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1. 发明申请

US20070004701A1 Topoisomerase inhibitors 失效
标题翻译：拓扑异构酶抑制剂
公开(公告)号：US20070004701A1
公开(公告)日：2007-01-04
申请号：US11138636
申请日：2005-05-25
申请人： Martin Murphy , John Schullek , John Ward , Gary Look , Brian Siesel
发明人： Martin Murphy , John Schullek , John Ward , Gary Look , Brian Siesel
IPC分类号： A61K31/55 , A61K31/53 , A61K31/497 , A61K31/506 , A61K31/4439 , C07D403/02
CPC分类号： C07D213/40 , C07C63/72 , C07C63/74 , C07C233/78 , C07C233/81 , C07C233/83 , C07C233/84 , C07C239/22 , C07C243/38 , C07C271/20 , C07C291/04 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07D207/14 , C07D211/26 , C07D213/75 , C07D213/77 , C07D217/26 , C07D239/42 , C07D239/47 , C07D241/20 , C07D277/18 , C07D285/135 , C07D295/13 , C07D317/66 , C07D401/04
摘要： The present invention provides compounds that are effective against inhibiting topoisomerase (i.e., topoisomerase I and/or topoisomerase II). These compounds are used for treating cell-proliferative disorders. In some instances, these compounds have anticancer activity, e.g., against multi-drug resistant cancers.
摘要翻译：本发明提供了有效抵抗拓扑异构酶（即拓扑异构酶I和/或拓扑异构酶II）的化合物。这些化合物用于治疗细胞增殖性疾病。在一些情况下，这些化合物具有抗癌活性，例如抗多药耐药性癌症。

2. 发明申请

US20060035932A1 N-aryl piperidine compounds 审中-公开
标题翻译： N-芳基哌啶化合物
公开(公告)号：US20060035932A1
公开(公告)日：2006-02-16
申请号：US11138618
申请日：2005-05-25
申请人： Martin Murphy , John Schullek , John Ward , Gary Look , Rama Jain , Laurence Lee
发明人： Martin Murphy , John Schullek , John Ward , Gary Look , Rama Jain , Laurence Lee
IPC分类号： A61K31/4545 , C07D401/14 , C07D401/02
CPC分类号： C07D409/14 , C07D401/14 , C07D405/14
摘要： The present invention provides N-aryl piperidine compounds having antiinfective activity (i.e., antibacterial, antiviral), their compositions and methods of use. The compounds of the invention prevent the entry of HIV into host cells. More particularly, the compounds are effective at in inhibiting the binding interaction of HIV glycoprotein gp120 and the cell surface receptor CD4. The compounds can be used alone or in combination with other antivirals, antiinfectives, immunomodulators, or HIV entry inhibitors. More particularly, the invention relates to the prevention and treatment of HIV infectivity and AIDS.
摘要翻译：本发明提供具有抗感染活性的N-芳基哌啶化合物（即抗细菌，抗病毒），其组成和使用方法。本发明的化合物防止HIV进入宿主细胞。更具体地，这些化合物在抑制HIV糖蛋白gp120与细胞表面受体CD4的结合相互作用方面是有效的。化合物可以单独使用或与其它抗病毒药，抗感染剂，免疫调节剂或HIV进入抑制剂组合使用。更具体地说，本发明涉及艾滋病毒感染和艾滋病的预防和治疗。

3. 发明申请

US20120071513A1 Compositions and Their Use as Anti-Tumor Agents 审中-公开
标题翻译：组合物及其作为抗肿瘤剂的用途
公开(公告)号：US20120071513A1
公开(公告)日：2012-03-22
申请号：US13305103
申请日：2011-11-28
申请人： David Kanne , John Ward , Gary Look , X. Michael Wang , Diva Chan , Tina Lee , Donald R. James , Richard Gless , John Schullek , Charles Vacin
发明人： David Kanne , John Ward , Gary Look , X. Michael Wang , Diva Chan , Tina Lee , Donald R. James , Richard Gless , John Schullek , Charles Vacin
IPC分类号： A61K31/44 , C07D401/12 , C07D241/20 , A61P35/00 , C07D307/02 , C07D277/18 , C07D271/113 , A61K31/444 , C07D213/75 , C07D253/07
CPC分类号： C07D213/75 , C07C233/65 , C07C233/81 , C07D213/74 , C07D239/42 , C07D253/07
摘要： The present invention provides novel compounds and pharmaceutical compositions thereof, as well as methods for using the compounds and pharmaceutical compositions for treating tumors. Examples of specific tumor types that the compounds may be used to treat include, but are not limited to sarcomas, melanomas, neuroblastomas, carcinomas (including but not limited to lung, renal cell, ovarian, liver, bladder, and pancreatic carcinomas), and mesotheliomas.
摘要翻译：本发明提供新的化合物及其药物组合物，以及使用该化合物和药物组合物治疗肿瘤的方法。化合物可用于治疗的特定肿瘤类型的实例包括但不限于肉瘤，黑素瘤，成神经细胞瘤，癌（包括但不限于肺，肾细胞，卵巢，肝，膀胱和胰腺癌），以及间皮瘤

