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1. 发明授权

US07235067B2 Sleeve valve catheters 有权
标题翻译：套管导管
公开(公告)号：US07235067B2
公开(公告)日：2007-06-26
申请号：US10382757
申请日：2003-03-06
申请人： Mary M. Morris , Timothy G. Laske , Kenneth T. Heruth , Michael R. Ujhelyi , Jesus W. Casas-Bejar , David S. Olson
发明人： Mary M. Morris , Timothy G. Laske , Kenneth T. Heruth , Michael R. Ujhelyi , Jesus W. Casas-Bejar , David S. Olson
IPC分类号： A61M25/16
CPC分类号： A61M25/0075
摘要： A catheter body includes an exit port over which a pressure responsive sleeve is formed that allows material to exit a lumen of the catheter body at a given pressure. In one embodiment, a surface of the sleeve is approximately flush with a surface of the catheter body. In another embodiment the sleeve includes a tapered edge.
摘要翻译：导管主体包括出口，在该出口处形成压力响应套筒，其允许材料在给定压力下离开导管体的内腔。在一个实施例中，套筒的表面与导管主体的表面大致齐平。在另一个实施例中，套筒包括锥形边缘。

2. 发明授权

US07413564B2 Slit valve catheters 有权
标题翻译：狭缝阀导管
公开(公告)号：US07413564B2
公开(公告)日：2008-08-19
申请号：US10382948
申请日：2003-03-06
申请人： Mary M. Morris , Timothy G. Laske , Kenneth T. Heruth , Michael R. Ujhelyi , Jesus W. Casas-Bejar
发明人： Mary M. Morris , Timothy G. Laske , Kenneth T. Heruth , Michael R. Ujhelyi , Jesus W. Casas-Bejar
IPC分类号： A61M25/16 , A61M25/18
CPC分类号： A61M25/0075
摘要： An external surface of a catheter body includes a pressure responsive slit formed in an indentation wherein a wall thickness of the catheter body within the indentation is less than a wall thickness of a major portion of the catheter body. Material exits a lumen of the catheter body, via the pressure responsive slit, when a pressure inside the lumen exceeds an external pressure.
摘要翻译：导管体的外表面包括形成在凹陷中的压力响应狭缝，其中压痕内导管体的壁厚小于导管主体的主要部分的壁厚。当内腔内的压力超过外部压力时，材料通过压力响应狭缝离开导管主体的内腔。

3. 发明授权

US07658727B1 Implantable medical device with enhanced biocompatibility and biostability 有权
标题翻译：具有增强生物相容性和生物稳定性的植入式医疗器械
公开(公告)号：US07658727B1
公开(公告)日：2010-02-09
申请号：US09301842
申请日：1999-04-29
申请人： Brian C. A. Fernandes , Maura G. Donovan , Randall V. Sparer , Jesus W. Casas-Bejar , Mark W. Torrianni
发明人： Brian C. A. Fernandes , Maura G. Donovan , Randall V. Sparer , Jesus W. Casas-Bejar , Mark W. Torrianni
IPC分类号： A61M5/32
CPC分类号： A61F2/2445 , A61F2/24 , A61F2/2403 , A61F2250/0067 , A61L27/34 , A61L27/40 , A61L27/54 , A61L29/06 , A61L29/085 , A61L29/16 , A61L31/06 , A61L31/10 , A61L2300/102 , A61L2300/41 , C08L75/04
摘要： An implantable medical device comprising a drug-loaded polymer overlaid with a fabric that promotes tissue ingrowth is useful in a wide variety of tissue engineering applications. The invention includes, for example, prosthetic heart valves, annuloplasty rings, and grafts, having enhanced biocompatibility and biostability. Methods of making and using the implantable medical devices of the invention are also included.
摘要翻译：包括覆盖有促进组织向内生长的织物的载药聚合物的可植入医疗装置可用于各种组织工程应用。本发明包括例如具有增强的生物相容性和生物稳定性的假体心脏瓣膜，瓣膜成形术环和移植物。还包括制造和使用本发明的可植入医疗器械的方法。

4. 发明授权

US07742809B2 Electroporation catheter with sensing capabilities 有权
标题翻译：具有感应能力的电穿孔导管
公开(公告)号：US07742809B2
公开(公告)日：2010-06-22
申请号：US10647522
申请日：2003-08-25
申请人： Daniel C. Sigg , Daisy P. Cross , Jesus W. Casas-Bejar , Rodolfo A. Padua
发明人： Daniel C. Sigg , Daisy P. Cross , Jesus W. Casas-Bejar , Rodolfo A. Padua
IPC分类号： A61N1/30
CPC分类号： A61N1/327 , A61N1/0575
摘要： In general, the invention is directed to techniques for delivering macromolecules to a tissue site via electroporation. Particularly, a catheter detects contact between a distal end of the catheter and a target tissue site via a sensing electrode at the distal end of the catheter. The catheter delivers a fluid containing macromolecules to the tissue site upon detecting contact between the tissue site and the catheter. Concurrently or soon after delivery of the fluid, an electrical stimulus is applied to the tissue site. The electrical stimulus can be applied by the catheter or directly from a power supply, such as an implanted pulse generator. The electrical stimulus causes membranes of cells within the tissue site to destabilize, in turn, forming pores through which the macromolecules migrate into the cells of the tissue site.
摘要翻译：通常，本发明涉及通过电穿孔将大分子递送到组织部位的技术。特别地，导管通过导管远端处的感测电极来检测导管的远端与目标组织部位之间的接触。当检测到组织部位和导管之间的接触时，导管将含有大分子的流体输送到组织部位。流体同时或不久之后，电刺激被施加到组织部位。电刺激可以由导管或直接从诸如注入脉冲发生器的电源施加。电刺激导致组织部位内的细胞膜破坏稳定，反过来，形成孔，大分子通过这些孔迁移到组织部位的细胞中。

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