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1. 发明申请

US20060079674A1 Contraceptive targets 审中-公开
标题翻译：避孕目标
公开(公告)号：US20060079674A1
公开(公告)日：2006-04-13
申请号：US10965103
申请日：2004-10-14
申请人： Martin Matzuk , Yuchen Bai , Pei Wang , Xuemei Wu
发明人： Martin Matzuk , Yuchen Bai , Pei Wang , Xuemei Wu
IPC分类号： C07K14/575 , C07K16/26 , C07H21/02 , C12P21/06
CPC分类号： C07K16/18 , C07K14/47
摘要： The present invention relates generally to ovary-specific genes (O1-180, O1-184 and O1-236) and the proteins they encode. Also provided are methods for detecting cell proliferative or degenerative disorders in reproductive tissues. Yet further, the invention provides methods for scrounge of compounds that interact and/or modulate the expression or activity of the ovary-specific genes. These compounds are possible contraceptive agents and/or fertility agents.
摘要翻译：本发明一般涉及卵巢特异性基因（O1-180，O1-184和O1-236）及其编码的蛋白质。还提供了用于检测生殖组织中细胞增殖或退行性疾病的方法。此外，本发明提供了相互作用和/或调节卵巢特异性基因的表达或活性的化合物的切割方法。这些化合物是可能的避孕药和/或生育剂。

2. 发明申请

US20060069243A1 Ovary-specific genes and proteins 失效
标题翻译：子宫特异性基因和蛋白质
公开(公告)号：US20060069243A1
公开(公告)日：2006-03-30
申请号：US11270717
申请日：2005-11-09
申请人： Martin Matzuk , Pei Wang
发明人： Martin Matzuk , Pei Wang
IPC分类号： C07K14/72 , C07K14/575 , C07H21/04 , C12N1/21 , C12N15/74
CPC分类号： C07K14/47
摘要： Ovary specific proteins O1 180, O1 184 and O1 236, polynucleotides encoding them, antibodies which are immunoreactive with them and vectors and host cells containing O1 180, O1 184 or O1 236 are provided. Also provided are methods for detecting cell proliferative or degenerative disorders of ovarian origin and which are associated with O1 180, O1 184 or O1 236. Further provided are methods for the evaluation of potential contraceptives using the proteins of the invention, as well as methods for the screening for genetic mutations in signaling pathways that are associated with some forms of human infertility or gynecological cancers, also using the proteins/mRNAs/genes of the invention. The proteins/mRNAs/genes of the invention may also be used as markers for identifying primary and metastatic neoplasms of ovarian origin and as indicators of developmental anomalies in prenatal screening procedures. Furthermore, assays of the proteins/mRNAs/genes of the invention can be used in diagnostic assays for detecting forms of infertility and other diseases, including germ cell tumors and polycystic ovary syndrome. The proteins of the invention may be useful targets for in vitro fertilization procedures or in enhancing the number of eggs that can be retrieved from the human donor, e.g., in enhancing the success rate.
摘要翻译：卵巢特异性蛋白O1 180，O184和O1 236，编码它们的多核苷酸，与它们免疫反应的抗体和载体以及含有O1 180，O184或O1 236的宿主细胞。还提供了用于检测卵巢起源的细胞增殖性或退行性病症的方法，其与O1 180，O1 184或O1 236相关。还提供了使用本发明的蛋白质评估潜在避孕药物的方法，以及用于筛选与某些形式的人类不育症或妇科癌症相关的信号通路中的基因突变，也使用本发明的蛋白质/ mRNAs /基因。本发明的蛋白质/ mRNAs /基因也可用作识别卵巢原发性和转移性肿瘤的标志物，以及作为产前筛查程序发育异常的指标。此外，本发明的蛋白质/ mRNA /基因的测定可用于检测不育症和其他疾病形式的诊断测定，包括生殖细胞肿瘤和多囊卵巢综合征。本发明的蛋白质可以是体外受精程序的有用靶标，或增强可从人类供体获取的卵数，例如提高成功率。

3. 发明申请

US20120268408A1 METHOD AND TERMINAL FOR DISPLAYING PICTURE/INTERFACE 有权
标题翻译：用于显示图像/界面的方法和终端
公开(公告)号：US20120268408A1
公开(公告)日：2012-10-25
申请号：US13541450
申请日：2012-07-03
申请人： Zhigang Chen , Pei Wang
发明人： Zhigang Chen , Pei Wang
IPC分类号： G06F3/041
CPC分类号： H04M1/72544 , G06F3/0414 , G06F3/0488 , G06F2203/04806
摘要： A method for displaying a picture/interface on a screen of a terminal comprises obtaining relevant information on a pressure, when the pressure is detected to be applied on the screen, obtaining a corresponding display mode according to the relevant information on the pressure, and displaying the picture/interface according to the display mode. The terminal may adjust the display mode automatically according to the pressure applied on the screen of the terminal by the user, with strong real-time property, simplifying the operations by the user on the terminal and improving the user's experience.
摘要翻译：一种用于在终端屏幕上显示图像/界面的方法包括获取有关压力的相关信息，当检测到压力被施加在屏幕上时，根据关于压力的相关信息获得相应的显示模式，并且显示图片/界面根据显示模式。终端可以根据用户屏幕上施加的压力自动调整显示模式，实时性强，简化了用户对终端的操作，提高了用户体验。

