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1. 发明授权

US08164052B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08164052B2
公开(公告)日：2012-04-24
申请号：US12593006
申请日：2008-03-26
申请人： Martin R. Green , Jason Lee Wildgoose , Jeffery Mark Brown
发明人： Martin R. Green , Jason Lee Wildgoose , Jeffery Mark Brown
IPC分类号： H01J49/26 , H01J49/40
CPC分类号： H01J49/0481 , H01J49/0072 , H01J49/065 , H01J49/40 , Y10T436/24
摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell (1). Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell (1). The cell comprises a plurality of ring electrodes (1) which form a spherical trapping volume. Ions experience negligible RF heating over the majority, of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell (1) having an enhanced sensitivity is thereby provided. Fragment ions created within the cell (1) may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.
摘要翻译：公开了包含电子转移离解电池（1）的质谱仪。当与单体电荷的负试剂离子碰撞时，阳性分析物离子被碎裂成碎片离子（1）。电池包括形成球形捕获体积的多个环形电极（1）。离子经验可忽略大部分的RF加热，捕集体积使分析物和试剂离子的动能降低到高于热温度。由此提供了具有增强的灵敏度的电子转移解离单元（1）。在细胞（1）内产生的片段离子可以被冷却并且可以向内传播到正交加速时间飞行质量分析仪，能够显着提高质量分析仪的分辨率。

2. 发明申请

US20120208289A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20120208289A1
公开(公告)日：2012-08-16
申请号：US13453657
申请日：2012-04-23
申请人： Martin R. Green , Jason Lee Wildgoose , Jeffery Mark Brown
发明人： Martin R. Green , Jason Lee Wildgoose , Jeffery Mark Brown
IPC分类号： G01N27/62
CPC分类号： H01J49/0481 , H01J49/0072 , H01J49/065 , H01J49/40 , Y10T436/24
摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell. Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell. The cell comprises a plurality of ring electrodes which form a spherical trapping volume. Ions experience negligible RF heating over the majority of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell having an enhanced sensitivity is thereby provided. Fragment ions created within the cell may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.
摘要翻译：公开了一种质谱仪，其包括电子转移解离单元。当与单体电荷的负试剂离子碰撞时，阳性分析物离子被碎裂成碎片离子。电池包括形成球形捕获体积的多个环形电极。在大多数捕集体积下，离子经历可忽略的RF加热，使得分析物和试剂离子的动能能够降低到高于热温度。从而提供具有增强的灵敏度的电子转移解离电池。在细胞内产生的片段离子可以被冷却并且可以向内传播到正交加速时间飞行质量分析仪，使得可以获得质量分析仪的分辨率的显着提高。

3. 发明授权

US08426803B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08426803B2
公开(公告)日：2013-04-23
申请号：US12668813
申请日：2008-07-14
申请人： Martin R. Green , Daniel James Kenny , David Langridge , Jason Lee Wildgoose
发明人： Martin R. Green , Daniel James Kenny , David Langridge , Jason Lee Wildgoose
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/4205 , H01J49/02 , H01J49/4225
摘要： A mass spectrometer is disclosed comprising a quadrupole rod set ion trap wherein a potential field is created at the exit of the ion trap which decreases with increasing radius in one radial direction. Ions within the ion trap are mass selectively excited in a radial direction. Ions which have been excited in the radial direction experience a potential field which no longer confines the ions axially within the ion trap but which instead acts to extract the ions and hence causes the ions to be ejected axially from the ion trap.
摘要翻译：公开了一种质谱仪，其包括四极杆组离子阱，其中在一个径向方向上随半径增加而在离子阱的出口产生电势场。离子阱内的离子质量选择性地沿径向激发。已经在径向方向被激发的离子经历了不再将离子轴向限定在离子阱内的势场，而是作用于提取离子并因此导致离子从离子阱轴向喷出。

4. 发明授权

US5124354A Cosmetic composition containing an aryl-substituted ethylene 失效
标题翻译：含有ARYL取代的乙烯的化妆品组合物
公开(公告)号：US5124354A
公开(公告)日：1992-06-23
申请号：US536135
申请日：1990-06-11
申请人： Martin R. Green
发明人： Martin R. Green
IPC分类号： A61K8/00 , A61K8/31 , A61K8/33 , A61K8/35 , A61K8/36 , A61K8/365 , A61K8/368 , A61K8/40 , A61K8/42 , A61K8/46 , A61K8/49 , A61Q5/00 , A61Q5/02 , A61Q7/00
CPC分类号： A61K8/42 , A61K8/365 , A61K8/40 , A61K8/46 , A61Q7/00 , A61K2800/782
摘要： A composition suitable for topical application to mammalian skin or hair for inducing, maintaining or increasing hair growth comprises:(i) a special protein tyrosine kinase inhibitor; and(ii) a cosmetically acceptable vehicle for the inhibitor.

