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1. 发明授权

US06740107B2 Device for treatment of atrioventricular valve regurgitation 失效
标题翻译：用于治疗房室瓣膜反流的装置
公开(公告)号：US06740107B2
公开(公告)日：2004-05-25
申请号：US10024798
申请日：2001-12-19
申请人： Marvin P. Loeb , L. Dean Crawford , Randy P. Graham
发明人： Marvin P. Loeb , L. Dean Crawford , Randy P. Graham
IPC分类号： A61B1822
CPC分类号： A61B18/24 , A61B18/1492 , A61B2017/00243 , A61B2017/00867 , A61B2017/22059 , A61B2017/22069 , A61B2018/00196 , A61B2018/2211 , A61B2018/2277
摘要： A catheter device suitable for shrinking chordae tendineae of the human heart is provided having an energy conduit and a positioning device that facilitates the delivery of thermal energy, including coherent (laser) or non-coherent light, RF, microwave or ultrasound energy, to a predetermined region of the chordae tendineae or other collagen-containing tissue, such as the female urethra or the esophagus near the sphincter. The device comprises a tubular catheter containing an energy conduit, such as a fiber optic cable, adapted for delivering thermal energy to the tissue. The tubular catheter also contain a stabilizing device, disposed at its distal end, such as an asymmetrically shaped balloon or a retractable flexible metal hook. With the distal end of the catheter device positioned within a human heart, application of thermal energy to the chordae tendineae results in a shrinkage of the chordae, providing a treatment for primary mitral valve regurgitation.
摘要翻译：提供了适合于收缩人心脏腱索的导管装置，其具有能量导管和定位装置，该能量导管和定位装置有助于将包括相干（激光）或非相干光，RF，微波或超声能量的热能传递到腱索或其他含胶原的组织的预定区域，例如在括约肌附近的女性尿道或食管。该装置包括管状导管，其包含适于将热能输送到组织的能量导管，例如光纤电缆。管状导管还包含设置在其远端的稳定装置，例如不对称形状的气囊或可伸缩的柔性金属钩。随着导管装置的远端定位在人的心脏内，向腱索的腱索施加热能导致腱索的收缩，从而提供主要的二尖瓣关闭不全的治疗。

2. 发明授权

US07306588B2 Devices and methods for directed, interstitial ablation of tissue 有权
标题翻译：用于定向，间质消融组织的装置和方法
公开(公告)号：US07306588B2
公开(公告)日：2007-12-11
申请号：US10963213
申请日：2004-10-12
申请人： Marvin P. Loeb , L. Dean Crawford , James W. Pergl , Randy P. Graham
发明人： Marvin P. Loeb , L. Dean Crawford , James W. Pergl , Randy P. Graham
IPC分类号： A61B18/20
CPC分类号： A61B18/24 , A61B2018/00023 , A61B2018/2005 , A61B2018/2277
摘要： The invention relates to a catheter device including an optical fiber whose distal end is disposed within a hollow tube with a sharp or needle shaped distal end, which can penetrate tissue. The distal end of the optical fiber and the hollow tube are configured so as to emit, by refraction (total internal reflection) or reflection from a metal surface, laser energy at an angle of about 80° to about 90° relative to the longitudinal axis of the optical fiber and hollow tube. The hollow tube is mounted to a housing and may be surrounded by a sheath.
摘要翻译：本发明涉及一种导管装置，其包括光纤，其远端设置在具有尖锐或针状远端的中空管中，该远端可穿透组织。光纤的远端和中空管被配置为通过折射（全内反射）或来自金属表面的反射而发射相对于纵向轴线大约80°至大约90°的角度的激光能量的光纤和中空管。中空管安装到壳体上并且可以被护套包围。

3. 发明授权

US06802838B2 Devices and methods for directed, interstitial ablation of tissue 有权
标题翻译：用于定向，间质消融组织的装置和方法
公开(公告)号：US06802838B2
公开(公告)日：2004-10-12
申请号：US10127382
申请日：2002-04-22
申请人： Marvin P. Loeb , L. Dean Crawford , James W. Pergl , Randy P. Graham
发明人： Marvin P. Loeb , L. Dean Crawford , James W. Pergl , Randy P. Graham
IPC分类号： A61B1820
CPC分类号： A61B18/24 , A61B2018/00023 , A61B2018/2005 , A61B2018/2277
摘要： The invention relates to a catheter device including an optical fiber whose distal end is disposed within a hollow tube with a sharp or syringe shaped distal end, which may be inserted into tissue. The distal end of the optical fiber and the hollow tube are configured so as to emit, by refraction (total internal reflection) or reflection from a metal surface, laser energy at an angle of about 80° to about 90° relative to the longitudinal axis of the optical fiber and hollow tube. A first fluid channel within the distal end portion of the tube enables fluid to be infused to cool the distal end of the tube and to cool and clean the emission face of the optical fiber. A second, relatively larger diameter fluid channel in the tube enables the fluid, flowing through said first channel along with hot gasses from the vaporization of tissue, to exit the device through a second port in the tube, away from the tissue being treated. A vacuum can be applied to the second fluid channel to more effectively remove the infused, cooling fluid and hot gasses from the tissue being treated. Alternatively, the tube can incorporate a distal end portion which can be articulated to allow the insertion of the device into tissue perpendicular to the tissue's surface, from which laser energy can be emitted forwardly.
摘要翻译：本发明涉及一种导管装置，其包括光纤，其远端设置在具有尖锐或注射器形状的远端的中空管内，该中空管可插入组织中。光纤的远端和中空管被配置为通过折射（全内反射）或来自金属表面的反射而发射相对于纵向轴线大约80°至大约90°的角度的激光能量的光纤和中空管。在管的远端部分内的第一流体通道使流体能够被输注以冷却管的远端并且冷却和清洁光纤的发射面。管中的第二个相对较大直径的流体通道使得能够流过所述第一通道以及来自组织蒸发的热气体的流体通过管中的第二端口远离被处理的组织离开装置。可以向第二流体通道施加真空，以更有效地从被处理的组织中更清除地从输送的冷却流体和热气中去除。或者，管可以包括远端部分，其可被铰接以允许将装置插入垂直于组织表面的组织中，激光能量从该组织的表面向前发射。

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