazuo Oda , Yoshiaki Murakami , Masaaki Terada
发明人： Kazuo Oda , Yoshiaki Murakami , Masaaki Terada
IPC分类号： E02F3/32 , E02F3/34 , E02F3/38 , E02F9/08 , E02F3/96
CPC分类号： E02F9/0883 , E02F3/325 , E02F3/384 , E02F9/0875
摘要： A hydraulic excavator includes a revolving upper structure having a rear half swingable within the width of the machine. The revolving upper structure has a front portion on which a cab is disposed. An internal combustion engine is mounted in the rear of the cab. Various components including a direction control valve, a hydraulic oil tank, and a fuel tank are mounted alongside the cab. The revolving upper structure has a front end portion supporting thereon a bracket, and a boom pivotally mounted on the bracket for undertaking a swing motion within an angular range of an angle less than 180.degree.. The swing angle is so set as to extend over a greater extent on one side located close to the cab than on the other side remote from the cab. The revolving upper structure further includes a projecting portion swelling out into an area kept out of the swing range of the boom. With the projecting portion thus provided, an internal space of the revolving upper structure available for mounting various components can be enlarged.
摘要翻译：液压挖掘机包括具有在机器宽度内可摆动的后半部的旋转上部结构。旋转上部结构具有设置驾驶室的前部。内燃机安装在驾驶室的后部。包括方向控制阀，液压油箱和燃料箱的各种部件安装在驾驶室的旁边。旋转上部结构具有支撑在支架上的前端部和枢转地安装在托架上的起重臂，用于在角度小于180°的角度范围内进行摆动。摆动角被设定为在靠近驾驶室的一侧上比在远离驾驶室的另一侧更大程度地延伸。旋转的上部结构进一步包括突出部分，其膨胀到保持在悬臂的摆动范围之外的区域中。通过这样设置的突出部，可以扩大可用于安装各种部件的旋转上部结构的内部空间。

5. 发明授权

US4253448A Endoscope connector 失效
标题翻译：内窥镜连接器
公开(公告)号：US4253448A
公开(公告)日：1981-03-03
申请号：US77471
申请日：1979-09-20
申请人： Masaaki Terada
发明人： Masaaki Terada
IPC分类号： A61B1/06 , A61B1/00 , A61B1/31 , G02B23/26 , H01R24/58
CPC分类号： A61B1/31 , A61B1/00121 , A61B1/07 , H01R24/58 , H01R2107/00
摘要： An endoscope connector comprises a socket member which has a cylindrical penetrating bore, that portion of said socket member at which one end of the penetrating bore is opened being connected to a console containing a light source and a connection for an electric source, and whose peripheral wall is provided with a fluid-feeding fitting and suction fitting; a cylindrical plug member which is sealingly inserted into the cylindrical penetrating bore of the socket member to rotate around the axis, receives the distal end portions of an illumination optical fiber bundle, fluid-feeding tube and suction tube extending from an endoscope, said plug member having one end which is near the other end of the socket member and to which the free end of a protection tube receiving the illumination optical fiber bundle, fluid-feeding tube and suction tube is fixed; and a pair of annular chambers which are formed between the surface of the cylindrical penetrating bore of the socket member and the peripheral surface of the plug member, and one of which communicates with the fluid-feeding fitting and fluid-feeding tube, and the other of which communicates with the suction fitting and suction tube.
摘要翻译：内窥镜连接器包括具有圆柱形穿透孔的插座构件，所述插座构件的穿透孔的一端打开的部分连接到包含光源的控制台和用于电源的连接件，并且其外围壁上设有一个流体馈送配件和抽吸配件; 密封地插入到插座构件的圆筒形贯通孔中以绕轴线旋转的圆柱形塞构件，容纳从内窥镜延伸的照明光纤束，流体供给管和吸引管的前端部，所述插塞构件其一端靠近插座构件的另一端，并且固定有接收照明光纤束的保护管的自由端，流体供给管和吸入管; 以及一对环形室，其形成在插座构件的圆柱形穿透孔的表面和插塞构件的外周表面之间，并且其中一个与流体供给配件和流体供给管连通，另一个环形室其与吸入管和吸入管连通。