5. 发明授权

US5358714A Cosmetic composition 失效
标题翻译：化妆品组成
公开(公告)号：US5358714A
公开(公告)日：1994-10-25
申请号：US995312
申请日：1992-12-22
申请人： Martin R. Green
发明人： Martin R. Green
IPC分类号： A61K8/37 , A61Q7/00 , A61K9/00 , A61K7/06 , A61K37/02
CPC分类号： A61Q7/00 , A61K8/375 , A61K2800/70
摘要： A preserved composition suitable for topical application to mammalian skin or hair for inducing, maintaining or increasing hair growth comprises:(i) a chemical activator of protein kinase C enzymes chosen from diacylglycerols having the structure (1): ##STR1## where X is the same or different, and is represented by the grouping: ##STR2## where x is 0 , or an integer of from 1 to 28, and y is 0 or an integer of from 1 to 5;the R groups being of either stereochemical configuration with respect to the carbon backbone of the glycerol molecule, and the double bonds beings of either cis or trans configuration; and(ii) a cosmetically acceptable vehicle for the chemical activator.
摘要翻译：适于局部施用于哺乳动物皮肤或头发以用于诱导，维持或增加毛发生长的保存的组合物包括：（i）蛋白激酶C酶的化学活化剂，其选自具有以下结构的二酰基甘油：（1）其中 X是相同或不同的，并且由分组表示：其中x为0，或整数为1至28，y为0或整数为1至5; R基团相对于甘油分子的碳骨架具有立体化学构型，并且是双键或反式构型的双键; 和（ii）用于化学活化剂的美容上可接受的载体。

6. 发明授权

US5241433A Disk drive servo control 失效
标题翻译：磁盘驱动伺服控制
公开(公告)号：US5241433A
公开(公告)日：1993-08-31
申请号：US965038
申请日：1992-10-22
申请人： Todd B. Anderson , Mark E. Bofferding , Martin R. Green , Mark D. Hagen , Joseph M. Humel , William J. Hunt , Lawrence P. Segar , John J. Stephenson , Michael C. Stich
发明人： Todd B. Anderson , Mark E. Bofferding , Martin R. Green , Mark D. Hagen , Joseph M. Humel , William J. Hunt , Lawrence P. Segar , John J. Stephenson , Michael C. Stich
IPC分类号： G11B5/596
CPC分类号： G11B5/59655
摘要： In a disk storage device dedicated servo system, a reference track is written in the outer guardband of the servo surface and each of the data surfaces. Supplemental position error signal (PES) values are obtained from the difference of servo and data surface samples at a plurality of locations around the disk and stored for access during read/write operations. The supplemental PES values are combined with the dedicated surface PES values to yield a composite PES that more accurately follows the data track centerline of the disk surface being addressed. The supplemental PES values are also periodically updated. To provide a more accurate correction of the composite PES, two consecutive supplemental values are used and an interpolation is calculated to provide a continuously changing supplemental PES value for modification of each sector actuator drive pulse between the two current supplemental PES values. Provision is also made in the apparatus to make the correction technique tolerant of tangential skew that may make tracks unreadable because of early or late timing through the provision of sequences of alternative early and later sample sector sequences.
摘要翻译：在盘存储装置专用伺服系统中，将参考轨迹写入伺服表面的外保护带和每个数据表面。补充位置误差信号（PES）值是从磁盘周围的多个位置处的伺服和数据表面采样的差异获得的，并且在读/写操作期间被存储用于存取。补充的PES值与专用表面PES值组合以产生更精确地跟随被寻址的盘表面的数据轨道中心线的复合PES。补充的PES值也被定期更新。为了提供复合PES的更准确的校正，使用两个连续的补充值，并且计算插值以提供连续改变的补充PES值，以修改两个当前补充PES值之间的每个扇区致动器驱动脉冲。在装置中也作出规定，以使得校正技术能够容忍切向偏斜，由于提供替代的早期和后期采样扇区序列的序列，可能导致轨迹不可读，因为它们的早期或晚期定时。

7. 发明授权

US5193036A Transducer head skew arrangement for disk drive system 失效
标题翻译：用于磁盘驱动系统的传动头螺钉安装
公开(公告)号：US5193036A
公开(公告)日：1993-03-09
申请号：US591910
申请日：1990-10-02
申请人： Martin R. Green , Randolph B. Heineke , John J. Stephenson
发明人： Martin R. Green , Randolph B. Heineke , John J. Stephenson
IPC分类号： G11B5/48 , G11B19/02 , G11B19/20 , G11B20/12 , G11B21/08 , G11B21/10
CPC分类号： G11B19/20 , G11B19/02 , G11B21/083
摘要： A transducer head skew arrangement used in a multiple disk drive data storage system is provided. The disk drive unit includes a plurality of magnetic disk surfaces mounted for simultaneous rotation about an axis. A first sequence of servo information tracks are arrayed on a dedicated servo disk surface. At least one servo reference track is written on each data disk surface for storing servo reference information. The servo reference track is written on a first data disk surface aligned with a predefined servo information track on the dedicated servo disk surface. Then servo reference tracks are sequentially written on each successive consecutive data disk surface progressively offset radially from the last written servo reference track. A plurality of data information tracks for storing data are disposed at predetermined positions relative to the servo reference track on each the data disk surface. A servo transducer head is mounted for movement in a radial direction across the first dedicated servo information for reading servo information; and a plurality of data transducer heads are mounted for movement with the servo transducer head in a radial direction across the disk surfaces for reading the servo reference tracks and for reading and/or writing data to the data information tracks. The distance moved by transducer heads for a cylinder switch is the same distance moved for each head switch, so that track-to-track seek time is minimized without requiring any additional time delay for each head switch. An overall data transfer rate increases for every data transfer accessing more than one data cylinder.