4. 发明申请

US20110178087A1 Compositions and Their Use as Anti-Tumor Agents 审中-公开
标题翻译：组合物及其作为抗肿瘤剂的用途
公开(公告)号：US20110178087A1
公开(公告)日：2011-07-21
申请号：US13076127
申请日：2011-03-30
申请人： David Kanne , John Ward , Gary Look , X. Michael Wang , Diva Chan , Tina Lee , Donald R. James , Richard Gless , John Schullek , Charles Vacin
发明人： David Kanne , John Ward , Gary Look , X. Michael Wang , Diva Chan , Tina Lee , Donald R. James , Richard Gless , John Schullek , Charles Vacin
IPC分类号： A61K31/5377 , C07C229/50 , C07D209/20 , C07C229/36 , C07D277/06 , C07C323/59 , C07D401/14 , C07D405/12 , C07D253/07 , C07D241/20 , C07D213/75 , C07D401/12 , C07D413/04 , C07D271/07 , A61K31/196 , A61K31/405 , A61K31/426 , A61K31/198 , A61K31/4545 , A61K31/472 , A61K31/53 , A61P35/00
CPC分类号： C07D213/75 , C07C233/65 , C07C233/81 , C07D213/74 , C07D239/42 , C07D253/07
摘要： The present invention provides novel compounds and pharmaceutical compositions thereof, as well as methods for using the compounds and pharmaceutical compositions for treating tumors. Examples of specific tumor types that the compounds may be used to treat include, but are not limited to sarcomas, melanomas, neuroblastomas, carcinomas (including but not limited to lung, renal cell, ovarian, liver, bladder, and pancreatic carcinomas), and mesotheliomas.
摘要翻译：本发明提供新的化合物及其药物组合物，以及使用该化合物和药物组合物治疗肿瘤的方法。化合物可用于治疗的特定肿瘤类型的实例包括但不限于肉瘤，黑素瘤，成神经细胞瘤，癌（包括但不限于肺，肾细胞，卵巢，肝，膀胱和胰腺癌），以及间皮瘤

5. 发明申请

US20090018145A1 Compositions and their use as anti-tumor agents 审中-公开
标题翻译：组合物及其作为抗肿瘤剂的用途
公开(公告)号：US20090018145A1
公开(公告)日：2009-01-15
申请号：US11664900
申请日：2005-10-18
申请人： David Kanne , John Ward , Gary Look , X. Michael Wang , Diva Chan , Tina Lee , Donald R. James , Richard Gless , John Schullek , Charles Vacin
发明人： David Kanne , John Ward , Gary Look , X. Michael Wang , Diva Chan , Tina Lee , Donald R. James , Richard Gless , John Schullek , Charles Vacin
IPC分类号： A61K31/44 , C07C229/50 , C07C229/36 , C07D209/18 , C07D277/04 , A61K31/426 , A61K31/4965 , C07D401/12 , A61K31/34 , A61K31/506 , A61K31/444 , A61K31/42 , C07D401/14 , C07D405/12 , C07D213/72 , A61K31/4545
CPC分类号： C07D213/75 , C07C233/65 , C07C233/81 , C07D213/74 , C07D239/42 , C07D253/07
摘要： The present invention provides novel compounds and pharmaceutical compositions thereof, as well as methods for using the compounds and pharmaceutical compositions for treating tumors. Examples of specific tumor types that the compounds may be used to treat include, but are not limited to sarcomas, melanomas, neuroblastomas, carcinomas (including but not limited to lung, renal cell, ovarian, liver, bladder, and pancreating carcinomas) and mesotheliomas.
摘要翻译：本发明提供新的化合物及其药物组合物，以及使用该化合物和药物组合物治疗肿瘤的方法。化合物可用于治疗的特定肿瘤类型的实例包括但不限于肉瘤，黑素瘤，成神经细胞瘤，癌（包括但不限于肺，肾细胞，卵巢，肝，膀胱和胰腺癌）和间皮瘤。