6. 发明申请

US20100081202A1 PROCESS FOR FACILITATING NUCLEIC ACID TRANSFER 审中-公开
标题翻译：促进核酸转运的方法
公开(公告)号：US20100081202A1
公开(公告)日：2010-04-01
申请号：US12554846
申请日：2009-09-04
申请人： Masaaki Terada , Takahiro Ochiya , Yu Aso , Kimi Honma , Akihiko Sano , Shunji Nagahara
发明人： Masaaki Terada , Takahiro Ochiya , Yu Aso , Kimi Honma , Akihiko Sano , Shunji Nagahara
IPC分类号： C12N15/63
CPC分类号： A61K48/0008 , A61K47/6435 , A61K48/00 , C12N15/87
摘要： Means for transferring efficiently a desired nucleic acid into a cell is provided.The present invention comprises using a complex comprising a collagen or a collagen derivative, and a desired nucleic acid.
摘要翻译：提供了将期望的核酸有效转移到细胞中的方法。本发明包括使用包含胶原蛋白或胶原衍生物和所需核酸的复合物。

7. 发明申请

US20050048480A1 Method of detecting cancer 审中-公开
标题翻译：检测癌症的方法
公开(公告)号：US20050048480A1
公开(公告)日：2005-03-03
申请号：US10333015
申请日：2001-07-18
申请人： Yasuhhiro Tsubosa , Kazuhiko Aoyagi , Hiroki Sasaki , Masaaki Terada , Junichi Mineno , Kiyozo Asada , Ikunoshin Kato
发明人： Yasuhhiro Tsubosa , Kazuhiko Aoyagi , Hiroki Sasaki , Masaaki Terada , Junichi Mineno , Kiyozo Asada , Ikunoshin Kato
IPC分类号： C12N15/12 , C12Q1/68 , C12Q1/6837 , C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q1/6837 , C12Q2600/158
摘要： To provide a method for selecting a marker gene useful for cancer classification; a method for classifying cancer using the gene; a method for detecting cancer; a kit usable for the classification method or detection method; and a DNA array carrying the gene. According to the present invention, there can be obtained a gene, wherein expression of the above gene is altered independently from genes each of which expression is altered specifically during cell proliferation and expression level of the above gene is specifically altered depending on every type of cancer samples to be tested, whereby the classification or detection of cancer can be carried out conveniently and quickly without giving surgical treatment. Therefore, the present invention is useful for the diagnosis, the treatment, and the like of cancer.
摘要翻译：提供选择用于癌症分类的标记基因的方法; 使用该基因分类癌症的方法; 一种检测癌症的方法; 可用于分类方法或检测方法的试剂盒; 和携带该基因的DNA阵列。根据本发明，可以获得上述基因的表达独立于在细胞增殖期间特异性改变的基因的各基因的变化，并且根据每种类型的癌症特异性地改变上述基因的表达水平待测试的样品，从而可以方便快捷地进行癌症的分类或检测，而无需外科治疗。因此，本发明对癌症的诊断，治疗等有用。

