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1. 发明申请

US20060040903A1 Methods of use related to xerostomia 审中-公开
标题翻译：使用方法与口腔干燥有关
公开(公告)号：US20060040903A1
公开(公告)日：2006-02-23
申请号：US11258335
申请日：2005-10-25
申请人： Martin Stogniew , David Alberts , Edward Kaplan
发明人： Martin Stogniew , David Alberts , Edward Kaplan
IPC分类号： A61K31/13 , A61K31/66
CPC分类号： A61K31/661 , A61K31/13 , A61K31/135 , A61K31/145 , A61K31/16 , A61K31/195 , A61K31/426 , A61K31/66 , A61K45/06 , A61K2300/00
摘要： The present invention relates to new uses of thermally stable, crystalline S-2-(3-aminopropylamino)ethyl dihydrogen phosphorothioate, (amifostine) and other aminothiol compounds to treat and reverse toxicities caused by radiation treatment. In particular, the invention provides a method for treating or preventing xerostomia associated with the administration of radiation treatment of head and neck cancer.
摘要翻译：本发明涉及热稳定的结晶S-2-（3-氨基丙基氨基）乙基二硫代磷酸酯（氨磷汀）和其它氨基硫醇化合物治疗和逆转放射治疗引起的毒性的新用途。特别地，本发明提供了治疗或预防与头颈癌的放射治疗相关的口腔干燥症的方法。

2. 发明申请

US20060270636A1 Methods for treatment of neuro- and nephro- disorders and therapeutic toxicities using aminothiol compounds 审中-公开
公开(公告)号：US20060270636A1
公开(公告)日：2006-11-30
申请号：US11501949
申请日：2006-08-09
申请人： Martin Stogniew , David Alberts , Edward Kaplan
发明人： Martin Stogniew , David Alberts , Edward Kaplan
IPC分类号： A61K31/66 , A61K31/13
CPC分类号： A61K31/661 , A61K31/13 , A61K31/135 , A61K31/145 , A61K31/16 , A61K31/195 , A61K31/426 , A61K31/66 , A61K45/06 , A61K2300/00
摘要： The present invention relates to new uses of S-2-(3-aminopropylamino)ethyl dihydrogen phosphorothioate, (amifostine) and other aminothiol compounds to treat and reverse toxicities caused by therapeutic agents, radiation treatment or diabetes. In particular, the invention provides a method for treating neurotoxicity and nephrotoxicity associated with the administration of chemotherapeutic agents.

3. 发明申请

US20070213354A1 Compositions and Methods for the Treatment of Multiple Sclerosis 审中-公开
标题翻译：治疗多发性硬化症的组合物和方法
公开(公告)号：US20070213354A1
公开(公告)日：2007-09-13
申请号：US11681120
申请日：2007-03-01
申请人： Robert Dorr , Evan Hersh , David Alberts
发明人： Robert Dorr , Evan Hersh , David Alberts
IPC分类号： A61K31/473
CPC分类号： A61K31/473
摘要： Compositions and methods for treating multiple sclerosis are disclosed herein. Embodiments of the present invention include methods of treating a multiple sclerosis patient via the administration of a therapeutically effective amount of a composition comprising a compound of the formula: wherein, R1 is heteroalkyl, heterocycloalkyl, or heteroaryl; R2, R4 and R6 are independently hydrogen, halogen, nitro, amino, hydroxy, C1-C6 alkyl, C1-C6 heteroalkyl, heterocycloalkyl or aryl; R3, R5, and R7 are independently hydrogen or C1-C6 alkyl, or R3 and R4 taken together with the carbon atoms to which they are attached form a phenyl ring, or R4 and R5 taken together with the carbon atoms to which they are attached form a phenyl ring, or R5 and R7 taken together with the carbon atoms to which they are attached form a phenyl ring; and n1 and n2 are independently 0, 1 or 2; or a pharmaceutically acceptable salt, a prodrug, or a mixture thereof.
摘要翻译：本文公开了用于治疗多发性硬化的组合物和方法。本发明的实施方案包括通过施用治疗有效量的包含下式化合物的组合物治疗多发性硬化患者的方法：其中R 1是杂烷基，杂环烷基或杂芳基; R 2，R 4和R 6独立地是氢，卤素，硝基，氨基，羟基，C 1〜 C 6 -C 6烷基，C 1 -C 6 - 杂烷基，杂环烷基或芳基; R 3，R 5和R 7独立地是氢或C 1 -C 6烷基，或者R 3和R 4与它们所连接的碳原子一起形成苯环，或者R 4

4. 发明申请

US20050176696A1 Synergistic anit-cancer compounds 审中-公开
标题翻译：协同作用的癌症化合物
公开(公告)号：US20050176696A1
公开(公告)日：2005-08-11
申请号：US11007988
申请日：2004-12-08
申请人： Robert Dorr , David Alberts , Evan Hersh
发明人： Robert Dorr , David Alberts , Evan Hersh
IPC分类号： A61K20060101 , A61K31/33 , A61K31/335 , A61K31/396 , A61K31/415 , A61K31/70 , A61K33/26
CPC分类号： A61K31/33 , A61K31/335 , A61K31/415 , A61K31/4184 , A61K31/655 , A61K31/675 , A61K31/70 , A61K45/06 , A61K2300/00
摘要： The present invention provides compositions useful in treating cancer. The compositions include a synergistic combination of an antineoplastic thiol-binding mitochondrial oxidant with an antineoplastic nucleic acid binding agent, an antineoplastic antimetabolite base analog, or docetaxel. Also provided are methods of assaying the synergistic effects of the combinations and methods of treating cancer using the synergistic combinations.
摘要翻译：本发明提供了可用于治疗癌症的组合物。组合物包括抗肿瘤硫醇结合线粒体氧化剂与抗肿瘤性核酸结合剂，抗肿瘤抗代谢物碱类似物或多西紫杉醇的协同组合。还提供了使用协同组合来测定治疗癌症的组合和方法的协同效应的方法。

5. 发明申请

US20050142078A1 Method of stimulation of melanin production and induction of skin tanning 审中-公开
标题翻译：刺激黑色素生成和皮肤鞣制诱导的方法
公开(公告)号：US20050142078A1
公开(公告)日：2005-06-30
申请号：US10504492
申请日：2003-02-25
申请人： Robert Dorr , Norman Levine , Gregory Ertl , David Alberts
发明人： Robert Dorr , Norman Levine , Gregory Ertl , David Alberts
IPC分类号： A61K8/72 , A61K8/00 , A61K8/64 , A61K38/00 , A61K38/34 , A61P17/16 , A61Q19/04 , A61K38/08 , A61K7/42
CPC分类号： A61Q19/04 , A61K8/64 , A61K38/34 , A61K2300/00
摘要： A method of stimulating the production of melanin by the pigment-producing cells (keratinocytes and/or melanocytes) of the skin, in particular for the induction of skin tanning in humans, comprises administering alpha-MSH or an alpha-MSH analogue and exposing the skin to ultraviolet irradiation.
摘要翻译：刺激皮肤的颜料产生细胞（角质形成细胞和/或黑素细胞）产生黑色素的方法，特别是用于诱导人体皮肤鞣制的方法包括施用α-MSH或α-MSH类似物，并将皮肤紫外线照射。

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