6. 发明申请

US20060254938A1 Baseball bat game storage package/container 审中-公开
标题翻译：棒球蝙蝠游戏存储包/容器
公开(公告)号：US20060254938A1
公开(公告)日：2006-11-16
申请号：US11130383
申请日：2005-05-16
申请人： John Ward , John Ward
发明人： John Ward , John Ward
IPC分类号： B65D85/20
CPC分类号： B65D81/365
摘要： A baseball bat and batting donut weight storage/package container made through one or more, or a combination of processes of blown plastic molding, plastic injection molding, spun aluminum or a machined process in multiple pieces that screw together to form one container with multiple storage areas.
摘要翻译：通过一次或多次制成的棒球棒和打棒甜甜圈重量储存/包装容器，或吹塑塑料成型，塑料注射成型，纺丝铝或多个加工过程的多个部件的过程组合在一起形成一个具有多个容器的容器地区

7. 发明授权

US08631817B2 Central vacuum inlet valve assembly 有权
标题翻译：中央真空入口阀总成
公开(公告)号：US08631817B2
公开(公告)日：2014-01-21
申请号：US12759994
申请日：2010-04-14
申请人： James Mantyla , Andrew Bird , John Ward
发明人： James Mantyla , Andrew Bird , John Ward
IPC分类号： F16L5/00
CPC分类号： A47L5/38 , A47L9/246 , Y10T137/698
摘要： A subassembly for use in a vacuum inlet valve assembly for a central vacuum system, the subassembly having a valve body with a wiring compartment and at least one press connection detent means and a reversible mounting flange for connecting to the valve body. The mounting flange includes an attachment portion, a mounting flange wall sized and shaped to cover an open side of wiring compartment and press catch connection elements sized and shaped to interact with the detent to secure the mounting flange to the valve body. Also disclosed is a vacuum inlet valve assembly comprising the above subassembly in combination with a cover plate having a rectangular door, a hinge located on a long side of the rectangular door, and a face plate with a vacuum connection opening. In an alternate embodiment the valve body includes a perimeter wall, attachment openings internal but adjacent to said perimeter wall and a snap fit cover to close an open wall of a wiring compartment.
摘要翻译：一种用于中央真空系统的真空入口阀组件的子组件，所述子组件具有带有配线室的阀体和至少一个压力连接止动装置和用于连接到阀体的可逆安装凸缘。安装凸缘包括附接部分，安装凸缘壁，其大小和形状以覆盖布线室的开口侧，并且压配合连接元件的尺寸和形状与止动件相互作用以将安装凸缘固定到阀体。还公开了一种真空入口阀组件，其包括上述子组件与具有矩形门的盖板，位于矩形门的长边上的铰链和具有真空连接开口的面板组合。在替代实施例中，阀体包括周边壁，内部但邻近所述周边壁的附接开口和用于封闭配线室的敞开壁的卡扣配合盖。

8. 发明授权

US08343901B2 Lubricating composition containing multifunctional hydroxylated amine salt of a hindered phenolic acid 有权
标题翻译：含有受阻酚酸的多官能羟基化胺盐的润滑组合物
公开(公告)号：US08343901B2
公开(公告)日：2013-01-01
申请号：US12902729
申请日：2010-10-12
申请人： Yat Fan Suen , John Ward , Trevor Miller
发明人： Yat Fan Suen , John Ward , Trevor Miller
IPC分类号： C10M139/00 , C10M159/12 , C07C59/00
CPC分类号： C10M133/04 , C10M133/08 , C10M141/06 , C10M2203/1025 , C10M2207/028 , C10M2207/10 , C10M2207/126 , C10M2207/128 , C10M2207/16 , C10M2207/289 , C10M2215/04 , C10M2215/042 , C10M2215/064 , C10M2215/28 , C10M2219/046 , C10M2219/068 , C10M2223/045 , C10N2230/06 , C10N2230/10 , C10N2230/54 , C10N2240/10 , C10N2240/102 , C10N2210/02 , C10N2210/06 , C10N2260/14
摘要： Multi-functional additives which impart improved antioxidancy to lubricating oil compositions and frictional properties resulting in improved fuel economy in an internal combustion engine are disclosed. More particularly disclosed are lubricating oil compositions for internal combustion engines comprising a) a major amount of an oil of lubricating viscosity; and b) a minor amount of an oil soluble hydroxylated amine salt of a hindered phenolic acid, said salt having the general formula I: wherein A and Q are each independently C2-C6 alkylene group; R is methyl, alkyl or alkenyl group having C2-C24 carbon atoms; Y is hydrogen, C1-C6 alkyl group or A-OH; x is an integer of 1 or 2; and z is an integer of 0 or 1.
摘要翻译：公开了赋予润滑油组合物更好的抗氧化性和摩擦特性的多功能添加剂，从而在内燃机中提高了燃油经济性。更具体地公开了用于内燃机的润滑油组合物，其包含：a）主要量的润滑粘度的油; 和b）少量的受阻酚酸的油溶性羟基化胺盐，所述盐具有通式I：其中A和Q各自独立地为C 2 -C 6亚烷基; R是甲基，具有C 2 -C 24碳原子的烷基或烯基; Y是氢，C 1 -C 6烷基或A-OH; x是1或2的整数; z为0或1的整数。