8. 发明授权

US06471990B1 Gene-containing compositions 失效
标题翻译：含基因组合物
公开(公告)号：US06471990B1
公开(公告)日：2002-10-29
申请号：US09475086
申请日：1999-12-30
申请人： Makoto Tsukamoto , Takahiro Ochiya , Sho Yoshida , Takashi Sugimura , Masaaki Terada
发明人： Makoto Tsukamoto , Takahiro Ochiya , Sho Yoshida , Takashi Sugimura , Masaaki Terada
IPC分类号： A61K4800
CPC分类号： A61K48/00
摘要： The present invention provides a gene-containing composition including a gene and a transporter, the transporter being capable of transporting the gene from a pregnant body to fetal cells. When this composition is administered to a pregnant body, birth of offsprings with gene deficiency can be prevented, and gene deficiency can be treated during pregnancy. In animal experiments, when an unknown gene is introduced to animals during their embryogenic stage, the function of the gene in ontogenesis can be elucidated. Moreover, the composition can be used for breeding animals such as pets, industrial animals and cattle.
摘要翻译：本发明提供了包含基因和转运蛋白的基因的组合物，所述转运蛋白能够将所述基因从怀孕体转运至胎儿细胞。当将该组合物施用于怀孕的身体时，可以预防基因缺陷的后代的出生，并且可以在怀孕期间治疗基因缺陷。在动物实验中，当未知基因在其胚胎发生阶段被引入动物时，可以阐明基因在发育中的功能。此外，该组合物可用于养殖动物，例如宠物，工业动物和牛。

9. 发明授权

US08742091B2 Method of promoting nucleic acid transfer 有权
标题翻译：促进核酸转运的方法
公开(公告)号：US08742091B2
公开(公告)日：2014-06-03
申请号：US10481511
申请日：2002-06-20
申请人： Masaaki Terada , Takahiro Ochiya , Yu Aso , Kimi Honma , Akihiko Sano , Shunji Nagahara
发明人： Masaaki Terada , Takahiro Ochiya , Yu Aso , Kimi Honma , Akihiko Sano , Shunji Nagahara
IPC分类号： C07H21/02 , A61K38/17 , C12N15/11
CPC分类号： A61K48/0008 , A61K47/6435 , A61K48/00 , C12N15/87
摘要： Means for transferring efficiently a desired nucleic acid into a cell is provided.The present invention comprises using a complex comprising a collagen or a collagen derivative, and a desired nucleic acid.
摘要翻译：提供了将期望的核酸有效转移到细胞中的方法。本发明包括使用包含胶原蛋白或胶原衍生物和所需核酸的复合物。

10. 发明授权

US4329980A Flexible sheath for an endoscope 失效
标题翻译：用于内窥镜的柔性护套
公开(公告)号：US4329980A
公开(公告)日：1982-05-18
申请号：US124475
申请日：1980-02-25
申请人： Masaaki Terada
发明人： Masaaki Terada
IPC分类号： A61B1/005 , A61B1/00
CPC分类号： A61B1/0055 , A61B1/00078
摘要： A flexible sheath for an endoscope has a flexible hollow cylindrical tube and a helical coil spring which is inserted into the flexible hollow cylindrical tube. One end of the spring is made engageable with one end of the hollow cylindrical tube to adjust the flexibility of the flexible sheath. A mechanism for compressing the helical coil spring is provided at the other end of the hollow cylindrical tube. The mechanism comprises a spring-compressing member disposed at the other end of the helical coil spring and an actuating member for reciprocating the spring-compressing member between a position in which the spring-compressing member compresses the helical coil spring and a position in which the spring-compressing member is axially removed from the other end of the helical coil spring. The magnitude of a force axially applied to the helical coil spring is controlled in accordance with the extent to which the spring-compressing member is moved toward the helical coil spring by the actuating member, thereby adjusting the flexibility of the flexible sheath.
摘要翻译：用于内窥镜的柔性护套具有柔性中空圆柱形管和插入柔性中空圆柱形管中的螺旋形螺旋弹簧。弹簧的一端可与中空圆柱形管的一端接合，以调节柔性护套的柔性。用于压缩螺旋弹簧的机构设置在中空圆柱形管的另一端。该机构包括设置在螺旋形螺旋弹簧的另一端处的弹簧压缩构件和用于使弹簧压缩构件在弹簧压缩构件压缩螺旋形螺旋弹簧的位置和弹簧压缩构件之间的位置的致动构件，弹簧压缩构件从螺旋形螺旋弹簧的另一端轴向移除。根据弹簧压缩构件通过致动构件向螺旋形螺旋弹簧移动的程度来控制轴向施加到螺旋形螺旋弹簧的力的大小，从而调节柔性护套的柔性。

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