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    • 1. 发明申请
    • 1-N-Aminobenzimidazole derivatives
    • 1-N-氨基苯并咪唑衍生物
    • US20050148634A1
    • 2005-07-07
    • US10507361
    • 2003-03-28
    • Masaaki NagasawaHiroyasu NishiokaKazuyasu AsamiNaoyoshi MiuraHideki NakamuraHitoshi Morita
    • Masaaki NagasawaHiroyasu NishiokaKazuyasu AsamiNaoyoshi MiuraHideki NakamuraHitoshi Morita
    • A61P1/04A61P43/00C07D401/12A61K31/4439C07D43/02
    • C07D401/12C07D471/04C07D495/04
    • Provided are 1-N-aminobenzimidazole derivatives represented by the following formula (I): wherein R1 and R2 each represents a substituted or unsubstituted alkyl group or the like, R3, R5 and R6 each represents an alkyl group, alkoxy group, hydrogen atom or the like, R4 represents a substituted or unsubstituted alkyl group or the like, A represents a benzene ring or the like, B represents a hydrogen atom or the like, an n stands for an integer of from 0 to 2, or salts thereof; and medicines containing them. The compounds (I) according to the present invention do not bring about much individual differences in therapeutic effects despite the existence of individual differences in the CYP2C19 activity. At the same dose, they can hence bring about appropriate therapeutic effects for all patients. In addition, they are low in the risk of induction of an interaction or a cancer caused by induction of the CYP1A family. Accordingly, they are useful as peptic ulcer therapeutic agents which are safe and surely bring about therapeutic effects.
    • 提供由下式(I)表示的1-N-氨基苯并咪唑衍生物:其中R 1和R 2各自表示取代或未取代的烷基等,R R 5,R 5和R 6各自表示烷基,烷氧基,氢原子等,R 4, SUP>表示取代或未取代的烷基等,A表示苯环等,B表示氢原子等,n表示0〜2的整数,或其盐; 和含有它们的药物。 尽管CYP2C19活性存在个体差异,但是本发明的化合物(I)不会在治疗效果上产生太多的个体差异。 在相同剂量下,它们可以为所有患者带来适当的治疗效果。 此外,它们诱导由CYP1A家族诱导引起的相互作用或癌症的风险较低。 因此,它们可用作消化性溃疡治疗剂,其是安全的并且确实具有治疗效果。
    • 7. 发明授权
    • Twin clutch transmission
    • 双离合器传动
    • US08887589B2
    • 2014-11-18
    • US13700495
    • 2011-05-31
    • Masahiko IbamotoHideki NakamuraDaisuke Hagihara
    • Masahiko IbamotoHideki NakamuraDaisuke Hagihara
    • F16H3/08F16H3/00F16H37/04
    • F16H3/08F16H3/006F16H2037/044F16H2037/049F16H2200/006F16H2200/0095Y10T74/19233
    • A twin clutch transmission for a large horsepower vehicle having a compact size and a high transmission efficiency is obtained. In a twin clutch transmission, there are provided an input shaft, an odd-numbered level speed change mechanism 30, an even-numbered level speed change mechanism 60, a synchronizing speed change mechanism 100, and an output mechanism 90. The speed change mechanisms 30 and 60 include transmission gear trains 32 and 62, main clutches 34 and 64 for selectively transmitting the powers of the transmission gear trains 32 and 62 to the transmission shafts 40 and 70. The synchronizing speed change mechanism 100 includes synchronizing gear trains 110 and 120 for coupling the rotation of the odd-numbered level transmission shaft 32 with the rotation of the even-numbered level transmission shaft 62, and synchronizing clutches 112 and 122 for selecting coupling by this synchronizing gear train.
    • 获得具有紧凑尺寸和高传动效率的用于大功率车辆的双离合器变速器。 在双离合器变速器中,设置有输入轴,奇数级变速机构30,偶数级别变速机构60,同步变速机构100和输出机构90.变速机构 30和60包括传动齿轮系32和62,用于选择性地将传动齿轮系32和62的动力传递到传动轴40和70的主离合器34和64.同步变速机构100包括同步齿轮系110和120 用于将奇数级传动轴32的旋转与偶数级传动轴62的旋转联接,以及用于通过该同步齿轮系选择联接的同步离合器112和122。
    • 9. 发明申请
    • ELEVATOR SAFETY DEVICE AND ELEVATOR SAFETY DEVICE MOUNTING METHOD
    • 电梯安全装置和电梯安全装置安装方法
    • US20140151159A1
    • 2014-06-05
    • US14126695
    • 2011-09-07
    • Sachiomi MizunoHideki Nakamura
    • Sachiomi MizunoHideki Nakamura
    • B66B5/18
    • B66B5/18B66B5/22
    • A safety supporting body includes: a supporting body main body that is disposed inside a vertical stanchion groove of a car frame; and an engaging portion that protrudes outward from the supporting body main body, and that is hooked onto an upper end portion of a vertical stanchion. The safety supporting body is fixed to the vertical stanchion by a supporting body fixing apparatus. The supporting body fixing apparatus includes: a first fixing bolt that applies pressure between a side surface of the vertical stanchion groove and the supporting body main body; and a second fixing bolt that applies pressure between the engaging portion and a guiding apparatus mounting base that is fixed to the car frame. A safety device main body that applies a braking force to the car by placing a braking member in contact with the guide rail is disposed on the safety supporting body.
    • 安全支撑体包括:支撑体主体,其设置在轿厢架的垂直支柱槽内; 以及从支撑体主体向外突出并且被钩在垂直支柱的上端部的接合部。 安全支撑体通过支撑体固定装置固定在垂直支柱上。 支撑体固定装置包括:第一固定螺栓,其在垂直支柱槽的侧表面和支撑体主体之间施加压力; 以及第二固定螺栓,其在接合部和固定于轿厢架的引导装置安装基座之间施加压力。 通过将制动部件与导轨接触而向汽车施加制动力的安全装置主体设置在安全支撑体上。