9. 发明申请

US20120322702A1 LUBRICATING COMPOSITION CONTAINING MULTIFUNCTIONAL BORATED HYDROXYLATED AMINE SALT OF A HINDERED PHENOLIC ACID 审中-公开
标题翻译：含有多官能硼酸羟基磺酸盐的苯酚组合物的润滑组合物
公开(公告)号：US20120322702A1
公开(公告)日：2012-12-20
申请号：US13599952
申请日：2012-08-30
申请人： Yat Fan Suen , John Ward , Trevor Miller
发明人： Yat Fan Suen , John Ward , Trevor Miller
IPC分类号： C10M139/00 , C07F5/02
CPC分类号： C07C59/52 , C07F5/025 , C10M139/00 , C10M159/12 , C10M2207/026 , C10M2207/028 , C10M2207/289 , C10M2215/042 , C10M2215/064 , C10M2215/28 , C10M2219/046 , C10M2223/045 , C10N2230/06 , C10N2240/10 , C10N2240/102 , C10N2260/14 , C10N2210/02
摘要： Multi-functional additives which impart improved antioxidancy to lubricating oil compositions and frictional properties resulting in improved fuel economy in an internal combustion engine are disclosed. More particularly disclosed is a boron containing salt of an oil soluble hydroxylated amine and a hindered phenolic acid product prepared by: a) reacting an oil soluble hydroxylated amine of the general formula II: wherein A at each occurrence is each independently C2-C6 alkylene group; R is methyl or an alkyl or alkenyl group having C2-C24 carbon atoms; Y is hydrogen, C1-C6 alkyl group or A-OH; x is an integer of 1 or 2; and z is an integer of 0 or 1; with a boron containing compound under reactive conditions; and b) mixing the reaction product of step a) with a hindered phenolic acid.
摘要翻译：公开了赋予润滑油组合物更好的抗氧化性和摩擦特性的多功能添加剂，从而在内燃机中提高了燃油经济性。更具体地公开了通过以下方法制备的油溶性羟基化胺和受阻酚酸产物的含硼盐：a）使通式II的油溶性羟基化胺反应：其中A在每次出现时各自独立地为C 2 -C 6亚烷基 ; R是甲基或具有C 2 -C 24碳原子的烷基或烯基; Y是氢，C 1 -C 6烷基或A-OH; x是1或2的整数; z为0或1的整数; 在反应条件下含硼化合物; 和b）将步骤a）的反应产物与受阻酚酸混合。

10. 发明申请

US20120102208A1 MULTI-LAYER STACK PLATFORM FOR CLOUD COMMUNICATIONS 有权
标题翻译：云层多层通信平台
公开(公告)号：US20120102208A1
公开(公告)日：2012-04-26
申请号：US13014919
申请日：2011-01-27
申请人： John Ward , Haydar Haba
发明人： John Ward , Haydar Haba
IPC分类号： G06F15/16
CPC分类号： H04L65/4053 , H04L45/308 , H04M3/4228 , H04M7/006 , H04M7/12 , H04M2203/158
摘要： A multi-layer stack platform is provided for cloud communication connections and services between devices. The system includes three or more layers, including a directory component, an applications component, and a peering component. An interconnection component may also be provided for communication between the applications component and the peering component. The components operate to provide communication services, such as sessions, according to the functionality of a selected application by adhering to device, user, and routing rules and preferences. The device, user, and routing rules and preferences are maintained in and processed by the directory component. The applications component receives communication session requests and accesses corresponding application scripts to perform the requested session. The peering component receives the device, user, and routing rules and preferences, and establishes connection between devices based on the rules and preferences as defined by the directory component.
摘要翻译：提供了多层堆栈平台，用于云端通信连接和设备之间的服务。该系统包括三个或更多层，包括目录组件，应用程序组件和对等组件。还可以提供互连部件用于应用组件和对等部件之间的通信。这些组件通过遵守设备，用户和路由规则和偏好来操作以根据所选应用的功能来提供通信服务，例如会话。设备，用户和路由规则和首选项由目录组件维护和处理。应用程序组件接收通信会话请求并访问相应的应用程序脚本以执行请求的会话。对等组件接收设备，用户和路由规则和偏好，并根据目录组件定义的规则和首选项建立设备之间的连接。

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