4. 发明授权

US08084222B2 Methods for generating host cells 有权
标题翻译：生成宿主细胞的方法
公开(公告)号：US08084222B2
公开(公告)日：2011-12-27
申请号：US12507051
申请日：2009-07-21
申请人： Cheng Liu , Jingyi Xiang , Su Yan , Pei Wang , Wei Chan Tai
发明人： Cheng Liu , Jingyi Xiang , Su Yan , Pei Wang , Wei Chan Tai
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C07K16/18 , C07K2317/73 , C07K2317/732 , C12N9/1048 , C12P21/005
摘要： The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value.
摘要翻译：本公开提供包含产生具有变体糖基化模式的糖蛋白的细胞的组合物和方法。所述方法和组合物可用于产生具有治疗价值的抗体和蛋白质。

5. 发明授权

US08080415B2 Modified host cells and uses thereof 有权
标题翻译：修饰的宿主细胞及其用途
公开(公告)号：US08080415B2
公开(公告)日：2011-12-20
申请号：US12507046
申请日：2009-07-21
申请人： Cheng Liu , Jingyi Xiang , Su Yan , Pei Wang , Wei Chan Tai
发明人： Cheng Liu , Jingyi Xiang , Su Yan , Pei Wang , Wei Chan Tai
IPC分类号： C12M1/00
CPC分类号： C07K16/18 , C07K2317/73 , C07K2317/732 , C12N9/1048 , C12P21/005
摘要： The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value.
摘要翻译：本公开提供包含产生具有变体糖基化模式的糖蛋白的细胞的组合物和方法。所述方法和组合物可用于产生具有治疗价值的抗体和蛋白质。

6. 发明授权

US06995251B1 Ovary-specific genes and proteins 失效
标题翻译：子宫特异性基因和蛋白质
公开(公告)号：US06995251B1
公开(公告)日：2006-02-07
申请号：US09830810
申请日：1999-10-28
申请人： Martin M. Matzuk , Pei Wang
发明人： Martin M. Matzuk , Pei Wang
IPC分类号： C07H21/00
摘要： Ovary-specific proteins O1-180, O1-184 and O1-236, polynucleotides encoding them, antibodies which are immunoreactive with them and vectors and host cells containing O1-180, O1-184 or O1-236 are provided. Also provided are methods for detecting cell proliferative or degenerative disorders of ovarian origin and which are associated with O1-180, O1-184 or O1-236. Further provided are methods for the evaluation of potential contraceptives using the proteins of the invention, as well as methods for the screening for genetic mutations in signaling pathways that are associated with some forms of human infertility or gynecological cancers, also using the proteins/mRNAs/genes of the invention. The proteins/mRNAs/genes of the invention may also be used as markers for identifying primary and metastatic neoplasms of ovarian origin and as indicators of developmental anomalies in prenatal screening procedures. Furthermore, assays of the proteins/mRNAs/genes of the invention can be used in diagnostic assays for detecting forms of infertility and other diseases, including germ cell tumors and polycystic ovary syndrome. The proteins of the invention may be useful targets for in vitro fertilization procedures or in enhancing the number of eggs that can be retrieved from the human donor, e.g., in enhancing the success rate.
摘要翻译：提供卵巢特异性蛋白质O1-180，O1-184和O1-236，编码它们的多核苷酸，与它们免疫反应的抗体和载体以及含有O1-180，O1-184或O1-236的宿主细胞。还提供了用于检测卵巢起源的细胞增殖或退行性疾病的方法，其与O1-180，O1-184或O1-236相关。还提供了使用本发明的蛋白质评价潜在的避孕药物的方法，以及用于筛选与某些形式的人类不育症或妇科癌症相关的信号通路中的遗传突变的方法，也使用蛋白质/ mRNAs / 本发明的基因。本发明的蛋白质/ mRNAs /基因也可用作识别卵巢原发性和转移性肿瘤的标志物，以及作为产前筛查程序发育异常的指标。此外，本发明的蛋白质/ mRNA /基因的测定可用于检测不育症和其他疾病形式的诊断测定，包括生殖细胞肿瘤和多囊卵巢综合征。本发明的蛋白质可以是体外受精程序的有用靶标，或增强可从人类供体获取的卵数，例如提高成功率。