8. 发明授权

US4529587A Method of reducing sebum on the hair and skin 失效
标题翻译：减少头发和皮肤皮脂的方法
公开(公告)号：US4529587A
公开(公告)日：1985-07-16
申请号：US462859
申请日：1983-02-01
申请人： Martin R. Green
发明人： Martin R. Green
IPC分类号： C11D3/28 , A61K20060101 , A61K8/00 , A61K8/34 , A61K8/42 , A61K8/46 , A61K8/49 , A61K8/67 , A61K31/10 , A61K31/34 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/445 , A61P17/00 , A61Q5/00 , A61Q5/02 , A61Q7/00 , A61Q19/00 , A61K7/06 , A61K7/07
CPC分类号： A61Q19/008 , A61K8/67 , A61Q5/00 , A61Q5/008 , Y10S424/04 , Y10S514/846
摘要： A cosmetically acceptable composition for topical application to human skin or hair in order to reduce greasiness comprises, at a concentration of from 0.0001M to 0.5M, a biotin antagonist which is capable of blocking the activity of the biotin dependent enzyme acetyl-SCoA-carboxylase implicated in sebum production; together with a carrier other than water as an aid to delivering the biotin antagonist to the sebaceous gland.
摘要翻译：用于局部施用于人皮肤或头发以减少油脂的美容上可接受的组合物包含浓度为0.0001M至0.5M的能够阻断生物素依赖性酶乙酰-CoA-羧化酶活性的生物素拮抗剂涉及皮脂生产; 与水以外的载体一起帮助将生物素拮抗剂递送到皮脂腺。

9. 发明授权

US5545399A Cosmetic composition 失效
标题翻译：化妆品组成
公开(公告)号：US5545399A
公开(公告)日：1996-08-13
申请号：US327727
申请日：1994-10-24
申请人： Caroline M. Lee , Martin R. Green , Giuseppe Prota
发明人： Caroline M. Lee , Martin R. Green , Giuseppe Prota
IPC分类号： A61K8/00 , A61K8/33 , A61K8/34 , A61K8/35 , A61K8/37 , A61K8/67 , A61K31/07 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61K7/42 , A61K31/075 , A61K31/12 , A61K31/21
CPC分类号： A61Q19/02 , A61K8/347 , A61K8/35 , A61K8/375 , A61K8/671 , A61Q17/04 , A61Q19/00 , A61Q19/004 , A61Q19/08
摘要： A composition for topical application to the skin in order to promote the repair of photo-damaged or aged skin and/or to reduce or prevent damaging effects of ultra-violet light on skin and/or to lighten the skin comprising a hydrocalchone of general structure: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, represent H, --OH, --OR or --COR (where R is a C.sub.1-20 alkyl group);R.sub.4, R.sub.5, R.sub.6 and R.sub.7, which may be the same or different, represent H or --COR (where R is as herein before defined).Optional additional ingredients include sunscreens and other skin lightening skin lightening agents, particularly retinol or derivatives thereof.
摘要翻译：用于皮肤局部施用以促进光损伤或老化皮肤的修复和/或减少或防止紫外线对皮肤的损伤作用和/或减轻皮肤的组合物，其包含一般结构的氢化钙：其中R 1，R 2和R 3可以相同或不同，表示H，-OH，-OR或-COR（其中R是C 1-20烷基）; R 4，R 5，R 6和R 7可以相同或不同，表示H或-COR（其中R如本文中所定义）。可选的另外的成分包括防晒剂和其它皮肤增亮的皮肤亮白剂，特别是视黄醇或其衍生物。

10. 发明授权

US5119250A Method and apparatus for performing a seek 失效
标题翻译：实施SEEK的方法和装置
公开(公告)号：US5119250A
公开(公告)日：1992-06-02
申请号：US538958
申请日：1990-06-15
申请人： Martin R. Green , John J. Stephenson , Michael C. Stich
发明人： Martin R. Green , John J. Stephenson , Michael C. Stich
IPC分类号： G05D3/12 , G11B21/08
CPC分类号： G11B21/083
摘要： Disclosed is a method for performing a seek operation in a disk drive using current in the saturation mode to accelerate and decelerate the actuator arm. In a first embodiment, several measurements are made during the acceleration portion of the seek to estimate the deceleration available in saturation mode. In a second embodiment, the point at which the current is switched from acceleration current to deceleration current is adjusted based upon the position where the actuator arm comes within a desired amount of the velocity of a velocity profile assuming worst case conditions.

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