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1. 发明授权

US06337325B1 Combined preparation for the therapy of immune diseases 失效
标题翻译：联合用于免疫疾病治疗的准备
公开(公告)号：US06337325B1
公开(公告)日：2002-01-08
申请号：US09357230
申请日：1999-07-20
申请人： Martin Schönharting , Stefan Müllner , Peter Zabel
发明人： Martin Schönharting , Stefan Müllner , Peter Zabel
IPC分类号： A01N4300
CPC分类号： A61K31/522 , A61K31/554 , A61K38/13 , A61K45/06 , Y10S514/826 , Y10S514/885 , Y10S514/889 , A61K31/4375 , A61K31/4422 , A61K31/277 , A61K2300/00
摘要： A combination preparation comprising a compound which has a phosphodiesterase-inhibiting action, and a compound which reduces the biologically effective intracellular Ca2+ content, is suitable for the treatment of immunological diseases.
摘要翻译：包含具有磷酸二酯酶抑制作用的化合物和降低生物学有效细胞内Ca 2+含量的化合物的组合制剂适用于治疗免疫疾病。

2. 发明申请

US20100331201A1 PROTEIN BIOCHIP FOR THE DIFFERENTIAL SCREENING OF PROTEIN-PROTEIN INTERACTIONS 审中-公开
标题翻译：蛋白质蛋白质相互作用差异筛选蛋白生物
公开(公告)号：US20100331201A1
公开(公告)日：2010-12-30
申请号：US12304060
申请日：2007-06-11
申请人： Stefan Müllner , Angelika Lüking , Verena Trappe
发明人： Stefan Müllner , Angelika Lüking , Verena Trappe
IPC分类号： C40B30/04 , C40B40/10 , G01N33/53
CPC分类号： G01N33/6845 , C07K1/1077 , C07K17/02 , G01N33/6878
摘要： The present invention relates to a system of protein binders containing at least one protein binder presented in at least one native form and at least one non-native form and its use including a method for discrimination and/or differential screening of suitable protein binders in native and non-native form.
摘要翻译：本发明涉及含有至少一种以至少一种天然形式和至少一种非天然形式存在的至少一种蛋白质粘合剂的蛋白质粘合剂的系统，其用途包括鉴定和/或鉴别和/或差异筛选天然的蛋白质结合剂的方法和非本地形式。

3. 发明申请

US20130303395A1 MARKER SEQUENCES FOR SYSTEMIC LUPUS ERYTHEMATOSUS AND THE USE THEREOF 审中-公开
标题翻译：系统性红斑狼疮的标记序列及其用途
公开(公告)号：US20130303395A1
公开(公告)日：2013-11-14
申请号：US13879149
申请日：2011-10-12
申请人： Angelika Lueking , Axel Kowald , Stefan Müllner , Christian Scheer , Matthias Schneider
发明人： Angelika Lueking , Axel Kowald , Stefan Müllner , Christian Scheer , Matthias Schneider
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , C12Q1/6834 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158
摘要： The invention relates to novel marker sequences for systemic lupus erythematosus and to the use thereof in diagnosis as well as to a method for screening potential active ingredients for systemic lupus erythematosus diseases using said marker sequences. The invention further relates to a diagnostic device containing such marker sequences for systemic lupus erythematosus, especially to a protein biochip and the use thereof.
摘要翻译：本发明涉及用于系统性红斑狼疮的新型标志物序列及其在诊断中的应用以及使用所述标记序列筛选系统性红斑狼疮疾病潜在活性成分的方法。本发明还涉及包含用于系统性红斑狼疮，特别是蛋白质生物芯片的标记序列的诊断装置及其用途。