7. 发明申请

US20060005950A1 Structure of heat conductive plate 失效
公开(公告)号：US20060005950A1
公开(公告)日：2006-01-12
申请号：US10883709
申请日：2004-07-06
申请人： Chin Wang , Pei Wang , Ching Wang
发明人： Chin Wang , Pei Wang , Ching Wang
IPC分类号： F28D15/00
CPC分类号： H01L23/427 , F28D15/0233 , F28D15/046 , H01L2924/0002 , H01L2924/00
摘要： A heat conductive plate includes a hollow case and a plurality of grooves respectively formed on the inner top wall and the inner bottom wall of the case. In addition, a plurality of supporting members are positioned in the case by way of powder sintering, wherein each surface of the supporting members has a porous wick structure formed thereon. Thus, the case can be sustained by the supports with each wick structure firmly mounted in the grooves of the inner walls thereof. When performing heat transferring, the working fluid is heated to be formed as vapor by the electronic element mounted on the outer bottom surface so as to flow toward the inner top surface of the case. The working fluid is then cooled to be liquid again to be absorbed by the wick structures of the supporting members and be transported toward the inner bottom of the case.

8. 发明申请

US20050087327A1 Supporting structure for planar heat pipe 失效
标题翻译：平面热管支撑结构
公开(公告)号：US20050087327A1
公开(公告)日：2005-04-28
申请号：US10691510
申请日：2003-10-24
申请人： Chin Wang , Pei Wang , Ching Wang
发明人： Chin Wang , Pei Wang , Ching Wang
IPC分类号： F28D15/04 , H01L23/427 , F28D15/00
CPC分类号： F28D15/046 , F28F2225/02 , F28F2255/18 , H01L23/427 , H01L2924/0002 , H01L2924/00
摘要： An improved supporting structure for a planar heat pipe, having a housing and a supporting member installed in the shell is disclosed. The housing has an upper lid and a lower lid engaged with each other to form a hollow chamber therein. The hollow chamber is filled with a working fluid. The supporting member is a planar member perforated with a plurality of holes. The supporting member is sintered with the upper and lower lids in the hollow chamber. Therefore, the housing and the supporting member are integrated together.
摘要翻译：公开了一种用于平面热管的改进的支撑结构，其具有壳体和安装在壳体中的支撑构件。壳体具有彼此接合以在其中形成中空室的上盖和下盖。中空室填充有工作流体。支撑构件是穿孔有多个孔的平面构件。支撑构件与中空室中的上盖和下盖烧结。因此，壳体和支撑构件被集成在一起。

9. 发明授权

US06680174B1 Assay for growth differentiation factor 9 失效
标题翻译：生长分化因子9的测定
公开(公告)号：US06680174B1
公开(公告)日：2004-01-20
申请号：US09283909
申请日：1999-04-01
申请人： Martin M. Matzuk , Julia A. Elvin , Pei Wang
发明人： Martin M. Matzuk , Julia A. Elvin , Pei Wang
IPC分类号： G01N33567
CPC分类号： G01N33/74 , G01N33/689 , G01N2333/475
摘要： The present invention relates to a method of identifying an agent which alters (inhibits, enhances) activity of GDF-9. The method involves combining cells having a receptor for GDF-9 and a gene, wherein expression of the gene is regulated by binding of GDF-9 to the receptor; GDF-9; and an agent to be assessed. The combination produced is maintained under conditions appropriate for binding of GDF-9 to the receptors on the cells. The extent to which binding of GDF-9 to the receptors on the cells occurs is then determined, wherein binding of GDF-9 to the receptor to a lesser or greater extent in the presence of the agent to be assessed than in its absence, is indicative of an agent which alters GDF-9 activity.
摘要翻译：本发明涉及鉴定改变（抑制，增强）GDF-9活性的试剂的方法。该方法包括组合具有GDF-9受体的细胞和基因，其中基因的表达通过GDF-9与受体的结合来调节; GDF-9; 和待评估的代理人。产生的组合保持在适合于将GDF-9与细胞上的受体结合的条件下。然后确定GDF-9与细胞上的受体结合发生的程度，其中在待评估的试剂存在下，GDF-9与受体的结合程度要比在不存在的情况下更小或更大程度地结合，表明改变GDF-9活动的药剂。

10. 发明授权

US10342852B2 Methods of reducing blood glucose or triglyceride levels by administration of METRNL protein 有权
公开(公告)号：US10342852B2
公开(公告)日：2019-07-09
申请号：US15729420
申请日：2017-10-10
申请人： Chaoyu Miao , Zhiyong Li , Pei Wang
发明人： Chaoyu Miao , Zhiyong Li , Pei Wang
IPC分类号： A61K38/19 , C07K14/52 , A61K38/22 , A23L33/17 , A61K39/00 , C07K14/475
摘要： The present invention provides an application of Metrnl protein in preparing a hypolipidemic, hypoglycemic medicine or dietary supplement. The present invention further provides a method for preparing a mouse with fat-specific overexpression of Metrnl.

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