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    • 9. 发明申请
    • Handheld microcantilever-based sensor for detecting tobacco-specific nitrosamines
    • 用于检测烟草特异性亚硝胺的手持式微型悬臂梁传感器
    • US20080102532A1
    • 2008-05-01
    • US11902041
    • 2007-09-18
    • Seetharama DeeviFang Tian
    • Seetharama DeeviFang Tian
    • G01N33/00B01J19/00B05D1/36B05D3/10
    • G01N29/022G01N33/0047G01N2291/0255G01N2291/0256Y10T436/170769
    • A method and system for detecting tobacco-specific nitrosamines. The method includes exposing at least one microcantilever beam to a medium, which may contain tobacco-specific nitrosamines, and measuring a deflection of the microcantilever beam, wherein the deflection indicates a presence of tobacco-specific nitrosamines in the medium. The at least one microcantilever beam can include a silicon base layer and a gold-coated receptor layer with a plurality of thiol molecules having a sulfur head and carboxyl-terminated group. The at least one microcantilever beam can include a silicon base layer and a metal or metal oxide coated receptor layer. Alternatively, the microcantilever beam can be formed by co-absorbing tobacco-specific nitrosamines and silane molecules on a silicon microcantilever surface, wherein the template molecules of tobacco-specific nitrosamines physically co-adsorb between the silane molecules. The template molecules of tobacco-specific nitrosamines are then washed away with a solvent to form a silane monolayer having tobacco-specific nitrosamine cavities.
    • 一种用于检测烟草特异性亚硝胺的方法和系统。 该方法包括将至少一个微悬臂梁暴露于介质中,该培养基可含有烟草特异性亚硝胺,并测量微悬臂梁的挠曲,其中偏转指示介质中烟草特异性亚硝胺的存在。 所述至少一个微悬臂梁可以包括具有硫头和羧基封端基团的多个硫醇分子的硅基层和金涂覆的受体层。 所述至少一个微悬臂梁可以包括硅基层和金属或金属氧化物涂覆的受体层。 或者,可以通过在硅微悬臂梁表面上共同吸收烟草特异性亚硝胺和硅烷分子来形成微悬臂梁,其中烟草特异性亚硝胺的模板分子物理共吸附在硅烷分子之间。 然后用溶剂洗涤烟草特异性亚硝胺的模板分子以形成具有烟草特异性亚硝胺腔的硅烷单层。