4. 发明授权

US10060911B2 Method for diagnosis of high-affinity binders and marker sequences 有权
公开(公告)号：US10060911B2
公开(公告)日：2018-08-28
申请号：US14239224
申请日：2012-08-18
申请人： Stefan Müllner , Peter Schulz-Knappe , Angelika Lueking , Heike Göhler , Jessica Schwermann
发明人： Stefan Müllner , Peter Schulz-Knappe , Angelika Lueking , Heike Göhler , Jessica Schwermann
IPC分类号： G01N33/53 , G01N33/543 , G01N33/68 , G01N33/564
CPC分类号： G01N33/54306 , G01N33/564 , G01N33/6845 , G01N33/6854
摘要： The present invention relates to a novel method for diagnosing high-affinity binders, in particular antibodies or autoantibodies, and the identification, characterization and selection of marker sequences and diagnostic use thereof, in particular in the form of a panel. The invention also relates to a singleplex assay in which the discovered selection of marker sequences is used in the form of a panel and high-affinity binders are detected using a single signal.

5. 发明申请

US20130029864A1 BIOMARKERS FOR ALZHEIMER'S DISEASE 审中-公开
标题翻译：阿尔茨海默病的生物标志物
公开(公告)号：US20130029864A1
公开(公告)日：2013-01-31
申请号：US13499546
申请日：2010-10-01
申请人： Angelika Lueking , Stefan Müllner , Charlotte Teunissen , Jens Wiltfang
发明人： Angelika Lueking , Stefan Müllner , Charlotte Teunissen , Jens Wiltfang
IPC分类号： C40B30/04 , C40B40/08
CPC分类号： G01N33/6896 , G01N2800/2821
摘要： The invention relates to novel marker sequences for Alzheimer's disease, in particular Alzheimer's dementia, and their diagnostic use including a screening method in order to identify potential drugs for the treatment/prophylaxis of Alzheimer's disease by means of the said novel marker sequences. Moreover, the invention relates to a diagnostic device comprising said novel marker sequences for diagnosing Alzheimer's disease, particularly a protein array (chip) and its use hereto.
摘要翻译：本发明涉及阿尔茨海默病，特别是阿尔茨海默氏痴呆的新型标记序列及其诊断用途，包括筛选方法，以通过所述新型标记序列鉴定用于治疗/预防阿尔茨海默氏病的潜在药物。此外，本发明涉及包含用于诊断阿尔茨海默病的新型标记序列，特别是蛋白质阵列（芯片）的诊断装置及其用途。

6. 发明授权

US06265588B1 Isoxazole and crotonamide derivatives and their use as pharmaceuticals and diagnostics 有权
标题翻译：异恶唑和巴豆酰胺衍生物及其作为药物和诊断用途
公开(公告)号：US06265588B1
公开(公告)日：2001-07-24
申请号：US09580625
申请日：2000-05-30
申请人： Stefan Müllner , Bernd Kirschbaum , Wilfried Schwab
发明人： Stefan Müllner , Bernd Kirschbaum , Wilfried Schwab
IPC分类号： C07D26108
CPC分类号： G01N33/68 , C07C255/23 , C07D261/18 , G01N33/54393 , G01N33/558 , G01N33/94
摘要： A compound of the formula where R1 is the radical of the formula II or III is suitable for the production of a pharmaceutical for the treatment of inflammations, carcinomatous diseases, or autoimmune diseases. A compound of the formula IV is suitable for the production of specific antibodies against a compound of the formula I for the discovery of specific-binding proteins from cell extracts, serum, blood, or synovial fluids, for the purification of proteins, for the modification of microtiter plates, or for the preparation of chromatography material, in particular of affinity chromatography material, and for use in diagnostics.
摘要翻译：制剂R1的化合物是式II或III的基团，其适用于制备用于治疗炎症，癌性疾病或自身免疫性疾病的药物。式IV化合物适用于生产针对式I化合物的特异性抗体，用于从细胞提取物，血清，血液或滑液中发现特异性结合蛋白，用于蛋白质的纯化，用于修饰微量滴定板，或用于制备色谱材料，特别是亲和层析材料，并用于诊断。

7. 发明申请

US20140309133A1 Novel Method for Diagnosis of High-Affinity Binders and Marker Sequences 审中-公开
标题翻译：用于诊断高亲和力和标记序列的新方法
公开(公告)号：US20140309133A1
公开(公告)日：2014-10-16
申请号：US14239224
申请日：2012-08-18
申请人： Stefan Müllner , Peter Schulz-Knappe , Angelika Lueking , Heike Göhler , Jessica Schwermann
发明人： Stefan Müllner , Peter Schulz-Knappe , Angelika Lueking , Heike Göhler , Jessica Schwermann
IPC分类号： G01N33/543
CPC分类号： G01N33/54306 , G01N33/564 , G01N33/6845 , G01N33/6854
摘要： The present invention relates to a novel method for diagnosing high-affinity binders, in particular antibodies or autoantibodies, and the identification, characterisation and selection of marker sequences and diagnostic use thereof, in particular in the form of a panel. The invention also relates to a singleplex assay in which the discovered selection of marker sequences is used in the form of a panel and high-affinity binders are detected using a single signal.
摘要翻译：本发明涉及用于诊断高亲和力结合剂，特别是抗体或自身抗体的新方法，以及特别是面板形式的标记序列的鉴定，表征和选择及其诊断用途。本发明还涉及单重检测，其中所发现的标记序列的选择以面板的形式使用，并且使用单个信号检测高亲和力结合物。

8. 发明授权

US06589785B1 Disrupting cells and/or tissue in solid state in presence of solid denaturing substance 失效
标题翻译：在固体变性物质的存在下破坏固体的细胞和/或组织
公开(公告)号：US06589785B1
公开(公告)日：2003-07-08
申请号：US09581563
申请日：2000-07-31
申请人： Stefan Müllner , Thomas Neumann
发明人： Stefan Müllner , Thomas Neumann
IPC分类号： C12N106
CPC分类号： C12N15/1003 , C12N1/06
摘要： A method for disrupting frozen cells and/or tissue in a solid, frozen state in the presence of a solid denaturing substance is provided. The method comprises providing frozen cells and/or tissue in frozen solid form, adding thereto the solid denaturing substance in sold form, and applying mechanical force thereto for disruption of the frozen cells and/or tissue. The frozen cells and/or tissue include muscle cells and/or muscle tissue, wheat cells and/or wheat tissue, and maize cells and/or maize tissue. Further, the solid, denaturing substance in solid form is a crystalline substance and can be selected from urea, thiourea, guanidium chloride, guanidium thiocyanate and ammonium sulfate. Also the solid, denaturing substance in solid form is added to the frozen cells and/or tissue in frozen form in an approximately 1 to 20 fold (w/w) excess.
摘要翻译：提供了在固体变性物质存在下破坏固体，冷冻状态的冷冻细胞和/或组织的方法。该方法包括以冷冻固体形式提供冷冻细胞和/或组织，向其中以出售形式加入固体变性物质，并施加机械力以破坏冷冻的细胞和/或组织。冷冻细胞和/或组织包括肌肉细胞和/或肌肉组织，小麦细胞和/或小麦组织，以及玉米细胞和/或玉米组织。此外，固体形式的固体变性物质是结晶物质，可以选自脲，硫脲，氯化胍，硫氰酸胍和硫酸铵。此外，将固体形式的固体变性物质以约1至20倍（w / w）的过量加入到冷冻细胞和/或冷冻形式的组织中。

9. 发明授权

US06582691B1 Expression vector for the production of dead proteins 失效
标题翻译：用于生产死蛋白的表达载体
公开(公告)号：US06582691B1
公开(公告)日：2003-06-24
申请号：US09601537
申请日：2000-09-29
申请人： Karl-Christian Gallert , Stefan Müllner , Christoph Hüls , Britta Böhnisch
发明人： Karl-Christian Gallert , Stefan Müllner , Christoph Hüls , Britta Böhnisch
IPC分类号： A61K4800
CPC分类号： C12N15/86 , C07K2319/00 , C12N9/90 , C12N2710/14143
摘要： The invention relates to an insect cell vector for the production of proteins from the DEAD protein family.
摘要翻译：本发明涉及用于从DEAD蛋白家族生产蛋白质的昆虫细胞载体。

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